ZRdb KZFP & Repeats
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Human_ZNF658

  • Protein
    Zinc finger protein 658
  • Length
    1059
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5TYW1
  • NCBI_ID
    26149
Sequence:
MNMSQASVSFQDVTVEFTREEWQHLGPVERTLYRDVMLENYSHLISVGYCITKPKVISKLEKGEEPWSLEDEFLNQRYPGYFKVDHIKGIREKQEKPLWQEIFISDADKTLSKEGQKVLEKPFNLEIAPELSEKISCKCDSHRMNLPVASQLIISERKYSRKKTEYMNVCEKLQLDIKHEKAHAEEKSYEHGENAKAFSYKKDQHWKFQTLEESFECDGSGQGLYDKTICITPQSFLTGEKSCKDDEFRKNFDKITLFNHMRTDTRGKCSDLNEYGTSCDKTTAVEYNKVHMAMTHYECNERGINFSRKSPLTQSQRTITGWSAFESNKCEENFSQSSAHIVHQKTQAGDKFGEHNECTDALYQKLDFTAHQRIHTEDKFYLSDEHGKCRKSFYRKAHLIQHQRPHSGEKTYQYEECAKSFCSSSHPIQHPGTYVGFKLYECNECGKAFCQNSNLSKHLRIHTKEKPCDNNGCGRSYKSPLIGHQKTDAEMELCGGSEYGKTSHLKGHQRILMGEKPYECIECGKTFSKTSHLRAHQRIHTGEKPYECVECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEKPYECSDCEKTFAHNSALRAHHRIHTGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYECNECGRSFTYNSALRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQRIHTGEKPYECNECEKTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFSQKSYLSGHERIHTGEKPYECNVCGKTFVYKAALIVHQRIHTGEKPYECNQCGKTFSQRTHLCAHQRIHTGEKPYECNECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAHLRTRSGEKPYECSECGKTFSEKSYVSAHQRVHTGEKPYECNVCGKPFAHNSTLRVHQRIHTGEKSYECNDCGKTFSQKSHLSAHQRIHTGEKPYECNECGKAFAQNSTLRVHQRIHTGEKPYECDECGKTFVRKAALRVHHTRMHTREKTLACNGFGKS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 dec2h2 325..347
3 dec2h2 352..375
4 dec2h2 381..406
5 dec2h2 412..434
6 C2h2 440..462
7 C2h2 518..540
8 C2h2 546..568
9 C2h2 574..596
10 C2h2 602..624
11 C2h2 630..652
12 C2h2 658..680
13 C2h2 686..708
14 C2h2 714..736
15 C2h2 742..764
16 C2h2 770..792
17 C2h2 798..820
18 C2h2 826..848
19 C2h2 854..876
20 dec2h2 882..904
21 C2h2 910..932
22 C2h2 938..960
23 C2h2 966..988
24 C2h2 994..1016
25 C2h2 1022..1045
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Molecular Function transcription cis-regulatory region binding
6 Biological Process cellular response to zinc ion
7 Biological Process negative regulation of DNA-templated transcription
8 Biological Process regulation of transcription by RNA polymerase II
9 Biological Process ribosome biogenesis
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 17 n.s 74.0 Weakly correlated
2 LTR10F 16 **** 28.9 Weakly correlated
3 LTR8 12 **** 43.0 Weakly correlated
4 AluSp 10 n.s 74.0 Weakly correlated
5 L1P3 9 *** 74.0 Weakly correlated
6 LTR10A 9 **** 28.9 Weakly correlated
7 AluYj4 7 **** 0.0 Weakly correlated
8 MER4-int 7 *** 74.0 Weakly correlated
9 MIRb 7 n.s 99.0 Highly correlated
10 L1MC4 7 n.s 99.0 Highly correlated
11 AluSc8 6 n.s 74.0 Weakly correlated
12 AluSg 5 n.s 74.0 Weakly correlated
13 L2c 5 n.s 99.0 Highly correlated
14 L2a 5 n.s 99.0 Highly correlated
15 AluY 5 n.s 74.0 Weakly correlated
16 L1MEd 4 n.s 99.0 Highly correlated
17 HAL1 4 n.s 99.0 Highly correlated
18 MLT1B 4 n.s 99.0 Highly correlated
19 PRIMA4-int 4 **** 74.0 Weakly correlated
20 AluJo 4 n.s 74.0 Weakly correlated
21 AluSx1 4 n.s 74.0 Weakly correlated
22 AluSz6 4 n.s 74.0 Weakly correlated
23 AluYa5 4 ** 15.2 Weakly correlated
24 HERV17-int 3 ** 28.9 Weakly correlated
25 AluSq2 3 n.s 74.0 Weakly correlated
26 L1MB8 3 n.s 99.0 Highly correlated
27 L1MC1 3 n.s 99.0 Highly correlated
28 AluJr4 3 n.s 74.0 Weakly correlated
29 AluSx 2 n.s 74.0 Weakly correlated
30 LTR18A 2 **** 43.0 Weakly correlated
31 L2 2 n.s 99.0 Highly correlated
32 FRAM 2 n.s 74.0 Weakly correlated
33 L1PA5 2 n.s 19.6 Weakly correlated
34 L1PA2 2 n.s 15.2 Weakly correlated
35 AluSq 2 n.s 74.0 Weakly correlated
36 L1ME2z 2 n.s 99.0 Highly correlated
37 L1ME1 2 n.s 99.0 Highly correlated
38 AluJr 2 n.s 74.0 Weakly correlated
39 MLT1C 2 n.s 94.0 Weakly correlated
40 MLT1J1 2 n.s 99.0 Highly correlated
41 L1MA5 2 n.s 87.0 Weakly correlated
42 L1M4 2 n.s 99.0 Highly correlated
43 L1PB4 1 n.s 99.0 Highly correlated
44 LTR16C 1 n.s 99.0 Highly correlated
45 MSTA 1 n.s 43.0 Weakly correlated
46 MLT1L 1 n.s 99.0 Highly correlated
47 LTR76 1 ** 74.0 Weakly correlated
48 MLT1K 1 n.s 99.0 Highly correlated
49 MLT1J2 1 n.s 99.0 Highly correlated
50 MLT1H 1 n.s 99.0 Highly correlated
51 LTR81 1 ** 99.0 Highly correlated
52 MER4A 1 * 74.0 Weakly correlated
53 MIR 1 n.s 99.0 Highly correlated
54 MLT1A 1 n.s 99.0 Highly correlated
55 AluYa8 1 *** 15.2 Weakly correlated
56 ERVL-int 1 n.s 99.0 Highly correlated
57 HAL1b 1 n.s 99.0 Highly correlated
58 HERVH48-int 1 * 28.9 Weakly correlated
59 HERVIP10FH-int 1 n.s 28.9 Weakly correlated
60 L1M3 1 n.s 99.0 Highly correlated
61 L1MA9 1 n.s 99.0 Highly correlated
62 L1MB3 1 n.s 99.0 Highly correlated
63 L1MB7 1 n.s 99.0 Highly correlated
64 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
65 LTR10B1 1 ** 28.9 Weakly correlated
66 L1MEg 1 n.s 99.0 Highly correlated
67 L1MEg2 1 * 99.0 Highly correlated
68 L1P1 1 n.s 19.6 Weakly correlated
69 L1P4 1 n.s 74.0 Weakly correlated
70 L1PA14 1 n.s 74.0 Weakly correlated
71 L1PA4 1 n.s 19.6 Weakly correlated
72 L2b 1 n.s 99.0 Highly correlated
73 AluSx3 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10F 3 **** 28.9 Weakly correlated
2 L1PA2 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP