ZRdb KZFP & Repeats
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Human_ZNF583

  • Protein
    Zinc finger protein 583
  • Length
    569
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96ND8
  • NCBI_ID
    147949
Sequence:
MSKDLVTFGDVAVNFSQEEWEWLNPAQRNLYRKVMLENYRSLVSLGVSVSKPDVISLLEQGKEPWMVKKEGTRGPCPDWEYVFKNSEFSSKQETYEESSKVVTVGARHLSYSLDYPSLREDCQSEDWYKNQLGSQEVHLSQLIITHKEILPEVQNKEYNKSWQTFHQDTIFDIQQSFPTKEKAHKHEPQKKSYRKKSVEMKHRKVYVEKKLLKCNDCEKVFNQSSSLTLHQRIHTGEKPYACVECGKTFSQSANLAQHKRIHTGEKPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKECKKAFSQIAHLTQHQRVHTGERPFECIECGKAFSNGSFLAQHQRIHTGEKPYVCNVCGKAFSHRGYLIVHQRIHTGERPYECKECRKAFSQYAHLAQHQRVHTGEKPYECKVCRKAFSQIAYLDQHQRVHTGEKPYECIECGKAFSNSSSLAQHQRSHTGEKPYMCKECRKTFSQNAGLAQHQRIHTGEKPYECNVCGKAFSYSGSLTLHQRIHTGERPYECKDCRKSFRQRAHLAHHERIHTMESFLTLSSPSPSTSNQLPRPVGFIS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..77
2 C2h2 212..234
3 C2h2 240..262
4 C2h2 268..290
5 C2h2 296..318
6 C2h2 324..346
7 C2h2 352..374
8 C2h2 380..402
9 C2h2 408..430
10 C2h2 436..458
11 C2h2 464..486
12 C2h2 492..514
13 C2h2 520..542
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M5 38 **** 99.0 Highly correlated
2 AluJb 25 n.s 74.0 Weakly correlated
3 L1MEc 22 **** 99.0 Highly correlated
4 L1PA10 22 **** 74.0 Weakly correlated
5 L1MA9 21 **** 99.0 Highly correlated
6 L1MA4 20 **** 87.0 Weakly correlated
7 L1MA4A 19 **** 87.0 Weakly correlated
8 AluY 18 n.s 74.0 Weakly correlated
9 L1M2 18 **** 99.0 Highly correlated
10 AluSz 17 n.s 74.0 Weakly correlated
11 L1MA8 17 **** 87.0 Weakly correlated
12 AluSx 16 n.s 74.0 Weakly correlated
13 AluSx1 16 n.s 74.0 Weakly correlated
14 HAL1 15 **** 99.0 Highly correlated
15 L1M6 15 **** 99.0 Highly correlated
16 L1MA7 15 **** 87.0 Weakly correlated
17 L1P3 15 **** 74.0 Weakly correlated
18 HAL1ME 14 **** 99.0 Highly correlated
19 L1PA7 13 n.s 74.0 Weakly correlated
20 L1MA5 12 **** 87.0 Weakly correlated
21 L1PA8 12 *** 74.0 Weakly correlated
22 AluSp 11 n.s 74.0 Weakly correlated
23 AluYj4 11 **** 0.0 Weakly correlated
24 L1M3 11 **** 99.0 Highly correlated
25 L1M4 11 * 99.0 Highly correlated
26 L1PA11 11 **** 74.0 Weakly correlated
27 AluJr 10 n.s 74.0 Weakly correlated
28 L1MEd 10 * 99.0 Highly correlated
29 AluJo 9 n.s 74.0 Weakly correlated
30 AluSc8 9 ** 74.0 Weakly correlated
31 AluYm1 9 **** 19.6 Weakly correlated
32 L1MB7 9 n.s 99.0 Highly correlated
33 L1ME4b 9 ** 99.0 Highly correlated
34 L1PB4 9 *** 99.0 Highly correlated
35 L2c 9 n.s 99.0 Highly correlated
36 FRAM 8 **** 74.0 Weakly correlated
37 HAL1b 8 **** 99.0 Highly correlated
38 L1M7 8 **** 99.0 Highly correlated
39 L1ME1 8 n.s 99.0 Highly correlated
40 L1ME4a 8 n.s 99.0 Highly correlated
41 LTR8 8 **** 43.0 Weakly correlated
42 L1MA5A 6 *** 87.0 Weakly correlated
43 L1MC4a 6 * 99.0 Highly correlated
44 L1MD 6 ** 99.0 Highly correlated
45 AluSz6 5 n.s 74.0 Weakly correlated
46 L1MA6 5 * 87.0 Weakly correlated
47 L1MB3 5 n.s 99.0 Highly correlated
48 L1MB8 5 n.s 99.0 Highly correlated
49 L1MEg 5 n.s 99.0 Highly correlated
50 L1PA4 5 n.s 19.6 Weakly correlated
51 AluSc 4 n.s 74.0 Weakly correlated
52 AluSq2 4 n.s 74.0 Weakly correlated
53 AluSx3 4 n.s 74.0 Weakly correlated
54 L1MC4 4 n.s 99.0 Highly correlated
55 L1ME3G 4 n.s 99.0 Highly correlated
56 L1P4 4 ** 74.0 Weakly correlated
57 L1PA16 4 n.s 74.0 Weakly correlated
58 L1PA5 4 n.s 19.6 Weakly correlated
59 L1PA6 4 n.s 28.9 Weakly correlated
60 L2a 4 n.s 99.0 Highly correlated
61 LTR10A 4 **** 28.9 Weakly correlated
62 MER21B 4 ** 99.0 Highly correlated
63 MIRc 4 n.s 99.0 Highly correlated
64 AluSq 3 n.s 74.0 Weakly correlated
65 L1M4b 3 n.s 99.0 Highly correlated
66 L1MB2 3 n.s 99.0 Highly correlated
67 L1MC5 3 n.s 99.0 Highly correlated
68 L1MC5a 3 n.s 99.0 Highly correlated
69 L1ME2 3 n.s 99.0 Highly correlated
70 L1MEj 3 ** 99.0 Highly correlated
71 L1PA15 3 n.s 74.0 Weakly correlated
72 L1PA2 3 n.s 15.2 Weakly correlated
73 L1PA8A 3 n.s 74.0 Weakly correlated
74 LTR10F 3 **** 28.9 Weakly correlated
75 MIR 3 n.s 99.0 Highly correlated
76 MIRb 3 n.s 99.0 Highly correlated
77 AluSg 2 n.s 74.0 Weakly correlated
78 AluSx4 2 n.s 74.0 Weakly correlated
79 AluYa8 2 **** 15.2 Weakly correlated
80 AluYh9 2 **** 15.2 Weakly correlated
81 FLAM_A 2 n.s 74.0 Weakly correlated
82 FLAM_C 2 n.s 74.0 Weakly correlated
83 L1MB1 2 n.s 99.0 Highly correlated
84 L1MB4 2 n.s 99.0 Highly correlated
85 L1MC 2 n.s 99.0 Highly correlated
86 L1ME3A 2 n.s 99.0 Highly correlated
87 L1ME3E 2 n.s 99.0 Highly correlated
88 L1ME4c 2 n.s 99.0 Highly correlated
89 L1PA13 2 n.s 74.0 Weakly correlated
90 L1PA17 2 n.s 74.0 Weakly correlated
91 L1PA3 2 n.s 19.6 Weakly correlated
92 L2 2 n.s 99.0 Highly correlated
93 MER66B 2 ** 43.0 Weakly correlated
94 SVA_D 2 n.s 15.2 Weakly correlated
95 SVA_F 2 * 0.0 Weakly correlated
96 Alu 1 * 74.0 Weakly correlated
97 AluJr4 1 n.s 74.0 Weakly correlated
98 AluSg4 1 n.s 74.0 Weakly correlated
99 AluSg7 1 n.s 74.0 Weakly correlated
100 AluYi6 1 ** 15.2 Weakly correlated
101 CR1_Mam 1 * 99.0 Highly correlated
102 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
103 HAL1M8 1 n.s 99.0 Highly correlated
104 HERV17-int 1 n.s 28.9 Weakly correlated
105 HUERS-P3b-int 1 * 43.0 Weakly correlated
106 L1M1 1 n.s 74.0 Weakly correlated
107 L1M2a 1 * 87.0 Weakly correlated
108 L1M3f 1 n.s 87.0 Weakly correlated
109 L1M4c 1 n.s 99.0 Highly correlated
110 L1MA2 1 n.s 74.0 Weakly correlated
111 L1MA3 1 n.s 74.0 Weakly correlated
112 L1MB5 1 n.s 99.0 Highly correlated
113 L1MC1 1 n.s 99.0 Highly correlated
114 L1MC3 1 n.s 99.0 Highly correlated
115 L1MCc 1 n.s 99.0 Highly correlated
116 L1MDa 1 n.s 99.0 Highly correlated
117 L1ME3 1 n.s 99.0 Highly correlated
118 L1ME3F 1 n.s 99.0 Highly correlated
119 L1MEh 1 n.s 99.0 Highly correlated
120 L1MEi 1 n.s 99.0 Highly correlated
121 L1P 1 **** 19.6 Weakly correlated
122 L1P1 1 n.s 19.6 Weakly correlated
123 L1P5 1 ** 74.0 Weakly correlated
124 L1PB1 1 n.s 74.0 Weakly correlated
125 L1PB3 1 n.s 74.0 Weakly correlated
126 L3 1 n.s 99.0 Highly correlated
127 LTR10B1 1 *** 28.9 Weakly correlated
128 LTR12_ 1 * 28.9 Weakly correlated
129 LTR13 1 * 19.6 Weakly correlated
130 LTR40a 1 n.s 99.0 Highly correlated
131 LTR81B 1 * 99.0 Highly correlated
132 MER52A 1 n.s 74.0 Weakly correlated
133 MER57-int 1 n.s 87.0 Weakly correlated
134 MER65C 1 ** 74.0 Weakly correlated
135 MER89 1 * 99.0 Highly correlated
136 MIR3 1 n.s 99.0 Highly correlated
137 MLT1B 1 n.s 99.0 Highly correlated
138 MLT1H 1 n.s 99.0 Highly correlated
139 MLT1K 1 n.s 99.0 Highly correlated
140 MLT1L 1 n.s 99.0 Highly correlated
141 MSTB 1 n.s 43.0 Weakly correlated
142 MSTD 1 n.s 74.0 Weakly correlated
143 SVA_C 1 * 15.2 Weakly correlated
144 SVA_E 1 * 0.0 Weakly correlated
145 THE1B 1 n.s 43.0 Weakly correlated
146 THE1C 1 n.s 43.0 Weakly correlated
147 THE1C-int 1 n.s 43.0 Weakly correlated
148 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 7 **** 0.0 Weakly correlated
2 L1MEc 3 n.s 99.0 Highly correlated
3 L1MA4 3 n.s 87.0 Weakly correlated
4 FRAM 3 ** 74.0 Weakly correlated
5 L1MA4A 2 n.s 87.0 Weakly correlated
6 L1MA9 2 n.s 99.0 Highly correlated
7 L1MA8 2 n.s 87.0 Weakly correlated
8 L1MEd 2 n.s 99.0 Highly correlated
9 L1MA7 2 n.s 87.0 Weakly correlated
10 L1PA10 2 n.s 74.0 Weakly correlated
11 L2c 2 n.s 99.0 Highly correlated
12 AluYa8 2 **** 15.2 Weakly correlated
13 L1MB2 1 n.s 99.0 Highly correlated
14 HUERS-P3b-int 1 * 43.0 Weakly correlated
15 L1M4 1 n.s 99.0 Highly correlated
16 L1M3 1 n.s 99.0 Highly correlated
17 HAL1 1 n.s 99.0 Highly correlated
18 AluJb 1 n.s 74.0 Weakly correlated
19 L1PA11 1 n.s 74.0 Weakly correlated
20 L1ME4a 1 n.s 99.0 Highly correlated
21 L1M5 1 n.s 99.0 Highly correlated
22 L1ME2 1 n.s 99.0 Highly correlated
23 L1PA7 1 n.s 74.0 Weakly correlated
24 L1PA13 1 n.s 74.0 Weakly correlated
25 L1M6 1 n.s 99.0 Highly correlated
26 AluY 1 n.s 74.0 Weakly correlated
27 AluJo 1 n.s 74.0 Weakly correlated
28 L1ME3A 1 n.s 99.0 Highly correlated
29 L1MD 1 n.s 99.0 Highly correlated
30 L1P4 1 n.s 74.0 Weakly correlated
31 L1ME3G 1 n.s 99.0 Highly correlated
32 AluYh9 1 **** 15.2 Weakly correlated
33 AluSq 1 n.s 74.0 Weakly correlated
34 L1PA15 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP