ZRdb KZFP & Repeats
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Human_ZNF649

  • Protein
    Zinc finger protein 649
  • Length
    505
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q9BS31
  • NCBI_ID
    65251
Sequence:
MTKAQESLTLEDVAVDFTWEEWQFLSPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKLEQGEPLWTLEDEIHSPAHPEIEKADDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQSRRYNRKEPAEFNGDGAFLHDNHEQMPTEIEFPESRKPISTKSQFLKHQQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEKPHGCSLCGKAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFSRKSLLVVHQRTHTGEKPHTCSECGKGFIQKGNLNIHQRTHTGEKPYGCIDCGKAFSQKSCLVAHQRYHTGKTPFVCPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVHHRTHTGERPYGCDECEKAYFYMSCLVKHKRIHSREKRGDSVKVENPSTASHSLSPSEHVQGKSPVNMVTVAMVAGQCEFAHILHS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 178..200
3 C2h2 206..228
4 C2h2 234..256
5 C2h2 262..284
6 C2h2 290..312
7 C2h2 318..340
8 C2h2 346..368
9 C2h2 374..396
10 C2h2 402..424
11 C2h2 430..452
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component extracellular space
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA3 928 **** 19.6 Weakly correlated
2 L1PA4 900 **** 19.6 Weakly correlated
3 L1PA5 683 **** 19.6 Weakly correlated
4 L1PA2 249 **** 15.2 Weakly correlated
5 L1PA6 244 **** 28.9 Highly correlated
6 L1P1 216 **** 19.6 Weakly correlated
7 L1P2 109 **** 28.9 Highly correlated
8 SVA_D 54 **** 15.2 Weakly correlated
9 LTR12C 47 **** 19.6 Weakly correlated
10 L1HS 31 **** 8.6 Weakly correlated
11 AluY 30 n.s 74.0 Weakly correlated
12 L1PA7 17 n.s 74.0 Weakly correlated
13 SVA_F 17 **** 0.0 Weakly correlated
14 SVA_B 15 **** 15.2 Weakly correlated
15 SVA_C 13 **** 15.2 Weakly correlated
16 AluSx1 12 n.s 74.0 Weakly correlated
17 AluSg 9 n.s 74.0 Weakly correlated
18 LTR12D 8 **** 19.6 Weakly correlated
19 SVA_E 8 **** 0.0 Weakly correlated
20 AluSp 7 n.s 74.0 Weakly correlated
21 L1P3 7 n.s 74.0 Weakly correlated
22 AluJb 6 n.s 74.0 Weakly correlated
23 SVA_A 6 **** 19.6 Weakly correlated
24 AluSx 5 n.s 74.0 Weakly correlated
25 AluSz 5 n.s 74.0 Weakly correlated
26 L2a 5 n.s 99.0 Weakly correlated
27 L2b 5 n.s 99.0 Weakly correlated
28 AluSc 4 n.s 74.0 Weakly correlated
29 AluSq2 4 n.s 74.0 Weakly correlated
30 L1PA8 4 n.s 74.0 Weakly correlated
31 LTR10A 4 **** 28.9 Highly correlated
32 AluYa5 3 n.s 15.2 Weakly correlated
33 AluYj4 3 * 0.0 Weakly correlated
34 AluYk4 3 ** 15.2 Weakly correlated
35 MIRb 3 n.s 99.0 Weakly correlated
36 Alu 2 ** 74.0 Weakly correlated
37 AluSc8 2 n.s 74.0 Weakly correlated
38 AluSg4 2 n.s 74.0 Weakly correlated
39 AluSq 2 n.s 74.0 Weakly correlated
40 AluSx4 2 n.s 74.0 Weakly correlated
41 AluYc 2 n.s 74.0 Weakly correlated
42 AluYm1 2 n.s 19.6 Weakly correlated
43 L1M4 2 n.s 99.0 Weakly correlated
44 L1M5 2 n.s 99.0 Weakly correlated
45 L1MA9 2 n.s 99.0 Weakly correlated
46 L1MB8 2 n.s 99.0 Weakly correlated
47 L1PA16 2 n.s 74.0 Weakly correlated
48 L2c 2 n.s 99.0 Weakly correlated
49 LTR1A2 2 * 43.0 Moderately correlated
50 MER41A 2 n.s 74.0 Weakly correlated
51 MER50 2 n.s 43.0 Moderately correlated
52 MER61A 2 ** 43.0 Moderately correlated
53 MIR 2 n.s 99.0 Weakly correlated
54 MIRc 2 n.s 99.0 Weakly correlated
55 MLT1C 2 n.s 94.0 Weakly correlated
56 MLT1L 2 n.s 99.0 Weakly correlated
57 THE1D-int 2 n.s 28.9 Highly correlated
58 AluSq10 1 n.s 74.0 Weakly correlated
59 AluSq4 1 n.s 74.0 Weakly correlated
60 AluSx3 1 n.s 74.0 Weakly correlated
61 AluSz6 1 n.s 74.0 Weakly correlated
62 AluYb8 1 n.s 15.2 Weakly correlated
63 AluYe5 1 n.s 74.0 Weakly correlated
64 AluYh3 1 n.s 15.2 Weakly correlated
65 AluYh9 1 *** 15.2 Weakly correlated
66 AluYk3 1 n.s 19.6 Weakly correlated
67 ERVL-E-int 1 n.s 99.0 Weakly correlated
68 FLAM_A 1 n.s 74.0 Weakly correlated
69 FRAM 1 n.s 74.0 Weakly correlated
70 L1M1 1 n.s 74.0 Weakly correlated
71 L1M2 1 n.s 99.0 Weakly correlated
72 L1M3 1 n.s 99.0 Weakly correlated
73 L1MA1 1 n.s 74.0 Weakly correlated
74 L1MA2 1 n.s 74.0 Weakly correlated
75 L1MA4A 1 n.s 87.0 Weakly correlated
76 L1MA8 1 n.s 87.0 Weakly correlated
77 L1MB4 1 n.s 99.0 Weakly correlated
78 L1MD 1 n.s 99.0 Weakly correlated
79 L1MD1 1 n.s 99.0 Weakly correlated
80 L1ME1 1 n.s 99.0 Weakly correlated
81 L1ME3E 1 n.s 99.0 Weakly correlated
82 L1ME4a 1 n.s 99.0 Weakly correlated
83 L1MEb 1 n.s 99.0 Weakly correlated
84 L1MEf 1 n.s 99.0 Weakly correlated
85 L1P4 1 n.s 74.0 Weakly correlated
86 L1PA13 1 n.s 74.0 Weakly correlated
87 L1PA14 1 n.s 74.0 Weakly correlated
88 L1PA15 1 n.s 74.0 Weakly correlated
89 L1PA15-16 1 n.s 74.0 Weakly correlated
90 L1PB1 1 n.s 74.0 Weakly correlated
91 L1PB3 1 n.s 74.0 Weakly correlated
92 L1PB4 1 n.s 99.0 Weakly correlated
93 LTR1 1 * 43.0 Moderately correlated
94 LTR12E 1 * 19.6 Weakly correlated
95 LTR13 1 n.s 19.6 Weakly correlated
96 LTR16C 1 n.s 99.0 Weakly correlated
97 LTR1C3 1 *** 43.0 Moderately correlated
98 LTR28B 1 * 43.0 Moderately correlated
99 LTR71B 1 * 43.0 Moderately correlated
100 LTR8A 1 n.s 43.0 Moderately correlated
101 MER39B 1 n.s 74.0 Weakly correlated
102 MER50-int 1 n.s 43.0 Moderately correlated
103 MER52A 1 n.s 74.0 Weakly correlated
104 MER52C 1 n.s 74.0 Weakly correlated
105 MER57C2 1 * 87.0 Weakly correlated
106 MER61-int 1 n.s 43.0 Moderately correlated
107 MER74C 1 ** 99.0 Weakly correlated
108 MER9a2 1 * 19.6 Weakly correlated
109 MLT1A0 1 n.s 99.0 Weakly correlated
110 MLT1D 1 n.s 99.0 Weakly correlated
111 MLT1F1 1 n.s 99.0 Weakly correlated
112 MLT1H 1 n.s 99.0 Weakly correlated
113 MLT1I 1 n.s 99.0 Weakly correlated
114 MLT1J1 1 n.s 99.0 Weakly correlated
115 MLT1K 1 n.s 99.0 Weakly correlated
116 MLT2A1 1 n.s 74.0 Weakly correlated
117 PRIMA41-int 1 n.s 74.0 Weakly correlated
118 THE1C 1 n.s 43.0 Moderately correlated
119 THE1C-int 1 n.s 43.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA3 920 **** 19.6 Weakly correlated
2 L1PA4 905 **** 19.6 Weakly correlated
3 L1PA5 680 **** 19.6 Weakly correlated
4 L1PA2 245 **** 15.2 Weakly correlated
5 L1PA6 239 **** 28.9 Highly correlated
6 L1P1 209 **** 19.6 Weakly correlated
7 L1P2 104 **** 28.9 Highly correlated
8 L1HS 30 **** 8.6 Weakly correlated
9 L1PA7 17 n.s 74.0 Weakly correlated
10 L1PA8 4 n.s 74.0 Weakly correlated
11 L1PA14 1 n.s 74.0 Weakly correlated
12 L1MB8 1 n.s 99.0 Weakly correlated
13 L1MA4A 1 n.s 87.0 Weakly correlated
14 L1ME1 1 n.s 99.0 Weakly correlated
15 L2a 1 n.s 99.0 Weakly correlated
16 LTR1C3 1 *** 43.0 Moderately correlated
17 L1PA16 1 n.s 74.0 Weakly correlated
18 L1MA9 1 n.s 99.0 Weakly correlated
19 L1PA8A 1 n.s 74.0 Weakly correlated
20 L1PA15 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP