ZRdb KZFP & Repeats
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Human_ZNF573

  • Protein
    Zinc finger protein 573
  • Length
    665
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q86YE8
  • NCBI_ID
    126231
Sequence:
MFPVLEPHQVGLIRSYNSKTMTCFQELVTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLGGHSISKPVVVDLLERGKEPWMILREETQFTDLDLQCEIISYIEVPTYETDISSTQLQSIYKREKLYECKKCQKKFSSGYQLILHHRFHVIERPYECKECGKNFRSGYQLTLHQRFHTGEKPYECTECGKNFRSGYQLTVHQRFHTGEKTYECRQCGKAFIYASHIVQHERIHTGGKPYECQECGRAFSQGGHLRIHQRVHTGEKPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIHTGEKLFECKQCGKTYTTGSKLFQHQKTHTGEKPYECKECGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLTRHQNIHTGKKLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKTFSLHGYLNQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFRRSSHLTAHQSIHADKKPYECKECGKAFKMYGYLTQHQKIHTGGKPYECKECGKAFSRASNLVQHERIHTGEKPYVCKQCGKTFRYGSALKAHQRIHRSIKV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 28..100
2 C2h2 134..156
3 C2h2 162..184
4 C2h2 190..212
5 C2h2 218..240
6 C2h2 246..268
7 C2h2 274..296
8 C2h2 302..324
9 C2h2 330..352
10 C2h2 358..380
11 C2h2 386..408
12 C2h2 414..436
13 C2h2 442..464
14 C2h2 470..492
15 C2h2 498..520
16 C2h2 526..548
17 C2h2 554..576
18 C2h2 582..604
19 C2h2 610..632
20 C2h2 638..660
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR41 56 **** 99.0 Moderately correlated
2 MLT1C 55 **** 94.0 Highly correlated
3 LTR41B 41 **** 99.0 Moderately correlated
4 LTR41C 38 **** 99.0 Moderately correlated
5 L2a 37 n.s 99.0 Moderately correlated
6 LTR50 33 **** 99.0 Moderately correlated
7 MIRb 32 * 99.0 Moderately correlated
8 AluJb 31 * 74.0 Weakly correlated
9 L2c 25 n.s 99.0 Moderately correlated
10 AluJr 24 ** 74.0 Weakly correlated
11 L2b 23 ** 99.0 Moderately correlated
12 LTR33A_ 19 **** 99.0 Moderately correlated
13 AluSz 18 n.s 74.0 Weakly correlated
14 AluY 18 n.s 74.0 Weakly correlated
15 AluJo 16 n.s 74.0 Weakly correlated
16 AluSx 16 n.s 74.0 Weakly correlated
17 AluSx1 15 n.s 74.0 Weakly correlated
18 L2 13 n.s 99.0 Moderately correlated
19 L3 13 ** 99.0 Moderately correlated
20 MIR 13 n.s 99.0 Moderately correlated
21 AluSp 12 n.s 74.0 Weakly correlated
22 HAL1 10 * 99.0 Moderately correlated
23 LTR8 10 **** 43.0 Weakly correlated
24 MIRc 9 n.s 99.0 Moderately correlated
25 LTR1A2 8 **** 43.0 Weakly correlated
26 AluSx3 6 n.s 74.0 Weakly correlated
27 ERVL-E-int 6 * 99.0 Moderately correlated
28 FLAM_C 6 ** 74.0 Weakly correlated
29 LTR33 6 ** 99.0 Moderately correlated
30 MLT1D 6 n.s 99.0 Moderately correlated
31 SVA_D 6 *** 15.2 Weakly correlated
32 AluSq2 5 n.s 74.0 Weakly correlated
33 L1MEd 5 n.s 99.0 Moderately correlated
34 LTR12C 5 * 19.6 Weakly correlated
35 MIR3 5 n.s 99.0 Moderately correlated
36 L1M5 4 n.s 99.0 Moderately correlated
37 L1MC4 4 n.s 99.0 Moderately correlated
38 L1ME2 4 n.s 99.0 Moderately correlated
39 L1ME3Cz 4 n.s 99.0 Moderately correlated
40 L3b 4 ** 99.0 Moderately correlated
41 L4_A_Mam 4 ** 99.0 Moderately correlated
42 LTR16A 4 ** 99.0 Moderately correlated
43 LTR33A 4 **** 99.0 Moderately correlated
44 MER50 4 ** 43.0 Weakly correlated
45 MLT1B 4 n.s 99.0 Moderately correlated
46 MLT1K 4 n.s 99.0 Moderately correlated
47 MLT1M 4 **** 99.0 Moderately correlated
48 AluSc8 3 n.s 74.0 Weakly correlated
49 AluSg 3 n.s 74.0 Weakly correlated
50 AluSz6 3 n.s 74.0 Weakly correlated
51 L1MC4a 3 n.s 99.0 Moderately correlated
52 L1ME3 3 n.s 99.0 Moderately correlated
53 L1ME4b 3 n.s 99.0 Moderately correlated
54 L1MEc 3 n.s 99.0 Moderately correlated
55 L1MEf 3 n.s 99.0 Moderately correlated
56 L1MEh 3 ** 99.0 Moderately correlated
57 L1PA10 3 n.s 74.0 Weakly correlated
58 L1PA2 3 n.s 15.2 Weakly correlated
59 LTR10A 3 **** 28.9 Weakly correlated
60 LTR22A 3 **** 43.0 Weakly correlated
61 MER68 3 *** 99.0 Moderately correlated
62 MIR1_Amn 3 ** 319.0 Weakly correlated
63 MLT1N2 3 ** 99.0 Moderately correlated
64 AluYc 2 * 74.0 Weakly correlated
65 HAL1M8 2 * 99.0 Moderately correlated
66 HERV16-int 2 * 99.0 Moderately correlated
67 L1M4c 2 n.s 99.0 Moderately correlated
68 L1MA9 2 n.s 99.0 Moderately correlated
69 L1MB3 2 n.s 99.0 Moderately correlated
70 L1MB5 2 n.s 99.0 Moderately correlated
71 L1MC3 2 n.s 99.0 Moderately correlated
72 L1MC5 2 n.s 99.0 Moderately correlated
73 L1MC5a 2 n.s 99.0 Moderately correlated
74 L1MCa 2 n.s 99.0 Moderately correlated
75 L1MDa 2 n.s 99.0 Moderately correlated
76 L1ME1 2 n.s 99.0 Moderately correlated
77 L1ME4a 2 n.s 99.0 Moderately correlated
78 L1P3 2 n.s 74.0 Weakly correlated
79 L1P4 2 n.s 74.0 Weakly correlated
80 L1PA15 2 n.s 74.0 Weakly correlated
81 L1PA5 2 n.s 19.6 Weakly correlated
82 L1PA6 2 n.s 28.9 Weakly correlated
83 L1PB1 2 n.s 74.0 Weakly correlated
84 LTR10F 2 *** 28.9 Weakly correlated
85 LTR16C 2 n.s 99.0 Moderately correlated
86 LTR40c 2 *** 99.0 Moderately correlated
87 LTR88b 2 *** 99.0 Moderately correlated
88 LTR88c 2 *** 99.0 Moderately correlated
89 MER11A 2 * 28.9 Weakly correlated
90 MER21C 2 n.s 99.0 Moderately correlated
91 MER50-int 2 ** 43.0 Weakly correlated
92 MER66B 2 ** 43.0 Weakly correlated
93 MER90a 2 ** 99.0 Moderately correlated
94 MLT1G 2 * 99.0 Moderately correlated
95 MLT1G3 2 * 99.0 Moderately correlated
96 MLT1H 2 n.s 99.0 Moderately correlated
97 MLT1L 2 n.s 99.0 Moderately correlated
98 MLT1O 2 * 99.0 Moderately correlated
99 MLT2F 2 ** 99.0 Moderately correlated
100 MamRTE1 2 n.s 99.0 Moderately correlated
101 MamSINE1 2 * 99.0 Moderately correlated
102 Plat_L3 2 ** 99.0 Moderately correlated
103 SVA_C 2 ** 15.2 Weakly correlated
104 AluJr4 1 n.s 74.0 Weakly correlated
105 AluSc 1 n.s 74.0 Weakly correlated
106 AluSc5 1 n.s 74.0 Weakly correlated
107 AluSg4 1 n.s 74.0 Weakly correlated
108 AluSg7 1 n.s 74.0 Weakly correlated
109 AluSq 1 n.s 74.0 Weakly correlated
110 AluSq10 1 * 74.0 Weakly correlated
111 AluSq4 1 n.s 74.0 Weakly correlated
112 AluYa5 1 n.s 15.2 Weakly correlated
113 AluYe5 1 * 74.0 Weakly correlated
114 AluYh3 1 n.s 15.2 Weakly correlated
115 AluYh3a3 1 ** 15.2 Weakly correlated
116 AluYh9 1 **** 15.2 Weakly correlated
117 AluYj4 1 n.s 0.0 Weakly correlated
118 AluYk11 1 ** 15.2 Weakly correlated
119 AluYm1 1 n.s 19.6 Weakly correlated
120 CR1-3_Croc 1 ** 319.0 Weakly correlated
121 ERVL-B4-int 1 n.s 99.0 Moderately correlated
122 FAM 1 n.s 87.0 Weakly correlated
123 FRAM 1 n.s 74.0 Weakly correlated
124 HERVIP10B3-int 1 * 28.9 Weakly correlated
125 HERVL40-int 1 * 99.0 Moderately correlated
126 L1M2 1 n.s 99.0 Moderately correlated
127 L1M4 1 n.s 99.0 Moderately correlated
128 L1M4a2 1 n.s 99.0 Moderately correlated
129 L1M4b 1 n.s 99.0 Moderately correlated
130 L1MA1 1 n.s 74.0 Weakly correlated
131 L1MA3 1 n.s 74.0 Weakly correlated
132 L1MA4A 1 n.s 87.0 Weakly correlated
133 L1MA5 1 n.s 87.0 Weakly correlated
134 L1MA8 1 n.s 87.0 Weakly correlated
135 L1MB2 1 n.s 99.0 Moderately correlated
136 L1MC 1 n.s 99.0 Moderately correlated
137 L1MC1 1 n.s 99.0 Moderately correlated
138 L1MD2 1 n.s 99.0 Moderately correlated
139 L1MD3 1 n.s 99.0 Moderately correlated
140 L1ME2z 1 n.s 99.0 Moderately correlated
141 L1ME3A 1 n.s 99.0 Moderately correlated
142 L1ME3D 1 n.s 99.0 Moderately correlated
143 L1ME3E 1 n.s 99.0 Moderately correlated
144 L1ME3F 1 n.s 99.0 Moderately correlated
145 L1ME4c 1 n.s 99.0 Moderately correlated
146 L1MEb 1 n.s 99.0 Moderately correlated
147 L1MEg 1 n.s 99.0 Moderately correlated
148 L1MEj 1 n.s 99.0 Moderately correlated
149 L1P1 1 n.s 19.6 Weakly correlated
150 L1PA11 1 n.s 74.0 Weakly correlated
151 L1PA15-16 1 n.s 74.0 Weakly correlated
152 L1PA16 1 n.s 74.0 Weakly correlated
153 L1PA3 1 n.s 19.6 Weakly correlated
154 L1PA4 1 n.s 19.6 Weakly correlated
155 L1PBa 1 n.s 74.0 Weakly correlated
156 L1PBa1 1 n.s 74.0 Weakly correlated
157 LFSINE_Vert 1 * 319.0 Weakly correlated
158 LTR10B1 1 *** 28.9 Weakly correlated
159 LTR13 1 * 19.6 Weakly correlated
160 LTR16 1 n.s 99.0 Moderately correlated
161 LTR16A1 1 n.s 99.0 Moderately correlated
162 LTR16A2 1 * 99.0 Moderately correlated
163 LTR16B2 1 * 99.0 Moderately correlated
164 LTR19B 1 ** 43.0 Weakly correlated
165 LTR1F1 1 ** 43.0 Weakly correlated
166 LTR2 1 * 28.9 Weakly correlated
167 LTR27D 1 ** 43.0 Weakly correlated
168 LTR2B 1 ** 19.6 Weakly correlated
169 LTR33B 1 * 99.0 Moderately correlated
170 LTR37B 1 * 99.0 Moderately correlated
171 LTR39 1 * 43.0 Weakly correlated
172 LTR40a 1 n.s 99.0 Moderately correlated
173 LTR48 1 * 74.0 Weakly correlated
174 LTR78B 1 n.s 99.0 Moderately correlated
175 LTR8A 1 n.s 43.0 Weakly correlated
176 LTR9 1 * 43.0 Weakly correlated
177 MER110 1 ** 99.0 Moderately correlated
178 MER39B 1 * 74.0 Weakly correlated
179 MER51-int 1 * 43.0 Weakly correlated
180 MER51A 1 * 43.0 Weakly correlated
181 MER51B 1 * 43.0 Weakly correlated
182 MER54A 1 * 87.0 Weakly correlated
183 MER57D 1 ** 87.0 Weakly correlated
184 MER66-int 1 n.s 43.0 Weakly correlated
185 MER90 1 * 99.0 Moderately correlated
