ZRdb KZFP & Repeats
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Human_ZNF607

  • Protein
    Zinc finger protein 607
  • Length
    696
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q96SK3
  • NCBI_ID
    84775
Sequence:
MSYGSITFGDVAIDFSHQEWEYLSLVQKTLYQEVMMENYDNLVSLAGHSVSKPDLITLLEQGKEPWMIVREETRGECTDLDSRCEIISDGKMQLYRKHSCVTLHQRIHNGQKPYECKQCQKSFSHLTELMVHQTIHTSEEPDQCEKFRKAFSHLTDLRKHQKINAREKPYECEECGKVFSYPANLAQHGKVHVEKPYECKECGEAFRTSRQLTVHHRFHYGEKPYECKECGKAFSVYGRLSRHQSIHTGEKPFECNKCGKSFRLKAGLKVHQSIHTGEKPHECKECGKAFRQFSHLVGHKRIHTGEKPYECKECGKGFTCRYQLTMHQRIYSGEKHYECKENGEAFSSGHQLTAPHTFESVEKPYKCEECGKAFSVHGRLTRHQGIHSGKKPYECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAFSQRAHLAHHNRIHTGYKPFECKECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIHRRVHTGEKPYECKECGKAFSVSGQLTQHLSIHSGKKPFECNKCGKSFRFISVLKAHQNIHSAEKPYECKECGKAFRHATSLIYHDRTHAGEKSYECKECGETFSHASHLIIHERIHTSDKPYECKRCGKAFHCASYLVRHESVHADGNPYMCEECGKAFNSSHELSIHHRVHTGEKPFKCNKCRRSFRLRSILEVHQRIHI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..78
2 C2h2 114..136
3 dec2h2 142..164
4 C2h2 170..192
5 C2h2 197..219
6 C2h2 225..247
7 C2h2 253..275
8 C2h2 281..303
9 dec2h2 309..331
10 C2h2 365..387
11 C2h2 393..415
12 C2h2 421..443
13 C2h2 449..471
14 C2h2 477..499
15 C2h2 505..527
16 C2h2 533..555
17 C2h2 561..583
18 C2h2 589..611
19 C2h2 617..639
20 C2h2 645..667
21 C2h2 673..695
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER50 251 **** 43.0 Highly correlated
2 SVA_F 24 **** 0.0 Weakly correlated
3 L2a 15 n.s 99.0 Weakly correlated
4 AluJb 13 n.s 74.0 Weakly correlated
5 AluY 12 n.s 74.0 Weakly correlated
6 SVA_D 12 **** 15.2 Weakly correlated
7 L1P3 10 **** 74.0 Weakly correlated
8 L2c 10 n.s 99.0 Weakly correlated
9 AluYj4 9 **** 0.0 Weakly correlated
10 AluSc8 8 * 74.0 Weakly correlated
11 AluSp 8 n.s 74.0 Weakly correlated
12 L2 8 n.s 99.0 Weakly correlated
13 LTR8 8 **** 43.0 Highly correlated
14 AluSx1 7 n.s 74.0 Weakly correlated
15 AluYm1 6 **** 19.6 Weakly correlated
16 FRAM 6 **** 74.0 Weakly correlated
17 MER34-int 6 **** 99.0 Weakly correlated
18 AluSx 5 n.s 74.0 Weakly correlated
19 AluSz 5 n.s 74.0 Weakly correlated
20 AluJo 4 n.s 74.0 Weakly correlated
21 L1MC4 4 n.s 99.0 Weakly correlated
22 LTR10A 4 **** 28.9 Weakly correlated
23 LTR12C 4 n.s 19.6 Weakly correlated
24 MER34A 4 **** 99.0 Weakly correlated
25 MLT1J 4 n.s 99.0 Weakly correlated
26 SVA_E 4 **** 0.0 Weakly correlated
27 THE1B 4 n.s 43.0 Highly correlated
28 AluSc 3 n.s 74.0 Weakly correlated
29 HAL1 3 n.s 99.0 Weakly correlated
30 LTR10F 3 **** 28.9 Weakly correlated
31 MER21B 3 ** 99.0 Weakly correlated
32 MER31-int 3 *** 99.0 Weakly correlated
33 MER39 3 ** 74.0 Weakly correlated
34 MIR 3 n.s 99.0 Weakly correlated
35 SVA_C 3 *** 15.2 Weakly correlated
36 AluSq2 2 n.s 74.0 Weakly correlated
37 AluSx3 2 n.s 74.0 Weakly correlated
38 AluYa8 2 **** 15.2 Weakly correlated
39 HAL1ME 2 n.s 99.0 Weakly correlated
40 HUERS-P3b-int 2 ** 43.0 Highly correlated
41 L1M1 2 n.s 74.0 Weakly correlated
42 L1MA7 2 n.s 87.0 Weakly correlated
43 L1MA8 2 n.s 87.0 Weakly correlated
44 L1MB7 2 n.s 99.0 Weakly correlated
45 L1MC3 2 n.s 99.0 Weakly correlated
46 L1MEd 2 n.s 99.0 Weakly correlated
47 L1PA2 2 n.s 15.2 Weakly correlated
48 L2b 2 n.s 99.0 Weakly correlated
49 L3 2 n.s 99.0 Weakly correlated
50 LTR13 2 ** 19.6 Weakly correlated
51 LTR48B 2 ** 74.0 Weakly correlated
52 LTR49-int 2 * 74.0 Weakly correlated
53 MER34B-int 2 *** 99.0 Weakly correlated
54 MER50-int 2 ** 43.0 Highly correlated
55 MIR3 2 n.s 99.0 Weakly correlated
56 MIRb 2 n.s 99.0 Weakly correlated
57 Alu 1 * 74.0 Weakly correlated
58 AluSg4 1 n.s 74.0 Weakly correlated
59 AluSq 1 n.s 74.0 Weakly correlated
60 AluSz6 1 n.s 74.0 Weakly correlated
61 AluYa5 1 n.s 15.2 Weakly correlated
62 AluYb8 1 n.s 15.2 Weakly correlated
63 AluYh9 1 **** 15.2 Weakly correlated
64 AluYi6 1 ** 15.2 Weakly correlated
65 AluYk2 1 * 19.6 Weakly correlated
66 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
67 FAM 1 n.s 87.0 Weakly correlated
68 FLAM_C 1 n.s 74.0 Weakly correlated
69 HAL1b 1 n.s 99.0 Weakly correlated
70 HERV17-int 1 n.s 28.9 Weakly correlated
71 HUERS-P3-int 1 n.s 43.0 Highly correlated
72 L1HS 1 n.s 8.6 Weakly correlated
73 L1M3 1 n.s 99.0 Weakly correlated
74 L1M3f 1 n.s 87.0 Weakly correlated
75 L1M4 1 n.s 99.0 Weakly correlated
76 L1M5 1 n.s 99.0 Weakly correlated
77 L1M8 1 n.s 99.0 Weakly correlated
78 L1MA4 1 n.s 87.0 Weakly correlated
79 L1MA9 1 n.s 99.0 Weakly correlated
80 L1MB8 1 n.s 99.0 Weakly correlated
81 L1MC 1 n.s 99.0 Weakly correlated
82 L1MC2 1 n.s 99.0 Weakly correlated
83 L1MCb 1 n.s 99.0 Weakly correlated
84 L1MD 1 n.s 99.0 Weakly correlated
85 L1ME2 1 n.s 99.0 Weakly correlated
86 L1ME3E 1 n.s 99.0 Weakly correlated
87 L1ME3G 1 n.s 99.0 Weakly correlated
88 L1ME4a 1 n.s 99.0 Weakly correlated
89 L1ME4c 1 n.s 99.0 Weakly correlated
90 L1P1 1 n.s 19.6 Weakly correlated
91 L1P4 1 n.s 74.0 Weakly correlated
92 L1PA15 1 n.s 74.0 Weakly correlated
93 L1PA15-16 1 n.s 74.0 Weakly correlated
94 L1PA4 1 n.s 19.6 Weakly correlated
95 L1PA5 1 n.s 19.6 Weakly correlated
96 L1PB1 1 n.s 74.0 Weakly correlated
97 L1PB2 1 n.s 74.0 Weakly correlated
98 L4_A_Mam 1 n.s 99.0 Weakly correlated
99 LTR10B1 1 *** 28.9 Weakly correlated
100 LTR12D 1 * 19.6 Weakly correlated
101 LTR16A 1 n.s 99.0 Weakly correlated
102 LTR16B2 1 * 99.0 Weakly correlated
103 LTR18B 1 ** 43.0 Highly correlated
104 LTR23 1 ** 74.0 Weakly correlated
105 LTR29 1 ** 43.0 Highly correlated
106 LTR31 1 ** 74.0 Weakly correlated
107 LTR33 1 n.s 99.0 Weakly correlated
108 LTR38A1 1 *** 74.0 Weakly correlated
109 LTR44 1 ** 74.0 Weakly correlated
110 LTR49 1 * 74.0 Weakly correlated
111 LTR52 1 * 99.0 Weakly correlated
112 LTR71B 1 ** 43.0 Highly correlated
113 LTR88b 1 * 99.0 Weakly correlated
114 MER21A 1 n.s 74.0 Weakly correlated
115 MER34 1 * 87.0 Weakly correlated
116 MER34C2 1 ** 74.0 Weakly correlated
117 MER39B 1 * 74.0 Weakly correlated
118 MER41B 1 n.s 74.0 Weakly correlated
119 MER4E 1 * 74.0 Weakly correlated
120 MER50B 1 * 43.0 Highly correlated
121 MER50C 1 *** 43.0 Highly correlated
122 MER57-int 1 n.s 87.0 Weakly correlated
123 MER57A-int 1 n.s 43.0 Highly correlated
124 MER61E 1 ** 43.0 Highly correlated
125 MER66-int 1 * 43.0 Highly correlated
126 MIR1_Amn 1 n.s 319.0 Weakly correlated
127 MIRc 1 n.s 99.0 Weakly correlated
128 MLT1B 1 n.s 99.0 Weakly correlated
129 MLT1C 1 n.s 94.0 Weakly correlated
130 MLT1D 1 n.s 99.0 Weakly correlated
131 MLT1F2 1 n.s 99.0 Weakly correlated
132 MLT1G3 1 n.s 99.0 Weakly correlated
133 MLT1I 1 n.s 99.0 Weakly correlated
134 MLT1L 1 n.s 99.0 Weakly correlated
135 MSTA 1 n.s 43.0 Highly correlated
136 MSTB 1 n.s 43.0 Highly correlated
137 MSTB1 1 n.s 74.0 Weakly correlated
138 MamGypLTR3a 1 * 99.0 Weakly correlated
139 SVA_A 1 * 19.6 Weakly correlated
140 THE1A-int 1 n.s 43.0 Highly correlated
141 THE1C 1 n.s 43.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER50 246 **** 43.0 Highly correlated
2 AluYj4 4 *** 0.0 Weakly correlated
3 FRAM 3 ** 74.0 Weakly correlated
4 L2c 2 n.s 99.0 Weakly correlated
5 MER57-int 1 n.s 87.0 Weakly correlated
6 THE1A-int 1 n.s 43.0 Highly correlated
7 L2a 1 n.s 99.0 Weakly correlated
8 MLT1F2 1 n.s 99.0 Weakly correlated
9 MER50C 1 *** 43.0 Highly correlated
10 LTR16A 1 n.s 99.0 Weakly correlated
11 L1MD 1 n.s 99.0 Weakly correlated
12 AluSz 1 n.s 74.0 Weakly correlated
13 AluSc8 1 n.s 74.0 Weakly correlated
14 HAL1 1 n.s 99.0 Weakly correlated
15 L1PA15-16 1 n.s 74.0 Weakly correlated
16 L2b 1 n.s 99.0 Weakly correlated
17 L1MCb 1 n.s 99.0 Weakly correlated
18 AluY 1 n.s 74.0 Weakly correlated
19 MER39B 1 * 74.0 Weakly correlated
20 L4_A_Mam 1 n.s 99.0 Weakly correlated
21 L1P1 1 n.s 19.6 Weakly correlated
22 AluSx1 1 n.s 74.0 Weakly correlated
23 AluJb 1 n.s 74.0 Weakly correlated
24 MER50B 1 * 43.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MER50 43.0 Highly correlated