Human_ZNF587
-
ProteinZinc finger protein 587
-
Length575
-
OrganismHomo sapiens (Human)
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Time of emergence43.0 Mya
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Time of Changing in binding specificity28.9 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MAAAVPRRPTQQGTVTFEDVAVNFSQEEWCLLSEAQRCLYRDVMLENLALISSLGCWCGSKDEEAPCKQRISVQRESQSRTPRAGVSPKKAHPCEMCGLILEDVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSVREASFVKKRKLRVSQEPFVFREFGKDVLPSSGLCQEEAAVEKTDSETMHGPPFQEGKTNYSCGKRTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGQTAYPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQHQQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVHHQRGHTGERPYECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGNKHSVTIHQRIHTGERPYECSECGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFSECSSLIKHRRIHTGERPYECTKCGKTFQRSSTLLHHQSSHRRKAL
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 15..88 | |
| 2 | C2h2 | 92..114 | |
| 3 | C2h2 | 240..262 | |
| 4 | C2h2 | 268..290 | |
| 5 | C2h2 | 296..318 | |
| 6 | C2h2 | 324..346 | |
| 7 | C2h2 | 352..374 | |
| 8 | C2h2 | 380..402 | |
| 9 | C2h2 | 408..430 | |
| 10 | C2h2 | 436..458 | |
| 11 | C2h2 | 464..486 | |
| 12 | C2h2 | 492..514 | |
| 13 | C2h2 | 520..542 | |
| 14 | C2h2 | 548..570 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | metal ion binding | |
| 4 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 5 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER61-int | 29 | **** | 43.0 | Moderately correlated | |
| 2 | HERVK-int | 25 | **** | 28.9 | Highly correlated | |
| 3 | MER61A | 25 | **** | 43.0 | Moderately correlated | |
| 4 | LTR5B | 15 | **** | 28.9 | Highly correlated | |
| 5 | AluY | 11 | n.s | 74.0 | Weakly correlated | |
| 6 | HERVK9-int | 11 | **** | 28.9 | Highly correlated | |
| 7 | AluJb | 9 | n.s | 74.0 | Weakly correlated | |
| 8 | LTR5_Hs | 9 | **** | 0.0 | Weakly correlated | |
| 9 | AluSx1 | 8 | n.s | 74.0 | Weakly correlated | |
| 10 | HERVK14-int | 7 | **** | 28.9 | Highly correlated | |
| 11 | MER9a3 | 7 | **** | 28.9 | Highly correlated | |
| 12 | L1PA5 | 6 | n.s | 19.6 | Weakly correlated | |
| 13 | L2a | 6 | n.s | 99.0 | Weakly correlated | |
| 14 | LTR14C | 6 | **** | 28.9 | Highly correlated | |
| 15 | LTR5A | 6 | **** | 19.6 | Weakly correlated | |
| 16 | AluJr | 5 | n.s | 74.0 | Weakly correlated | |
| 17 | AluSx | 5 | n.s | 74.0 | Weakly correlated | |
| 18 | HERVK14C-int | 5 | **** | 28.9 | Highly correlated | |
| 19 | MER4B-int | 5 | **** | 99.0 | Weakly correlated | |
| 20 | AluSg | 4 | n.s | 74.0 | Weakly correlated | |
| 21 | L1PA3 | 4 | n.s | 19.6 | Weakly correlated | |
| 22 | L2b | 4 | n.s | 99.0 | Weakly correlated | |
| 23 | L2c | 4 | n.s | 99.0 | Weakly correlated | |
| 24 | LTR10A | 4 | **** | 28.9 | Highly correlated | |
| 25 | LTR14B | 4 | **** | 28.9 | Highly correlated | |
| 26 | MER61B | 4 | **** | 43.0 | Moderately correlated | |
| 27 | MIRb | 4 | n.s | 99.0 | Weakly correlated | |
| 28 | AluSg7 | 3 | ** | 74.0 | Weakly correlated | |
| 29 | HERV9N-int | 3 | **** | 19.6 | Weakly correlated | |
| 30 | HERVK11-int | 3 | **** | 28.9 | Highly correlated | |
| 31 | HERVK13-int | 3 | **** | 19.6 | Weakly correlated | |
| 32 | LTR12 | 3 | **** | 28.9 | Highly correlated | |
| 33 | LTR13 | 3 | **** | 19.6 | Weakly correlated | |
| 34 | LTR14A | 3 | **** | 28.9 | Highly correlated | |
| 35 | MIR | 3 | n.s | 99.0 | Weakly correlated | |
| 36 | AluJo | 2 | n.s | 74.0 | Weakly correlated | |
| 37 | AluSc | 2 | n.s | 74.0 | Weakly correlated | |
| 38 | AluSz | 2 | n.s | 74.0 | Weakly correlated | |
| 39 | AluYj4 | 2 | *** | 0.0 | Weakly correlated | |
| 40 | FLAM_A | 2 | ** | 74.0 | Weakly correlated | |
| 41 | HERVK11D-int | 2 | **** | 19.6 | Weakly correlated | |
| 42 | HERVKC4-int | 2 | **** | 28.9 | Highly correlated | |
| 43 | L1M1 | 2 | n.s | 74.0 | Weakly correlated | |
| 44 | L1M4a1 | 2 | ** | 99.0 | Weakly correlated | |
| 45 | L1M5 | 2 | n.s | 99.0 | Weakly correlated | |
| 46 | L1MC5a | 2 | n.s | 99.0 | Weakly correlated | |
| 47 | L1P1 | 2 | * | 19.6 | Weakly correlated | |
| 48 | L1P3 | 2 | * | 74.0 | Weakly correlated | |
| 49 | L1PA16 | 2 | n.s | 74.0 | Weakly correlated | |
| 50 | L1PA2 | 2 | n.s | 15.2 | Weakly correlated | |
| 51 | L2 | 2 | n.s | 99.0 | Weakly correlated | |
| 52 | L3 | 2 | n.s | 99.0 | Weakly correlated | |
| 53 | LTR10F | 2 | **** | 28.9 | Highly correlated | |
| 54 | LTR12_ | 2 | **** | 28.9 | Highly correlated | |
| 55 | LTR14 | 2 | **** | 28.9 | Highly correlated | |
| 56 | LTR18A | 2 | **** | 43.0 | Moderately correlated | |
| 57 | LTR3A | 2 | **** | 28.9 | Highly correlated | |
| 58 | MER11D | 2 | **** | 19.6 | Weakly correlated | |
| 59 | MER4E | 2 | **** | 74.0 | Weakly correlated | |
| 60 | MER66-int | 2 | *** | 43.0 | Moderately correlated | |
| 61 | MER66C | 2 | **** | 43.0 | Moderately correlated | |
| 62 | MER9a1 | 2 | **** | 19.6 | Weakly correlated | |
| 63 | MER9a2 | 2 | **** | 19.6 | Weakly correlated | |
| 64 | MIR3 | 2 | n.s | 99.0 | Weakly correlated | |
| 65 | MamRTE1 | 2 | ** | 99.0 | Weakly correlated | |
| 66 | AluSc8 | 1 | n.s | 74.0 | Weakly correlated | |
| 67 | AluSp | 1 | n.s | 74.0 | Weakly correlated | |
| 68 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 69 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated | |
| 70 | AluSz6 | 1 | n.s | 74.0 | Weakly correlated | |
| 71 | AluYd8 | 1 | **** | 15.2 | Weakly correlated | |
| 72 | AluYh3 | 1 | ** | 15.2 | Weakly correlated | |
| 73 | AluYh9 | 1 | **** | 15.2 | Weakly correlated | |
| 74 | AluYk2 | 1 | ** | 19.6 | Weakly correlated | |
| 75 | AluYm1 | 1 | * | 19.6 | Weakly correlated | |
| 76 | ERV3-16A3_LTR | 1 | ** | 99.0 | Weakly correlated | |
| 77 | FRAM | 1 | * | 74.0 | Weakly correlated | |
| 78 | HAL1 | 1 | n.s | 99.0 | Weakly correlated | |
| 79 | HERV3-int | 1 | ** | 28.9 | Highly correlated | |
| 80 | HERV9NC-int | 1 | * | 19.6 | Weakly correlated | |
| 81 | HERVH-int | 1 | n.s | 28.9 | Highly correlated | |
| 82 | HERVK3-int | 1 | ** | 28.9 | Highly correlated | |
| 83 | L1HS | 1 | n.s | 8.6 | Weakly correlated | |
| 84 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 85 | L1MA9 | 1 | n.s | 99.0 | Weakly correlated | |
| 86 | L1MB3 | 1 | n.s | 99.0 | Weakly correlated | |
| 87 | L1MC5 | 1 | n.s | 99.0 | Weakly correlated | |
| 88 | L1MD1 | 1 | n.s | 99.0 | Weakly correlated | |
| 89 | L1MD2 | 1 | n.s | 99.0 | Weakly correlated | |
| 90 | L1ME4b | 1 | n.s | 99.0 | Weakly correlated | |
| 91 | L1P4 | 1 | n.s | 74.0 | Weakly correlated | |
| 92 | L1PA10 | 1 | n.s | 74.0 | Weakly correlated | |
| 93 | L1PA6 | 1 | n.s | 28.9 | Highly correlated | |
| 94 | L1PB4 | 1 | n.s | 99.0 | Weakly correlated | |
| 95 | LTR105_Mam | 1 | *** | 99.0 | Weakly correlated | |
| 96 | LTR10B1 | 1 | **** | 28.9 | Highly correlated | |
| 97 | LTR10C | 1 | ** | 28.9 | Highly correlated | |
| 98 | LTR13_ | 1 | **** | 28.9 | Highly correlated | |
| 99 | LTR16A | 1 | * | 99.0 | Weakly correlated | |
| 100 | LTR16B1 | 1 | ** | 99.0 | Weakly correlated | |
| 101 | LTR38-int | 1 | **** | 74.0 | Weakly correlated | |
| 102 | LTR3B_ | 1 | *** | 28.9 | Highly correlated | |
| 103 | LTR48 | 1 | ** | 74.0 | Weakly correlated | |
| 104 | LTR6A | 1 | *** | 28.9 | Highly correlated | |
| 105 | LTR78 | 1 | * | 99.0 | Weakly correlated | |
| 106 | MER11A | 1 | * | 28.9 | Highly correlated | |
| 107 | MER11B | 1 | ** | 19.6 | Weakly correlated | |
| 108 | MER11C | 1 | * | 19.6 | Weakly correlated | |
| 109 | MER34C2 | 1 | *** | 74.0 | Weakly correlated | |
| 110 | MER34D | 1 | *** | 74.0 | Weakly correlated | |
| 111 | MER39B | 1 | ** | 74.0 | Weakly correlated | |
| 112 | MER4D | 1 | ** | 74.0 | Weakly correlated | |
| 113 | MER50 | 1 | * | 43.0 | Moderately correlated | |
| 114 | MER52D | 1 | ** | 74.0 | Weakly correlated | |
| 115 | MER57-int | 1 | * | 87.0 | Weakly correlated | |
| 116 | MER61C | 1 | *** | 43.0 | Moderately correlated | |
| 117 | MER66B | 1 | ** | 43.0 | Moderately correlated | |
| 118 | MER70B | 1 | ** | 87.0 | Weakly correlated | |
| 119 | MER74A | 1 | ** | 99.0 | Weakly correlated | |
| 120 | MER76 | 1 | ** | 99.0 | Weakly correlated | |
| 121 | MER9B | 1 | **** | 28.9 | Highly correlated | |
| 122 | MIRc | 1 | n.s | 99.0 | Weakly correlated | |
| 123 | MLT1F2 | 1 | n.s | 99.0 | Weakly correlated | |
| 124 | MLT1G3 | 1 | * | 99.0 | Weakly correlated | |
| 125 | MLT1H2 | 1 | * | 99.0 | Weakly correlated | |
| 126 | MLT1J | 1 | n.s | 99.0 | Weakly correlated | |
| 127 | MamGypLTR3 | 1 | *** | 99.0 | Weakly correlated | |
| 128 | MamGypLTR3a | 1 | ** | 99.0 | Weakly correlated | |
| 129 | SVA_A | 1 | ** | 19.6 | Weakly correlated | |
| 130 | THE1B-int | 1 | n.s | 43.0 | Moderately correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER61-int | 28 | **** | 43.0 | Moderately correlated | |
| 2 | HERVK-int | 23 | **** | 28.9 | Highly correlated | |
| 3 | HERVK9-int | 11 | **** | 28.9 | Highly correlated | |
| 4 | MER61A | 9 | **** | 43.0 | Moderately correlated | |
| 5 | HERVK14-int | 7 | **** | 28.9 | Highly correlated | |
| 6 | AluSx1 | 7 | n.s | 74.0 | Weakly correlated | |
| 7 | AluJb | 5 | n.s | 74.0 | Weakly correlated | |
| 8 | HERVK14C-int | 5 | **** | 28.9 | Highly correlated | |
| 9 | AluY | 4 | n.s | 74.0 | Weakly correlated | |
| 10 | MER4B-int | 4 | **** | 99.0 | Weakly correlated | |
| 11 | L1PA3 | 4 | n.s | 19.6 | Weakly correlated | |
| 12 | L2b | 4 | n.s | 99.0 | Weakly correlated | |
| 13 | AluSx | 3 | n.s | 74.0 | Weakly correlated | |
| 14 | HERVK13-int | 3 | **** | 19.6 | Weakly correlated | |
| 15 | L2a | 3 | n.s | 99.0 | Weakly correlated | |
| 16 | AluJr | 3 | n.s | 74.0 | Weakly correlated | |
| 17 | MamRTE1 | 2 | ** | 99.0 | Weakly correlated | |
| 18 | HERV9N-int | 2 | *** | 19.6 | Weakly correlated | |
| 19 | L2c | 2 | n.s | 99.0 | Weakly correlated | |
| 20 | MER66C | 2 | **** | 43.0 | Moderately correlated | |
| 21 | L1PA16 | 2 | n.s | 74.0 | Weakly correlated | |
| 22 | HERVK11-int | 2 | *** | 28.9 | Highly correlated | |
| 23 | HERVK11D-int | 2 | **** | 19.6 | Weakly correlated | |
| 24 | L1M1 | 2 | n.s | 74.0 | Weakly correlated | |
| 25 | L1PA5 | 2 | n.s | 19.6 | Weakly correlated | |
| 26 | AluSg7 | 2 | * | 74.0 | Weakly correlated | |
| 27 | HERVKC4-int | 2 | **** | 28.9 | Highly correlated | |
| 28 | L3 | 1 | n.s | 99.0 | Weakly correlated | |
| 29 | MER57-int | 1 | * | 87.0 | Weakly correlated | |
| 30 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 31 | LTR105_Mam | 1 | *** | 99.0 | Weakly correlated | |
| 32 | LTR14 | 1 | **** | 28.9 | Highly correlated | |
| 33 | MER34D | 1 | *** | 74.0 | Weakly correlated | |
| 34 | L1M5 | 1 | n.s | 99.0 | Weakly correlated | |
| 35 | MER11C | 1 | * | 19.6 | Weakly correlated | |
| 36 | MER50 | 1 | * | 43.0 | Moderately correlated | |
| 37 | MER66-int | 1 | ** | 43.0 | Moderately correlated | |
| 38 | MLT1J | 1 | n.s | 99.0 | Weakly correlated | |
| 39 | L1PA2 | 1 | n.s | 15.2 | Weakly correlated | |
| 40 | L1P1 | 1 | n.s | 19.6 | Weakly correlated | |
| 41 | MLT1H2 | 1 | * | 99.0 | Weakly correlated | |
| 42 | AluYk2 | 1 | ** | 19.6 | Weakly correlated | |
| 43 | ERV3-16A3_LTR | 1 | ** | 99.0 | Weakly correlated | |
| 44 | HERVK3-int | 1 | ** | 28.9 | Highly correlated | |
| 45 | AluSz | 1 | n.s | 74.0 | Weakly correlated | |
| 46 | AluSp | 1 | n.s | 74.0 | Weakly correlated | |
| 47 | L1MD1 | 1 | n.s | 99.0 | Weakly correlated | |
| 48 | LTR48 | 1 | ** | 74.0 | Weakly correlated | |
| 49 | MamGypLTR3a | 1 | ** | 99.0 | Weakly correlated | |
| 50 | AluJo | 1 | n.s | 74.0 | Weakly correlated | |
| 51 | L1HS | 1 | n.s | 8.6 | Weakly correlated | |
| 52 | L1MC5a | 1 | n.s | 99.0 | Weakly correlated | |
| 53 | LTR3A | 1 | *** | 28.9 | Highly correlated | |
| 54 | MER76 | 1 | ** | 99.0 | Weakly correlated | |
| 55 | LTR16B1 | 1 | ** | 99.0 | Weakly correlated | |
| 56 | MER74A | 1 | ** | 99.0 | Weakly correlated | |
| 57 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated | |
| 58 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 59 | AluYj4 | 1 | * | 0.0 | Weakly correlated | |
| 60 | FLAM_A | 1 | n.s | 74.0 | Weakly correlated | |
| 61 | HAL1 | 1 | n.s | 99.0 | Weakly correlated | |
| 62 | L1MB3 | 1 | n.s | 99.0 | Weakly correlated | |
| 63 | LTR18A | 1 | **** | 43.0 | Moderately correlated | |
| 64 | MER52D | 1 | ** | 74.0 | Weakly correlated | |
| 65 | AluSg | 1 | n.s | 74.0 | Weakly correlated | |
| 66 | THE1B-int | 1 | n.s | 43.0 | Moderately correlated | |
| 67 | AluYh3 | 1 | ** | 15.2 | Weakly correlated | |
| 68 | L1M4a1 | 1 | * | 99.0 | Weakly correlated | |
| 69 | LTR6A | 1 | *** | 28.9 | Highly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|
| 1 | HERVK-INT | 28.9 | Highly correlated | |
| 2 | HERVK14-INT | 28.9 | Highly correlated | |
| 3 | MER61-INT | 43.0 | Moderately correlated |