ZRdb KZFP & Repeats
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Human_ZNF611

  • Protein
    Zinc finger protein 611
  • Length
    705
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q8N823
  • NCBI_ID
    81856
Sequence:
MLREEAAQKRKGKEPGMALPQGRLTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNLEAVDISSKCMMKEVLSTGQGNTEVIHTGTLQRHESHHIGDFCFQEIEKEIHDIEFQCQEDERNGLEAPMTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLPELHIFQIKGEIGNQLEKSTNDAPSVSTFQRISCRPQTQISNNYGNNPLNSSLLPQKQEVHMREKSFQCNKSGKAFNCSSLLRKHQIPHLGDKQYKCDVCGKLFNHEQYLACHDRCHTVEKPYKCKECGKTFSQESSLTCHRRLHTGVKRYNCNECGKIFGQNSALLIDKAIDTGENPYKCNECDKAFNQQSQLSHHRIHTGEKPYKCEECDKVFSRKSTIETHKRIHTGEKPYRCKVCDTAFTWHSQLARHRRIHTAKKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFVWSSQLAKHTRIDCGEKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKCDECEKVFSRKSSLETHKIGHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECSKTFSHRSYLVCHHRVHSGEKPYKCNECSKTFSRRSSLHCHRRLHSGEKPYKCNECGNTFRHCSSLIYHRRLHTGEKSYKCTICDKAFVRNSLLSRHTRIHTAEKPYKCNECGKAFNQQSHLSRHHRIHTGEKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 24..97
2 dec2h2 231..253
3 C2h2 259..281
4 C2h2 287..309
5 dec2h2 315..337
6 C2h2 343..364
7 C2h2 370..392
8 C2h2 398..420
9 C2h2 426..448
10 dec2h2 454..476
11 C2h2 482..504
12 C2h2 510..532
13 C2h2 538..560
14 C2h2 566..588
15 C2h2 594..616
16 C2h2 622..644
17 C2h2 650..672
18 C2h2 678..700
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_D 764 **** 15.2 Weakly correlated
2 SVA_F 344 **** 0.0 Weakly correlated
3 SVA_A 249 **** 19.6 Highly correlated
4 SVA_B 249 **** 15.2 Weakly correlated
5 SVA_C 197 **** 15.2 Weakly correlated
6 MER11A 149 **** 28.9 Moderately correlated
7 MER11D 144 **** 19.6 Highly correlated
8 SVA_E 52 **** 0.0 Weakly correlated
9 AluY 35 n.s 74.0 Weakly correlated
10 AluJb 22 n.s 74.0 Weakly correlated
11 L2a 20 n.s 99.0 Weakly correlated
12 L2b 17 n.s 99.0 Weakly correlated
13 AluSc 16 n.s 74.0 Weakly correlated
14 AluSx 15 n.s 74.0 Weakly correlated
15 L2c 15 n.s 99.0 Weakly correlated
16 AluJo 12 n.s 74.0 Weakly correlated
17 AluSz6 10 n.s 74.0 Weakly correlated
18 L2 10 n.s 99.0 Weakly correlated
19 MIR3 10 n.s 99.0 Weakly correlated
20 AluJr 9 n.s 74.0 Weakly correlated
21 AluSx1 9 n.s 74.0 Weakly correlated
22 MIR 9 n.s 99.0 Weakly correlated
23 MIRb 9 n.s 99.0 Weakly correlated
24 AluSz 8 n.s 74.0 Weakly correlated
25 MIRc 7 n.s 99.0 Weakly correlated
26 AluSg 6 n.s 74.0 Weakly correlated
27 AluSx3 5 n.s 74.0 Weakly correlated
28 L1PA2 5 n.s 15.2 Weakly correlated
29 MER11B 5 **** 19.6 Highly correlated
30 THE1B 5 n.s 43.0 Weakly correlated
31 AluSp 4 n.s 74.0 Weakly correlated
32 AluSq 4 n.s 74.0 Weakly correlated
33 AluSq2 4 n.s 74.0 Weakly correlated
34 FLAM_A 4 n.s 74.0 Weakly correlated
35 L1M5 4 n.s 99.0 Weakly correlated
36 L1P1 4 n.s 19.6 Highly correlated
37 L1P3 4 n.s 74.0 Weakly correlated
38 LTR10A 4 **** 28.9 Moderately correlated
39 LTR12C 4 n.s 19.6 Highly correlated
40 LTR7B 4 *** 28.9 Moderately correlated
41 MER50 4 * 43.0 Weakly correlated
42 MLT1B 4 n.s 99.0 Weakly correlated
43 MLT1C 4 n.s 94.0 Weakly correlated
44 MSTA 4 n.s 43.0 Weakly correlated
45 AluSc8 3 n.s 74.0 Weakly correlated
46 L1M4 3 n.s 99.0 Weakly correlated
47 L1MB5 3 n.s 99.0 Weakly correlated
48 L1MB7 3 n.s 99.0 Weakly correlated
49 L1MB8 3 n.s 99.0 Weakly correlated
50 LTR10F 3 *** 28.9 Moderately correlated
51 LTR33 3 n.s 99.0 Weakly correlated
52 LTR41B 3 *** 99.0 Weakly correlated
53 LTR52 3 *** 99.0 Weakly correlated
54 MLT1A0 3 n.s 99.0 Weakly correlated
55 MLT1D 3 n.s 99.0 Weakly correlated
56 MLT1H 3 n.s 99.0 Weakly correlated
57 AluJr4 2 n.s 74.0 Weakly correlated
58 AluYj4 2 n.s 0.0 Weakly correlated
59 AluYm1 2 n.s 19.6 Highly correlated
60 FRAM 2 n.s 74.0 Weakly correlated
61 HERVE_a-int 2 * 28.9 Moderately correlated
62 L1MA9 2 n.s 99.0 Weakly correlated
63 L1MB4 2 n.s 99.0 Weakly correlated
64 L1MC4 2 n.s 99.0 Weakly correlated
65 L1ME3A 2 n.s 99.0 Weakly correlated
66 L1MEg2 2 ** 99.0 Weakly correlated
67 L1PA10 2 n.s 74.0 Weakly correlated
68 L1PA16 2 n.s 74.0 Weakly correlated
69 L1PA3 2 n.s 19.6 Highly correlated
70 L1PA4 2 n.s 19.6 Highly correlated
71 L1PA7 2 n.s 74.0 Weakly correlated
72 L1PBa 2 n.s 74.0 Weakly correlated
73 L1PREC2 2 n.s 43.0 Weakly correlated
74 L3 2 n.s 99.0 Weakly correlated
75 LTR16E2 2 n.s 99.0 Weakly correlated
76 MER21B 2 n.s 99.0 Weakly correlated
77 MER21C 2 n.s 99.0 Weakly correlated
78 MER41A 2 n.s 74.0 Weakly correlated
79 MLT1I 2 n.s 99.0 Weakly correlated
80 MLT1J1 2 n.s 99.0 Weakly correlated
81 Alu 1 n.s 74.0 Weakly correlated
82 AluSc5 1 n.s 74.0 Weakly correlated
83 AluSg4 1 n.s 74.0 Weakly correlated
84 AluSg7 1 n.s 74.0 Weakly correlated
85 AluSq10 1 n.s 74.0 Weakly correlated
86 AluSx4 1 n.s 74.0 Weakly correlated
87 AluYa5 1 n.s 15.2 Weakly correlated
88 AluYh3 1 n.s 15.2 Weakly correlated
89 AluYh9 1 *** 15.2 Weakly correlated
90 AluYk11 1 ** 15.2 Weakly correlated
91 ERV3-16A3_LTR 1 n.s 99.0 Weakly correlated
92 ERVL-E-int 1 n.s 99.0 Weakly correlated
93 FLAM_C 1 n.s 74.0 Weakly correlated
94 HAL1 1 n.s 99.0 Weakly correlated
95 HAL1M8 1 n.s 99.0 Weakly correlated
96 HERV9N-int 1 n.s 19.6 Highly correlated
97 HERVE-int 1 n.s 19.6 Highly correlated
98 HERVH-int 1 n.s 28.9 Moderately correlated
99 HERVK-int 1 n.s 28.9 Moderately correlated
100 HERVK9-int 1 n.s 28.9 Moderately correlated
101 HUERS-P3-int 1 n.s 43.0 Weakly correlated
102 Harlequin-int 1 n.s 74.0 Weakly correlated
103 L1M1 1 n.s 74.0 Weakly correlated
104 L1M4c 1 n.s 99.0 Weakly correlated
105 L1MA1 1 n.s 74.0 Weakly correlated
106 L1MA3 1 n.s 74.0 Weakly correlated
107 L1MA4A 1 n.s 87.0 Weakly correlated
108 L1MB1 1 n.s 99.0 Weakly correlated
109 L1MC2 1 n.s 99.0 Weakly correlated
110 L1MC5 1 n.s 99.0 Weakly correlated
111 L1MD 1 n.s 99.0 Weakly correlated
112 L1MD1 1 n.s 99.0 Weakly correlated
113 L1MDa 1 n.s 99.0 Weakly correlated
114 L1MDb 1 n.s 99.0 Weakly correlated
115 L1ME1 1 n.s 99.0 Weakly correlated
116 L1ME2 1 n.s 99.0 Weakly correlated
117 L1ME2z 1 n.s 99.0 Weakly correlated
118 L1ME3 1 n.s 99.0 Weakly correlated
119 L1ME3E 1 n.s 99.0 Weakly correlated
120 L1ME3G 1 n.s 99.0 Weakly correlated
121 L1ME4b 1 n.s 99.0 Weakly correlated
122 L1MEc 1 n.s 99.0 Weakly correlated
123 L1MEd 1 n.s 99.0 Weakly correlated
124 L1MEj 1 n.s 99.0 Weakly correlated
125 L1P2 1 n.s 28.9 Moderately correlated
126 L1P3b 1 ** 43.0 Weakly correlated
127 L1P4 1 n.s 74.0 Weakly correlated
128 L1PA13 1 n.s 74.0 Weakly correlated
129 L1PA15-16 1 n.s 74.0 Weakly correlated
130 L1PA5 1 n.s 19.6 Highly correlated
131 L1PA8 1 n.s 74.0 Weakly correlated
132 L1PA8A 1 n.s 74.0 Weakly correlated
133 L1PB3 1 n.s 74.0 Weakly correlated
134 LFSINE_Vert 1 n.s 319.0 Weakly correlated
135 LTR104_Mam 1 n.s 99.0 Weakly correlated
136 LTR12D 1 n.s 19.6 Highly correlated
137 LTR13 1 n.s 19.6 Highly correlated
138 LTR16B 1 * 99.0 Weakly correlated
139 LTR16B2 1 n.s 99.0 Weakly correlated
140 LTR16E1 1 n.s 99.0 Weakly correlated
141 LTR18A 1 ** 43.0 Weakly correlated
142 LTR19-int 1 * 43.0 Weakly correlated
143 LTR1A2 1 n.s 43.0 Weakly correlated
144 LTR1D 1 * 43.0 Weakly correlated
145 LTR26 1 n.s 74.0 Weakly correlated
146 LTR33A 1 n.s 99.0 Weakly correlated
147 LTR33B 1 n.s 99.0 Weakly correlated
148 LTR35A 1 ** 43.0 Weakly correlated
149 LTR40a 1 n.s 99.0 Weakly correlated
150 LTR48 1 n.s 74.0 Weakly correlated
151 LTR50 1 n.s 99.0 Weakly correlated
152 LTR55 1 * 99.0 Weakly correlated
153 LTR67B 1 n.s 99.0 Weakly correlated
154 LTR88a 1 * 99.0 Weakly correlated
155 LTR8B 1 n.s 43.0 Weakly correlated
156 MER11C 1 n.s 19.6 Highly correlated
157 MER31-int 1 n.s 99.0 Weakly correlated
158 MER39B 1 n.s 74.0 Weakly correlated
159 MER50-int 1 n.s 43.0 Weakly correlated
160 MER50B 1 n.s 43.0 Weakly correlated
161 MER52A 1 n.s 74.0 Weakly correlated
162 MER57E3 1 ** 74.0 Weakly correlated
163 MER61A 1 * 43.0 Weakly correlated
164 MER61F 1 ** 43.0 Weakly correlated
165 MER66A 1 * 43.0 Weakly correlated
166 MER66B 1 n.s 43.0 Weakly correlated
167 MIR1_Amn 1 n.s 319.0 Weakly correlated
168 MLT1A 1 n.s 99.0 Weakly correlated
169 MLT1A0-int 1 n.s 99.0 Weakly correlated
170 MLT1F 1 n.s 99.0 Weakly correlated
171 MLT1F1 1 n.s 99.0 Weakly correlated
172 MLT1G1 1 n.s 99.0 Weakly correlated
173 MLT1H2 1 n.s 99.0 Weakly correlated
174 MLT1J2 1 n.s 99.0 Weakly correlated
175 MLT1K 1 n.s 99.0 Weakly correlated
176 MLT1N2 1 n.s 99.0 Weakly correlated
177 MLT2B3 1 n.s 99.0 Weakly correlated
178 MSTB1 1 n.s 74.0 Weakly correlated
179 MSTD 1 n.s 74.0 Weakly correlated
180 MamGypLTR1a 1 * 99.0 Weakly correlated
181 MamRTE1 1 n.s 99.0 Weakly correlated
182 PABL_B 1 * 43.0 Weakly correlated
183 THE1A 1 n.s 43.0 Weakly correlated
184 THE1D 1 n.s 43.0 Weakly correlated
185 THE1D-int 1 n.s 28.9 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_D 738 **** 15.2 Weakly correlated
2 SVA_F 319 **** 0.0 Weakly correlated
3 SVA_B 248 **** 15.2 Weakly correlated
4 SVA_A 229 **** 19.6 Highly correlated
5 SVA_C 195 **** 15.2 Weakly correlated
6 MER11D 52 **** 19.6 Highly correlated
7 SVA_E 48 **** 0.0 Weakly correlated
8 LTR7B 4 *** 28.9 Moderately correlated
9 MER11A 3 * 28.9 Moderately correlated
10 MIR3 3 n.s 99.0 Weakly correlated
11 L2a 2 n.s 99.0 Weakly correlated
12 MER11B 1 n.s 19.6 Highly correlated
13 LTR48 1 n.s 74.0 Weakly correlated
14 L1MDa 1 n.s 99.0 Weakly correlated
15 L2b 1 n.s 99.0 Weakly correlated
16 MER61A 1 * 43.0 Weakly correlated
17 MER41A 1 n.s 74.0 Weakly correlated
18 MLT1A0 1 n.s 99.0 Weakly correlated
19 AluYj4 1 n.s 0.0 Weakly correlated
20 L3 1 n.s 99.0 Weakly correlated
21 MER11C 1 n.s 19.6 Highly correlated
22 L2c 1 n.s 99.0 Weakly correlated
23 FRAM 1 n.s 74.0 Weakly correlated
24 FLAM_A 1 n.s 74.0 Weakly correlated
25 MLT1A 1 n.s 99.0 Weakly correlated
26 AluJr 1 n.s 74.0 Weakly correlated
27 HERVE_a-int 1 n.s 28.9 Moderately correlated
28 HAL1M8 1 n.s 99.0 Weakly correlated
29 AluSz 1 n.s 74.0 Weakly correlated
30 MER50 1 n.s 43.0 Weakly correlated
31 L1MA3 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 SVA_A 19.6 Highly correlated
2 SVA_B 15.2 Weakly correlated
3 SVA_C 15.2 Weakly correlated
4 SVA_D 15.2 Weakly correlated
5 SVA_E 0.0 Weakly correlated
6 SVA_F 0.0 Weakly correlated