ZRdb KZFP & Repeats
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Human_ZNF582

  • Protein
    Zinc finger protein 582
  • Length
    517
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96NG8
  • NCBI_ID
    147948
Sequence:
MSLGSELFRDVAIVFSQEEWQWLAPAQRDLYRDVMLETYSNLVSLGLAVSKPDVISFLEQGKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVYEVESPQWEIMESLTSYGLECSSFQDDWECRNQFDRQQGNPDRHFHQMIIRHEEMPTFDQHASLTFYQKIHTREKPFGYNKCRKDFWQKELLINHQGIYTNEKPYKCKECGKAFKYGSRLIQHENIHSGKKPYECKECGKAFNSGSNFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQRTHTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHTGRKLYECKECGKAFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQRIHTGEKPYQCKVCGRAFKRVSHLTVHYRIHTGEKPYECKECGKAFSHCSQLIHHQVIHTEKKPYEYKECEKTLSHDSTTVQPQRMHNRETHVNIINVEKPSISSYPLLIIREFMLASNHMNGSNGESPLA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..77
2 dec2h2 171..193
3 C2h2 199..221
4 C2h2 227..249
5 C2h2 255..277
6 C2h2 283..305
7 C2h2 311..333
8 C2h2 339..361
9 C2h2 367..389
10 C2h2 395..417
11 C2h2 423..445
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1L 105 **** 99.0 Highly correlated
2 MLT1J 16 **** 99.0 Highly correlated
3 L1MCb 13 **** 99.0 Highly correlated
4 AluJb 9 n.s 74.0 Weakly correlated
5 L2c 9 n.s 99.0 Highly correlated
6 MIR 8 n.s 99.0 Highly correlated
7 L2b 8 n.s 99.0 Highly correlated
8 LTR8 8 **** 43.0 Weakly correlated
9 L1PA5 6 n.s 19.6 Weakly correlated
10 LTR10A 6 **** 28.9 Weakly correlated
11 MIRb 5 n.s 99.0 Highly correlated
12 AluYj4 5 **** 0.0 Weakly correlated
13 L1MCa 4 * 99.0 Highly correlated
14 L1PA2 4 n.s 15.2 Weakly correlated
15 MER50-int 4 **** 43.0 Weakly correlated
16 AluSc8 4 n.s 74.0 Weakly correlated
17 MER50 3 ** 43.0 Weakly correlated
18 MLT1H 3 * 99.0 Highly correlated
19 AluJr 3 n.s 74.0 Weakly correlated
20 AluSz 3 n.s 74.0 Weakly correlated
21 AluSx 3 n.s 74.0 Weakly correlated
22 L1MA8 2 n.s 87.0 Weakly correlated
23 LTR85a 2 *** 99.0 Highly correlated
24 LTR41B 2 *** 99.0 Highly correlated
25 LTR40a 2 ** 99.0 Highly correlated
26 LTR10F 2 **** 28.9 Weakly correlated
27 L3 2 n.s 99.0 Highly correlated
28 FLAM_A 2 * 74.0 Weakly correlated
29 L2 2 n.s 99.0 Highly correlated
30 AluSp 2 n.s 74.0 Weakly correlated
31 MLT1K 2 n.s 99.0 Highly correlated
32 L1P1 2 n.s 19.6 Weakly correlated
33 L1MC2 2 n.s 99.0 Highly correlated
34 L1ME4b 2 n.s 99.0 Highly correlated
35 L1MC4a 2 n.s 99.0 Highly correlated
36 HAL1 2 n.s 99.0 Highly correlated
37 HUERS-P3-int 2 ** 43.0 Weakly correlated
38 MLT1N2 2 ** 99.0 Highly correlated
39 PRIMA4_LTR 1 ** 74.0 Weakly correlated
40 AluSz6 1 n.s 74.0 Weakly correlated
41 L1M1 1 n.s 74.0 Weakly correlated
42 MER57E1 1 ** 87.0 Weakly correlated
43 AluSx1 1 n.s 74.0 Weakly correlated
44 MIR1_Amn 1 n.s 319.0 Weakly correlated
45 MIR3 1 n.s 99.0 Highly correlated
46 AluSc 1 n.s 74.0 Weakly correlated
47 MIRc 1 n.s 99.0 Highly correlated
48 MLT1D 1 n.s 99.0 Highly correlated
49 MLT1F1 1 n.s 99.0 Highly correlated
50 AluSg7 1 n.s 74.0 Weakly correlated
51 MLT1J1 1 n.s 99.0 Highly correlated
52 L1PB3 1 n.s 74.0 Weakly correlated
53 L1MC3 1 n.s 99.0 Highly correlated
54 L1MC5 1 n.s 99.0 Highly correlated
55 L1MD2 1 n.s 99.0 Highly correlated
56 L1PA13 1 n.s 74.0 Weakly correlated
57 L1PA15-16 1 n.s 74.0 Weakly correlated
58 FRAM 1 n.s 74.0 Weakly correlated
59 L1PA4 1 n.s 19.6 Weakly correlated
60 FLAM_C 1 n.s 74.0 Weakly correlated
61 MER39B 1 * 74.0 Weakly correlated
62 L2a 1 n.s 99.0 Highly correlated
63 AluYm1 1 n.s 19.6 Weakly correlated
64 LTR103_Mam 1 ** 99.0 Highly correlated
65 AluYh9 1 **** 15.2 Weakly correlated
66 LTR13 1 * 19.6 Weakly correlated
67 LTR16A 1 n.s 99.0 Highly correlated
68 LTR16E1 1 * 99.0 Highly correlated
69 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1L 64 **** 99.0 Highly correlated
2 MLT1J 11 **** 99.0 Highly correlated
3 AluJb 2 n.s 74.0 Weakly correlated
4 AluYh9 1 **** 15.2 Weakly correlated
5 MLT1K 1 n.s 99.0 Highly correlated
6 MIR 1 n.s 99.0 Highly correlated
7 MIR3 1 n.s 99.0 Highly correlated
8 L1PA15-16 1 n.s 74.0 Weakly correlated
9 L1MCa 1 n.s 99.0 Highly correlated
10 AluJr 1 n.s 74.0 Weakly correlated
11 MER50-int 1 * 43.0 Weakly correlated
12 L2c 1 n.s 99.0 Highly correlated
13 FRAM 1 n.s 74.0 Weakly correlated
14 MER50 1 n.s 43.0 Weakly correlated
15 LTR10F 1 ** 28.9 Weakly correlated
16 AluSx1 1 n.s 74.0 Weakly correlated
17 MLT1H 1 n.s 99.0 Highly correlated
18 LTR16A 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MLT1L 99.0 Highly correlated