ZRdb KZFP & Repeats
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Human_ZNF559

  • Protein
    Zinc finger protein 559
  • Length
    538
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q9BR84
  • NCBI_ID
    84527
Sequence:
MVAGWLTNYSQDSVTFEDVAVDFTQEEWTLLDQTQRNLYRDVMLENYKNLVAVDWESHINTKWSAPQQNFLQGKTSSVVEMERNHFGEELFDFNQCEKALSEHSCLKTHRRTYFRKKTCECNQCEKAFRKPSIFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKTHTQEKPYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKFYECKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGKAFANSSHLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHSAERPFECEECGKAFRYSSHLSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTHTGERPFECQECGKAFTRSTYLIRHLRSHSVEKPYKECGQTFSNSSCLTECV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..89
2 dec2h2 91..113
3 dec2h2 119..141
4 dec2h2 147..179
5 dec2h2 185..207
6 C2h2 241..263
7 C2h2 297..319
8 C2h2 325..347
9 C2h2 353..375
10 C2h2 381..403
11 C2h2 409..431
12 C2h2 437..459
13 C2h2 465..487
14 C2h2 493..515
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR41C 48 **** 99.0 Weakly correlated
2 MIRb 17 n.s 99.0 Weakly correlated
3 L1PA2 14 n.s 15.2 Weakly correlated
4 L2a 14 n.s 99.0 Weakly correlated
5 AluJb 13 n.s 74.0 Highly correlated
6 L2c 13 n.s 99.0 Weakly correlated
7 L1P3 12 **** 74.0 Highly correlated
8 AluSx1 10 n.s 74.0 Highly correlated
9 MER57B2 10 **** 43.0 Weakly correlated
10 MIRc 10 n.s 99.0 Weakly correlated
11 AluSc8 8 n.s 74.0 Highly correlated
12 AluYj4 8 **** 0.0 Weakly correlated
13 L1MB8 8 n.s 99.0 Weakly correlated
14 LTR8 8 **** 43.0 Weakly correlated
15 MIR 8 n.s 99.0 Weakly correlated
16 MIR3 8 n.s 99.0 Weakly correlated
17 AluJo 7 n.s 74.0 Highly correlated
18 AluJr 7 n.s 74.0 Highly correlated
19 AluSx 7 n.s 74.0 Highly correlated
20 AluSz 7 n.s 74.0 Highly correlated
21 HUERS-P3-int 7 **** 43.0 Weakly correlated
22 L1MC4 7 n.s 99.0 Weakly correlated
23 AluY 6 n.s 74.0 Highly correlated
24 L1PA3 6 n.s 19.6 Weakly correlated
25 L2b 6 n.s 99.0 Weakly correlated
26 LTR12C 6 n.s 19.6 Weakly correlated
27 SVA_F 6 **** 0.0 Weakly correlated
28 L1HS 5 n.s 8.6 Weakly correlated
29 L1M4 5 n.s 99.0 Weakly correlated
30 L1MB7 5 n.s 99.0 Weakly correlated
31 L2 5 n.s 99.0 Weakly correlated
32 LTR13 5 **** 19.6 Weakly correlated
33 LTR41B 5 **** 99.0 Weakly correlated
34 MER21B 5 ** 99.0 Weakly correlated
35 AluSc 4 n.s 74.0 Highly correlated
36 ERV3-16A3_I-int 4 n.s 99.0 Weakly correlated
37 L1MA7 4 n.s 87.0 Moderately correlated
38 L1MB3 4 n.s 99.0 Weakly correlated
39 LTR10A 4 **** 28.9 Weakly correlated
40 MER57B1 4 **** 43.0 Weakly correlated
41 MLT1A0 4 n.s 99.0 Weakly correlated
42 MLT1D 4 n.s 99.0 Weakly correlated
43 AluSz6 3 n.s 74.0 Highly correlated
44 L1M2a 3 ** 87.0 Moderately correlated
45 L1M5 3 n.s 99.0 Weakly correlated
46 L1MD2 3 n.s 99.0 Weakly correlated
47 L1ME1 3 n.s 99.0 Weakly correlated
48 L3 3 n.s 99.0 Weakly correlated
49 LTR10F 3 **** 28.9 Weakly correlated
50 LTR8B 3 * 43.0 Weakly correlated
51 MLT1G 3 * 99.0 Weakly correlated
52 MLT1J 3 n.s 99.0 Weakly correlated
53 SVA_D 3 n.s 15.2 Weakly correlated
54 AluSg7 2 n.s 74.0 Highly correlated
55 AluSp 2 n.s 74.0 Highly correlated
56 AluSq2 2 n.s 74.0 Highly correlated
57 AluSx3 2 n.s 74.0 Highly correlated
58 ERVL-E-int 2 n.s 99.0 Weakly correlated
59 HAL1 2 n.s 99.0 Weakly correlated
60 HERVK13-int 2 **** 19.6 Weakly correlated
61 L1M3de 2 ** 99.0 Weakly correlated
62 L1MA8 2 n.s 87.0 Moderately correlated
63 L1MA9 2 n.s 99.0 Weakly correlated
64 L1MB5 2 n.s 99.0 Weakly correlated
65 L1MC5 2 n.s 99.0 Weakly correlated
66 L1MDa 2 n.s 99.0 Weakly correlated
67 L1ME2 2 n.s 99.0 Weakly correlated
68 L1ME3A 2 n.s 99.0 Weakly correlated
69 L1ME3Cz 2 n.s 99.0 Weakly correlated
70 L1ME3G 2 n.s 99.0 Weakly correlated
71 L1MEc 2 n.s 99.0 Weakly correlated
72 L1MEg 2 n.s 99.0 Weakly correlated
73 L1P1 2 n.s 19.6 Weakly correlated
74 L1P2 2 n.s 28.9 Weakly correlated
75 L1PA16 2 n.s 74.0 Highly correlated
76 L1PA4 2 n.s 19.6 Weakly correlated
77 L1PA5 2 n.s 19.6 Weakly correlated
78 L1PA7 2 n.s 74.0 Highly correlated
79 L1PB1 2 n.s 74.0 Highly correlated
80 LTR24C 2 *** 74.0 Highly correlated
81 LTR26 2 ** 74.0 Highly correlated
82 LTR28C 2 ** 43.0 Weakly correlated
83 LTR33 2 n.s 99.0 Weakly correlated
84 MER52D 2 * 74.0 Highly correlated
85 MLT1C 2 n.s 94.0 Weakly correlated
86 MLT1E3 2 * 99.0 Weakly correlated
87 MLT1G1 2 n.s 99.0 Weakly correlated
88 MLT1K 2 n.s 99.0 Weakly correlated
89 MLT2F 2 * 99.0 Weakly correlated
90 MSTB 2 n.s 43.0 Weakly correlated
91 MamSINE1 2 * 99.0 Weakly correlated
92 THE1B-int 2 n.s 43.0 Weakly correlated
93 THE1D 2 n.s 43.0 Weakly correlated
94 THE1D-int 2 n.s 28.9 Weakly correlated
95 Alu 1 * 74.0 Highly correlated
96 AluSg4 1 n.s 74.0 Highly correlated
97 AluSq 1 n.s 74.0 Highly correlated
98 AluYa5 1 n.s 15.2 Weakly correlated
99 AluYh9 1 **** 15.2 Weakly correlated
100 AluYk3 1 n.s 19.6 Weakly correlated
101 AluYm1 1 n.s 19.6 Weakly correlated
102 AmnSINE1 1 * 319.0 Weakly correlated
103 CR1_Mam 1 * 99.0 Weakly correlated
104 FAM 1 n.s 87.0 Moderately correlated
105 FLAM_A 1 n.s 74.0 Highly correlated
106 FLAM_C 1 n.s 74.0 Highly correlated
107 FRAM 1 n.s 74.0 Highly correlated
108 HERV9N-int 1 n.s 19.6 Weakly correlated
109 HERVL40-int 1 n.s 99.0 Weakly correlated
110 L1M3 1 n.s 99.0 Weakly correlated
111 L1M4b 1 n.s 99.0 Weakly correlated
112 L1MA4 1 n.s 87.0 Moderately correlated
113 L1MA4A 1 n.s 87.0 Moderately correlated
114 L1MA5 1 n.s 87.0 Moderately correlated
115 L1MA6 1 n.s 87.0 Moderately correlated
116 L1MB1 1 n.s 99.0 Weakly correlated
117 L1MB2 1 n.s 99.0 Weakly correlated
118 L1MC5a 1 n.s 99.0 Weakly correlated
119 L1MD1 1 n.s 99.0 Weakly correlated
120 L1MDb 1 n.s 99.0 Weakly correlated
121 L1ME4a 1 n.s 99.0 Weakly correlated
122 L1ME4b 1 n.s 99.0 Weakly correlated
123 L1ME5 1 n.s 99.0 Weakly correlated
124 L1MEf 1 n.s 99.0 Weakly correlated
125 L1P4 1 n.s 74.0 Highly correlated
126 L1PA10 1 n.s 74.0 Highly correlated
127 L1PA13 1 n.s 74.0 Highly correlated
128 L1PA15-16 1 n.s 74.0 Highly correlated
129 L1PA17 1 n.s 74.0 Highly correlated
130 L1PA6 1 n.s 28.9 Weakly correlated
131 LOR1a 1 * 74.0 Highly correlated
132 LTR10B1 1 ** 28.9 Weakly correlated
133 LTR16A 1 n.s 99.0 Weakly correlated
134 LTR1A1 1 * 43.0 Weakly correlated
135 LTR1A2 1 n.s 43.0 Weakly correlated
136 LTR1F2 1 ** 43.0 Weakly correlated
137 LTR2 1 n.s 28.9 Weakly correlated
138 LTR37B 1 n.s 99.0 Weakly correlated
139 LTR4 1 ** 28.9 Weakly correlated
140 LTR41 1 n.s 99.0 Weakly correlated
141 LTR57-int 1 * 74.0 Highly correlated
142 LTR8A 1 n.s 43.0 Weakly correlated
143 MER21C 1 n.s 99.0 Weakly correlated
144 MER4B 1 n.s 74.0 Highly correlated
145 MER52A 1 n.s 74.0 Highly correlated
146 MER66B 1 n.s 43.0 Weakly correlated
147 MER73 1 ** 87.0 Moderately correlated
148 MIR1_Amn 1 n.s 319.0 Weakly correlated
149 MLT1B 1 n.s 99.0 Weakly correlated
150 MLT1C-int 1 * 94.0 Weakly correlated
151 MLT1E1 1 * 99.0 Weakly correlated
152 MLT1F1 1 n.s 99.0 Weakly correlated
153 MLT1G3 1 n.s 99.0 Weakly correlated
154 MLT1H1 1 n.s 99.0 Weakly correlated
155 MLT1J1 1 n.s 99.0 Weakly correlated
156 MLT1J2 1 n.s 99.0 Weakly correlated
157 MLT1J2-int 1 * 99.0 Weakly correlated
158 MLT1L 1 n.s 99.0 Weakly correlated
159 MLT1N2 1 n.s 99.0 Weakly correlated
160 MLT1O 1 n.s 99.0 Weakly correlated
161 MSTB1 1 n.s 74.0 Highly correlated
162 MamGypLTR1a 1 * 99.0 Weakly correlated
163 SVA_A 1 n.s 19.6 Weakly correlated
164 SVA_E 1 * 0.0 Weakly correlated
165 THE1C-int 1 n.s 43.0 Weakly correlated
166 X7A_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 n.s 74.0 Highly correlated
2 L1HS 2 n.s 8.6 Weakly correlated
3 MER57B2 2 ** 43.0 Weakly correlated
4 HUERS-P3-int 2 * 43.0 Weakly correlated
5 MIR3 1 n.s 99.0 Weakly correlated
6 MER4B 1 n.s 74.0 Highly correlated
7 L1ME1 1 n.s 99.0 Weakly correlated
8 MLT1J 1 n.s 99.0 Weakly correlated
9 THE1B-int 1 n.s 43.0 Weakly correlated
10 L2a 1 n.s 99.0 Weakly correlated
11 L1MEc 1 n.s 99.0 Weakly correlated
12 L1MB1 1 n.s 99.0 Weakly correlated
13 MIRc 1 n.s 99.0 Weakly correlated
14 LTR41B 1 * 99.0 Weakly correlated
15 L1MB7 1 n.s 99.0 Weakly correlated
16 L1PA2 1 n.s 15.2 Weakly correlated
17 L1M3 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP