ZRdb KZFP & Repeats
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Human_ZNF57

  • Protein
    Zinc finger protein 57
  • Length
    555
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q68EA5
  • NCBI_ID
    126295
Sequence:
MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFRNLASVDDGTQFKANGSVSLQDMYGQEKSKEQTIPNFTGNNSCAYTLEKNCEGYGTEDHHKNLRNHMVDRFCTHNEGNQYGEAIHQMPDLTLHKKVSAGEKPYECTKCRTVFTHLSSLKRHVKSHCGRKAPPGEECKQACICPSHLHSHGRTDTEEKPYKCQACGQTFQHPRYLSHHVKTHTAEKTYKCEQCRMAFNGFASFTRHVRTHTKDRPYKCQECGRAFIYPSTFQRHMTTHTGEKPYKCQHCGKAFTYPQAFQRHEKTHTGEKPYECKQCGKTFSWSETLRVHMRIHTGDKLYKCEHCGKAFTSSRSFQGHLRTHTGEKPYECKQCGKAFTWSSTFREHVRIHTQEQLYKCEQCGKAFTSSRSFRGHLRTHTGEKPYECKQCGKTFTWSSTFREHVRIHTQEQLHKCEHCGKAFTSSRAFQGHLRMHTGEKPYECKQCGKTFTWSSTLHNHVRMHTGEKPHKCKQCGMSFKWHSSFRNHLRMHTGQKSHECQSYSKAFSCQVILSKTSESTH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..76
2 C2h2 140..162
3 dec2h2 196..218
4 C2h2 224..246
5 C2h2 252..274
6 C2h2 280..302
7 C2h2 308..330
8 C2h2 336..358
9 C2h2 364..386
10 C2h2 392..414
11 C2h2 420..442
12 C2h2 448..470
13 C2h2 476..498
14 C2h2 504..526
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER52A 8 **** 74.0 Weakly correlated
2 AluYj4 5 **** 0.0 Weakly correlated
3 AluSc8 4 * 74.0 Weakly correlated
4 LTR10A 4 **** 28.9 Highly correlated
5 MER50 4 **** 43.0 Moderately correlated
6 AluJb 3 n.s 74.0 Weakly correlated
7 L1PA13 3 n.s 74.0 Weakly correlated
8 L2a 3 n.s 99.0 Weakly correlated
9 L2b 3 n.s 99.0 Weakly correlated
10 LTR10B1 3 **** 28.9 Highly correlated
11 LTR12C 3 ** 19.6 Weakly correlated
12 AluYa8 3 **** 15.2 Weakly correlated
13 MER50-int 2 **** 43.0 Moderately correlated
14 MER52D 2 *** 74.0 Weakly correlated
15 MLT1L 2 * 99.0 Weakly correlated
16 L2c 2 n.s 99.0 Weakly correlated
17 MSTA 2 n.s 43.0 Moderately correlated
18 SVA_B 2 *** 15.2 Weakly correlated
19 L1MEf 2 n.s 99.0 Weakly correlated
20 Alu 2 **** 74.0 Weakly correlated
21 AluJo 2 n.s 74.0 Weakly correlated
22 AluSq 2 n.s 74.0 Weakly correlated
23 AluSx1 2 n.s 74.0 Weakly correlated
24 HAL1 2 n.s 99.0 Weakly correlated
25 HERV16-int 1 * 99.0 Weakly correlated
26 THE1D-int 1 n.s 28.9 Highly correlated
27 SVA_F 1 * 0.0 Weakly correlated
28 AluSp 1 n.s 74.0 Weakly correlated
29 MIRb 1 n.s 99.0 Weakly correlated
30 MIR3 1 n.s 99.0 Weakly correlated
31 MER52C 1 ** 74.0 Weakly correlated
32 AluYe5 1 ** 74.0 Weakly correlated
33 AluYh9 1 **** 15.2 Weakly correlated
34 FRAM 1 * 74.0 Weakly correlated
35 MER39B 1 ** 74.0 Weakly correlated
36 L1MA2 1 n.s 74.0 Weakly correlated
37 L1HS 1 n.s 8.6 Weakly correlated
38 L1M2 1 n.s 99.0 Weakly correlated
39 L1M2b 1 *** 87.0 Weakly correlated
40 L1M2c 1 ** 87.0 Weakly correlated
41 L1PB3 1 n.s 74.0 Weakly correlated
42 L1PA7 1 n.s 74.0 Weakly correlated
43 L1PA2 1 n.s 15.2 Weakly correlated
44 L1PA15 1 n.s 74.0 Weakly correlated
45 L1M3 1 n.s 99.0 Weakly correlated
46 L1M3e 1 ** 99.0 Weakly correlated
47 L1ME3G 1 n.s 99.0 Weakly correlated
48 L1MB8 1 n.s 99.0 Weakly correlated
49 L1MB7 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYa8 2 **** 15.2 Weakly correlated
2 AluJb 1 n.s 74.0 Weakly correlated
3 AluYj4 1 ** 0.0 Weakly correlated
4 MLT1L 1 n.s 99.0 Weakly correlated
5 AluJo 1 n.s 74.0 Weakly correlated
6 L1MB8 1 n.s 99.0 Weakly correlated
7 SVA_B 1 ** 15.2 Weakly correlated
8 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP