ZRdb KZFP & Repeats
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Human_ZNF561

  • Protein
    Zinc finger protein 561
  • Length
    486
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q8N587
  • NCBI_ID
    93134
Sequence:
MAAIYLSRGFFSREPICPFEEKTKVERMVEDYLASGYQDSVTFDDVAVDFTPEEWALLDTTEKYLYRDVMLENYMNLASVEWEIQPRTKRSSLQQGFLKNQIFSGIQMTRGYSGWKLCDCKNCGEVFREQFCLKTHMRVQNGGNTSEGNCYGKDTLSVHKEASTGQELSKFNPCGKVFTLTPGLAVHLEVLNARQPYKCKECGKGFKYFASLDNHMGIHTDEKLCEFQEYGRAVTASSHLKQCVAVHTGKKSKKTKKCGKSFTNFSQLYAPVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTGIKPHKCTYCGKAFTRSTQLTEHVRTHTGIKPYECKECGQAFAQYSGLSIHIRSHSGKKPYQCKECGKAFTTSTSLIQHTRIHTGEKPYECVECGKTFITSSRRSKHLKTHSGEKPFVCKICGKAFLYSSRLNVHLRTHTGEKPFVCKECGKAFAVSSRLSRHERIHTGEKPYECKDMSVTI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 41..112
2 dec2h2 118..140
3 dec2h2 169..191
4 C2h2 197..219
5 dec2h2 223..247
6 dec2h2 253..275
7 C2h2 281..303
8 C2h2 309..331
9 C2h2 337..359
10 C2h2 365..387
11 C2h2 393..415
12 C2h2 421..443
13 C2h2 449..471
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10C 97 **** 28.9 Weakly correlated
2 LTR10E 70 **** 28.9 Weakly correlated
3 LTR10A 20 **** 28.9 Weakly correlated
4 L1PA3 14 n.s 19.6 Weakly correlated
5 L1PA2 10 * 15.2 Weakly correlated
6 L2a 10 n.s 99.0 Weakly correlated
7 AluY 8 n.s 74.0 Weakly correlated
8 LTR10G 8 **** 28.9 Weakly correlated
9 AluJb 7 n.s 74.0 Weakly correlated
10 AluSx 7 n.s 74.0 Weakly correlated
11 LTR8 7 **** 43.0 Highly correlated
12 L1P3 6 ** 74.0 Weakly correlated
13 L1PA5 6 n.s 19.6 Weakly correlated
14 LTR10B1 6 **** 28.9 Weakly correlated
15 LTR10B2 6 **** 28.9 Weakly correlated
16 MIR 6 n.s 99.0 Weakly correlated
17 AluSx1 5 n.s 74.0 Weakly correlated
18 AluSq2 4 n.s 74.0 Weakly correlated
19 AluSz 4 n.s 74.0 Weakly correlated
20 AluJo 3 n.s 74.0 Weakly correlated
21 AluSc 3 n.s 74.0 Weakly correlated
22 AluSc8 3 n.s 74.0 Weakly correlated
23 HERVIP10B3-int 3 **** 28.9 Weakly correlated
24 HERVIP10F-int 3 *** 28.9 Weakly correlated
25 LTR12C 3 n.s 19.6 Weakly correlated
26 MER61C 3 **** 43.0 Highly correlated
27 MIRc 3 n.s 99.0 Weakly correlated
28 Alu 2 *** 74.0 Weakly correlated
29 AluSp 2 n.s 74.0 Weakly correlated
30 AluYj4 2 ** 0.0 Weakly correlated
31 L1M4b 2 n.s 99.0 Weakly correlated
32 L1MEg 2 n.s 99.0 Weakly correlated
33 L1P1 2 n.s 19.6 Weakly correlated
34 L1PA8A 2 n.s 74.0 Weakly correlated
35 L2b 2 n.s 99.0 Weakly correlated
36 LTR10F 2 *** 28.9 Weakly correlated
37 LTR33A_ 2 ** 99.0 Weakly correlated
38 LTR41C 2 *** 99.0 Weakly correlated
39 LTR79 2 * 99.0 Weakly correlated
40 MER50 2 * 43.0 Highly correlated
41 MLT1D 2 n.s 99.0 Weakly correlated
42 MLT1L 2 n.s 99.0 Weakly correlated
43 MamRTE1 2 * 99.0 Weakly correlated
44 AluJr 1 n.s 74.0 Weakly correlated
45 AluSg7 1 n.s 74.0 Weakly correlated
46 AluSx4 1 n.s 74.0 Weakly correlated
47 AluSz6 1 n.s 74.0 Weakly correlated
48 AluYa5 1 n.s 15.2 Weakly correlated
49 AluYc 1 n.s 74.0 Weakly correlated
50 AluYh3 1 n.s 15.2 Weakly correlated
51 AluYh9 1 **** 15.2 Weakly correlated
52 FLAM_C 1 n.s 74.0 Weakly correlated
53 FRAM 1 n.s 74.0 Weakly correlated
54 HAL1 1 n.s 99.0 Weakly correlated
55 HAL1ME 1 n.s 99.0 Weakly correlated
56 HERV35I-int 1 * 43.0 Highly correlated
57 HERVI-int 1 ** 28.9 Weakly correlated
58 HERVIP10FH-int 1 * 28.9 Weakly correlated
59 L1HS 1 n.s 8.6 Weakly correlated
60 L1M1 1 n.s 74.0 Weakly correlated
61 L1M3d 1 * 99.0 Weakly correlated
62 L1M5 1 n.s 99.0 Weakly correlated
63 L1MA4A 1 n.s 87.0 Weakly correlated
64 L1MC4 1 n.s 99.0 Weakly correlated
65 L1MC5a 1 n.s 99.0 Weakly correlated
66 L1MD1 1 n.s 99.0 Weakly correlated
67 L1MDa 1 n.s 99.0 Weakly correlated
68 L1ME2 1 n.s 99.0 Weakly correlated
69 L1ME3A 1 n.s 99.0 Weakly correlated
70 L1ME4b 1 n.s 99.0 Weakly correlated
71 L1MEc 1 n.s 99.0 Weakly correlated
72 L1MEd 1 n.s 99.0 Weakly correlated
73 L1P4 1 n.s 74.0 Weakly correlated
74 L1PA17 1 n.s 74.0 Weakly correlated
75 L1PA4 1 n.s 19.6 Weakly correlated
76 L1PA7 1 n.s 74.0 Weakly correlated
77 L1PB1 1 n.s 74.0 Weakly correlated
78 L1PB3 1 n.s 74.0 Weakly correlated
79 L1PBb 1 * 74.0 Weakly correlated
80 L2 1 n.s 99.0 Weakly correlated
81 L2c 1 n.s 99.0 Weakly correlated
82 LTR10D 1 *** 28.9 Weakly correlated
83 LTR12E 1 ** 19.6 Weakly correlated
84 LTR13 1 * 19.6 Weakly correlated
85 LTR41 1 * 99.0 Weakly correlated
86 LTR81A 1 ** 99.0 Weakly correlated
87 LTR9 1 * 43.0 Highly correlated
88 MER11A 1 n.s 28.9 Weakly correlated
89 MER11C 1 n.s 19.6 Weakly correlated
90 MER39B 1 * 74.0 Weakly correlated
91 MER50-int 1 * 43.0 Highly correlated
92 MER52A 1 n.s 74.0 Weakly correlated
93 MER52C 1 * 74.0 Weakly correlated
94 MER52D 1 * 74.0 Weakly correlated
95 MER61-int 1 n.s 43.0 Highly correlated
96 MER66-int 1 * 43.0 Highly correlated
97 MER83A-int 1 *** 99.0 Weakly correlated
98 MIR3 1 n.s 99.0 Weakly correlated
99 MIRb 1 n.s 99.0 Weakly correlated
100 MLT1A1 1 n.s 87.0 Weakly correlated
101 MLT1C 1 n.s 94.0 Weakly correlated
102 MLT1F1 1 n.s 99.0 Weakly correlated
103 MLT1K 1 n.s 99.0 Weakly correlated
104 MSTA-int 1 n.s 43.0 Highly correlated
105 MamSINE1 1 n.s 99.0 Weakly correlated
106 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10C 94 **** 28.9 Weakly correlated
2 LTR10E 69 **** 28.9 Weakly correlated
3 LTR10A 16 **** 28.9 Weakly correlated
4 LTR10B1 6 **** 28.9 Weakly correlated
5 LTR10B2 6 **** 28.9 Weakly correlated
6 LTR10G 6 **** 28.9 Weakly correlated
7 LTR41C 2 *** 99.0 Weakly correlated
8 L1PA5 2 n.s 19.6 Weakly correlated
9 LTR10F 2 *** 28.9 Weakly correlated
10 AluY 1 n.s 74.0 Weakly correlated
11 HERVIP10F-int 1 * 28.9 Weakly correlated
12 AluJb 1 n.s 74.0 Weakly correlated
13 AluJo 1 n.s 74.0 Weakly correlated
14 L2 1 n.s 99.0 Weakly correlated
15 AluSz 1 n.s 74.0 Weakly correlated
16 L1PA17 1 n.s 74.0 Weakly correlated
17 L1PA7 1 n.s 74.0 Weakly correlated
18 MIRb 1 n.s 99.0 Weakly correlated
19 MER52C 1 * 74.0 Weakly correlated
20 L1ME3A 1 n.s 99.0 Weakly correlated
21 AluSx 1 n.s 74.0 Weakly correlated
22 MER52A 1 n.s 74.0 Weakly correlated
23 MER11A 1 n.s 28.9 Weakly correlated
24 LTR79 1 n.s 99.0 Weakly correlated
25 MIR 1 n.s 99.0 Weakly correlated
26 MER83A-int 1 *** 99.0 Weakly correlated
27 MER52D 1 * 74.0 Weakly correlated
28 MER50 1 n.s 43.0 Highly correlated
29 L2a 1 n.s 99.0 Weakly correlated
30 L1MEc 1 n.s 99.0 Weakly correlated
31 L1M3d 1 * 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR10C 28.9 Weakly correlated