Human_ZNF566
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ProteinZinc finger protein 566
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Length418
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OrganismHomo sapiens (Human)
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Time of emergence99.0 Mya
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Time of Changing in binding specificity99.0 Mya
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Uniprot_ID
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NCBI_ID
Sequence:
MAQESVMFSDVSVDFSQEEWECLNDDQRDLYRDVMLENYSNLVSMGHSISKPNVISYLEQGKEPWLADRELTRGQWPVLESRCETKKLFLKKEIYEIESTQWEIMEKLTRRDFQCSSFRDDWECNRQFKKELGSQGGHFNQLVFTHEDLPTLSHHPSFTLQQIINSKKKFCASKEYRKTFRHGSQFATHEIIHTIEKPYECKECGKSFRHPSRLTHHQKIHTGKKPFECKECGKTFICGSDLTRHHRIHTGEKPYECKECGKAFSSGSNFTRHQRIHTGEKPYECKECGKAFSSGSNFTQHQRIHTGEKPYECKECGNAFSQSSQLIKHQRIHTGEKPYECKECEKAFRSGSDLTRHQRIHTGEKPYECKICGKAYSQSSQLISHHRIHTSEKPYEYRECGKNFNYDPQLIQHQNLYW
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 6..77 | |
| 2 | dec2h2 | 169..193 | |
| 3 | C2h2 | 199..221 | |
| 4 | C2h2 | 227..249 | |
| 5 | C2h2 | 255..277 | |
| 6 | C2h2 | 283..395 | |
| 7 | C2h2 | 311..333 | |
| 8 | C2h2 | 339..361 | |
| 9 | C2h2 | 367..389 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
| 4 | Molecular Function | metal ion binding | |
| 5 | Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
| 6 | Biological Process | negative regulation of transcription by RNA polymerase II | |
| 7 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MLT1J | 87 | **** | 99.0 | Highly correlated | |
| 2 | LTR67B | 39 | **** | 99.0 | Highly correlated | |
| 3 | MLT1N2 | 24 | **** | 99.0 | Highly correlated | |
| 4 | MLT1L | 16 | **** | 99.0 | Highly correlated | |
| 5 | MLT1J2 | 8 | **** | 99.0 | Highly correlated | |
| 6 | AluY | 7 | n.s | 74.0 | Weakly correlated | |
| 7 | AluJr | 5 | n.s | 74.0 | Weakly correlated | |
| 8 | MLT1J1 | 5 | **** | 99.0 | Highly correlated | |
| 9 | AluJb | 4 | n.s | 74.0 | Weakly correlated | |
| 10 | L2c | 4 | n.s | 99.0 | Highly correlated | |
| 11 | L2 | 3 | n.s | 99.0 | Highly correlated | |
| 12 | MSTA | 3 | n.s | 43.0 | Weakly correlated | |
| 13 | MLT1C | 3 | n.s | 94.0 | Weakly correlated | |
| 14 | LTR10A | 3 | **** | 28.9 | Weakly correlated | |
| 15 | AluSx1 | 3 | n.s | 74.0 | Weakly correlated | |
| 16 | LTR83 | 2 | **** | 99.0 | Highly correlated | |
| 17 | LTR1 | 2 | **** | 43.0 | Weakly correlated | |
| 18 | MIRb | 2 | n.s | 99.0 | Highly correlated | |
| 19 | L2b | 2 | n.s | 99.0 | Highly correlated | |
| 20 | L2a | 2 | n.s | 99.0 | Highly correlated | |
| 21 | L1PA5 | 2 | n.s | 19.6 | Weakly correlated | |
| 22 | AluSx | 2 | n.s | 74.0 | Weakly correlated | |
| 23 | L1PA2 | 2 | n.s | 15.2 | Weakly correlated | |
| 24 | L1M4 | 2 | n.s | 99.0 | Highly correlated | |
| 25 | MSTB | 2 | * | 43.0 | Weakly correlated | |
| 26 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated | |
| 27 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 28 | AluSp | 1 | n.s | 74.0 | Weakly correlated | |
| 29 | AluSg | 1 | n.s | 74.0 | Weakly correlated | |
| 30 | MLT1A | 1 | n.s | 99.0 | Highly correlated | |
| 31 | AluSc8 | 1 | n.s | 74.0 | Weakly correlated | |
| 32 | MER74A | 1 | ** | 99.0 | Highly correlated | |
| 33 | MER66C | 1 | *** | 43.0 | Weakly correlated | |
| 34 | MER66B | 1 | ** | 43.0 | Weakly correlated | |
| 35 | MER41D | 1 | *** | 74.0 | Weakly correlated | |
| 36 | AluYf1 | 1 | ** | 19.6 | Weakly correlated | |
| 37 | MER39B | 1 | ** | 74.0 | Weakly correlated | |
| 38 | AluSz | 1 | n.s | 74.0 | Weakly correlated | |
| 39 | LTR13 | 1 | ** | 19.6 | Weakly correlated | |
| 40 | AluYm1 | 1 | * | 19.6 | Weakly correlated | |
| 41 | LTR103_Mam | 1 | *** | 99.0 | Highly correlated | |
| 42 | L3 | 1 | n.s | 99.0 | Highly correlated | |
| 43 | AluYk4 | 1 | ** | 15.2 | Weakly correlated | |
| 44 | Alu | 1 | ** | 74.0 | Weakly correlated | |
| 45 | L1PA4 | 1 | n.s | 19.6 | Weakly correlated | |
| 46 | L1PA16 | 1 | n.s | 74.0 | Weakly correlated | |
| 47 | L1PA13 | 1 | n.s | 74.0 | Weakly correlated | |
| 48 | L1P1 | 1 | n.s | 19.6 | Weakly correlated | |
| 49 | HAL1 | 1 | n.s | 99.0 | Highly correlated | |
| 50 | FRAM | 1 | * | 74.0 | Weakly correlated | |
| 51 | FLAM_C | 1 | n.s | 74.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MLT1J | 85 | **** | 99.0 | Highly correlated | |
| 2 | LTR67B | 37 | **** | 99.0 | Highly correlated | |
| 3 | MLT1N2 | 23 | **** | 99.0 | Highly correlated | |
| 4 | MLT1L | 14 | **** | 99.0 | Highly correlated | |
| 5 | MLT1J2 | 7 | **** | 99.0 | Highly correlated | |
| 6 | MLT1J1 | 5 | **** | 99.0 | Highly correlated | |
| 7 | MSTB | 2 | * | 43.0 | Weakly correlated | |
| 8 | MSTA | 2 | n.s | 43.0 | Weakly correlated | |
| 9 | L2a | 2 | n.s | 99.0 | Highly correlated | |
| 10 | AluJr | 2 | n.s | 74.0 | Weakly correlated | |
| 11 | L2 | 2 | n.s | 99.0 | Highly correlated | |
| 12 | MLT1C | 2 | n.s | 94.0 | Weakly correlated | |
| 13 | AluJb | 1 | n.s | 74.0 | Weakly correlated | |
| 14 | AluSc8 | 1 | n.s | 74.0 | Weakly correlated | |
| 15 | AluY | 1 | n.s | 74.0 | Weakly correlated | |
| 16 | AluYk4 | 1 | ** | 15.2 | Weakly correlated | |
| 17 | MLT1A | 1 | n.s | 99.0 | Highly correlated | |
| 18 | AluSx1 | 1 | n.s | 74.0 | Weakly correlated | |
| 19 | L1PA13 | 1 | n.s | 74.0 | Weakly correlated | |
| 20 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated |