ZRdb KZFP & Repeats
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Human_ZNF605

  • Protein
    Zinc finger protein 605
  • Length
    641
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q86T29
  • NCBI_ID
    100289635
Sequence:
MIQSQISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFLEVWLDNPKMWLRDNQDNLKSMERGHKYDVFGKIFNSSINIVHVGLRSHKCGTGEKSLKCPFDLLIPKNNCERKKIDELNKKLLFCIKPGRTHGGIKYCDCSTCRKSSNEEPWLTANHITHTGVYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCSECGKAFSQKSLLTVHQRTHSGEKPHGCSECQKAFSRKSLLILHQRIHTGEKPYGCSECGKAFSRKSQLKRHQITHTIEKPYSCSECGKAFSQKLKLITHQRAHTGEKPYPCSHCGKAFFWKSQLITHQRTHTGKKPYGCGECQKAFSRNSLLIRHQRIHTGEKPYECNECGEAFIRKPQLIKHQITHTGEKNYRCSDCEEAFFKKSELIRHQKIHLGEKPYGCIQCGKTFFGKSQLLTHHRTHTGEKPYECSECGKAFTQKSSLISHQRTHTGEKPYECSECRKTFSEKSSLIHHQRTHTGEKPFECSECRKAFAWKPQLLRHQRIHTGEKPYECSECGKAFVQKVQLIKHQRNHTGEKTYGCSDCAKAFFEKAQLIIHQRIHTGERPYKCGECGKSFTRKSHLMRHQRIHTGDKYYGCNECGTTFNRKSQLMIHQRNHII
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..77
2 C2h2 169..191
3 C2h2 197..219
4 C2h2 225..247
5 C2h2 253..275
6 C2h2 281..303
7 C2h2 309..331
8 C2h2 337..359
9 C2h2 365..387
10 C2h2 393..415
11 C2h2 421..443
12 C2h2 449..471
13 C2h2 477..499
14 C2h2 505..527
15 C2h2 533..555
16 C2h2 561..583
17 C2h2 589..611
18 C2h2 617..639
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC4 223 **** 99.0 Highly correlated
2 L1MC3 161 **** 99.0 Highly correlated
3 L1MC4a 116 **** 99.0 Highly correlated
4 L1MC5a 97 **** 99.0 Highly correlated
5 L1MC5 66 **** 99.0 Highly correlated
6 LTR12C 47 **** 19.6 Weakly correlated
7 AluY 45 *** 74.0 Weakly correlated
8 AluJb 36 * 74.0 Weakly correlated
9 L1MD3 26 **** 99.0 Highly correlated
10 L2c 24 n.s 99.0 Highly correlated
11 AluSx 23 n.s 74.0 Weakly correlated
12 MIRb 21 n.s 99.0 Highly correlated
13 AluJr 20 n.s 74.0 Weakly correlated
14 AluSx1 20 n.s 74.0 Weakly correlated
15 SVA_D 18 **** 15.2 Weakly correlated
16 AluJo 17 n.s 74.0 Weakly correlated
17 L2a 16 n.s 99.0 Highly correlated
18 L2b 13 n.s 99.0 Highly correlated
19 AluSp 11 n.s 74.0 Weakly correlated
20 AluSz 11 n.s 74.0 Weakly correlated
21 MIR 10 n.s 99.0 Highly correlated
22 MIRc 10 n.s 99.0 Highly correlated
23 AluSc 9 n.s 74.0 Weakly correlated
24 MIR3 9 n.s 99.0 Highly correlated
25 AluSz6 8 n.s 74.0 Weakly correlated
26 AluSg 7 n.s 74.0 Weakly correlated
27 AluSx3 7 n.s 74.0 Weakly correlated
28 L1PB1 7 n.s 74.0 Weakly correlated
29 MER52A 7 **** 74.0 Weakly correlated
30 MLT1D 7 n.s 99.0 Highly correlated
31 SVA_B 7 **** 15.2 Weakly correlated
32 AluSc8 6 n.s 74.0 Weakly correlated
33 AluSq2 6 n.s 74.0 Weakly correlated
34 AluSq 5 n.s 74.0 Weakly correlated
35 L1MEg 5 n.s 99.0 Highly correlated
36 L1P3 5 * 74.0 Weakly correlated
37 L1PA5 5 n.s 19.6 Weakly correlated
38 LTR12D 5 **** 19.6 Weakly correlated
39 LTR12E 5 **** 19.6 Weakly correlated
40 MLT1B 5 n.s 99.0 Highly correlated
41 AluJr4 4 n.s 74.0 Weakly correlated
42 FLAM_A 4 * 74.0 Weakly correlated
43 L1MA9 4 n.s 99.0 Highly correlated
44 L1MEd 4 n.s 99.0 Highly correlated
45 L2 4 n.s 99.0 Highly correlated
46 MER50 4 ** 43.0 Weakly correlated
47 SVA_F 4 *** 0.0 Weakly correlated
48 THE1A-int 4 * 43.0 Weakly correlated
49 THE1B-int 4 n.s 43.0 Weakly correlated
50 AluSq10 3 *** 74.0 Weakly correlated
51 AluSx4 3 n.s 74.0 Weakly correlated
52 HAL1 3 n.s 99.0 Highly correlated
53 HAL1M8 3 ** 99.0 Highly correlated
54 L1MC2 3 n.s 99.0 Highly correlated
55 L1MCa 3 n.s 99.0 Highly correlated
56 L1P1 3 n.s 19.6 Weakly correlated
57 L1PA14 3 n.s 74.0 Weakly correlated
58 L1PA8 3 n.s 74.0 Weakly correlated
59 LTR10A 3 **** 28.9 Weakly correlated
60 LTR33C 3 **** 99.0 Highly correlated
61 LTR8 3 * 43.0 Weakly correlated
62 MER21A 3 ** 74.0 Weakly correlated
63 MSTA-int 3 n.s 43.0 Weakly correlated
64 MamRTE1 3 * 99.0 Highly correlated
65 SVA_A 3 *** 19.6 Weakly correlated
66 THE1B 3 n.s 43.0 Weakly correlated
67 Alu 2 ** 74.0 Weakly correlated
68 AluSc5 2 n.s 74.0 Weakly correlated
69 AluYb8 2 * 15.2 Weakly correlated
70 AluYj4 2 * 0.0 Weakly correlated
71 AluYm1 2 n.s 19.6 Weakly correlated
72 ERVL-E-int 2 n.s 99.0 Highly correlated
73 HERVH-int 2 n.s 28.9 Weakly correlated
74 HERVP71A-int 2 ** 43.0 Weakly correlated
75 L1MB3 2 n.s 99.0 Highly correlated
76 L1MC 2 n.s 99.0 Highly correlated
77 L1MC1 2 n.s 99.0 Highly correlated
78 L1ME3A 2 n.s 99.0 Highly correlated
79 L1ME4b 2 n.s 99.0 Highly correlated
80 L1P4 2 n.s 74.0 Weakly correlated
81 L1PA16 2 n.s 74.0 Weakly correlated
82 L1PA3 2 n.s 19.6 Weakly correlated
83 L1PB3 2 n.s 74.0 Weakly correlated
84 L3 2 n.s 99.0 Highly correlated
85 LTR10F 2 *** 28.9 Weakly correlated
86 LTR14B 2 *** 28.9 Weakly correlated
87 LTR16A1 2 * 99.0 Highly correlated
88 LTR16C 2 n.s 99.0 Highly correlated
89 LTR1A2 2 ** 43.0 Weakly correlated
90 LTR28C 2 *** 43.0 Weakly correlated
91 LTR50 2 * 99.0 Highly correlated
92 MER39 2 n.s 74.0 Weakly correlated
93 MER39B 2 ** 74.0 Weakly correlated
94 MER50-int 2 ** 43.0 Weakly correlated
95 MER61-int 2 n.s 43.0 Weakly correlated
96 MLT1A0 2 n.s 99.0 Highly correlated
97 MLT1H 2 n.s 99.0 Highly correlated
98 MLT1J2 2 n.s 99.0 Highly correlated
99 MLT1K 2 n.s 99.0 Highly correlated
100 MLT1N2 2 * 99.0 Highly correlated
101 MSTB2 2 ** 74.0 Weakly correlated
102 THE1C-int 2 n.s 43.0 Weakly correlated
103 THE1D-int 2 n.s 28.9 Weakly correlated
104 AluSg4 1 n.s 74.0 Weakly correlated
105 AluSg7 1 n.s 74.0 Weakly correlated
106 AluYa5 1 n.s 15.2 Weakly correlated
107 AluYc3 1 ** 74.0 Weakly correlated
108 AluYe6 1 *** 74.0 Weakly correlated
109 AluYh3 1 n.s 15.2 Weakly correlated
110 AluYi6 1 ** 15.2 Weakly correlated
111 AluYk4 1 * 15.2 Weakly correlated
112 AmnSINE1 1 * 319.0 Weakly correlated
113 ERV24B_Prim-int 1 * 74.0 Weakly correlated
114 FLAM_C 1 n.s 74.0 Weakly correlated
115 FRAM 1 n.s 74.0 Weakly correlated
116 HAL1ME 1 n.s 99.0 Highly correlated
117 HERVI-int 1 ** 28.9 Weakly correlated
118 HERVK-int 1 n.s 28.9 Weakly correlated
119 HERVK3-int 1 * 28.9 Weakly correlated
120 HERVL-int 1 n.s 74.0 Weakly correlated
121 HERVL74-int 1 ** 99.0 Highly correlated
122 HUERS-P1-int 1 * 43.0 Weakly correlated
123 L1M1 1 n.s 74.0 Weakly correlated
124 L1M2 1 n.s 99.0 Highly correlated
125 L1M2a 1 * 87.0 Weakly correlated
126 L1M3 1 n.s 99.0 Highly correlated
127 L1M4 1 n.s 99.0 Highly correlated
128 L1M4a1 1 n.s 99.0 Highly correlated
129 L1M6 1 n.s 99.0 Highly correlated
130 L1MA3 1 n.s 74.0 Weakly correlated
131 L1MB1 1 n.s 99.0 Highly correlated
132 L1MB2 1 n.s 99.0 Highly correlated
133 L1MD2 1 n.s 99.0 Highly correlated
134 L1MDa 1 n.s 99.0 Highly correlated
135 L1ME1 1 n.s 99.0 Highly correlated
136 L1ME2z 1 n.s 99.0 Highly correlated
137 L1ME3Cz 1 n.s 99.0 Highly correlated
138 L1MEb 1 n.s 99.0 Highly correlated
139 L1MEf 1 n.s 99.0 Highly correlated
140 L1PA10 1 n.s 74.0 Weakly correlated
141 L1PA2 1 n.s 15.2 Weakly correlated
142 L1PA4 1 n.s 19.6 Weakly correlated
143 L1PA7 1 n.s 74.0 Weakly correlated
144 L1PA8A 1 n.s 74.0 Weakly correlated
145 L1PB 1 n.s 74.0 Weakly correlated
146 L1PB4 1 n.s 99.0 Highly correlated
147 L1PBa 1 n.s 74.0 Weakly correlated
148 LTR104_Mam 1 * 99.0 Highly correlated
149 LTR12 1 n.s 28.9 Weakly correlated
150 LTR13 1 * 19.6 Weakly correlated
151 LTR13A 1 ** 28.9 Weakly correlated
152 LTR16 1 n.s 99.0 Highly correlated
153 LTR16A2 1 n.s 99.0 Highly correlated
154 LTR16D1 1 *** 99.0 Highly correlated
155 LTR1D 1 * 43.0 Weakly correlated
156 LTR22B1 1 ** 28.9 Weakly correlated
157 LTR26 1 * 74.0 Weakly correlated
158 LTR2752 1 * 43.0 Weakly correlated
159 LTR27D 1 ** 43.0 Weakly correlated
160 LTR28 1 ** 43.0 Weakly correlated
161 LTR33A 1 n.s 99.0 Highly correlated
162 LTR33A_ 1 n.s 99.0 Highly correlated
163 LTR33B 1 * 99.0 Highly correlated
164 LTR41 1 * 99.0 Highly correlated
165 LTR48 1 * 74.0 Weakly correlated
166 LTR67B 1 n.s 99.0 Highly correlated
167 LTR69 1 *** 99.0 Highly correlated
168 LTR75B 1 ** 99.0 Highly correlated
169 LTR88b 1 * 99.0 Highly correlated
170 LTR9 1 * 43.0 Weakly correlated
171 MER110-int 1 * 99.0 Highly correlated
172 MER11D 1 * 19.6 Weakly correlated
173 MER21B 1 n.s 99.0 Highly correlated
174 MER21C 1 n.s 99.0 Highly correlated
175 MER31A 1 * 87.0 Weakly correlated
176 MER31B 1 n.s 99.0 Highly correlated
177 MER41-int 1 n.s 74.0 Weakly correlated
178 MER41B 1 n.s 74.0 Weakly correlated
179 MER4A 1 * 74.0 Weakly correlated
180 MER4B 1 n.s 74.0 Weakly correlated
181 MER4B-int 1 n.s 99.0 Highly correlated
182 MER4D 1 n.s 74.0 Weakly correlated
183 MER4D1 1 n.s 74.0 Weakly correlated
184 MER4E 1 * 74.0 Weakly correlated
185 MER51B 1 * 43.0 Weakly correlated
186 MER51E 1 ** 43.0 Weakly correlated
187 MER52D 1 n.s 74.0 Weakly correlated
188 MER57-int 1 n.s 87.0 Weakly correlated
189 MER57A1 1 * 43.0 Weakly correlated
190 MER66B 1 * 43.0 Weakly correlated
191 MER74C 1 ** 99.0 Highly correlated
192 MER76 1 * 99.0 Highly correlated
193 MER84 1 ** 43.0 Weakly correlated
194 MLT1A 1 n.s 99.0 Highly correlated
195 MLT1A0-int 1 n.s 99.0 Highly correlated
196 MLT1A1-int 1 * 87.0 Weakly correlated
197 MLT1F 1 n.s 99.0 Highly correlated
198 MLT1F2 1 n.s 99.0 Highly correlated
199 MLT1G 1 n.s 99.0 Highly correlated
200 MLT1G1 1 n.s 99.0 Highly correlated
201 MLT1H1 1 n.s 99.0 Highly correlated
202 MLT1J 1 n.s 99.0 Highly correlated
203 MLT1J-int 1 * 99.0 Highly correlated
204 MLT1L 1 n.s 99.0 Highly correlated
205 MSTA 1 n.s 43.0 Weakly correlated
206 MSTB1 1 n.s 74.0 Weakly correlated
207 MamGypLTR3 1 ** 99.0 Highly correlated
208 SVA_C 1 * 15.2 Weakly correlated
209 THE1A 1 n.s 43.0 Weakly correlated
210 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC4 203 **** 99.0 Highly correlated
2 L1MC3 150 **** 99.0 Highly correlated
3 L1MC4a 108 **** 99.0 Highly correlated
4 L1MC5a 93 **** 99.0 Highly correlated
5 L1MC5 63 **** 99.0 Highly correlated
6 L1MD3 23 **** 99.0 Highly correlated
7 L2c 6 n.s 99.0 Highly correlated
8 L2a 3 n.s 99.0 Highly correlated
9 AluJo 3 n.s 74.0 Weakly correlated
10 HAL1M8 3 ** 99.0 Highly correlated
11 MER21A 3 ** 74.0 Weakly correlated
12 L1PA8 2 n.s 74.0 Weakly correlated
13 L2 2 n.s 99.0 Highly correlated
14 AluSz6 2 n.s 74.0 Weakly correlated
15 MLT1J2 2 n.s 99.0 Highly correlated
16 MIR3 2 n.s 99.0 Highly correlated
17 L2b 2 n.s 99.0 Highly correlated
18 AluJb 2 n.s 74.0 Weakly correlated
19 L1ME3A 2 n.s 99.0 Highly correlated
20 LTR16C 1 n.s 99.0 Highly correlated
21 MER31B 1 n.s 99.0 Highly correlated
22 L1MC 1 n.s 99.0 Highly correlated
23 MLT1B 1 n.s 99.0 Highly correlated
24 MLT1K 1 n.s 99.0 Highly correlated
25 MER66B 1 * 43.0 Weakly correlated
26 MSTB2 1 n.s 74.0 Weakly correlated
27 L1MA3 1 n.s 74.0 Weakly correlated
28 LTR8 1 n.s 43.0 Weakly correlated
29 L1MC1 1 n.s 99.0 Highly correlated
30 THE1D-int 1 n.s 28.9 Weakly correlated
31 MER4E 1 * 74.0 Weakly correlated
32 MER39 1 n.s 74.0 Weakly correlated
33 SVA_A 1 * 19.6 Weakly correlated
34 MER21B 1 n.s 99.0 Highly correlated
35 L1MEg 1 n.s 99.0 Highly correlated
36 LTR16A2 1 n.s 99.0 Highly correlated
37 MER84 1 ** 43.0 Weakly correlated
38 L1MB2 1 n.s 99.0 Highly correlated
39 L1P3 1 n.s 74.0 Weakly correlated
40 L1PB1 1 n.s 74.0 Weakly correlated
41 L1PB3 1 n.s 74.0 Weakly correlated
42 MER11D 1 * 19.6 Weakly correlated
43 MER31A 1 * 87.0 Weakly correlated
44 MIRb 1 n.s 99.0 Highly correlated
45 MLT1J-int 1 * 99.0 Highly correlated
46 AluSx1 1 n.s 74.0 Weakly correlated
47 L1PA16 1 n.s 74.0 Weakly correlated
48 MER4B 1 n.s 74.0 Weakly correlated
49 MIRc 1 n.s 99.0 Highly correlated
50 MLT1A0 1 n.s 99.0 Highly correlated
51 MamRTE1 1 n.s 99.0 Highly correlated
52 AluYc3 1 ** 74.0 Weakly correlated
53 HAL1ME 1 n.s 99.0 Highly correlated
54 L1MD2 1 n.s 99.0 Highly correlated
55 MER50 1 n.s 43.0 Weakly correlated
56 MER57-int 1 n.s 87.0 Weakly correlated
57 HAL1 1 n.s 99.0 Highly correlated
58 L1MEd 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1MC3 99.0 Highly correlated
2 L1MC4 99.0 Highly correlated
3 L1MC4A 99.0 Highly correlated
4 L1MC5 99.0 Highly correlated
5 L1MC5A 99.0 Highly correlated
6 L1MD3 99.0 Highly correlated