Human_ZNF586
-
ProteinZinc finger protein 586
-
Length402
-
OrganismHomo sapiens (Human)
-
Time of emergence69.0 Mya
-
Time of Changing in binding specificity43.0 Mya
-
Uniprot_ID
-
NCBI_ID
Sequence:
MAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEAQRCLYRDVMLETLTLISSLGCWHGGEDEAAPSKQSTCIHIYKDQGGHSGERPYECGEYRKLFKNKSCLTEPRRDHKHRNVRTGERPYECSKYGKLFHQKPTLHIHERFHTGQKTYECSECGKSFHQSSSLLQRQTLHTRERPYECIECGKAFAEKSSLINHRKVHSGAKRYECNECGKSFAYTSSLIKHRRIHTGERPYECSECGRSFAENSSLIKHLRVHTGERPYECVECGKSFRRSSSLLQHQRVHTRERPYECSECGKSFSLRSNLIHHQRVHTGERHECGQCGKSFSRKSSLIIHLRVHTGERPYECSDCGKSFAENSSLIKHLRVHTGERPYECIDCGKSFRHSSSFRRHQRVHTGMRPYK
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 15..87 | |
| 2 | dec2h2 | 88..116 | |
| 3 | dec2h2 | 122..144 | |
| 4 | dec2h2 | 150..172 | |
| 5 | C2h2 | 178..200 | |
| 6 | C2h2 | 206..228 | |
| 7 | C2h2 | 234..256 | |
| 8 | C2h2 | 262..284 | |
| 9 | C2h2 | 290..312 | |
| 10 | C2h2 | 317..339 | |
| 11 | C2h2 | 345..367 | |
| 12 | C2h2 | 373..395 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | metal ion binding | |
| 4 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 5 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | THE1B-int | 1156 | **** | 43.0 | Highly correlated | |
| 2 | MSTA-int | 559 | **** | 43.0 | Highly correlated | |
| 3 | THE1C-int | 512 | **** | 43.0 | Highly correlated | |
| 4 | THE1D-int | 484 | **** | 28.9 | Weakly correlated | |
| 5 | THE1A-int | 402 | **** | 43.0 | Highly correlated | |
| 6 | MSTB-int | 142 | **** | 43.0 | Highly correlated | |
| 7 | MSTB1-int | 28 | **** | 74.0 | Weakly correlated | |
| 8 | THE1-int | 27 | **** | 43.0 | Highly correlated | |
| 9 | MSTC-int | 19 | **** | 74.0 | Weakly correlated | |
| 10 | MSTD-int | 18 | **** | 74.0 | Weakly correlated | |
| 11 | MST-int | 17 | **** | 74.0 | Weakly correlated | |
| 12 | L2a | 14 | n.s | 99.0 | Weakly correlated | |
| 13 | L2b | 14 | n.s | 99.0 | Weakly correlated | |
| 14 | MIRb | 14 | n.s | 99.0 | Weakly correlated | |
| 15 | AluJo | 12 | n.s | 74.0 | Weakly correlated | |
| 16 | AluJb | 11 | n.s | 74.0 | Weakly correlated | |
| 17 | MSTA | 10 | n.s | 43.0 | Highly correlated | |
| 18 | THE1B | 10 | n.s | 43.0 | Highly correlated | |
| 19 | AluSx | 9 | n.s | 74.0 | Weakly correlated | |
| 20 | AluSx1 | 8 | n.s | 74.0 | Weakly correlated | |
| 21 | MIR | 7 | n.s | 99.0 | Weakly correlated | |
| 22 | AluJr | 6 | n.s | 74.0 | Weakly correlated | |
| 23 | AluY | 6 | n.s | 74.0 | Weakly correlated | |
| 24 | MIRc | 6 | n.s | 99.0 | Weakly correlated | |
| 25 | MSTB2-int | 6 | **** | 74.0 | Weakly correlated | |
| 26 | AluSz | 5 | n.s | 74.0 | Weakly correlated | |
| 27 | L2 | 5 | n.s | 99.0 | Weakly correlated | |
| 28 | L2c | 5 | n.s | 99.0 | Weakly correlated | |
| 29 | LTR18A | 5 | **** | 43.0 | Highly correlated | |
| 30 | MLT1L | 5 | n.s | 99.0 | Weakly correlated | |
| 31 | AluSp | 4 | n.s | 74.0 | Weakly correlated | |
| 32 | AluSz6 | 4 | n.s | 74.0 | Weakly correlated | |
| 33 | L1MA2 | 4 | n.s | 74.0 | Weakly correlated | |
| 34 | L1MEg | 4 | n.s | 99.0 | Weakly correlated | |
| 35 | MIR3 | 4 | n.s | 99.0 | Weakly correlated | |
| 36 | THE1A | 4 | * | 43.0 | Highly correlated | |
| 37 | THE1C | 4 | n.s | 43.0 | Highly correlated | |
| 38 | AluSc8 | 3 | n.s | 74.0 | Weakly correlated | |
| 39 | L1MB8 | 3 | n.s | 99.0 | Weakly correlated | |
| 40 | L1MC2 | 3 | n.s | 99.0 | Weakly correlated | |
| 41 | L1ME2 | 3 | n.s | 99.0 | Weakly correlated | |
| 42 | L1ME3 | 3 | n.s | 99.0 | Weakly correlated | |
| 43 | MLT1F2 | 3 | n.s | 99.0 | Weakly correlated | |
| 44 | MSTA1-int | 3 | **** | 74.0 | Weakly correlated | |
| 45 | THE1D | 3 | n.s | 43.0 | Highly correlated | |
| 46 | AluSc | 2 | n.s | 74.0 | Weakly correlated | |
| 47 | AluSg | 2 | n.s | 74.0 | Weakly correlated | |
| 48 | AluSg7 | 2 | n.s | 74.0 | Weakly correlated | |
| 49 | AluYj4 | 2 | n.s | 0.0 | Weakly correlated | |
| 50 | AluYm1 | 2 | n.s | 19.6 | Weakly correlated | |
| 51 | FLAM_A | 2 | n.s | 74.0 | Weakly correlated | |
| 52 | FRAM | 2 | n.s | 74.0 | Weakly correlated | |
| 53 | L1M5 | 2 | n.s | 99.0 | Weakly correlated | |
| 54 | L1MA4 | 2 | n.s | 87.0 | Weakly correlated | |
| 55 | L1MA5 | 2 | n.s | 87.0 | Weakly correlated | |
| 56 | L1MA9 | 2 | n.s | 99.0 | Weakly correlated | |
| 57 | L1MC4 | 2 | n.s | 99.0 | Weakly correlated | |
| 58 | L1ME1 | 2 | n.s | 99.0 | Weakly correlated | |
| 59 | L1ME4a | 2 | n.s | 99.0 | Weakly correlated | |
| 60 | L1ME4b | 2 | n.s | 99.0 | Weakly correlated | |
| 61 | L1MEc | 2 | n.s | 99.0 | Weakly correlated | |
| 62 | L1MEd | 2 | n.s | 99.0 | Weakly correlated | |
| 63 | L1PA16 | 2 | n.s | 74.0 | Weakly correlated | |
| 64 | L1PA2 | 2 | n.s | 15.2 | Weakly correlated | |
| 65 | L1PA4 | 2 | n.s | 19.6 | Weakly correlated | |
| 66 | L1PB1 | 2 | n.s | 74.0 | Weakly correlated | |
| 67 | L1PB4 | 2 | n.s | 99.0 | Weakly correlated | |
| 68 | LTR33 | 2 | n.s | 99.0 | Weakly correlated | |
| 69 | LTR76 | 2 | *** | 74.0 | Weakly correlated | |
| 70 | MER50-int | 2 | * | 43.0 | Highly correlated | |
| 71 | MER52A | 2 | n.s | 74.0 | Weakly correlated | |
| 72 | MLT-int | 2 | *** | 99.0 | Weakly correlated | |
| 73 | MLT1A | 2 | n.s | 99.0 | Weakly correlated | |
| 74 | MLT1B | 2 | n.s | 99.0 | Weakly correlated | |
| 75 | MLT1D | 2 | n.s | 99.0 | Weakly correlated | |
| 76 | MLT1K | 2 | n.s | 99.0 | Weakly correlated | |
| 77 | MSTB | 2 | n.s | 43.0 | Highly correlated | |
| 78 | MSTC | 2 | n.s | 74.0 | Weakly correlated | |
| 79 | AluJr4 | 1 | n.s | 74.0 | Weakly correlated | |
| 80 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated | |
| 81 | AluSx3 | 1 | n.s | 74.0 | Weakly correlated | |
| 82 | AluYc | 1 | n.s | 74.0 | Weakly correlated | |
| 83 | AluYg6 | 1 | * | 15.2 | Weakly correlated | |
| 84 | AluYh3 | 1 | n.s | 15.2 | Weakly correlated | |
| 85 | CR1_Mam | 1 | n.s | 99.0 | Weakly correlated | |
| 86 | ERVL-B4-int | 1 | n.s | 99.0 | Weakly correlated | |
| 87 | FLAM_C | 1 | n.s | 74.0 | Weakly correlated | |
| 88 | HAL1 | 1 | n.s | 99.0 | Weakly correlated | |
| 89 | HAL1b | 1 | n.s | 99.0 | Weakly correlated | |
| 90 | HERV3-int | 1 | n.s | 28.9 | Weakly correlated | |
| 91 | HERVL18-int | 1 | n.s | 43.0 | Highly correlated | |
| 92 | HUERS-P3b-int | 1 | n.s | 43.0 | Highly correlated | |
| 93 | L1M1 | 1 | n.s | 74.0 | Weakly correlated | |
| 94 | L1M2 | 1 | n.s | 99.0 | Weakly correlated | |
| 95 | L1M2a | 1 | n.s | 87.0 | Weakly correlated | |
| 96 | L1M4 | 1 | n.s | 99.0 | Weakly correlated | |
| 97 | L1M4a2 | 1 | n.s | 99.0 | Weakly correlated | |
| 98 | L1M4b | 1 | n.s | 99.0 | Weakly correlated | |
| 99 | L1M7 | 1 | n.s | 99.0 | Weakly correlated | |
| 100 | L1MA1 | 1 | n.s | 74.0 | Weakly correlated | |
| 101 | L1MA10 | 1 | n.s | 99.0 | Weakly correlated | |
| 102 | L1MA5A | 1 | n.s | 87.0 | Weakly correlated | |
| 103 | L1MA6 | 1 | n.s | 87.0 | Weakly correlated | |
| 104 | L1MA7 | 1 | n.s | 87.0 | Weakly correlated | |
| 105 | L1MA8 | 1 | n.s | 87.0 | Weakly correlated | |
| 106 | L1MB7 | 1 | n.s | 99.0 | Weakly correlated | |
| 107 | L1MC5 | 1 | n.s | 99.0 | Weakly correlated | |
| 108 | L1MC5a | 1 | n.s | 99.0 | Weakly correlated | |
| 109 | L1MCb | 1 | n.s | 99.0 | Weakly correlated | |
| 110 | L1MD1 | 1 | n.s | 99.0 | Weakly correlated | |
| 111 | L1MD2 | 1 | n.s | 99.0 | Weakly correlated | |
| 112 | L1MDa | 1 | n.s | 99.0 | Weakly correlated | |
| 113 | L1ME2z | 1 | n.s | 99.0 | Weakly correlated | |
| 114 | L1ME3A | 1 | n.s | 99.0 | Weakly correlated | |
| 115 | L1ME3Cz | 1 | n.s | 99.0 | Weakly correlated | |
| 116 | L1ME3G | 1 | n.s | 99.0 | Weakly correlated | |
| 117 | L1MEf | 1 | n.s | 99.0 | Weakly correlated | |
| 118 | L1MEh | 1 | n.s | 99.0 | Weakly correlated | |
| 119 | L1P3 | 1 | n.s | 74.0 | Weakly correlated | |
| 120 | L1P4 | 1 | n.s | 74.0 | Weakly correlated | |
| 121 | L1PA11 | 1 | n.s | 74.0 | Weakly correlated | |
| 122 | L1PA5 | 1 | n.s | 19.6 | Weakly correlated | |
| 123 | L1PA6 | 1 | n.s | 28.9 | Weakly correlated | |
| 124 | L1PREC2 | 1 | n.s | 43.0 | Highly correlated | |
| 125 | L3 | 1 | n.s | 99.0 | Weakly correlated | |
| 126 | L3b | 1 | n.s | 99.0 | Weakly correlated | |
| 127 | L4_A_Mam | 1 | n.s | 99.0 | Weakly correlated | |
| 128 | LTR12C | 1 | n.s | 19.6 | Weakly correlated | |
| 129 | LTR12D | 1 | n.s | 19.6 | Weakly correlated | |
| 130 | LTR12_ | 1 | n.s | 28.9 | Weakly correlated | |
| 131 | LTR1A1 | 1 | * | 43.0 | Highly correlated | |
| 132 | LTR4 | 1 | ** | 28.9 | Weakly correlated | |
| 133 | LTR40b | 1 | n.s | 99.0 | Weakly correlated | |
| 134 | LTR49 | 1 | n.s | 74.0 | Weakly correlated | |
| 135 | LTR54 | 1 | n.s | 74.0 | Weakly correlated | |
| 136 | LTR82A | 1 | n.s | 99.0 | Weakly correlated | |
| 137 | LTR88a | 1 | * | 99.0 | Weakly correlated | |
| 138 | MER11A | 1 | n.s | 28.9 | Weakly correlated | |
| 139 | MER21B | 1 | n.s | 99.0 | Weakly correlated | |
| 140 | MER39 | 1 | n.s | 74.0 | Weakly correlated | |
| 141 | MER4A | 1 | n.s | 74.0 | Weakly correlated | |
| 142 | MER50 | 1 | n.s | 43.0 | Highly correlated | |
| 143 | MER51B | 1 | * | 43.0 | Highly correlated | |
| 144 | MER61-int | 1 | n.s | 43.0 | Highly correlated | |
| 145 | MER61C | 1 | ** | 43.0 | Highly correlated | |
| 146 | MER92B | 1 | * | 99.0 | Weakly correlated | |
| 147 | MLT1A1 | 1 | n.s | 87.0 | Weakly correlated | |
| 148 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 149 | MLT1D-int | 1 | n.s | 99.0 | Weakly correlated | |
| 150 | MLT1F | 1 | n.s | 99.0 | Weakly correlated | |
| 151 | MLT1N2 | 1 | n.s | 99.0 | Weakly correlated | |
| 152 | MLT2A1 | 1 | n.s | 74.0 | Weakly correlated | |
| 153 | MLT2A2 | 1 | n.s | 74.0 | Weakly correlated | |
| 154 | MamSINE1 | 1 | n.s | 99.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | THE1B-int | 1145 | **** | 43.0 | Highly correlated | |
| 2 | MSTA-int | 549 | **** | 43.0 | Highly correlated | |
| 3 | THE1C-int | 506 | **** | 43.0 | Highly correlated | |
| 4 | THE1D-int | 477 | **** | 28.9 | Weakly correlated | |
| 5 | THE1A-int | 400 | **** | 43.0 | Highly correlated | |
| 6 | MSTB-int | 139 | **** | 43.0 | Highly correlated | |
| 7 | MSTB1-int | 27 | **** | 74.0 | Weakly correlated | |
| 8 | THE1-int | 24 | **** | 43.0 | Highly correlated | |
| 9 | MSTC-int | 19 | **** | 74.0 | Weakly correlated | |
| 10 | MST-int | 17 | **** | 74.0 | Weakly correlated | |
| 11 | MSTD-int | 16 | **** | 74.0 | Weakly correlated | |
| 12 | MSTB2-int | 4 | **** | 74.0 | Weakly correlated | |
| 13 | MSTA1-int | 3 | **** | 74.0 | Weakly correlated | |
| 14 | MLT-int | 2 | *** | 99.0 | Weakly correlated | |
| 15 | MLT1D | 1 | n.s | 99.0 | Weakly correlated | |
| 16 | L1MA5 | 1 | n.s | 87.0 | Weakly correlated | |
| 17 | MLT1D-int | 1 | n.s | 99.0 | Weakly correlated | |
| 18 | MER52A | 1 | n.s | 74.0 | Weakly correlated | |
| 19 | THE1B | 1 | n.s | 43.0 | Highly correlated | |
| 20 | L1M1 | 1 | n.s | 74.0 | Weakly correlated | |
| 21 | MLT1A | 1 | n.s | 99.0 | Weakly correlated | |
| 22 | LTR12_ | 1 | n.s | 28.9 | Weakly correlated | |
| 23 | L1MEg | 1 | n.s | 99.0 | Weakly correlated | |
| 24 | MSTA | 1 | n.s | 43.0 | Highly correlated | |
| 25 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 26 | MLT1A1 | 1 | n.s | 87.0 | Weakly correlated | |
| 27 | LTR18A | 1 | ** | 43.0 | Highly correlated | |
| 28 | THE1A | 1 | n.s | 43.0 | Highly correlated | |
| 29 | MLT1B | 1 | n.s | 99.0 | Weakly correlated | |
| 30 | L1MA5A | 1 | n.s | 87.0 | Weakly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|