ZRdb KZFP & Repeats
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Human_ZNF596

  • Protein
    Zinc finger protein 596
  • Length
    504
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q8TC21
  • NCBI_ID
    169270
Sequence:
MPSPDSMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLSTQRISLLQGREVGIKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFLCNDLGEDFTQHIALTQNVITYMRTKHFVSKKFGKIFSDWLSFNQHKEIHTKCKSYGSHLFDYAFIQNSALRPHSVTHTREITLECRVCGKTFSKNSNLRRHEMIHTGEKPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHLCGKAFSKSSNLRRHEMIHTREKAQICHLCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQHERTHNGEKPYECHLCGKAFSHCSHLRQHERSHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRHERTHTGEKPYECHLCGKAFNHSSVLRRHERTHTGEKPYECNICGKAFNRSYNFRLHRRVHTGEKPYVCPLCGKAFSKFFNLRQHERTHTKKAMNM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..78
2 C2h2 195..217
3 C2h2 223..245
4 C2h2 251..273
5 C2h2 279..301
6 C2h2 307..329
7 C2h2 335..357
8 C2h2 363..385
9 C2h2 391..413
10 C2h2 419..441
11 C2h2 447..469
12 C2h2 475..497
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIR 10 n.s 99.0 Moderately correlated
2 AluJb 7 n.s 74.0 Weakly correlated
3 L2c 7 n.s 99.0 Moderately correlated
4 AluJo 6 n.s 74.0 Weakly correlated
5 L2a 6 n.s 99.0 Moderately correlated
6 HERVIP10FH-int 6 **** 28.9 Weakly correlated
7 HERV17-int 6 **** 28.9 Weakly correlated
8 AluJr 5 n.s 74.0 Weakly correlated
9 MIRc 5 n.s 99.0 Moderately correlated
10 AluSx1 5 n.s 74.0 Weakly correlated
11 HAL1 5 * 99.0 Moderately correlated
12 THE1D 4 ** 43.0 Weakly correlated
13 MLT1A 4 *** 99.0 Moderately correlated
14 MIR3 4 n.s 99.0 Moderately correlated
15 AluSc8 4 * 74.0 Weakly correlated
16 L2b 3 n.s 99.0 Moderately correlated
17 LTR35A 3 **** 43.0 Weakly correlated
18 L1M1 3 n.s 74.0 Weakly correlated
19 LTR33A 2 *** 99.0 Moderately correlated
20 MLT1B 2 n.s 99.0 Moderately correlated
21 L1MEf 2 n.s 99.0 Moderately correlated
22 L1MEd 2 n.s 99.0 Moderately correlated
23 MLT1E2 2 ** 99.0 Moderately correlated
24 AluSc 2 n.s 74.0 Weakly correlated
25 LTR10A 2 **** 28.9 Weakly correlated
26 HUERS-P3b-int 2 *** 43.0 Weakly correlated
27 MSTA 2 n.s 43.0 Weakly correlated
28 AluY 2 n.s 74.0 Weakly correlated
29 AluSp 2 n.s 74.0 Weakly correlated
30 MER21A 2 *** 74.0 Weakly correlated
31 AmnSINE1 2 **** 319.0 Weakly correlated
32 MIRb 2 n.s 99.0 Moderately correlated
33 MER52-int 1 ** 99.0 Moderately correlated
34 AluSg4 1 n.s 74.0 Weakly correlated
35 LTR9D 1 ** 43.0 Weakly correlated
36 MER50-int 1 ** 43.0 Weakly correlated
37 MER50 1 * 43.0 Weakly correlated
38 AluJr4 1 n.s 74.0 Weakly correlated
39 AluSc5 1 n.s 74.0 Weakly correlated
40 MLT1F2 1 n.s 99.0 Moderately correlated
41 MLT1G3 1 * 99.0 Moderately correlated
42 MLT1L 1 n.s 99.0 Moderately correlated
43 MLT1O 1 * 99.0 Moderately correlated
44 MLT2F 1 ** 99.0 Moderately correlated
45 MamGypLTR1a 1 ** 99.0 Moderately correlated
46 MamRTE1 1 * 99.0 Moderately correlated
47 PRIMA4-int 1 ** 74.0 Weakly correlated
48 AluYh3 1 ** 15.2 Weakly correlated
49 L1ME4a 1 n.s 99.0 Moderately correlated
50 AluYj4 1 * 0.0 Weakly correlated
51 CR1-16_AMi 1 *** 319.0 Weakly correlated
52 CR1_Mam 1 ** 99.0 Moderately correlated
53 FLAM_A 1 n.s 74.0 Weakly correlated
54 AluSz 1 n.s 74.0 Weakly correlated
55 HERVFH21-int 1 *** 28.9 Weakly correlated
56 AluSx3 1 n.s 74.0 Weakly correlated
57 L1M6B 1 *** 99.0 Moderately correlated
58 L1MB5 1 n.s 99.0 Moderately correlated
59 L1MC4 1 n.s 99.0 Moderately correlated
60 LTR88c 1 *** 99.0 Moderately correlated
61 L1MEg 1 n.s 99.0 Moderately correlated
62 L2 1 n.s 99.0 Moderately correlated
63 AluSx 1 n.s 74.0 Weakly correlated
64 L3 1 n.s 99.0 Moderately correlated
65 LTR10B1 1 **** 28.9 Weakly correlated
66 LTR1A2 1 ** 43.0 Weakly correlated
67 LTR27 1 **** 43.0 Weakly correlated
68 LTR81A 1 ** 99.0 Moderately correlated
69 LTR86C 1 *** 99.0 Moderately correlated
70 LTR88b 1 ** 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERVIP10FH-int 6 **** 28.9 Weakly correlated
2 HERV17-int 6 **** 28.9 Weakly correlated
3 L2a 6 n.s 99.0 Moderately correlated
4 HAL1 5 * 99.0 Moderately correlated
5 AluJo 5 n.s 74.0 Weakly correlated
6 THE1D 4 ** 43.0 Weakly correlated
7 L1M1 3 n.s 74.0 Weakly correlated
8 LTR35A 3 **** 43.0 Weakly correlated
9 AluJr 2 n.s 74.0 Weakly correlated
10 AluJb 2 n.s 74.0 Weakly correlated
11 MER21A 2 *** 74.0 Weakly correlated
12 L2c 2 n.s 99.0 Moderately correlated
13 L1MEd 2 n.s 99.0 Moderately correlated
14 MIR 2 n.s 99.0 Moderately correlated
15 AluSc 2 n.s 74.0 Weakly correlated
16 MLT1B 2 n.s 99.0 Moderately correlated
17 MLT1A 2 * 99.0 Moderately correlated
18 LTR33A 2 *** 99.0 Moderately correlated
19 L2b 2 n.s 99.0 Moderately correlated
20 AluSp 2 n.s 74.0 Weakly correlated
21 L1MEf 2 n.s 99.0 Moderately correlated
22 MSTA 2 n.s 43.0 Weakly correlated
23 HUERS-P3b-int 2 *** 43.0 Weakly correlated
24 MLT2F 1 ** 99.0 Moderately correlated
25 MIR3 1 n.s 99.0 Moderately correlated
26 AluSx 1 n.s 74.0 Weakly correlated
27 MER52-int 1 ** 99.0 Moderately correlated
28 AluSz 1 n.s 74.0 Weakly correlated
29 MLT1G3 1 * 99.0 Moderately correlated
30 HERVFH21-int 1 *** 28.9 Weakly correlated
31 AluSx1 1 n.s 74.0 Weakly correlated
32 LTR88c 1 *** 99.0 Moderately correlated
33 PRIMA4-int 1 ** 74.0 Weakly correlated
34 LTR9D 1 ** 43.0 Weakly correlated
35 FLAM_A 1 n.s 74.0 Weakly correlated
36 CR1-16_AMi 1 *** 319.0 Weakly correlated
37 AluY 1 n.s 74.0 Weakly correlated
38 AluSc8 1 n.s 74.0 Weakly correlated
39 MamGypLTR1a 1 ** 99.0 Moderately correlated
40 MER50-int 1 ** 43.0 Weakly correlated
41 L1M6B 1 *** 99.0 Moderately correlated
42 MLT1F2 1 n.s 99.0 Moderately correlated
43 AmnSINE1 1 ** 319.0 Weakly correlated
44 AluSc5 1 n.s 74.0 Weakly correlated
45 MIRc 1 n.s 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 HERV17-INT 28.9 Weakly correlated