186 MLT1A 1 n.s 99.0 Moderately correlated
187 MLT1A-int 1 ** 99.0 Moderately correlated
188 MLT1A0 1 n.s 99.0 Moderately correlated
189 MLT1C-int 1 ** 94.0 Highly correlated
190 MLT1E2 1 n.s 99.0 Moderately correlated
191 MLT1F-int 1 ** 99.0 Moderately correlated
192 MLT1F2 1 n.s 99.0 Moderately correlated
193 MLT1G1 1 n.s 99.0 Moderately correlated
194 MLT1H2 1 n.s 99.0 Moderately correlated
195 MLT1I 1 n.s 99.0 Moderately correlated
196 MLT1J-int 1 * 99.0 Moderately correlated
197 MLT1J1 1 n.s 99.0 Moderately correlated
198 MLT1J1-int 1 ** 99.0 Moderately correlated
199 MLT1J2 1 n.s 99.0 Moderately correlated
200 MLT2B4 1 n.s 99.0 Moderately correlated
201 MLT2C1 1 n.s 99.0 Moderately correlated
202 MLT2D 1 n.s 99.0 Moderately correlated
203 MSTA 1 n.s 43.0 Weakly correlated
204 MSTB1-int 1 ** 74.0 Weakly correlated
205 MSTC 1 n.s 74.0 Weakly correlated
206 MSTD 1 n.s 74.0 Weakly correlated
207 MamGypLTR2c 1 ** 99.0 Moderately correlated
208 MamGypLTR3a 1 * 99.0 Moderately correlated
209 MamGypsy2-I 1 n.s 99.0 Moderately correlated
210 MamRep605 1 n.s 99.0 Moderately correlated
211 PABL_B 1 ** 43.0 Weakly correlated
212 SVA_A 1 * 19.6 Weakly correlated
213 SVA_E 1 * 0.0 Weakly correlated
214 SVA_F 1 n.s 0.0 Weakly correlated
215 THE1B 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1C 49 **** 94.0 Highly correlated
2 LTR41 48 **** 99.0 Moderately correlated
3 LTR41C 36 **** 99.0 Moderately correlated
4 LTR41B 33 **** 99.0 Moderately correlated
5 LTR50 30 **** 99.0 Moderately correlated
6 L2a 18 n.s 99.0 Moderately correlated
7 LTR33A_ 17 **** 99.0 Moderately correlated
8 L2c 12 n.s 99.0 Moderately correlated
9 AluJr 12 n.s 74.0 Weakly correlated
10 AluJb 11 n.s 74.0 Weakly correlated
11 L2b 9 n.s 99.0 Moderately correlated
12 MIRb 8 n.s 99.0 Moderately correlated
13 L2 7 n.s 99.0 Moderately correlated
14 L3 6 n.s 99.0 Moderately correlated
15 LTR33 6 ** 99.0 Moderately correlated
16 LTR1A2 5 **** 43.0 Weakly correlated
17 MLT1D 4 n.s 99.0 Moderately correlated
18 AluJo 4 n.s 74.0 Weakly correlated
19 L1MEc 3 n.s 99.0 Moderately correlated
20 AluSz 3 n.s 74.0 Weakly correlated
21 MIR 3 n.s 99.0 Moderately correlated
22 AluSx 3 n.s 74.0 Weakly correlated
23 LTR16A 3 * 99.0 Moderately correlated
24 L1PA10 3 n.s 74.0 Weakly correlated
25 LTR33A 3 *** 99.0 Moderately correlated
26 MIR3 2 n.s 99.0 Moderately correlated
27 L1MC5 2 n.s 99.0 Moderately correlated
28 L1ME2 2 n.s 99.0 Moderately correlated
29 MLT1L 2 n.s 99.0 Moderately correlated
30 HAL1 2 n.s 99.0 Moderately correlated
31 L1MEd 2 n.s 99.0 Moderately correlated
32 MLT1M 2 ** 99.0 Moderately correlated
33 FLAM_C 2 n.s 74.0 Weakly correlated
34 L1MC5a 2 n.s 99.0 Moderately correlated
35 MLT1G3 2 * 99.0 Moderately correlated
36 AluSp 2 n.s 74.0 Weakly correlated
37 AluSx1 2 n.s 74.0 Weakly correlated
38 L4_A_Mam 2 n.s 99.0 Moderately correlated
39 MLT1G 2 * 99.0 Moderately correlated
40 L1MEh 2 * 99.0 Moderately correlated
41 HAL1M8 2 * 99.0 Moderately correlated
42 LTR22A 2 **** 43.0 Weakly correlated
43 L1MC4a 1 n.s 99.0 Moderately correlated
44 L1ME2z 1 n.s 99.0 Moderately correlated
45 L1PB1 1 n.s 74.0 Weakly correlated
46 L1PBa 1 n.s 74.0 Weakly correlated
47 LTR16A2 1 * 99.0 Moderately correlated
48 MLT1E2 1 n.s 99.0 Moderately correlated
49 MLT2F 1 n.s 99.0 Moderately correlated
50 Plat_L3 1 * 99.0 Moderately correlated
51 ERVL-B4-int 1 n.s 99.0 Moderately correlated
52 L1M4a2 1 n.s 99.0 Moderately correlated
53 L1MD3 1 n.s 99.0 Moderately correlated
54 L1MEb 1 n.s 99.0 Moderately correlated
55 L1MEg 1 n.s 99.0 Moderately correlated
56 L1PA15-16 1 n.s 74.0 Weakly correlated
57 L1PA6 1 n.s 28.9 Weakly correlated
58 LTR19B 1 ** 43.0 Weakly correlated
59 MER50 1 n.s 43.0 Weakly correlated
60 MLT1G1 1 n.s 99.0 Moderately correlated
61 MLT1O 1 n.s 99.0 Moderately correlated
62 L1MC3 1 n.s 99.0 Moderately correlated
63 LTR10B1 1 *** 28.9 Weakly correlated
64 LTR16 1 n.s 99.0 Moderately correlated
65 LTR40c 1 ** 99.0 Moderately correlated
66 LTR8A 1 n.s 43.0 Weakly correlated
67 MER11A 1 n.s 28.9 Weakly correlated
68 MLT1I 1 n.s 99.0 Moderately correlated
69 PABL_B 1 ** 43.0 Weakly correlated
70 L1MA5 1 n.s 87.0 Weakly correlated
71 L1ME1 1 n.s 99.0 Moderately correlated
72 L1PA11 1 n.s 74.0 Weakly correlated
73 L1PA15 1 n.s 74.0 Weakly correlated
74 L1PA2 1 n.s 15.2 Weakly correlated
75 L3b 1 n.s 99.0 Moderately correlated
76 LTR12C 1 n.s 19.6 Weakly correlated
77 MER66B 1 * 43.0 Weakly correlated
78 MLT1A 1 n.s 99.0 Moderately correlated
79 MLT1J1 1 n.s 99.0 Moderately correlated
80 LTR9 1 * 43.0 Weakly correlated
81 MER68 1 n.s 99.0 Moderately correlated
82 MER90 1 * 99.0 Moderately correlated
83 MLT1H 1 n.s 99.0 Moderately correlated
84 MLT1H2 1 n.s 99.0 Moderately correlated
85 MLT1K 1 n.s 99.0 Moderately correlated
86 MLT1N2 1 n.s 99.0 Moderately correlated
87 L1MB5 1 n.s 99.0 Moderately correlated
88 L1MD2 1 n.s 99.0 Moderately correlated
89 LTR16A1 1 n.s 99.0 Moderately correlated
90 LTR78B 1 n.s 99.0 Moderately correlated
91 MER110 1 ** 99.0 Moderately correlated
92 MLT1F-int 1 ** 99.0 Moderately correlated
93 HERV16-int 1 n.s 99.0 Moderately correlated
94 L1MDa 1 n.s 99.0 Moderately correlated
95 L1PA16 1 n.s 74.0 Weakly correlated
96 LTR16C 1 n.s 99.0 Moderately correlated
97 LTR88c 1 ** 99.0 Moderately correlated
98 MER66-int 1 n.s 43.0 Weakly correlated
99 MLT1B 1 n.s 99.0 Moderately correlated
100 MLT1J2 1 n.s 99.0 Moderately correlated
101 FAM 1 n.s 87.0 Weakly correlated
102 L1MC1 1 n.s 99.0 Moderately correlated
103 LTR48 1 * 74.0 Weakly correlated
104 LTR88b 1 * 99.0 Moderately correlated
105 MER51-int 1 * 43.0 Weakly correlated
106 MER90a 1 * 99.0 Moderately correlated
107 MLT1J1-int 1 ** 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR33 99.0 Moderately correlated
2 LTR33A_ 99.0 Moderately correlated
3 LTR41 99.0 Moderately correlated
4 LTR41B 99.0 Moderately correlated
5 LTR41C 99.0 Moderately correlated
6 LTR50 99.0 Moderately correlated