ZRdb KZFP & Repeats
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Human_ZNF578

  • Protein
    Zinc finger protein 578
  • Length
    590
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    15.2 Mya
  • Uniprot_ID
    Q96N58
  • NCBI_ID
    147660
Sequence:
MLHEEAAQKRKGKEPGMALPQGRLTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVDISSKRMMKEVLSTGQGNTEVIHTGMLQRHESYHTGDFCFQEIEKDIHDFEFQSQKDERNGHEASMPKIKELMGSTDRHDQRHAGNKPIKDQLGLSFHLHLPELHIFQPEEKIANQVEKSVNDASSISTSQRISCRPETHTPNNYGNNFFHSSLLTQKQEVHMREKSFQCNETGEAFNCSSFVRKHQIIHLGEKQYKFDICGKVFNEKRYLARHRRCHTSEKPYKCNECGKSFSYKSSLTCHRRCHTGEKPYKCNECGKSFSYKSSLTCHHRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQNSTLVIHKAIHTGEKPYKCNECGKAFNQQSHLSRHHRLHTGEKPYKCNDCGKAFIHQSSLARHHRLHTGEKSYKCEECDRVFSQKSNLERHKIIHTGEKPYKCNECHKTFSHRSSLPCHRRLHSGEKPYKCNECGKTFNVQSHLSRHHRLHTGEKPYKCKVCDKAFMCHSYLANHTRIHSGEKPYKCNECGKAHNHLIDSSIKPCMSS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 24..98
2 dec2h2 231..253
3 dec2h2 259..281
4 C2h2 287..309
5 C2h2 315..337
6 C2h2 343..365
7 C2h2 371..393
8 C2h2 399..421
9 C2h2 427..449
10 C2h2 455..477
11 C2h2 483..505
12 C2h2 511..533
13 C2h2 539..561
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 290 **** 19.6 Moderately correlated
2 MER11B 110 **** 19.6 Moderately correlated
3 MER11A 58 **** 28.9 Moderately correlated
4 AluYj4 9 **** 0.0 Weakly correlated
5 AluSc8 8 * 74.0 Weakly correlated
6 LTR8 8 **** 43.0 Weakly correlated
7 L1PA8 8 * 74.0 Weakly correlated
8 L1P3 7 *** 74.0 Weakly correlated
9 MIRc 5 n.s 99.0 Weakly correlated
10 FRAM 5 **** 74.0 Weakly correlated
11 AluYm1 4 ** 19.6 Moderately correlated
12 MIR3 4 n.s 99.0 Weakly correlated
13 L2a 4 n.s 99.0 Weakly correlated
14 L2b 4 n.s 99.0 Weakly correlated
15 LTR10A 4 **** 28.9 Moderately correlated
16 AluY 4 n.s 74.0 Weakly correlated
17 L2c 3 n.s 99.0 Weakly correlated
18 MER21B 3 ** 99.0 Weakly correlated
19 L1PA7 3 n.s 74.0 Weakly correlated
20 L1PA5 3 n.s 19.6 Moderately correlated
21 MER41B 3 ** 74.0 Weakly correlated
22 LTR10F 3 **** 28.9 Moderately correlated
23 MIRb 3 n.s 99.0 Weakly correlated
24 AluJb 3 n.s 74.0 Weakly correlated
25 L1MC4 2 n.s 99.0 Weakly correlated
26 MER41A 2 * 74.0 Weakly correlated
27 LTR16 2 * 99.0 Weakly correlated
28 L1ME1 2 n.s 99.0 Weakly correlated
29 L1MC1 2 n.s 99.0 Weakly correlated
30 AluSp 2 n.s 74.0 Weakly correlated
31 AluSq 2 n.s 74.0 Weakly correlated
32 AluSx1 2 n.s 74.0 Weakly correlated
33 AluYa8 2 **** 15.2 Highly correlated
34 MLT1L 2 n.s 99.0 Weakly correlated
35 HUERS-P3-int 2 ** 43.0 Weakly correlated
36 MLT1J 2 n.s 99.0 Weakly correlated
37 L1M3 2 n.s 99.0 Weakly correlated
38 L1MB3 2 n.s 99.0 Weakly correlated
39 L1M5 2 n.s 99.0 Weakly correlated
40 MLT2B4 1 n.s 99.0 Weakly correlated
41 LTR65 1 ** 99.0 Weakly correlated
42 LTR78 1 n.s 99.0 Weakly correlated
43 THE1B-int 1 n.s 43.0 Weakly correlated
44 MLT1C 1 n.s 94.0 Weakly correlated
45 SVA_B 1 n.s 15.2 Highly correlated
46 MamRTE1 1 n.s 99.0 Weakly correlated
47 MamGyp-int 1 ** 99.0 Weakly correlated
48 MER50 1 n.s 43.0 Weakly correlated
49 MIR1_Amn 1 n.s 319.0 Weakly correlated
50 MLT1K-int 1 *** 99.0 Weakly correlated
51 MLT1K 1 n.s 99.0 Weakly correlated
52 MER21C 1 n.s 99.0 Weakly correlated
53 MIR 1 n.s 99.0 Weakly correlated
54 MLT1D 1 n.s 99.0 Weakly correlated
55 MLT1F1 1 n.s 99.0 Weakly correlated
56 MLT1E2 1 n.s 99.0 Weakly correlated
57 MER65C 1 ** 74.0 Weakly correlated
58 L1MEc 1 n.s 99.0 Weakly correlated
59 AluJo 1 n.s 74.0 Weakly correlated
60 AluSx3 1 n.s 74.0 Weakly correlated
61 AluSx4 1 n.s 74.0 Weakly correlated
62 AluSz 1 n.s 74.0 Weakly correlated
63 AluYi6 1 ** 15.2 Highly correlated
64 AluYk4 1 * 15.2 Highly correlated
65 ERVL-E-int 1 n.s 99.0 Weakly correlated
66 HERV17-int 1 n.s 28.9 Moderately correlated
67 HUERS-P3b-int 1 * 43.0 Weakly correlated
68 L1HS 1 n.s 8.6 Weakly correlated
69 L1M2 1 n.s 99.0 Weakly correlated
70 L1M4c 1 n.s 99.0 Weakly correlated
71 L1MB8 1 n.s 99.0 Weakly correlated
72 L1MD2 1 n.s 99.0 Weakly correlated
73 L1ME4b 1 n.s 99.0 Weakly correlated
74 LTR52 1 * 99.0 Weakly correlated
75 L1MEd 1 n.s 99.0 Weakly correlated
76 L1MEi 1 n.s 99.0 Weakly correlated
77 L1P4 1 n.s 74.0 Weakly correlated
78 L1PA10 1 n.s 74.0 Weakly correlated
79 L1PA2 1 n.s 15.2 Highly correlated
80 L1PB3 1 n.s 74.0 Weakly correlated
81 L2 1 n.s 99.0 Weakly correlated
82 L3 1 n.s 99.0 Weakly correlated
83 LTR10B1 1 *** 28.9 Moderately correlated
84 LTR12D 1 * 19.6 Moderately correlated
85 LTR12E 1 ** 19.6 Moderately correlated
86 LTR13 1 * 19.6 Moderately correlated
87 LTR1A1 1 * 43.0 Weakly correlated
88 LTR48 1 * 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 284 **** 19.6 Moderately correlated
2 MER11B 111 **** 19.6 Moderately correlated
3 MER11A 48 **** 28.9 Moderately correlated
4 L2a 1 n.s 99.0 Weakly correlated
5 AluY 1 n.s 74.0 Weakly correlated
6 L1MEc 1 n.s 99.0 Weakly correlated
7 LTR13 1 * 19.6 Moderately correlated
8 MIR1_Amn 1 n.s 319.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MER11A 28.9 Moderately correlated
2 MER11B 19.6 Moderately correlated
3 MER11C 19.6 Moderately correlated