ZRdb KZFP & Repeats
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Human_ZNF577

  • Protein
    Zinc finger protein 577
  • Length
    485
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q9BSK1
  • NCBI_ID
    84765
Sequence:
MKNATIVMSVRREQGSSSGEGSLSFEDVAVGFTREEWQFLDQSQKVLYKEVMLENYINLVSIGYRGTKPDSLFKLEQGEPPGIAEGAAHSQICPGFVIQSRRYAGKDSDAFGGYGRSCLHIKRDKTLTGVKYHRCVKPSSPKSQLNDLQKICAGGKPHECSVCGRAFSRKAQLIQHQRTERGEKPHGCGECGKTFMRKIQLTEHQRTHTGEKPHECSECGKAFSRKSQLMVHQRTHTGEKPYRCSKCGKAFSRKCRLNRHQRSHTGEKLYGCSVCGKAFSQKAYLTAHQRLHTGDKPYKCSDCGRTFYFKSDLTRHQRIHTGEKPYECSECEKAFRSKSKLIQHQRTHTGERPYSCRECGKAFAHMSVLIKHEKTHIRETAINSLTVEKPSSRSHTSLYMSELIQEQKTVNTVPIEMPSSGTPPLLNKSERLVGRNVVIVEQPFPRNQAFVVNQEFEQRISLTNEVNVAPSVINYILYLTDIVSE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 23..94
2 dec2h2 158..180
3 C2h2 186..208
4 C2h2 214..236
5 C2h2 242..264
6 C2h2 270..292
7 C2h2 298..320
8 C2h2 326..348
9 C2h2 354..376
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1H 24 **** 99.0 Moderately correlated
2 L2a 4 n.s 99.0 Moderately correlated
3 L1PA2 4 ** 15.2 Weakly correlated
4 MIRb 3 n.s 99.0 Moderately correlated
5 LTR10A 3 **** 28.9 Weakly correlated
6 AluJb 3 n.s 74.0 Weakly correlated
7 MLT1H2 3 **** 99.0 Moderately correlated
8 AluSc8 3 ** 74.0 Weakly correlated
9 L1PA3 2 n.s 19.6 Weakly correlated
10 MLT1G1 1 * 99.0 Moderately correlated
11 MLT1A0-int 1 ** 99.0 Moderately correlated
12 MIRc 1 n.s 99.0 Moderately correlated
13 L1PA4 1 n.s 19.6 Weakly correlated
14 MIR 1 n.s 99.0 Moderately correlated
15 LTR23 1 *** 74.0 Weakly correlated
16 LTR16C 1 * 99.0 Moderately correlated
17 MLT1H1-int 1 *** 99.0 Moderately correlated
18 LTR16 1 ** 99.0 Moderately correlated
19 MLT1K 1 n.s 99.0 Moderately correlated
20 L3 1 n.s 99.0 Moderately correlated
21 L1P4a 1 ** 74.0 Weakly correlated
22 L1ME2 1 n.s 99.0 Moderately correlated
23 L1MC4 1 n.s 99.0 Moderately correlated
24 L1MB3 1 n.s 99.0 Moderately correlated
25 L1M2a1 1 **** 79.0 Weakly correlated
26 HAL1 1 n.s 99.0 Moderately correlated
27 AluSx1 1 n.s 74.0 Weakly correlated
28 AluSx 1 n.s 74.0 Weakly correlated
29 AluSq2 1 n.s 74.0 Weakly correlated
30 AluSp 1 n.s 74.0 Weakly correlated
31 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSc8 1 n.s 74.0 Weakly correlated
2 MLT1H 1 * 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP