ZRdb KZFP & Repeats
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Human_ZNF571

  • Protein
    Zinc finger protein 571
  • Length
    609
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q7Z3V5
  • NCBI_ID
    51276
Sequence:
MPHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHLQYNGLGDNMECKGNLEGQEASQEGLYMCVKITCEEKATESHSTSSTFHRIIPTKEKLYKCKECRQGFSYLSCLIQHEENHNIEKCSEVKKHRNTFSKKPSYIQHQRIQTGEKPYECMECGKAFGRTSDLIQHQKIHTNEKPYQCNACGKAFIRGSQLTEHQRVHTGEKPYECKKCGKAFSYCSQYTLHQRIHSGEKPYECKDCGKAFILGSQLTYHQRIHSGEKPYECKECGKAFILGSHLTYHQRVHTGEKPYICKECGKAFLCASQLNEHQRIHTGEKPYECKECGKTFFRGSQLTYHLRVHSGERPYKCKECGKAFISNSNLIQHQRIHTGEKPYKCKECGKAFICGKQLSEHQRIHTGEKPFECKECGKAFIRVAYLTQHEKIHGEKHYECKECGKTFVRATQLTYHQRIHTGEKPYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQCGKAFIRGSHLTEHLRTHTGEKPYECKECGRAFSRGSELTLHQRIHTGEKPYTCVQCGKDFRCPSQLTQHTRLHN
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..84
2 C2h2 139..161
3 C2h2 164..189
4 C2h2 195..217
5 C2h2 223..245
6 C2h2 251..273
7 C2h2 279..301
8 C2h2 307..329
9 C2h2 335..357
10 C2h2 363..385
11 C2h2 391..413
12 C2h2 419..441
13 C2h2 447..469
14 C2h2 474..496
15 C2h2 502..524
16 C2h2 530..552
17 C2h2 558..580
18 C2h2 586..608
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 ERVL-E-int 10 **** 99.0 Highly correlated
2 AluJb 8 n.s 74.0 Weakly correlated
3 L2a 7 n.s 99.0 Highly correlated
4 AluSx1 7 n.s 74.0 Weakly correlated
5 MIRb 5 n.s 99.0 Highly correlated
6 AluJo 4 n.s 74.0 Weakly correlated
7 AluY 4 n.s 74.0 Weakly correlated
8 LTR10A 4 **** 28.9 Weakly correlated
9 AluSp 3 n.s 74.0 Weakly correlated
10 MIR 3 n.s 99.0 Highly correlated
11 MIR3 3 n.s 99.0 Highly correlated
12 L1P3 3 ** 74.0 Weakly correlated
13 AluJr 3 n.s 74.0 Weakly correlated
14 ERVL-B4-int 3 ** 99.0 Highly correlated
15 MER50-int 2 *** 43.0 Weakly correlated
16 MIRc 2 n.s 99.0 Highly correlated
17 L2b 2 n.s 99.0 Highly correlated
18 AluSc5 2 * 74.0 Weakly correlated
19 AluSc8 2 n.s 74.0 Weakly correlated
20 AluSz 2 n.s 74.0 Weakly correlated
21 AluSq2 2 n.s 74.0 Weakly correlated
22 MLT1O 1 * 99.0 Highly correlated
23 MSTD 1 n.s 74.0 Weakly correlated
24 L3 1 n.s 99.0 Highly correlated
25 LTR13 1 ** 19.6 Weakly correlated
26 LTR41 1 ** 99.0 Highly correlated
27 LTR91 1 **** 99.0 Highly correlated
28 MER50 1 * 43.0 Weakly correlated
29 MLT2D 1 * 99.0 Highly correlated
30 MLT1J1-int 1 *** 99.0 Highly correlated
31 MLT1K 1 n.s 99.0 Highly correlated
32 MLT1J2 1 * 99.0 Highly correlated
33 MLT1D 1 n.s 99.0 Highly correlated
34 MLT1G 1 * 99.0 Highly correlated
35 MLT1G3 1 * 99.0 Highly correlated
36 MLT1H 1 n.s 99.0 Highly correlated
37 MLT1I 1 n.s 99.0 Highly correlated
38 L1M4 1 n.s 99.0 Highly correlated
39 AluSc 1 n.s 74.0 Weakly correlated
40 AluSg 1 n.s 74.0 Weakly correlated
41 AluSg7 1 n.s 74.0 Weakly correlated
42 AluSx 1 n.s 74.0 Weakly correlated
43 AluSz6 1 n.s 74.0 Weakly correlated
44 FLAM_A 1 n.s 74.0 Weakly correlated
45 FLAM_C 1 n.s 74.0 Weakly correlated
46 FRAM 1 * 74.0 Weakly correlated
47 HERVL-int 1 n.s 74.0 Weakly correlated
48 L1M2 1 n.s 99.0 Highly correlated
49 L1M3c 1 ** 99.0 Highly correlated
50 L2c 1 n.s 99.0 Highly correlated
51 L1M4b 1 n.s 99.0 Highly correlated
52 L1M5 1 n.s 99.0 Highly correlated
53 L1MA9 1 n.s 99.0 Highly correlated
54 L1MC5a 1 n.s 99.0 Highly correlated
55 L1P4 1 n.s 74.0 Weakly correlated
56 L1PA2 1 n.s 15.2 Weakly correlated
57 L1PA3 1 n.s 19.6 Weakly correlated
58 L1PA5 1 n.s 19.6 Weakly correlated
59 L1PA7 1 n.s 74.0 Weakly correlated
60 L1PB1 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 ERVL-E-int 3 * 99.0 Highly correlated
2 MLT1H 1 n.s 99.0 Highly correlated
3 AluSz6 1 n.s 74.0 Weakly correlated
4 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP