ZRdb KZFP & Repeats
...

Human_ZNF616

  • Protein
    Zinc finger protein 616
  • Length
    781
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q08AN1
  • NCBI_ID
    90317
Sequence:
MATQGHLTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLGISPKCVIKELPPTENSNTGERFQTVALERHQSYDIENLYFREIQKHLHDLEFQWKDGETNDKEVPVPHENNLTGKRDQHSQGDVENNHIENQLTSNFESRLAELQKVQTEGRLYECNETEKTGNNGCLVSPHIREKTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGKAFHRASLLTVHKVVHTRGKSYQCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGKSFSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVFSKRSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHTGEKPYKCHECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGNSFSQRVHLRLHQTVHTGDRPYKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKVFRHSSHLVSHQRIHTGEKRYKCIECGKAFGRLFSLSKHQRIHSGKKPYKCNECGKSFICRSGLTKHRIRHTGESLTTKLNVTRP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 7..84
2 C2h2 185..207
3 C2h2 213..235
4 C2h2 241..263
5 C2h2 269..291
6 C2h2 297..319
7 C2h2 325..347
8 C2h2 353..375
9 C2h2 381..403
10 C2h2 409..431
11 C2h2 437..459
12 C2h2 465..487
13 C2h2 493..515
14 C2h2 521..543
15 C2h2 549..571
16 C2h2 577..599
17 C2h2 605..627
18 C2h2 633..655
19 C2h2 661..683
20 C2h2 689..711
21 C2h2 717..739
22 C2h2 745..767
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 90 **** 74.0 Weakly correlated
2 MER61-int 47 **** 43.0 Highly correlated
3 AluJb 42 **** 74.0 Weakly correlated
4 AluSx1 34 *** 74.0 Weakly correlated
5 LTR25-int 32 **** 43.0 Highly correlated
6 MER52-int 27 **** 99.0 Weakly correlated
7 HUERS-P3-int 24 **** 43.0 Highly correlated
8 AluSz 23 * 74.0 Weakly correlated
9 MER52A 21 **** 74.0 Weakly correlated
10 L2c 20 n.s 99.0 Weakly correlated
11 AluJr 18 * 74.0 Weakly correlated
12 L2a 17 n.s 99.0 Weakly correlated
13 HUERS-P3b-int 16 **** 43.0 Highly correlated
14 MIRb 16 n.s 99.0 Weakly correlated
15 AluSx 15 n.s 74.0 Weakly correlated
16 AluSc 14 *** 74.0 Weakly correlated
17 L2b 13 n.s 99.0 Weakly correlated
18 AluSg 12 ** 74.0 Weakly correlated
19 AluSp 12 n.s 74.0 Weakly correlated
20 AluJo 10 n.s 74.0 Weakly correlated
21 MER52D 10 **** 74.0 Weakly correlated
22 AluSq2 8 n.s 74.0 Weakly correlated
23 HERV9NC-int 8 **** 19.6 Weakly correlated
24 MIR3 8 n.s 99.0 Weakly correlated
25 AluSc8 7 * 74.0 Weakly correlated
26 AluSx4 7 *** 74.0 Weakly correlated
27 MER41-int 7 **** 74.0 Weakly correlated
28 AluSz6 6 n.s 74.0 Weakly correlated
29 L1PA5 6 n.s 19.6 Weakly correlated
30 AluSx3 5 n.s 74.0 Weakly correlated
31 AluYj4 5 **** 0.0 Weakly correlated
32 HERV9N-int 5 **** 19.6 Weakly correlated
33 MER50 5 **** 43.0 Highly correlated
34 MIR 5 n.s 99.0 Weakly correlated
35 MLT1A0 5 n.s 99.0 Weakly correlated
36 AluYh3 4 **** 15.2 Weakly correlated
37 AluYm1 4 ** 19.6 Weakly correlated
38 HAL1M8 4 *** 99.0 Weakly correlated
39 L1PA16 4 n.s 74.0 Weakly correlated
40 L1PB1 4 n.s 74.0 Weakly correlated
41 L3 4 n.s 99.0 Weakly correlated
42 LTR10A 4 **** 28.9 Weakly correlated
43 MLT1B 4 n.s 99.0 Weakly correlated
44 AluJr4 3 n.s 74.0 Weakly correlated
45 AluYf1 3 *** 19.6 Weakly correlated
46 FLAM_A 3 * 74.0 Weakly correlated
47 FLAM_C 3 n.s 74.0 Weakly correlated
48 HAL1 3 n.s 99.0 Weakly correlated
49 L1MA9 3 n.s 99.0 Weakly correlated
50 L1MEc 3 n.s 99.0 Weakly correlated
51 L1PA2 3 n.s 15.2 Weakly correlated
52 LTR2752 3 **** 43.0 Highly correlated
53 MLT1H 3 n.s 99.0 Weakly correlated
54 MLT1L 3 * 99.0 Weakly correlated
55 AluSc5 2 n.s 74.0 Weakly correlated
56 AluYk3 2 ** 19.6 Weakly correlated
57 HERV9-int 2 * 28.9 Weakly correlated
58 L1M5 2 n.s 99.0 Weakly correlated
59 L1MB3 2 n.s 99.0 Weakly correlated
60 L1MC4 2 n.s 99.0 Weakly correlated
61 L1MC5a 2 n.s 99.0 Weakly correlated
62 L1MEd 2 n.s 99.0 Weakly correlated
63 L1P1 2 n.s 19.6 Weakly correlated
64 LTR10F 2 *** 28.9 Weakly correlated
65 MER101 2 **** 74.0 Weakly correlated
66 MER41A 2 * 74.0 Weakly correlated
67 MER50B 2 *** 43.0 Highly correlated
68 MER51A 2 ** 43.0 Highly correlated
69 MIRc 2 n.s 99.0 Weakly correlated
70 MLT1A 2 n.s 99.0 Weakly correlated
71 MLT1A-int 2 *** 99.0 Weakly correlated
72 MLT1I 2 n.s 99.0 Weakly correlated
73 MLT1K 2 n.s 99.0 Weakly correlated
74 MLT2C2 2 *** 99.0 Weakly correlated
75 SVA_E 2 *** 0.0 Weakly correlated
76 THE1B 2 n.s 43.0 Highly correlated
77 Alu 1 ** 74.0 Weakly correlated
78 AluSg4 1 n.s 74.0 Weakly correlated
79 AluSg7 1 n.s 74.0 Weakly correlated
80 AluSq 1 n.s 74.0 Weakly correlated
81 AluSq4 1 * 74.0 Weakly correlated
82 AluYa5 1 n.s 15.2 Weakly correlated
83 AluYh9 1 **** 15.2 Weakly correlated
84 ERVL-B4-int 1 n.s 99.0 Weakly correlated
85 FAM 1 * 87.0 Weakly correlated
86 FRAM 1 n.s 74.0 Weakly correlated
87 HERVFH19-int 1 ** 43.0 Highly correlated
88 HERVL40-int 1 * 99.0 Weakly correlated
89 HERVL74-int 1 ** 99.0 Weakly correlated
90 Harlequin-int 1 n.s 74.0 Weakly correlated
91 L1M1 1 n.s 74.0 Weakly correlated
92 L1M2 1 n.s 99.0 Weakly correlated
93 L1M2a 1 * 87.0 Weakly correlated
94 L1M4 1 n.s 99.0 Weakly correlated
95 L1M4b 1 n.s 99.0 Weakly correlated
96 L1MA3 1 n.s 74.0 Weakly correlated
97 L1MA4A 1 n.s 87.0 Weakly correlated
98 L1MA5 1 n.s 87.0 Weakly correlated
99 L1MA6 1 n.s 87.0 Weakly correlated
100 L1MA8 1 n.s 87.0 Weakly correlated
101 L1MB2 1 n.s 99.0 Weakly correlated
102 L1MB4 1 n.s 99.0 Weakly correlated
103 L1MB8 1 n.s 99.0 Weakly correlated
104 L1MC5 1 n.s 99.0 Weakly correlated
105 L1MD 1 n.s 99.0 Weakly correlated
106 L1MD1 1 n.s 99.0 Weakly correlated
107 L1MD2 1 n.s 99.0 Weakly correlated
108 L1MD3 1 n.s 99.0 Weakly correlated
109 L1ME1 1 n.s 99.0 Weakly correlated
110 L1ME3D 1 n.s 99.0 Weakly correlated
111 L1ME3G 1 n.s 99.0 Weakly correlated
112 L1ME4a 1 n.s 99.0 Weakly correlated
113 L1PA13 1 n.s 74.0 Weakly correlated
114 L1PA3 1 n.s 19.6 Weakly correlated
115 L1PA8A 1 n.s 74.0 Weakly correlated
116 L1PBa 1 n.s 74.0 Weakly correlated
117 L1PREC2 1 n.s 43.0 Highly correlated
118 L2 1 n.s 99.0 Weakly correlated
119 L2-1_Crp 1 **** 319.0 Weakly correlated
120 L4_B_Mam 1 n.s 99.0 Weakly correlated
121 LTR1 1 ** 43.0 Highly correlated
122 LTR13 1 * 19.6 Weakly correlated
123 LTR16A 1 n.s 99.0 Weakly correlated
124 LTR16B 1 ** 99.0 Weakly correlated
125 LTR16C 1 n.s 99.0 Weakly correlated
126 LTR16E1 1 * 99.0 Weakly correlated
127 LTR18A 1 *** 43.0 Highly correlated
128 LTR21A 1 *** 28.9 Weakly correlated
129 LTR23 1 ** 74.0 Weakly correlated
130 LTR27 1 *** 43.0 Highly correlated
131 LTR27B 1 *** 43.0 Highly correlated
132 LTR33 1 n.s 99.0 Weakly correlated
133 LTR50 1 n.s 99.0 Weakly correlated
134 LTR56 1 * 74.0 Weakly correlated
135 LTR5_Hs 1 * 0.0 Weakly correlated
136 LTR78 1 n.s 99.0 Weakly correlated
137 LTR8 1 n.s 43.0 Highly correlated
138 LTR80A 1 ** 99.0 Weakly correlated
139 MER11A 1 n.s 28.9 Weakly correlated
140 MER21B 1 n.s 99.0 Weakly correlated
141 MER39 1 n.s 74.0 Weakly correlated
142 MER39B 1 * 74.0 Weakly correlated
143 MER4C 1 ** 74.0 Weakly correlated
144 MER50-int 1 * 43.0 Highly correlated
145 MER51B 1 ** 43.0 Highly correlated
146 MER54A 1 * 87.0 Weakly correlated
147 MER54B 1 ** 87.0 Weakly correlated
148 MER57-int 1 n.s 87.0 Weakly correlated
149 MER61D 1 ** 43.0 Highly correlated
150 MER74A 1 * 99.0 Weakly correlated
151 MER76 1 ** 99.0 Weakly correlated
152 MIR1_Amn 1 n.s 319.0 Weakly correlated
153 MLT1E1A 1 n.s 99.0 Weakly correlated
154 MLT1E2 1 n.s 99.0 Weakly correlated
155 MLT1F1 1 n.s 99.0 Weakly correlated
156 MLT1F2 1 n.s 99.0 Weakly correlated
157 MLT1G1 1 n.s 99.0 Weakly correlated
158 MLT1H2-int 1 ** 99.0 Weakly correlated
159 MLT1J1 1 n.s 99.0 Weakly correlated
160 MLT2A2 1 n.s 74.0 Weakly correlated
161 MLT2B1 1 n.s 99.0 Weakly correlated
162 MLT2B3 1 n.s 99.0 Weakly correlated
163 MSTB 1 n.s 43.0 Highly correlated
164 MSTB-int 1 n.s 43.0 Highly correlated
165 MSTD 1 n.s 74.0 Weakly correlated
166 MamGypLTR1c 1 ** 99.0 Weakly correlated
167 MamRTE1 1 n.s 99.0 Weakly correlated
168 Plat_L3 1 * 99.0 Weakly correlated
169 SVA_C 1 * 15.2 Weakly correlated
170 SVA_F 1 n.s 0.0 Weakly correlated
171 THE1D 1 n.s 43.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 75 **** 74.0 Weakly correlated
2 AluSx1 29 ** 74.0 Weakly correlated
3 AluJb 29 ** 74.0 Weakly correlated
4 AluSz 19 n.s 74.0 Weakly correlated
5 AluJr 14 n.s 74.0 Weakly correlated
6 HUERS-P3b-int 12 **** 43.0 Highly correlated
7 AluSg 11 * 74.0 Weakly correlated
8 AluSc 10 * 74.0 Weakly correlated
9 AluSx 9 n.s 74.0 Weakly correlated
10 AluJo 8 n.s 74.0 Weakly correlated
11 AluSp 7 n.s 74.0 Weakly correlated
12 AluSq2 6 n.s 74.0 Weakly correlated
13 AluSx4 6 ** 74.0 Weakly correlated
14 AluSx3 5 n.s 74.0 Weakly correlated
15 AluYh3 4 **** 15.2 Weakly correlated
16 MER41-int 4 *** 74.0 Weakly correlated
17 HUERS-P3-int 4 **** 43.0 Highly correlated
18 LTR25-int 3 *** 43.0 Highly correlated
19 AluSc8 3 n.s 74.0 Weakly correlated
20 AluYj4 3 *** 0.0 Weakly correlated
21 AluYf1 3 *** 19.6 Weakly correlated
22 AluJr4 3 n.s 74.0 Weakly correlated
23 MER61-int 2 * 43.0 Highly correlated
24 HERV9N-int 2 ** 19.6 Weakly correlated
25 L1PA16 2 n.s 74.0 Weakly correlated
26 AluYm1 2 * 19.6 Weakly correlated
27 MER52-int 2 ** 99.0 Weakly correlated
28 AluSz6 2 n.s 74.0 Weakly correlated
29 HERV9-int 2 * 28.9 Weakly correlated
30 AluYa5 1 n.s 15.2 Weakly correlated
31 HERV9NC-int 1 n.s 19.6 Weakly correlated
32 LTR16C 1 n.s 99.0 Weakly correlated
33 FRAM 1 n.s 74.0 Weakly correlated
34 L2b 1 n.s 99.0 Weakly correlated
35 AluSg4 1 n.s 74.0 Weakly correlated
36 L2c 1 n.s 99.0 Weakly correlated
37 L1M2a 1 * 87.0 Weakly correlated
38 FLAM_A 1 n.s 74.0 Weakly correlated
39 MLT1A 1 n.s 99.0 Weakly correlated
40 AluSg7 1 n.s 74.0 Weakly correlated
41 MLT1E1A 1 n.s 99.0 Weakly correlated
42 AluSq4 1 * 74.0 Weakly correlated
43 AluSq 1 n.s 74.0 Weakly correlated
44 L1MC4 1 n.s 99.0 Weakly correlated
45 AluYk3 1 * 19.6 Weakly correlated
46 MER52A 1 n.s 74.0 Weakly correlated
47 FLAM_C 1 n.s 74.0 Weakly correlated
48 AluSc5 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP