ZRdb KZFP & Repeats
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Human_ZNF567

  • Protein
    Zinc finger protein 567
  • Length
    647
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8N184
  • NCBI_ID
    163081
Sequence:
MAQGSVSFNDVTVDFTQEEWQHLDHAQKTLYMDVMLENYCHLISVGCHMTKPDVILKLERGEEPWTSFAGHTCLEENWKAEDFLVKFKEHQEKYSRSVVSINHKKLVKEKSKIYEKTFTLGKNPVNSKNLPPEYDTHGRILKNVSELIISNLNPARKRLSEYNGYGKSLLSTKQETTHPEVKSHNQSARAFSHNEVLMQYQKTETPAQSFGYNDCEKSFLQRGGLITHSRPYKGENPSVYNKKRRATNIEKKHTCNECGKSFCRKSVLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQRTHTGEKPFVCNECGKSFRLKTALTDHQRTHTGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPYECNDCGKSFRQKTTLSLHQRIHTGEKPYICKECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLALHEKTHNEEKPYICSECGKSFRQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGEKPYECNECGKSFSQKTNLNLHQRIHTGEKPYVCNECGKSFRQKATLTVHQKIHTGQKSYECPQCGKAFSRKSYLIHHQRTHTGEKPYKCSECGKCFRQKTNLIVHQRTHTGEKPYVCNECGKSFSYKRNLIVHQRTHKGENIEMQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 6..77
2 dec2h2 210..232
3 C2h2 253..275
4 C2h2 281..303
5 C2h2 309..331
6 C2h2 337..359
7 C2h2 365..387
8 C2h2 393..415
9 C2h2 421..443
10 C2h2 449..471
11 C2h2 477..499
12 C2h2 505..527
13 C2h2 533..555
14 C2h2 561..583
15 C2h2 589..611
16 C2h2 617..639
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEg 158 **** 99.0 Highly correlated
2 L1MEc 142 **** 99.0 Highly correlated
3 L1MEf 99 **** 99.0 Highly correlated
4 L1MCc 82 **** 99.0 Highly correlated
5 L1M4a1 36 **** 99.0 Highly correlated
6 L1ME1 34 **** 99.0 Highly correlated
7 L1MEd 30 **** 99.0 Highly correlated
8 L1ME2 25 **** 99.0 Highly correlated
9 AluJb 23 * 74.0 Weakly correlated
10 L1MCa 22 **** 99.0 Highly correlated
11 LTR16A2 19 **** 99.0 Highly correlated
12 L1ME3 17 **** 99.0 Highly correlated
13 L1MC1 14 **** 99.0 Highly correlated
14 L1MEb 14 **** 99.0 Highly correlated
15 L1MEg2 14 **** 99.0 Highly correlated
16 L2a 14 n.s 99.0 Highly correlated
17 AluJr 13 n.s 74.0 Weakly correlated
18 L1ME3A 13 **** 99.0 Highly correlated
19 AluJo 12 n.s 74.0 Weakly correlated
20 AluSz 12 n.s 74.0 Weakly correlated
21 LTR16C 12 **** 99.0 Highly correlated
22 AluSx1 10 n.s 74.0 Weakly correlated
23 AluSz6 10 n.s 74.0 Weakly correlated
24 AluSx 9 n.s 74.0 Weakly correlated
25 AluY 9 n.s 74.0 Weakly correlated
26 L1M5 9 n.s 99.0 Highly correlated
27 L1MCb 9 **** 99.0 Highly correlated
28 L1MC4 8 * 99.0 Highly correlated
29 MIR 8 n.s 99.0 Highly correlated
30 MIRb 8 n.s 99.0 Highly correlated
31 L1MC 7 **** 99.0 Highly correlated
32 L1MEg1 7 **** 99.0 Highly correlated
33 L2c 7 n.s 99.0 Highly correlated
34 AluSp 6 n.s 74.0 Weakly correlated
35 AluSx3 6 n.s 74.0 Weakly correlated
36 L1M4a2 6 **** 99.0 Highly correlated
37 L1MB7 6 n.s 99.0 Highly correlated
38 L1MC5a 6 * 99.0 Highly correlated
39 L1ME4a 6 n.s 99.0 Highly correlated
40 L2 6 n.s 99.0 Highly correlated
41 MIR3 6 n.s 99.0 Highly correlated
42 L1ME2z 5 ** 99.0 Highly correlated
43 L3 5 n.s 99.0 Highly correlated
44 LTR16A1 5 **** 99.0 Highly correlated
45 AluJr4 4 n.s 74.0 Weakly correlated
46 AluSq2 4 n.s 74.0 Weakly correlated
47 L1MB5 4 n.s 99.0 Highly correlated
48 L1MC3 4 n.s 99.0 Highly correlated
49 L1MD2 4 n.s 99.0 Highly correlated
50 L1ME3B 4 * 99.0 Highly correlated
51 L1ME3D 4 ** 99.0 Highly correlated
52 L1PA16 4 n.s 74.0 Weakly correlated
53 L2b 4 n.s 99.0 Highly correlated
54 LTR12D 4 **** 19.6 Weakly correlated
55 MIRc 4 n.s 99.0 Highly correlated
56 AluSc8 3 n.s 74.0 Weakly correlated
57 AluSg 3 n.s 74.0 Weakly correlated
58 FLAM_A 3 * 74.0 Weakly correlated
59 HAL1 3 n.s 99.0 Highly correlated
60 L1MD3 3 * 99.0 Highly correlated
61 L1PA2 3 n.s 15.2 Weakly correlated
62 L1PA5 3 n.s 19.6 Weakly correlated
63 L1PA7 3 n.s 74.0 Weakly correlated
64 L1PB3 3 n.s 74.0 Weakly correlated
65 LTR10A 3 **** 28.9 Weakly correlated
66 LTR12C 3 n.s 19.6 Weakly correlated
67 LTR13 3 **** 19.6 Weakly correlated
68 LTR2 3 **** 28.9 Weakly correlated
69 MLT1A 3 * 99.0 Highly correlated
70 MLT1F 3 ** 99.0 Highly correlated
71 MSTA 3 n.s 43.0 Weakly correlated
72 AluSc 2 n.s 74.0 Weakly correlated
73 AluSq10 2 ** 74.0 Weakly correlated
74 AluYa5 2 * 15.2 Weakly correlated
75 AluYf1 2 ** 19.6 Weakly correlated
76 AluYm1 2 * 19.6 Weakly correlated
77 FLAM_C 2 n.s 74.0 Weakly correlated
78 L1M1 2 n.s 74.0 Weakly correlated
79 L1M2 2 n.s 99.0 Highly correlated
80 L1M4 2 n.s 99.0 Highly correlated
81 L1M4c 2 n.s 99.0 Highly correlated
82 L1MA4 2 n.s 87.0 Weakly correlated
83 L1MA8 2 n.s 87.0 Weakly correlated
84 L1MB1 2 n.s 99.0 Highly correlated
85 L1MB4 2 n.s 99.0 Highly correlated
86 L1MB8 2 n.s 99.0 Highly correlated
87 L1MC2 2 n.s 99.0 Highly correlated
88 L1MC4a 2 n.s 99.0 Highly correlated
89 L1MD1 2 n.s 99.0 Highly correlated
90 L1ME3Cz 2 n.s 99.0 Highly correlated
91 L1ME3G 2 n.s 99.0 Highly correlated
92 L1ME4b 2 n.s 99.0 Highly correlated
93 L1MEi 2 n.s 99.0 Highly correlated
94 L1P1 2 n.s 19.6 Weakly correlated
95 L1P4 2 n.s 74.0 Weakly correlated
96 L1PA11 2 n.s 74.0 Weakly correlated
97 L1PA15 2 n.s 74.0 Weakly correlated
98 L1PA6 2 n.s 28.9 Weakly correlated
99 L1PB4 2 n.s 99.0 Highly correlated
100 L1PREC2 2 n.s 43.0 Weakly correlated
101 LTR10F 2 *** 28.9 Weakly correlated
102 LTR16E1 2 ** 99.0 Highly correlated
103 LTR16E2 2 ** 99.0 Highly correlated
104 LTR78 2 * 99.0 Highly correlated
105 LTR9 2 *** 43.0 Weakly correlated
106 MER57A-int 2 * 43.0 Weakly correlated
107 MLT1C 2 n.s 94.0 Weakly correlated
108 MLT1D 2 n.s 99.0 Highly correlated
109 MSTD 2 n.s 74.0 Weakly correlated
110 MamRTE1 2 * 99.0 Highly correlated
111 THE1D 2 n.s 43.0 Weakly correlated
112 AluSx4 1 n.s 74.0 Weakly correlated
113 AluYc3 1 ** 74.0 Weakly correlated
114 AluYe5 1 * 74.0 Weakly correlated
115 AluYh9 1 **** 15.2 Weakly correlated
116 AluYk2 1 ** 19.6 Weakly correlated
117 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
118 ERVL-E-int 1 n.s 99.0 Highly correlated
119 FRAM 1 n.s 74.0 Weakly correlated
120 HAL1M8 1 n.s 99.0 Highly correlated
121 HERV16-int 1 n.s 99.0 Highly correlated
122 HERV35I-int 1 * 43.0 Weakly correlated
123 L1MA2 1 n.s 74.0 Weakly correlated
124 L1MA3 1 n.s 74.0 Weakly correlated
125 L1MA4A 1 n.s 87.0 Weakly correlated
126 L1MB2 1 n.s 99.0 Highly correlated
127 L1MB3 1 n.s 99.0 Highly correlated
128 L1MC5 1 n.s 99.0 Highly correlated
129 L1MD 1 n.s 99.0 Highly correlated
130 L1MDa 1 n.s 99.0 Highly correlated
131 L1MDb 1 * 99.0 Highly correlated
132 L1ME3C 1 n.s 99.0 Highly correlated
133 L1ME3E 1 n.s 99.0 Highly correlated
134 L1ME5 1 n.s 99.0 Highly correlated
135 L1MEa 1 ** 99.0 Highly correlated
136 L1P4a 1 * 74.0 Weakly correlated
137 L1PA10 1 n.s 74.0 Weakly correlated
138 L1PA12 1 n.s 74.0 Weakly correlated
139 L1PA13 1 n.s 74.0 Weakly correlated
140 L1PA15-16 1 n.s 74.0 Weakly correlated
141 L1PA17 1 n.s 74.0 Weakly correlated
142 L1PA4 1 n.s 19.6 Weakly correlated
143 L1PA8 1 n.s 74.0 Weakly correlated
144 L1PB1 1 n.s 74.0 Weakly correlated
145 L1PB2 1 n.s 74.0 Weakly correlated
146 L1PBa 1 n.s 74.0 Weakly correlated
147 L2-3_Crp 1 * 431.0 Weakly correlated
148 L3b 1 n.s 99.0 Highly correlated
149 LOR1a 1 * 74.0 Weakly correlated
150 LTR101_Mam 1 * 99.0 Highly correlated
151 LTR107_Mam 1 *** 99.0 Highly correlated
152 LTR12 1 * 28.9 Weakly correlated
153 LTR16B1 1 * 99.0 Highly correlated
154 LTR25-int 1 * 43.0 Weakly correlated
155 LTR26 1 ** 74.0 Weakly correlated
156 LTR35 1 *** 43.0 Weakly correlated
157 LTR37-int 1 * 99.0 Highly correlated
158 LTR40b 1 * 99.0 Highly correlated
159 LTR41B 1 ** 99.0 Highly correlated
160 LTR47A 1 ** 74.0 Weakly correlated
161 LTR50 1 * 99.0 Highly correlated
162 LTR55 1 ** 99.0 Highly correlated
163 LTR85b 1 ** 99.0 Highly correlated
164 LTR88c 1 ** 99.0 Highly correlated
165 MER11A 1 n.s 28.9 Weakly correlated
166 MER21C 1 n.s 99.0 Highly correlated
167 MER39 1 n.s 74.0 Weakly correlated
168 MER39B 1 * 74.0 Weakly correlated
169 MER41B 1 n.s 74.0 Weakly correlated
170 MER4A1_ 1 ** 74.0 Weakly correlated
171 MER4E1 1 * 74.0 Weakly correlated
172 MER50 1 n.s 43.0 Weakly correlated
173 MER73 1 ** 87.0 Weakly correlated
174 MLT1A0 1 n.s 99.0 Highly correlated
175 MLT1B 1 n.s 99.0 Highly correlated
176 MLT1F1 1 n.s 99.0 Highly correlated
177 MLT1F1-int 1 *** 99.0 Highly correlated
178 MLT1H 1 n.s 99.0 Highly correlated
179 MLT1H-int 1 * 99.0 Highly correlated
180 MLT1H1 1 n.s 99.0 Highly correlated
181 MLT1I 1 n.s 99.0 Highly correlated
182 MLT1J2 1 n.s 99.0 Highly correlated
183 MLT1K 1 n.s 99.0 Highly correlated
184 MLT2B3 1 n.s 99.0 Highly correlated
185 MLT2B4 1 n.s 99.0 Highly correlated
186 MLT2D 1 n.s 99.0 Highly correlated
187 MSTB 1 n.s 43.0 Weakly correlated
188 MSTB2 1 * 74.0 Weakly correlated
189 MSTC 1 n.s 74.0 Weakly correlated
190 MamGypLTR1d 1 ** 99.0 Highly correlated
191 SVA_A 1 * 19.6 Weakly correlated
192 THE1C 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEg 128 **** 99.0 Highly correlated
2 L1MEc 119 **** 99.0 Highly correlated
3 L1MEf 79 **** 99.0 Highly correlated
4 L1MCc 71 **** 99.0 Highly correlated
5 L1M4a1 31 **** 99.0 Highly correlated
6 L1ME1 28 **** 99.0 Highly correlated
7 L1MEd 24 **** 99.0 Highly correlated
8 L1MCa 19 **** 99.0 Highly correlated
9 L1ME2 18 **** 99.0 Highly correlated
10 LTR16A2 17 **** 99.0 Highly correlated
11 L1MEb 13 **** 99.0 Highly correlated
12 L1ME3 12 **** 99.0 Highly correlated
13 L1MC1 10 ** 99.0 Highly correlated
14 L1MEg2 10 **** 99.0 Highly correlated
15 L1MCb 9 **** 99.0 Highly correlated
16 LTR16C 9 **** 99.0 Highly correlated
17 L1ME3A 9 ** 99.0 Highly correlated
18 L1MEg1 7 **** 99.0 Highly correlated
19 L1ME4a 6 n.s 99.0 Highly correlated
20 LTR12D 4 **** 19.6 Weakly correlated
21 LTR16A1 4 **** 99.0 Highly correlated
22 L1PA16 4 n.s 74.0 Weakly correlated
23 L1MB7 4 n.s 99.0 Highly correlated
24 L1MC3 3 n.s 99.0 Highly correlated
25 MIRb 3 n.s 99.0 Highly correlated
26 L2c 3 n.s 99.0 Highly correlated
27 L2a 3 n.s 99.0 Highly correlated
28 AluSz 3 n.s 74.0 Weakly correlated
29 L1ME2z 3 * 99.0 Highly correlated
30 L1ME3D 3 ** 99.0 Highly correlated
31 L1M5 3 n.s 99.0 Highly correlated
32 HAL1 3 n.s 99.0 Highly correlated
33 L1MC4 3 n.s 99.0 Highly correlated
34 AluSp 3 n.s 74.0 Weakly correlated
35 L1M4a2 2 * 99.0 Highly correlated
36 L1ME3B 2 n.s 99.0 Highly correlated
37 L1MD2 2 n.s 99.0 Highly correlated
38 L1PA15 2 n.s 74.0 Weakly correlated
39 MER57A-int 2 * 43.0 Weakly correlated
40 MLT1F 2 * 99.0 Highly correlated
41 MIR3 2 n.s 99.0 Highly correlated
42 L1MB4 2 n.s 99.0 Highly correlated
43 L1PB3 2 n.s 74.0 Weakly correlated
44 L1ME4b 2 n.s 99.0 Highly correlated
45 L2 2 n.s 99.0 Highly correlated
46 L1MB8 2 n.s 99.0 Highly correlated
47 L1MC 2 n.s 99.0 Highly correlated
48 L1MD3 2 n.s 99.0 Highly correlated
49 L1MA4A 1 n.s 87.0 Weakly correlated
50 MLT1F1-int 1 *** 99.0 Highly correlated
51 L1M1 1 n.s 74.0 Weakly correlated
52 L1ME3Cz 1 n.s 99.0 Highly correlated
53 LTR12 1 * 28.9 Weakly correlated
54 LTR37-int 1 * 99.0 Highly correlated
55 LTR85b 1 ** 99.0 Highly correlated
56 AluJo 1 n.s 74.0 Weakly correlated
57 AluSz6 1 n.s 74.0 Weakly correlated
58 HERV16-int 1 n.s 99.0 Highly correlated
59 HERV35I-int 1 * 43.0 Weakly correlated
60 L1MA4 1 n.s 87.0 Weakly correlated
61 LOR1a 1 * 74.0 Weakly correlated
62 LTR12C 1 n.s 19.6 Weakly correlated
63 LTR16B1 1 * 99.0 Highly correlated
64 AluSx3 1 n.s 74.0 Weakly correlated
65 MER11A 1 n.s 28.9 Weakly correlated
66 L1ME3E 1 n.s 99.0 Highly correlated
67 L1MB1 1 n.s 99.0 Highly correlated
68 L1M4c 1 n.s 99.0 Highly correlated
69 FLAM_A 1 n.s 74.0 Weakly correlated
70 AluJr 1 n.s 74.0 Weakly correlated
71 L1MA8 1 n.s 87.0 Weakly correlated
72 AluSg 1 n.s 74.0 Weakly correlated
73 MLT1A 1 n.s 99.0 Highly correlated
74 LTR101_Mam 1 * 99.0 Highly correlated
75 L1PREC2 1 n.s 43.0 Weakly correlated
76 AluSq2 1 n.s 74.0 Weakly correlated
77 MER21C 1 n.s 99.0 Highly correlated
78 L1P4 1 n.s 74.0 Weakly correlated
79 L1ME5 1 n.s 99.0 Highly correlated
80 L1MD1 1 n.s 99.0 Highly correlated
81 L1MC5a 1 n.s 99.0 Highly correlated
82 L1MA3 1 n.s 74.0 Weakly correlated
83 LTR50 1 * 99.0 Highly correlated
84 MER41B 1 n.s 74.0 Weakly correlated
85 L1PB4 1 n.s 99.0 Highly correlated
86 L1PA17 1 n.s 74.0 Weakly correlated
87 L1PA15-16 1 n.s 74.0 Weakly correlated
88 L1M2 1 n.s 99.0 Highly correlated
89 MLT1B 1 n.s 99.0 Highly correlated
90 MIRc 1 n.s 99.0 Highly correlated
91 MER39B 1 * 74.0 Weakly correlated
92 AluJb 1 n.s 74.0 Weakly correlated
93 L1PA12 1 n.s 74.0 Weakly correlated
94 L1MC2 1 n.s 99.0 Highly correlated
95 L1M4 1 n.s 99.0 Highly correlated
96 HAL1M8 1 n.s 99.0 Highly correlated
97 AluJr4 1 n.s 74.0 Weakly correlated
98 MIR 1 n.s 99.0 Highly correlated
99 LTR25-int 1 * 43.0 Weakly correlated
100 LTR16E1 1 * 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M4A1 99.0 Highly correlated
2 L1MCA 99.0 Highly correlated
3 L1MCB 99.0 Highly correlated
4 L1MCC 99.0 Highly correlated
5 L1ME2 99.0 Highly correlated
6 L1ME3 99.0 Highly correlated
7 L1ME3A 99.0 Highly correlated
8 L1MEB 99.0 Highly correlated
9 L1MEC 99.0 Highly correlated
10 L1MED 99.0 Highly correlated
11 L1MEF 99.0 Highly correlated
12 L1MEG 99.0 Highly correlated