ZRdb KZFP & Repeats
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Human_ZNF627

  • Protein
    Zinc finger protein 627
  • Length
    461
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    87.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q7L945
  • NCBI_ID
    199692
Sequence:
MDSVAFEDVAVNFTLEEWALLDPSQKNLYRDVMRETFRNLASVGKQWEDQNIEDPFKIPRRNISHIPERLCESKEGGQGEETFSQIPDGILNKKTPGVKPCESSVCGEVGMGPSSLNRHIRDHTGREPNEYQEYGKKSYTRNQCGRALSYHRSFPVRERTHPGGKPYDCKECGETFISLVSIRRHMLTHRGGVPYKCKVCGKAFDYPSLFRIHERSHTGEKPYECKQCGKAFSCSSYIRIHERTHTGDKPYECKQCGKAFSCSKYIRIHERTHTGEKPYECKQCGKAFRCASSVRSHERTHTGEKLFECKECGKALTCLASVRRHMIKHTGNGPYKCKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHERIHTGEKPYKCTKCGKAFSRSSYFRIHERTHTGEKPYECKQCGKAFSRSTYFRVHEKIHTGEKPYENPNPNASVVPVLS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..80
2 C2h2 99..123
3 C2h2 167..189
4 C2h2 195..217
5 C2h2 223..245
6 C2h2 251..273
7 C2h2 279..301
8 C2h2 307..329
9 C2h2 335..357
10 C2h2 363..385
11 C2h2 391..413
12 C2h2 419..441
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 19 n.s 74.0 Highly correlated
2 AluJb 11 n.s 74.0 Highly correlated
3 AluSz 10 n.s 74.0 Highly correlated
4 AluSq2 10 n.s 74.0 Highly correlated
5 AluSx1 8 n.s 74.0 Highly correlated
6 AluSx 7 n.s 74.0 Highly correlated
7 AluSq 6 * 74.0 Highly correlated
8 AluJo 5 n.s 74.0 Highly correlated
9 AluSz6 5 n.s 74.0 Highly correlated
10 AluSg 5 n.s 74.0 Highly correlated
11 L2a 5 n.s 99.0 Weakly correlated
12 AluJr 5 n.s 74.0 Highly correlated
13 FLAM_A 4 ** 74.0 Highly correlated
14 AluSp 4 n.s 74.0 Highly correlated
15 L1MEc 4 n.s 99.0 Weakly correlated
16 FLAM_C 3 n.s 74.0 Highly correlated
17 L1MC4 3 n.s 99.0 Weakly correlated
18 LTR10A 3 **** 28.9 Weakly correlated
19 L1PA2 3 n.s 15.2 Weakly correlated
20 AluSg7 3 * 74.0 Highly correlated
21 L1MA9 2 n.s 99.0 Weakly correlated
22 L1MC1 2 n.s 99.0 Weakly correlated
23 MIRc 2 n.s 99.0 Weakly correlated
24 MER50 2 * 43.0 Weakly correlated
25 L1M5 2 n.s 99.0 Weakly correlated
26 L1M4 2 n.s 99.0 Weakly correlated
27 L1MEd 2 n.s 99.0 Weakly correlated
28 LTR10F 2 *** 28.9 Weakly correlated
29 L1PA16 2 n.s 74.0 Highly correlated
30 L2c 2 n.s 99.0 Weakly correlated
31 L2b 2 n.s 99.0 Weakly correlated
32 L1PA5 2 n.s 19.6 Weakly correlated
33 L3 2 n.s 99.0 Weakly correlated
34 AluJr4 2 n.s 74.0 Highly correlated
35 AluSc8 2 n.s 74.0 Highly correlated
36 AluSg4 2 n.s 74.0 Highly correlated
37 AluSx3 2 n.s 74.0 Highly correlated
38 AluSx4 2 n.s 74.0 Highly correlated
39 AluYm1 2 * 19.6 Weakly correlated
40 MLT1K 1 n.s 99.0 Weakly correlated
41 THE1B 1 n.s 43.0 Weakly correlated
42 Mam_R4 1 ** 99.0 Weakly correlated
43 MamRTE1 1 n.s 99.0 Weakly correlated
44 MLT2A2 1 n.s 74.0 Highly correlated
45 LTR13 1 * 19.6 Weakly correlated
46 LTR33 1 n.s 99.0 Weakly correlated
47 LTR41B 1 ** 99.0 Weakly correlated
48 LTR43-int 1 ** 74.0 Highly correlated
49 LTR48 1 * 74.0 Highly correlated
50 MLT1A0 1 n.s 99.0 Weakly correlated
51 LTR50 1 n.s 99.0 Weakly correlated
52 MER34C_ 1 ** 87.0 Moderately correlated
53 MER4C 1 ** 74.0 Highly correlated
54 MLT1H1 1 n.s 99.0 Weakly correlated
55 MER50-int 1 * 43.0 Weakly correlated
56 MLT1H-int 1 * 99.0 Weakly correlated
57 MLT1F2 1 n.s 99.0 Weakly correlated
58 MER76 1 ** 99.0 Weakly correlated
59 MER9a3 1 ** 28.9 Weakly correlated
60 MIR3 1 n.s 99.0 Weakly correlated
61 MIRb 1 n.s 99.0 Weakly correlated
62 MLT1E3 1 * 99.0 Weakly correlated
63 MLT1E1A 1 n.s 99.0 Weakly correlated
64 MLT1C 1 n.s 94.0 Weakly correlated
65 L1MB3 1 n.s 99.0 Weakly correlated
66 AluSc 1 n.s 74.0 Highly correlated
67 AluYa5 1 n.s 15.2 Weakly correlated
68 AluYh3 1 * 15.2 Weakly correlated
69 AluYj4 1 n.s 0.0 Weakly correlated
70 AmnSINE1 1 ** 319.0 Weakly correlated
71 FRAM 1 n.s 74.0 Highly correlated
72 HAL1 1 n.s 99.0 Weakly correlated
73 HAL1b 1 n.s 99.0 Weakly correlated
74 HERVK9-int 1 n.s 28.9 Weakly correlated
75 L1M2 1 n.s 99.0 Weakly correlated
76 L1M3 1 n.s 99.0 Weakly correlated
77 L1M3a 1 * 99.0 Weakly correlated
78 L1MA10 1 n.s 99.0 Weakly correlated
79 L1MB2 1 n.s 99.0 Weakly correlated
80 L1PA7 1 n.s 74.0 Highly correlated
81 L1MB4 1 n.s 99.0 Weakly correlated
82 L1MC 1 n.s 99.0 Weakly correlated
83 L1MC5a 1 n.s 99.0 Weakly correlated
84 L1MCc 1 n.s 99.0 Weakly correlated
85 L1MDa 1 n.s 99.0 Weakly correlated
86 L1ME1 1 n.s 99.0 Weakly correlated
87 L1ME2 1 n.s 99.0 Weakly correlated
88 L1MEg 1 n.s 99.0 Weakly correlated
89 L1MEg2 1 ** 99.0 Weakly correlated
90 L1P1 1 n.s 19.6 Weakly correlated
91 L1P4a 1 * 74.0 Highly correlated
92 L1PA10 1 n.s 74.0 Highly correlated
93 L1PA11 1 n.s 74.0 Highly correlated
94 L1PA13 1 n.s 74.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4 2 n.s 99.0 Weakly correlated
2 L2a 2 n.s 99.0 Weakly correlated
3 L2c 1 n.s 99.0 Weakly correlated
4 MER34C_ 1 ** 87.0 Moderately correlated
5 L1MB4 1 n.s 99.0 Weakly correlated
6 MLT2A2 1 n.s 74.0 Highly correlated
7 LTR48 1 * 74.0 Highly correlated
8 L1MEd 1 n.s 99.0 Weakly correlated
9 MER76 1 ** 99.0 Weakly correlated
10 AluSz 1 n.s 74.0 Highly correlated
11 AmnSINE1 1 ** 319.0 Weakly correlated
12 L1MCc 1 n.s 99.0 Weakly correlated
13 L3 1 n.s 99.0 Weakly correlated
14 MIRc 1 n.s 99.0 Weakly correlated
15 LTR43-int 1 ** 74.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP