ZRdb KZFP & Repeats
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Human_ZNF624

  • Protein
    Zinc finger protein 624
  • Length
    865
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9P2J8
  • NCBI_ID
    57547
Sequence:
MSLQDSTLSREGKPEGEIMAAVFFSVGRLSPEVTQPDEDLHLQAEETQLVKESVTFKDVAIDFTLEEWRLMDPTQRNLHKDVMLENYRNLVSLGLAVSKPDMISHLENGKGPWVTVREISRIPYPDMEPKPATKKATRTKAISEDLSQEAILEKLTENGLWDSRMEGLWKWNDRILRLQNNQENHLSQRIIPLKKTPTSQRGFRFESILIPEPGIATEELHSRCQTQEENFTENLNLITDTHLGKIICKEMKGSKAIRQTSELTLGKKSNNKEKPYKCSTCEKAFHYRSLLIQHQRTHTKEKPYECNECGKTFSQPSYLSQHKKIHTGEKPYKCNECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGEKPYKCDDCGKAFRNKSYLSVHQKTHTEEKPYQCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECNECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLTVHHRMHTGEKPYKCTECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYKCYDCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYKCEECGKAFRTNSDFTVHLRMHTGEKPYKCNECGKAFRSSSSLTVHQRIHQRETQLI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 54..125
2 C2h2 276..298
3 C2h2 304..326
4 C2h2 332..354
5 dec2h2 360..382
6 C2h2 388..410
7 C2h2 416..438
8 C2h2 444..466
9 C2h2 472..494
10 C2h2 500..522
11 C2h2 528..550
12 C2h2 556..578
13 C2h2 584..606
14 C2h2 612..634
15 C2h2 640..662
16 C2h2 668..690
17 C2h2 696..718
18 C2h2 724..746
19 C2h2 752..774
20 C2h2 780..802
21 C2h2 808..830
22 C2h2 836..858
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 15 **** 0.0 Weakly correlated
2 SVA_D 8 **** 15.2 Weakly correlated
3 MER21B 8 **** 99.0 Highly correlated
4 SVA_E 7 **** 0.0 Weakly correlated
5 L1PA10 6 * 74.0 Weakly correlated
6 AluJb 4 n.s 74.0 Weakly correlated
7 AluY 4 n.s 74.0 Weakly correlated
8 LTR10A 4 **** 28.9 Weakly correlated
9 L1MB8 4 n.s 99.0 Highly correlated
10 AluJo 2 n.s 74.0 Weakly correlated
11 MIRc 2 n.s 99.0 Highly correlated
12 L1MB3 2 n.s 99.0 Highly correlated
13 L1M4 2 n.s 99.0 Highly correlated
14 AluSx 2 n.s 74.0 Weakly correlated
15 AluSx1 2 n.s 74.0 Weakly correlated
16 L1MA8 2 n.s 87.0 Weakly correlated
17 AluSz6 2 n.s 74.0 Weakly correlated
18 LTR12D 1 * 19.6 Weakly correlated
19 AluJr 1 n.s 74.0 Weakly correlated
20 MSTA-int 1 n.s 43.0 Weakly correlated
21 MLT1L 1 n.s 99.0 Highly correlated
22 MLT1E3 1 * 99.0 Highly correlated
23 MLT1C 1 n.s 94.0 Weakly correlated
24 AluSz 1 n.s 74.0 Weakly correlated
25 MIR3 1 n.s 99.0 Highly correlated
26 MER52C 1 ** 74.0 Weakly correlated
27 MER52A 1 n.s 74.0 Weakly correlated
28 LTR5_Hs 1 * 0.0 Weakly correlated
29 LTR12C 1 n.s 19.6 Weakly correlated
30 LTR10B1 1 *** 28.9 Weakly correlated
31 AluYj4 1 * 0.0 Weakly correlated
32 L2b 1 n.s 99.0 Highly correlated
33 L1PA5 1 n.s 19.6 Weakly correlated
34 L1PA17 1 n.s 74.0 Weakly correlated
35 L1PA13 1 n.s 74.0 Weakly correlated
36 L1HS 1 n.s 8.6 Weakly correlated
37 L1P4 1 n.s 74.0 Weakly correlated
38 L1MC4 1 n.s 99.0 Highly correlated
39 L1MA4A 1 n.s 87.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP