ZRdb KZFP & Repeats
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Human_ZNF570

  • Protein
    Zinc finger protein 570
  • Length
    536
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96NI8
  • NCBI_ID
    148268
Sequence:
MAVGLLKAMYQELVTFRDVAVDFSQEEWDCLDSSQRHLYSNVMLENYRILVSLGLCFSKPSVILLLEQGKAPWMVKRELTKGLCSGWEPICETEELTPKQDFYEEHQSQKIIETLTSYNLEYSSLREEWKCEGYFERQPGNQKACFKEEIITHEEPLFDEREQEYKSWGSFHQNPLLCTQKIIPKEEKVHKHDTQKRSFKKNLMAIKPKSVCAEKKLLKCNDCEKVFSQSSSLTLHQRIHTGEKPYKCIECGKAFSQRSNLVQHQRIHTGEKPYECKECRKAFSQNAHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQHQRVHTGEKPYECIECGKAFSNRSSIAQHQRVHTGEKPYECNVCGKAFSLRAYLTVHQRIHTGERPYECKECGKAFSQNSHLAQHQRIHTGEKPYKCQECRKAFSQIAYLAQHQRVHTGEKPYECIECGKAFSNDSSLTQHQRVHTGEKPYECTVCGKAFSYCGSLAQHQRIHTGERPYECKECKKTFRQHAHLAHHQRIHIGESLSPPNPVNHQVL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 218..240
3 C2h2 246..268
4 C2h2 274..296
5 C2h2 302..324
6 C2h2 330..352
7 C2h2 358..380
8 C2h2 386..408
9 C2h2 414..436
10 C2h2 442..464
11 C2h2 470..492
12 C2h2 498..520
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HAL1 16 **** 99.0 Highly correlated
2 L1M7 5 **** 99.0 Highly correlated
3 HAL1b 5 **** 99.0 Highly correlated
4 L1MEc 4 ** 99.0 Highly correlated
5 L1M1 3 * 74.0 Weakly correlated
6 L1MDa 3 ** 99.0 Highly correlated
7 L1M4 3 * 99.0 Highly correlated
8 LTR10A 3 **** 28.9 Weakly correlated
9 AluY 3 n.s 74.0 Weakly correlated
10 AluSp 3 n.s 74.0 Weakly correlated
11 L1M6 2 ** 99.0 Highly correlated
12 L1M5 2 n.s 99.0 Highly correlated
13 AluSx 2 n.s 74.0 Weakly correlated
14 L1MA9 2 n.s 99.0 Highly correlated
15 MIRb 2 n.s 99.0 Highly correlated
16 AluSz 2 n.s 74.0 Weakly correlated
17 FLAM_C 2 ** 74.0 Weakly correlated
18 L1ME2 2 * 99.0 Highly correlated
19 L1PA15 1 n.s 74.0 Weakly correlated
20 L1MEg 1 n.s 99.0 Highly correlated
21 L1PA5 1 n.s 19.6 Weakly correlated
22 L1PB1 1 n.s 74.0 Weakly correlated
23 L1PB2 1 * 74.0 Weakly correlated
24 MIRc 1 n.s 99.0 Highly correlated
25 L1MEd 1 n.s 99.0 Highly correlated
26 AluJb 1 n.s 74.0 Weakly correlated
27 L2 1 n.s 99.0 Highly correlated
28 L2b 1 n.s 99.0 Highly correlated
29 L2c 1 n.s 99.0 Highly correlated
30 L3 1 n.s 99.0 Highly correlated
31 MLT1H 1 * 99.0 Highly correlated
32 LTR13 1 ** 19.6 Weakly correlated
33 MIR 1 n.s 99.0 Highly correlated
34 LTR43-int 1 **** 74.0 Weakly correlated
35 LTR52 1 *** 99.0 Highly correlated
36 MER34B-int 1 *** 99.0 Highly correlated
37 MER39B 1 ** 74.0 Weakly correlated
38 L1M2c 1 *** 87.0 Weakly correlated
39 AluJr 1 n.s 74.0 Weakly correlated
40 AluSq 1 n.s 74.0 Weakly correlated
41 AluSx1 1 n.s 74.0 Weakly correlated
42 AluSz6 1 n.s 74.0 Weakly correlated
43 AluYa5 1 ** 15.2 Weakly correlated
44 AluYm1 1 * 19.6 Weakly correlated
45 FAM 1 ** 87.0 Weakly correlated
46 FRAM 1 ** 74.0 Weakly correlated
47 HAL1M8 1 ** 99.0 Highly correlated
48 HAL1ME 1 * 99.0 Highly correlated
49 L1ME3D 1 * 99.0 Highly correlated
50 L1M3 1 * 99.0 Highly correlated
51 L1M3a 1 *** 99.0 Highly correlated
52 L1M4b 1 * 99.0 Highly correlated
53 L1M8 1 ** 99.0 Highly correlated
54 L1MA4A 1 n.s 87.0 Weakly correlated
55 L1MB8 1 n.s 99.0 Highly correlated
56 L1MD1 1 n.s 99.0 Highly correlated
57 L1ME1 1 n.s 99.0 Highly correlated
58 L1ME3Cz 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HAL1 2 n.s 99.0 Highly correlated
2 HAL1b 2 *** 99.0 Highly correlated
3 L1M4 1 n.s 99.0 Highly correlated
4 L1PB2 1 * 74.0 Weakly correlated
5 L1MA9 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP