ZRdb KZFP & Repeats
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Human_ZNF620

  • Protein
    Zinc finger protein 620
  • Length
    422
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6ZNG0
  • NCBI_ID
    253639
Sequence:
MFQTAWRQEPVTFEDVAVYFTQNEWASLDSVQRALYREVMLENYANVASLAFPFTTPVLVSQLEQGELPWGLDPWEPMGREALRGICPGDEARTEKEGLTPKDHVSKETESFRLMVGGLPGNVSQHLDFGSSLEQPQGHWIIKTKSKRRHFTDTSARHHEAYEVKNGEKFEKLGKNISVSTQLTTNQTNPSGQISYECGQCGRYFIQMADFHRHEKCHTGEKSFECKECGKYFRYNSLLIRHQIIHTGKKPFKCKECGKGLSSDTALIQHQRIHTGEKPYECKECGKAFSSSSVFLQHQRFHTGEKLYECNECWKTFSCSSSFTVHQRMHTGEKPYECKECGKRLSSNTALTQHQRIHTGEKPFECKECGKAFNQKITLIQHQRVHTGEKPYECKVCGKTFSWCGRFILHQKLHTQKTPVQA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 11..82
2 C2h2 196..218
3 C2h2 224..246
4 C2h2 252..274
5 C2h2 280..302
6 C2h2 308..330
7 C2h2 336..358
8 C2h2 364..386
9 C2h2 392..414
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HAL1 3 ** 99.0 Highly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 AluJb 3 n.s 74.0 Weakly correlated
4 L1PA5 2 n.s 19.6 Weakly correlated
5 L1PA17 1 * 74.0 Weakly correlated
6 MLT2B4 1 ** 99.0 Highly correlated
7 MLT1J 1 * 99.0 Highly correlated
8 MIRb 1 n.s 99.0 Highly correlated
9 MER39B 1 *** 74.0 Weakly correlated
10 LTR8A 1 ** 43.0 Weakly correlated
11 LTR13 1 *** 19.6 Weakly correlated
12 L1PB4 1 n.s 99.0 Highly correlated
13 L1PA2 1 n.s 15.2 Weakly correlated
14 L1P1 1 * 19.6 Weakly correlated
15 L1MA8 1 n.s 87.0 Weakly correlated
16 FRAM 1 ** 74.0 Weakly correlated
17 AluYj4 1 ** 0.0 Weakly correlated
18 AluY 1 n.s 74.0 Weakly correlated
19 AluSx3 1 n.s 74.0 Weakly correlated
20 AluSg7 1 * 74.0 Weakly correlated
21 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER83 1 *** 43.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP