ZRdb KZFP & Repeats
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Human_ZNF630

  • Protein
    Zinc finger protein 630
  • Length
    657
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q2M218
  • NCBI_ID
    57232
Sequence:
MIESQEPVTFEDVAVDFTQEEWQQLNPAQKTLHRDVMLETYNHLVSVGCSGIKPDVIFKLEHGKDPWIIESELSRWIYPDRVKGLESSQQIISGELLFQREILERAPKDNSLYSVLKIWHIDNQMDRYQGNQDRVLRQVTVISRETLTDEMGSKYSAFGKMFNRCTDLAPLSQKFHKFDSCENSLKSNSDLLNYNRSYARKNPTKRFRCGRPPKYNASCSVPEKEGFIHTGMEPYGDSQCEKVLSHKQAHVQYKKFQAREKPNVCSMCGKAFIKKSQLIIHQRIHTGEKPYVCGDCRKAFSEKSHLIVHQRIHTGEKPYECTKYGRAFSRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQRVHTREKPFECSECRKAFCEMSHLFIHQITHTGKKPYECTECGKTFPRKTQLIIHQRTHTGEKPYKCGECGKTFCQQSHLIGHQRIHTGEKPYVCTDCGKAFSQKSHLTGHQRLHTGEKPYMCTECGKSFSQKSPLIIHQRIHTGEKPYQCGECGKTFSQKSLLIIHLRVHTGEKPYECTECGRAFSLKSHLILHQRGHTGEKPYECSECGKAFCGKSPLIIHQKTHPREKTPECAESGMTFFWKSQMITYQRRHTGEKPSRCSDCGKAFCQHVYFTGHQNPYRKDTLYIC
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 263..285
3 C2h2 291..313
4 dec2h2 319..341
5 C2h2 347..369
6 C2h2 375..397
7 C2h2 403..425
8 C2h2 431..453
9 C2h2 459..481
10 C2h2 487..509
11 C2h2 515..537
12 C2h2 543..565
13 C2h2 571..593
14 dec2h2 599..621
15 dec2h2 627..649
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJr 4 n.s 74.0 Weakly correlated
2 LTR10A 4 **** 28.9 Weakly correlated
3 L1M5 3 n.s 99.0 Moderately correlated
4 AluYj4 2 *** 0.0 Weakly correlated
5 L1PA2 2 n.s 15.2 Weakly correlated
6 L1PA7 2 n.s 74.0 Weakly correlated
7 L1MCc 2 ** 99.0 Moderately correlated
8 L1PA14 2 * 74.0 Weakly correlated
9 FRAM 2 ** 74.0 Weakly correlated
10 L1PA10 2 n.s 74.0 Weakly correlated
11 AluY 2 n.s 74.0 Weakly correlated
12 MER21B 2 ** 99.0 Moderately correlated
13 AluJb 2 n.s 74.0 Weakly correlated
14 AluJo 2 n.s 74.0 Weakly correlated
15 L1P2 1 n.s 28.9 Weakly correlated
16 L1PA11 1 n.s 74.0 Weakly correlated
17 MLT1L 1 n.s 99.0 Moderately correlated
18 L1PA17 1 n.s 74.0 Weakly correlated
19 L1PA3 1 n.s 19.6 Weakly correlated
20 L1PB1 1 n.s 74.0 Weakly correlated
21 L1PB2 1 n.s 74.0 Weakly correlated
22 L1PB3 1 n.s 74.0 Weakly correlated
23 L1PREC2 1 n.s 43.0 Weakly correlated
24 LTR10B1 1 **** 28.9 Weakly correlated
25 L1MB4 1 n.s 99.0 Moderately correlated
26 AluJr4 1 n.s 74.0 Weakly correlated
27 AluSc8 1 n.s 74.0 Weakly correlated
28 AluSp 1 n.s 74.0 Weakly correlated
29 AluSz 1 n.s 74.0 Weakly correlated
30 AluYa5 1 * 15.2 Weakly correlated
31 FLAM_C 1 n.s 74.0 Weakly correlated
32 L1HS 1 n.s 8.6 Weakly correlated
33 L1M4 1 n.s 99.0 Moderately correlated
34 L1ME4a 1 n.s 99.0 Moderately correlated
35 L1MB5 1 n.s 99.0 Moderately correlated
36 L1MB7 1 n.s 99.0 Moderately correlated
37 L1MC 1 n.s 99.0 Moderately correlated
38 L1MD 1 n.s 99.0 Moderately correlated
39 L1MD1 1 n.s 99.0 Moderately correlated
40 L1MD2 1 n.s 99.0 Moderately correlated
41 L1ME2 1 n.s 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 1 ** 0.0 Weakly correlated
2 AluSc8 1 n.s 74.0 Weakly correlated
3 L1MD 1 n.s 99.0 Moderately correlated
4 L1PA10 1 n.s 74.0 Weakly correlated
5 AluJr 1 n.s 74.0 Weakly correlated
6 L1MC 1 n.s 99.0 Moderately correlated
7 AluY 1 n.s 74.0 Weakly correlated
8 AluYa5 1 * 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP