Human_ZNF568
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ProteinZinc finger protein 568
-
Length644
-
OrganismHomo sapiens (Human)
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Time of emergence99.0 Mya
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Time of Changing in binding specificity99.0 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MTSQSSVISNSCVTMERLSHMMERKAWCSQESALSEEEEDTTRPLETVTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQEEEPWVMEEEMFGRHCPEVWEVDEQIKKQQETLVRKVTSISKKILIKEKVIECKKVAKIFPLSSDIVTSRQSFYDCDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASYVVTPFKCNQCGQDFSHKFDLIRHERIHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVTLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECKECGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRSHTGEKPFECNECGKAFSQRASLSIHKRGHTGERHQVY
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 48..119 | |
| 2 | C2h2 | 222..244 | |
| 3 | C2h2 | 250..272 | |
| 4 | C2h2 | 278..300 | |
| 5 | C2h2 | 306..328 | |
| 6 | C2h2 | 334..356 | |
| 7 | C2h2 | 362..384 | |
| 8 | C2h2 | 390..412 | |
| 9 | C2h2 | 418..440 | |
| 10 | C2h2 | 446..468 | |
| 11 | C2h2 | 474..496 | |
| 12 | C2h2 | 502..524 | |
| 13 | C2h2 | 530..552 | |
| 14 | C2h2 | 558..580 | |
| 15 | C2h2 | 586..608 | |
| 16 | C2h2 | 614..636 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | metal ion binding | |
| 4 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 5 | Molecular Function | transcription cis-regulatory region binding | |
| 6 | Biological Process | embryonic placenta morphogenesis | |
| 7 | Biological Process | in utero embryonic development | |
| 8 | Biological Process | negative regulation of DNA-templated transcription | |
| 9 | Biological Process | negative regulation of transcription by RNA polymerase II | |
| 10 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | HAL1 | 41 | **** | 99.0 | Highly correlated | |
| 2 | HAL1ME | 14 | **** | 99.0 | Highly correlated | |
| 3 | L1MEd | 10 | *** | 99.0 | Highly correlated | |
| 4 | LTR8 | 10 | **** | 43.0 | Weakly correlated | |
| 5 | L1PA16 | 9 | * | 74.0 | Weakly correlated | |
| 6 | AluSc8 | 8 | ** | 74.0 | Weakly correlated | |
| 7 | L1MEi | 8 | **** | 99.0 | Highly correlated | |
| 8 | MER61E | 8 | **** | 43.0 | Weakly correlated | |
| 9 | L1P3 | 7 | **** | 74.0 | Weakly correlated | |
| 10 | AluJb | 6 | n.s | 74.0 | Weakly correlated | |
| 11 | L1PA7 | 6 | n.s | 74.0 | Weakly correlated | |
| 12 | AluJr | 4 | n.s | 74.0 | Weakly correlated | |
| 13 | AluSx | 4 | n.s | 74.0 | Weakly correlated | |
| 14 | AluY | 4 | n.s | 74.0 | Weakly correlated | |
| 15 | AluYj4 | 4 | **** | 0.0 | Weakly correlated | |
| 16 | L1M5 | 4 | n.s | 99.0 | Highly correlated | |
| 17 | L1MCa | 4 | * | 99.0 | Highly correlated | |
| 18 | L2a | 4 | n.s | 99.0 | Highly correlated | |
| 19 | LTR10A | 4 | **** | 28.9 | Weakly correlated | |
| 20 | MER21B | 4 | *** | 99.0 | Highly correlated | |
| 21 | AluSq2 | 3 | n.s | 74.0 | Weakly correlated | |
| 22 | L1M4 | 3 | n.s | 99.0 | Highly correlated | |
| 23 | L1M4b | 3 | * | 99.0 | Highly correlated | |
| 24 | L1MB7 | 3 | n.s | 99.0 | Highly correlated | |
| 25 | L1MC4 | 3 | n.s | 99.0 | Highly correlated | |
| 26 | L1ME1 | 3 | n.s | 99.0 | Highly correlated | |
| 27 | L2c | 3 | n.s | 99.0 | Highly correlated | |
| 28 | LTR10F | 3 | **** | 28.9 | Weakly correlated | |
| 29 | MER11C | 3 | *** | 19.6 | Weakly correlated | |
| 30 | MIR3 | 3 | n.s | 99.0 | Highly correlated | |
| 31 | MIRb | 3 | n.s | 99.0 | Highly correlated | |
| 32 | AluJo | 2 | n.s | 74.0 | Weakly correlated | |
| 33 | AluSg | 2 | n.s | 74.0 | Weakly correlated | |
| 34 | AluSp | 2 | n.s | 74.0 | Weakly correlated | |
| 35 | AluSx1 | 2 | n.s | 74.0 | Weakly correlated | |
| 36 | AluSz | 2 | n.s | 74.0 | Weakly correlated | |
| 37 | AluSz6 | 2 | n.s | 74.0 | Weakly correlated | |
| 38 | AluYa8 | 2 | **** | 15.2 | Weakly correlated | |
| 39 | AluYm1 | 2 | * | 19.6 | Weakly correlated | |
| 40 | FLAM_C | 2 | n.s | 74.0 | Weakly correlated | |
| 41 | FRAM | 2 | * | 74.0 | Weakly correlated | |
| 42 | L1M6 | 2 | * | 99.0 | Highly correlated | |
| 43 | L1MA10 | 2 | * | 99.0 | Highly correlated | |
| 44 | L1MA7 | 2 | n.s | 87.0 | Weakly correlated | |
| 45 | L1MA9 | 2 | n.s | 99.0 | Highly correlated | |
| 46 | L1MB4 | 2 | n.s | 99.0 | Highly correlated | |
| 47 | L1MB8 | 2 | n.s | 99.0 | Highly correlated | |
| 48 | L1MC3 | 2 | n.s | 99.0 | Highly correlated | |
| 49 | L1MC5a | 2 | n.s | 99.0 | Highly correlated | |
| 50 | L1ME4a | 2 | n.s | 99.0 | Highly correlated | |
| 51 | L1MEc | 2 | n.s | 99.0 | Highly correlated | |
| 52 | L1PA2 | 2 | n.s | 15.2 | Weakly correlated | |
| 53 | L1PA4 | 2 | n.s | 19.6 | Weakly correlated | |
| 54 | L1PA5 | 2 | n.s | 19.6 | Weakly correlated | |
| 55 | L1PA8 | 2 | n.s | 74.0 | Weakly correlated | |
| 56 | L1PB | 2 | ** | 74.0 | Weakly correlated | |
| 57 | L1PB1 | 2 | n.s | 74.0 | Weakly correlated | |
| 58 | L2 | 2 | n.s | 99.0 | Highly correlated | |
| 59 | L2b | 2 | n.s | 99.0 | Highly correlated | |
| 60 | MER41B | 2 | * | 74.0 | Weakly correlated | |
| 61 | MIR | 2 | n.s | 99.0 | Highly correlated | |
| 62 | MLT1L | 2 | n.s | 99.0 | Highly correlated | |
| 63 | MamGypsy2-LTR | 2 | **** | 99.0 | Highly correlated | |
| 64 | Alu | 1 | ** | 74.0 | Weakly correlated | |
| 65 | AluJr4 | 1 | n.s | 74.0 | Weakly correlated | |
| 66 | AluSc | 1 | n.s | 74.0 | Weakly correlated | |
| 67 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 68 | AluYa5 | 1 | n.s | 15.2 | Weakly correlated | |
| 69 | AluYc | 1 | n.s | 74.0 | Weakly correlated | |
| 70 | AluYf1 | 1 | * | 19.6 | Weakly correlated | |
| 71 | AluYi6 | 1 | *** | 15.2 | Weakly correlated | |
| 72 | ERVL-B4-int | 1 | n.s | 99.0 | Highly correlated | |
| 73 | FLAM_A | 1 | n.s | 74.0 | Weakly correlated | |
| 74 | HAL1b | 1 | n.s | 99.0 | Highly correlated | |
| 75 | HERV1_I-int | 1 | *** | 43.0 | Weakly correlated | |
| 76 | L1HS | 1 | n.s | 8.6 | Weakly correlated | |
| 77 | L1M4c | 1 | n.s | 99.0 | Highly correlated | |
| 78 | L1M8 | 1 | * | 99.0 | Highly correlated | |
| 79 | L1MA1 | 1 | n.s | 74.0 | Weakly correlated | |
| 80 | L1MA4A | 1 | n.s | 87.0 | Weakly correlated | |
| 81 | L1MA5 | 1 | n.s | 87.0 | Weakly correlated | |
| 82 | L1MB3 | 1 | n.s | 99.0 | Highly correlated | |
| 83 | L1MC5 | 1 | n.s | 99.0 | Highly correlated | |
| 84 | L1MD2 | 1 | n.s | 99.0 | Highly correlated | |
| 85 | L1ME3F | 1 | n.s | 99.0 | Highly correlated | |
| 86 | L1ME3G | 1 | n.s | 99.0 | Highly correlated | |
| 87 | L1ME4b | 1 | n.s | 99.0 | Highly correlated | |
| 88 | L1MEf | 1 | n.s | 99.0 | Highly correlated | |
| 89 | L1MEg | 1 | n.s | 99.0 | Highly correlated | |
| 90 | L1MEj | 1 | * | 99.0 | Highly correlated | |
| 91 | L1P4 | 1 | n.s | 74.0 | Weakly correlated | |
| 92 | L2-3_Crp | 1 | * | 431.0 | Weakly correlated | |
| 93 | L3 | 1 | n.s | 99.0 | Highly correlated | |
| 94 | LOR1-int | 1 | * | 74.0 | Weakly correlated | |
| 95 | LTR104_Mam | 1 | * | 99.0 | Highly correlated | |
| 96 | LTR10B1 | 1 | *** | 28.9 | Weakly correlated | |
| 97 | LTR13 | 1 | * | 19.6 | Weakly correlated | |
| 98 | LTR27C | 1 | *** | 43.0 | Weakly correlated | |
| 99 | LTR29 | 1 | ** | 43.0 | Weakly correlated | |
| 100 | LTR34 | 1 | *** | 74.0 | Weakly correlated | |
| 101 | LTR37B | 1 | * | 99.0 | Highly correlated | |
| 102 | LTR41B | 1 | ** | 99.0 | Highly correlated | |
| 103 | LTR50 | 1 | * | 99.0 | Highly correlated | |
| 104 | LTR54 | 1 | ** | 74.0 | Weakly correlated | |
| 105 | LTR7B | 1 | ** | 28.9 | Weakly correlated | |
| 106 | LTR9D | 1 | ** | 43.0 | Weakly correlated | |
| 107 | MER21C | 1 | n.s | 99.0 | Highly correlated | |
| 108 | MER31A | 1 | * | 87.0 | Weakly correlated | |
| 109 | MER41A | 1 | n.s | 74.0 | Weakly correlated | |
| 110 | MER51A | 1 | * | 43.0 | Weakly correlated | |
| 111 | MER57A-int | 1 | n.s | 43.0 | Weakly correlated | |
| 112 | MIR1_Amn | 1 | n.s | 319.0 | Weakly correlated | |
| 113 | MIRc | 1 | n.s | 99.0 | Highly correlated | |
| 114 | MLT1A | 1 | n.s | 99.0 | Highly correlated | |
| 115 | MLT1F | 1 | n.s | 99.0 | Highly correlated | |
| 116 | MLT1F1 | 1 | n.s | 99.0 | Highly correlated | |
| 117 | MLT1H | 1 | n.s | 99.0 | Highly correlated | |
| 118 | MLT1H1 | 1 | n.s | 99.0 | Highly correlated | |
| 119 | MLT1H2 | 1 | n.s | 99.0 | Highly correlated | |
| 120 | MLT1J | 1 | n.s | 99.0 | Highly correlated | |
| 121 | MLT1N2 | 1 | n.s | 99.0 | Highly correlated | |
| 122 | MSTD | 1 | n.s | 74.0 | Weakly correlated | |
| 123 | MamGypLTR3a | 1 | ** | 99.0 | Highly correlated | |
| 124 | MamSINE1 | 1 | * | 99.0 | Highly correlated | |
| 125 | Plat_L3 | 1 | * | 99.0 | Highly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | L1PA16 | 6 | n.s | 74.0 | Weakly correlated | |
| 2 | AluSc8 | 3 | n.s | 74.0 | Weakly correlated | |
| 3 | L1MA7 | 1 | n.s | 87.0 | Weakly correlated | |
| 4 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 5 | AluSx | 1 | n.s | 74.0 | Weakly correlated | |
| 6 | MIR | 1 | n.s | 99.0 | Highly correlated | |
| 7 | AluSz | 1 | n.s | 74.0 | Weakly correlated | |
| 8 | AluY | 1 | n.s | 74.0 | Weakly correlated | |
| 9 | HERV1_I-int | 1 | *** | 43.0 | Weakly correlated | |
| 10 | AluYj4 | 1 | * | 0.0 | Weakly correlated | |
| 11 | L1MEi | 1 | n.s | 99.0 | Highly correlated | |
| 12 | AluSg | 1 | n.s | 74.0 | Weakly correlated | |
| 13 | AluYa8 | 1 | *** | 15.2 | Weakly correlated | |
| 14 | L1MD2 | 1 | n.s | 99.0 | Highly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|