ZRdb KZFP & Repeats
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Human_ZNF564

  • Protein
    Zinc finger protein 564
  • Length
    553
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q8TBZ8
  • NCBI_ID
    163050
Sequence:
MDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECGKAFNYASSIRIHERTHTGEKPYECKQCGKTFSYSSSFQRHERAHNGDKPYVKNVGKLSFITQPSNTCENE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..83
2 C2h2 103..125
3 C2h2 141..163
4 C2h2 169..191
5 C2h2 197..219
6 C2h2 225..247
7 C2h2 253..275
8 C2h2 281..303
9 C2h2 309..331
10 C2h2 337..359
11 C2h2 365..387
12 C2h2 393..415
13 C2h2 421..443
14 C2h2 449..471
15 C2h2 477..499
16 C2h2 505..527
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MSTD 239 **** 74.0 Highly correlated
2 MLT1A0 95 **** 99.0 Weakly correlated
3 MLT1A1 43 **** 87.0 Moderately correlated
4 MSTB2 34 **** 74.0 Highly correlated
5 MSTC 20 **** 74.0 Highly correlated
6 MLT1A 16 **** 99.0 Weakly correlated
7 MLT2D 11 **** 99.0 Weakly correlated
8 AluSx1 9 n.s 74.0 Highly correlated
9 MLT2C1 5 **** 99.0 Weakly correlated
10 AluSz 4 n.s 74.0 Highly correlated
11 AluJb 4 n.s 74.0 Highly correlated
12 AluSx 4 n.s 74.0 Highly correlated
13 MLT2B4 3 *** 99.0 Weakly correlated
14 AluSq 3 * 74.0 Highly correlated
15 MLT1B 3 * 99.0 Weakly correlated
16 LTR10A 3 **** 28.9 Weakly correlated
17 MLT2C2 3 **** 99.0 Weakly correlated
18 MSTA1 3 **** 74.0 Highly correlated
19 AluY 3 n.s 74.0 Highly correlated
20 AluSq2 3 n.s 74.0 Highly correlated
21 L1MA8 2 n.s 87.0 Moderately correlated
22 AluSp 2 n.s 74.0 Highly correlated
23 AluSg 2 n.s 74.0 Highly correlated
24 MIRb 2 n.s 99.0 Weakly correlated
25 LTR13 1 ** 19.6 Weakly correlated
26 MLT2B5 1 *** 87.0 Moderately correlated
27 MSTA 1 n.s 43.0 Weakly correlated
28 MLT2A1 1 * 74.0 Highly correlated
29 MLT1J-int 1 ** 99.0 Weakly correlated
30 MLT1C-int 1 ** 94.0 Weakly correlated
31 MLT1C 1 n.s 94.0 Weakly correlated
32 MSTB1 1 n.s 74.0 Highly correlated
33 MIRc 1 n.s 99.0 Weakly correlated
34 L1P1 1 n.s 19.6 Weakly correlated
35 AluJo 1 n.s 74.0 Highly correlated
36 AluJr 1 n.s 74.0 Highly correlated
37 AluSx3 1 n.s 74.0 Highly correlated
38 AluSx4 1 n.s 74.0 Highly correlated
39 FLAM_C 1 n.s 74.0 Highly correlated
40 L1MA4A 1 n.s 87.0 Moderately correlated
41 L1MC4 1 n.s 99.0 Weakly correlated
42 L1ME1 1 n.s 99.0 Weakly correlated
43 L1ME4b 1 n.s 99.0 Weakly correlated
44 MER4D0 1 *** 74.0 Highly correlated
45 L1PA2 1 n.s 15.2 Weakly correlated
46 L1PA5 1 n.s 19.6 Weakly correlated
47 L2a 1 n.s 99.0 Weakly correlated
48 L2b 1 n.s 99.0 Weakly correlated
49 L2c 1 n.s 99.0 Weakly correlated
50 LTR50 1 * 99.0 Weakly correlated
51 LTR7B 1 ** 28.9 Weakly correlated
52 MER11A 1 * 28.9 Weakly correlated
53 MER11C 1 * 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MSTD 209 **** 74.0 Highly correlated
2 MLT1A0 87 **** 99.0 Weakly correlated
3 MLT1A1 32 **** 87.0 Moderately correlated
4 MSTB2 31 **** 74.0 Highly correlated
5 MSTC 16 **** 74.0 Highly correlated
6 MLT1A 14 **** 99.0 Weakly correlated
7 MLT2D 10 **** 99.0 Weakly correlated
8 MLT2C1 5 **** 99.0 Weakly correlated
9 MLT1B 3 * 99.0 Weakly correlated
10 MLT2C2 3 **** 99.0 Weakly correlated
11 MSTA1 3 **** 74.0 Highly correlated
12 MLT2B4 3 *** 99.0 Weakly correlated
13 LTR7B 1 ** 28.9 Weakly correlated
14 MSTB1 1 n.s 74.0 Highly correlated
15 MLT2B5 1 *** 87.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP