ZRdb KZFP & Repeats
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Human_ZNF565

  • Protein
    Zinc finger protein 565
  • Length
    539
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8N9K5
  • NCBI_ID
    147929
Sequence:
MRRGPWERWSLASHRLDAGLCTCPREESREIRAGQIVLKAMAQGLVTFRDVAIEFSLEEWKCLEPAQRDLYREVTLENFGHLASLGLSISKPDVVSLLEQGKEPWMIANDVTGPWCPDLESRCEKFLQKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQVNVTYGHMPVFQHHTSHTVRQSRETGEKLMECHECGKAFSRGSHLIQHQKIHTGEKPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCGKAFGRTSELILHQRLHTGVKPYECKECGKTFRQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARPYECKECGKAFRQHSQLTVHQRIHTGEKPYECKECGKGFIHSSEVTRHQRIHSGEKPYECKECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQRIHTGDKPYECKECGKAFIRVSQLTHHQRIHTCEKPYECRECGMAFIRSSQLTEHQRIHPGIKPYECRECGQAFILGSQLIEHYRIHTG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 46..117
2 C2h2 207..229
3 C2h2 235..257
4 C2h2 263..285
5 C2h2 291..313
6 C2h2 319..341
7 C2h2 347..369
8 C2h2 375..397
9 C2h2 403..425
10 C2h2 431..453
11 C2h2 459..481
12 C2h2 487..509
13 C2h2 515..537
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1G1 194 **** 99.0 Highly correlated
2 MLT1G 144 **** 99.0 Highly correlated
3 MLT1G3 117 **** 99.0 Highly correlated
4 MLT1F 101 **** 99.0 Highly correlated
5 MLT1F1 64 **** 99.0 Highly correlated
6 MLT1H1 26 **** 99.0 Highly correlated
7 MLT1H2 17 **** 99.0 Highly correlated
8 L1M7 15 **** 99.0 Highly correlated
9 AluJb 7 n.s 74.0 Weakly correlated
10 MIRb 7 n.s 99.0 Highly correlated
11 AluSx 7 n.s 74.0 Weakly correlated
12 AluY 7 n.s 74.0 Weakly correlated
13 MLT1F2 6 **** 99.0 Highly correlated
14 MIR3 5 n.s 99.0 Highly correlated
15 MIR 5 n.s 99.0 Highly correlated
16 L2c 5 n.s 99.0 Highly correlated
17 L2a 5 n.s 99.0 Highly correlated
18 L2b 5 n.s 99.0 Highly correlated
19 AluSz6 5 n.s 74.0 Weakly correlated
20 MLT1H 4 ** 99.0 Highly correlated
21 AluSx1 4 n.s 74.0 Weakly correlated
22 MLT1J 4 * 99.0 Highly correlated
23 LTR10A 4 **** 28.9 Weakly correlated
24 AluSz 4 n.s 74.0 Weakly correlated
25 AluSc8 3 n.s 74.0 Weakly correlated
26 AluJo 3 n.s 74.0 Weakly correlated
27 AluSq2 3 n.s 74.0 Weakly correlated
28 LTR10F 2 **** 28.9 Weakly correlated
29 ERV3-16A3_I-int 2 n.s 99.0 Highly correlated
30 L1PA5 2 n.s 19.6 Weakly correlated
31 L1PA4 2 n.s 19.6 Weakly correlated
32 L1PA3 2 n.s 19.6 Weakly correlated
33 MLT1C 2 n.s 94.0 Weakly correlated
34 L1PA2 2 n.s 15.2 Weakly correlated
35 L1P3 2 n.s 74.0 Weakly correlated
36 AluSx3 2 n.s 74.0 Weakly correlated
37 L1ME2z 2 n.s 99.0 Highly correlated
38 L1MC4 2 n.s 99.0 Highly correlated
39 HAL1 2 n.s 99.0 Highly correlated
40 SVA_F 1 n.s 0.0 Weakly correlated
41 MER68 1 * 99.0 Highly correlated
42 MER72B 1 *** 43.0 Weakly correlated
43 MER77B 1 * 99.0 Highly correlated
44 X6B_LINE 1 *** 99.0 Highly correlated
45 MIR1_Amn 1 n.s 319.0 Weakly correlated
46 AluYm1 1 n.s 19.6 Weakly correlated
47 THE1D 1 n.s 43.0 Weakly correlated
48 MIRc 1 n.s 99.0 Highly correlated
49 MLT1A 1 n.s 99.0 Highly correlated
50 AluSq 1 n.s 74.0 Weakly correlated
51 THE1C-int 1 n.s 43.0 Weakly correlated
52 AluSc 1 n.s 74.0 Weakly correlated
53 AluSp 1 n.s 74.0 Weakly correlated
54 Plat_L3 1 * 99.0 Highly correlated
55 AluSg 1 n.s 74.0 Weakly correlated
56 MSTD 1 n.s 74.0 Weakly correlated
57 MSTB 1 n.s 43.0 Weakly correlated
58 AluSc5 1 n.s 74.0 Weakly correlated
59 MLT2F 1 * 99.0 Highly correlated
60 MLT2B3 1 n.s 99.0 Highly correlated
61 AluJr 1 n.s 74.0 Weakly correlated
62 MLT1G1-int 1 ** 99.0 Highly correlated
63 L1PA6 1 n.s 28.9 Weakly correlated
64 FLAM_C 1 n.s 74.0 Weakly correlated
65 FRAM 1 n.s 74.0 Weakly correlated
66 HERVK-int 1 * 28.9 Weakly correlated
67 HERVK13-int 1 *** 19.6 Weakly correlated
68 AluYa5 1 n.s 15.2 Weakly correlated
69 L1MB3 1 n.s 99.0 Highly correlated
70 L1MB5 1 n.s 99.0 Highly correlated
71 L1MC2 1 n.s 99.0 Highly correlated
72 L1MC3 1 n.s 99.0 Highly correlated
73 L1MC5a 1 n.s 99.0 Highly correlated
74 L1ME3Cz 1 n.s 99.0 Highly correlated
75 L1ME4b 1 n.s 99.0 Highly correlated
76 L1MEc 1 n.s 99.0 Highly correlated
77 L1P1 1 n.s 19.6 Weakly correlated
78 L1P2 1 n.s 28.9 Weakly correlated
79 MER57A-int 1 n.s 43.0 Weakly correlated
80 L1PB4 1 n.s 99.0 Highly correlated
81 Alu 1 ** 74.0 Weakly correlated
82 LFSINE_Vert 1 ** 319.0 Weakly correlated
83 LTR13 1 * 19.6 Weakly correlated
84 LTR1A2 1 * 43.0 Weakly correlated
85 LTR2B 1 ** 19.6 Weakly correlated
86 LTR47B2 1 *** 74.0 Weakly correlated
87 LTR50 1 * 99.0 Highly correlated
88 LTR56 1 ** 74.0 Weakly correlated
89 LTR78B 1 * 99.0 Highly correlated
90 LTR88b 1 ** 99.0 Highly correlated
91 LTR9B 1 ** 43.0 Weakly correlated
92 MER21C 1 n.s 99.0 Highly correlated
93 MER39B 1 * 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1G1 176 **** 99.0 Highly correlated
2 MLT1G 135 **** 99.0 Highly correlated
3 MLT1G3 114 **** 99.0 Highly correlated
4 MLT1F 96 **** 99.0 Highly correlated
5 MLT1F1 61 **** 99.0 Highly correlated
6 MLT1H1 22 **** 99.0 Highly correlated
7 MLT1H2 15 **** 99.0 Highly correlated
8 L1M7 13 **** 99.0 Highly correlated
9 MLT1F2 6 **** 99.0 Highly correlated
10 MLT1H 3 * 99.0 Highly correlated
11 L1MC4 2 n.s 99.0 Highly correlated
12 MLT1C 1 n.s 94.0 Weakly correlated
13 L1PA6 1 n.s 28.9 Weakly correlated
14 L2a 1 n.s 99.0 Highly correlated
15 Plat_L3 1 * 99.0 Highly correlated
16 L1MC2 1 n.s 99.0 Highly correlated
17 L2b 1 n.s 99.0 Highly correlated
18 HERVK13-int 1 *** 19.6 Weakly correlated
19 MIR 1 n.s 99.0 Highly correlated
20 LTR9B 1 ** 43.0 Weakly correlated
21 AluSq2 1 n.s 74.0 Weakly correlated
22 L2c 1 n.s 99.0 Highly correlated
23 L1MC5a 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M7 99.0 Highly correlated
2 MLT1F 99.0 Highly correlated
3 MLT1F1 99.0 Highly correlated
4 MLT1G 99.0 Highly correlated
5 MLT1G1 99.0 Highly correlated
6 MLT1G3 99.0 Highly correlated
7 MLT1H1 99.0 Highly correlated
8 MLT1H2 99.0 Highly correlated