ZRdb KZFP & Repeats
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Human_ZNF614

  • Protein
    Zinc finger protein 614
  • Length
    585
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8N883
  • NCBI_ID
    80110
Sequence:
MIKTQESLTLEDVAVEFSWEEWQLLDTAQKNLYRDVMVENYNHLVSLGYQTSKPDVLSKLAHGQEPWTTDAKIQNKNCPGIGKVDSHLQEHSPNQRLLKSVQQCNGQNTLRNIVHLSKTHFPIVQNHDTFDLYRKNLKSSLSLINQKRRHGINNPVEFIGGEKTLLHGKHERTHTKTRFSENAKCIHTKFQVFKHQRTQKIEKPHACIECEQTFLRKSQLIYHENICIQENPGSGQCEKLSRSVLFTKHLKTNTTDKICIPNEYRKGSTVKSSLITHQQTHTEEKSYMCSECGKGFTMKRYLIAHQRTHSGEKPYVCKECGKGFTVKSNLIVHQRTHTGEKPYICSECGKGFTMKRYLVVHQRTHTGEKPYMCSECGKGFTVKSNLIVHQRSHTGEKSYICSECGKGFTVKRTLVIHQRTHTGEKSYICNECGKGFTTKRTLIIHQRTHTGEKPYECNECGKAFSQKICLIQHERCHTGKTPFVCTECGKSYSHKYGLITHQRIHTGEKPYECNECGKAFTTKSVLNVHQRTHTGERPYGCSDCEKAFSHLSNLVKHKKMHTREMGRISQVENSCNGESQLLPYK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 205..227
3 dec2h2 257..281
4 C2h2 287..309
5 C2h2 315..337
6 C2h2 343..365
7 C2h2 371..393
8 C2h2 399..421
9 C2h2 427..449
10 C2h2 455..477
11 C2h2 483..505
12 C2h2 511..533
13 C2h2 539..561
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEc 14 **** 99.0 Highly correlated
2 MLT2B3 11 **** 99.0 Highly correlated
3 L1MCa 6 **** 99.0 Highly correlated
4 LTR10A 3 **** 28.9 Weakly correlated
5 L2a 3 n.s 99.0 Highly correlated
6 AluSx1 3 n.s 74.0 Weakly correlated
7 L1PA5 3 n.s 19.6 Weakly correlated
8 AluY 3 n.s 74.0 Weakly correlated
9 L1ME1 3 n.s 99.0 Highly correlated
10 L1MB3 3 * 99.0 Highly correlated
11 AluJb 2 n.s 74.0 Weakly correlated
12 MIRb 2 n.s 99.0 Highly correlated
13 MER92C 2 **** 99.0 Highly correlated
14 L1P1 2 * 19.6 Weakly correlated
15 L1MEd 2 n.s 99.0 Highly correlated
16 L1MC3 2 n.s 99.0 Highly correlated
17 L1MC 2 ** 99.0 Highly correlated
18 AluSz6 2 n.s 74.0 Weakly correlated
19 L1M5 2 n.s 99.0 Highly correlated
20 AluYa5 2 *** 15.2 Weakly correlated
21 AluSg4 1 * 74.0 Weakly correlated
22 LTR13 1 ** 19.6 Weakly correlated
23 LTR8 1 * 43.0 Weakly correlated
24 MER21A 1 ** 74.0 Weakly correlated
25 MER39B 1 ** 74.0 Weakly correlated
26 MER4D1 1 ** 74.0 Weakly correlated
27 MER66C 1 *** 43.0 Weakly correlated
28 MER73 1 *** 87.0 Weakly correlated
29 AluSx 1 n.s 74.0 Weakly correlated
30 MIR 1 n.s 99.0 Highly correlated
31 AluSc8 1 n.s 74.0 Weakly correlated
32 MLT1C 1 n.s 94.0 Weakly correlated
33 MLT1F1 1 * 99.0 Highly correlated
34 MLT1J2 1 * 99.0 Highly correlated
35 MLT2B2 1 ** 99.0 Highly correlated
36 Alu 1 *** 74.0 Weakly correlated
37 MamRTE1 1 * 99.0 Highly correlated
38 AluSg7 1 n.s 74.0 Weakly correlated
39 L2b 1 n.s 99.0 Highly correlated
40 L2-3_Crp 1 ** 431.0 Weakly correlated
41 L1PA4 1 n.s 19.6 Weakly correlated
42 L1PA2 1 n.s 15.2 Weakly correlated
43 L1MEg 1 n.s 99.0 Highly correlated
44 L1MEf 1 n.s 99.0 Highly correlated
45 AluYm1 1 * 19.6 Weakly correlated
46 L1M4c 1 * 99.0 Highly correlated
47 L1ME3B 1 n.s 99.0 Highly correlated
48 L1ME3A 1 n.s 99.0 Highly correlated
49 L1MD 1 n.s 99.0 Highly correlated
50 L1M6 1 * 99.0 Highly correlated
51 L1MC5a 1 n.s 99.0 Highly correlated
52 L1MC5 1 n.s 99.0 Highly correlated
53 L1MB2 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1F1 1 * 99.0 Highly correlated
2 L1MB2 1 n.s 99.0 Highly correlated
3 MLT2B3 1 * 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP