ZRdb KZFP & Repeats
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Human_ZNF557

  • Protein
    Zinc finger protein 557
  • Length
    423
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    15.2 Mya
  • Uniprot_ID
    Q8N988
  • NCBI_ID
    79230
Sequence:
MAAVVLPPTAASQREGHTEGGELVNELLKSWLKGLVTFEDVAVEFTQEEWALLDPAQRTLYRDVMLENCRNLASLGNQVDKPRLISQLEQEDKVMTEERGILSGTCPDVENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKVFSTKSSLTRHRKIHTGERPYGCSECGKSYSSRSYLAVHKRIHNGEKPYECNDCGKTFSSRSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCFREFRTQSIFTRHKRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSNLTQHIRTHTGEKPYTCNECGKSFTNSFSLTIHRRIHNGEKSYECSDCGKSFNVLSSVKKHMRTHTGKKPYECNYCGKSFTSNSYLSVHTRMHNRQM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 36..107
2 C2h2 145..167
3 C2h2 173..195
4 C2h2 201..223
5 C2h2 229..251
6 C2h2 257..279
7 C2h2 285..307
8 C2h2 313..335
9 C2h2 341..363
10 C2h2 369..391
11 C2h2 397..419
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIRb 16 n.s 99.0 Weakly correlated
2 L2a 14 n.s 99.0 Weakly correlated
3 AluJb 9 n.s 74.0 Weakly correlated
4 AluSx 8 n.s 74.0 Weakly correlated
5 L2c 8 n.s 99.0 Weakly correlated
6 LTR13 7 **** 19.6 Moderately correlated
7 MIR3 7 n.s 99.0 Weakly correlated
8 L2b 6 n.s 99.0 Weakly correlated
9 LTR8 6 **** 43.0 Weakly correlated
10 AluJo 5 n.s 74.0 Weakly correlated
11 AluJr 5 n.s 74.0 Weakly correlated
12 AluSq2 5 n.s 74.0 Weakly correlated
13 AluSz 5 n.s 74.0 Weakly correlated
14 AluY 5 n.s 74.0 Weakly correlated
15 L1PA2 5 n.s 15.2 Highly correlated
16 MLT1L 5 *** 99.0 Weakly correlated
17 AluSc 4 n.s 74.0 Weakly correlated
18 L1MB7 4 n.s 99.0 Weakly correlated
19 L1MC1 4 n.s 99.0 Weakly correlated
20 AluSc8 3 n.s 74.0 Weakly correlated
21 AluSx1 3 n.s 74.0 Weakly correlated
22 L1MA2 3 n.s 74.0 Weakly correlated
23 L1MB2 3 n.s 99.0 Weakly correlated
24 L1MC3 3 n.s 99.0 Weakly correlated
25 L1ME3B 3 * 99.0 Weakly correlated
26 L1PA5 3 n.s 19.6 Moderately correlated
27 LTR10A 3 **** 28.9 Moderately correlated
28 MER61C 3 **** 43.0 Weakly correlated
29 MIR 3 n.s 99.0 Weakly correlated
30 MIRc 3 n.s 99.0 Weakly correlated
31 AluSg 2 n.s 74.0 Weakly correlated
32 AluSp 2 n.s 74.0 Weakly correlated
33 AluYm1 2 * 19.6 Moderately correlated
34 HERVH48-int 2 *** 28.9 Moderately correlated
35 L1MA9 2 n.s 99.0 Weakly correlated
36 L1MC4 2 n.s 99.0 Weakly correlated
37 L1ME2 2 n.s 99.0 Weakly correlated
38 L1ME3Cz 2 n.s 99.0 Weakly correlated
39 L1PBa 2 n.s 74.0 Weakly correlated
40 LTR12E 2 **** 19.6 Moderately correlated
41 LTR18C 2 **** 43.0 Weakly correlated
42 LTR1A2 2 ** 43.0 Weakly correlated
43 LTR41 2 *** 99.0 Weakly correlated
44 MLT1J2 2 * 99.0 Weakly correlated
45 MSTC 2 ** 74.0 Weakly correlated
46 Alu 1 ** 74.0 Weakly correlated
47 AluJr4 1 n.s 74.0 Weakly correlated
48 AluSq 1 n.s 74.0 Weakly correlated
49 AluSx3 1 n.s 74.0 Weakly correlated
50 AluSz6 1 n.s 74.0 Weakly correlated
51 AluYa5 1 n.s 15.2 Highly correlated
52 AluYc 1 n.s 74.0 Weakly correlated
53 AluYh9 1 **** 15.2 Highly correlated
54 AmnSINE1 1 ** 319.0 Weakly correlated
55 ERV24_Prim-int 1 ** 74.0 Weakly correlated
56 HAL1 1 n.s 99.0 Weakly correlated
57 HERVK-int 1 * 28.9 Moderately correlated
58 HERVK13-int 1 *** 19.6 Moderately correlated
59 HERVK22-int 1 * 43.0 Weakly correlated
60 HERVKC4-int 1 *** 28.9 Moderately correlated
61 HERVL-int 1 n.s 74.0 Weakly correlated
62 L1HS 1 n.s 8.6 Weakly correlated
63 L1M3f 1 * 87.0 Weakly correlated
64 L1M4a1 1 n.s 99.0 Weakly correlated
65 L1M4c 1 n.s 99.0 Weakly correlated
66 L1M5 1 n.s 99.0 Weakly correlated
67 L1M6 1 n.s 99.0 Weakly correlated
68 L1MA4 1 n.s 87.0 Weakly correlated
69 L1MA7 1 n.s 87.0 Weakly correlated
70 L1MA8 1 n.s 87.0 Weakly correlated
71 L1MB3 1 n.s 99.0 Weakly correlated
72 L1MB4 1 n.s 99.0 Weakly correlated
73 L1MC2 1 n.s 99.0 Weakly correlated
74 L1MC5 1 n.s 99.0 Weakly correlated
75 L1MC5a 1 n.s 99.0 Weakly correlated
76 L1MCc 1 n.s 99.0 Weakly correlated
77 L1MD2 1 n.s 99.0 Weakly correlated
78 L1MDa 1 n.s 99.0 Weakly correlated
79 L1ME2z 1 n.s 99.0 Weakly correlated
80 L1ME4b 1 n.s 99.0 Weakly correlated
81 L1MEb 1 * 99.0 Weakly correlated
82 L1MEc 1 n.s 99.0 Weakly correlated
83 L1MEd 1 n.s 99.0 Weakly correlated
84 L1MEg 1 n.s 99.0 Weakly correlated
85 L1P1 1 n.s 19.6 Moderately correlated
86 L1P2 1 n.s 28.9 Moderately correlated
87 L1P4 1 n.s 74.0 Weakly correlated
88 L1P4a 1 * 74.0 Weakly correlated
89 L1PA10 1 n.s 74.0 Weakly correlated
90 L1PA4 1 n.s 19.6 Moderately correlated
91 L4_A_Mam 1 n.s 99.0 Weakly correlated
92 L4_C_Mam 1 n.s 99.0 Weakly correlated
93 LOR1a 1 ** 74.0 Weakly correlated
94 LTR10E 1 ** 28.9 Moderately correlated
95 LTR16A1 1 * 99.0 Weakly correlated
96 LTR22A 1 *** 43.0 Weakly correlated
97 LTR22C0 1 *** 28.9 Moderately correlated
98 LTR27D 1 ** 43.0 Weakly correlated
99 LTR27E 1 ** 43.0 Weakly correlated
100 LTR71B 1 *** 43.0 Weakly correlated
101 LTR83 1 ** 99.0 Weakly correlated
102 LTR8B 1 * 43.0 Weakly correlated
103 MER11A 1 n.s 28.9 Moderately correlated
104 MER39B 1 * 74.0 Weakly correlated
105 MER41-int 1 n.s 74.0 Weakly correlated
106 MER4A1 1 * 74.0 Weakly correlated
107 MER50 1 n.s 43.0 Weakly correlated
108 MER50-int 1 * 43.0 Weakly correlated
109 MER57-int 1 n.s 87.0 Weakly correlated
110 MER57B1 1 ** 43.0 Weakly correlated
111 MER57D 1 ** 87.0 Weakly correlated
112 MER65C 1 ** 74.0 Weakly correlated
113 MER65D 1 ** 87.0 Weakly correlated
114 MER66A 1 ** 43.0 Weakly correlated
115 MER66C 1 ** 43.0 Weakly correlated
116 MER74B 1 ** 99.0 Weakly correlated
117 MER89 1 * 99.0 Weakly correlated
118 MLT1D 1 n.s 99.0 Weakly correlated
119 MLT1D-int 1 ** 99.0 Weakly correlated
120 MLT1E3 1 * 99.0 Weakly correlated
121 MLT1G1 1 n.s 99.0 Weakly correlated
122 MLT1J 1 n.s 99.0 Weakly correlated
123 MLT1J1 1 n.s 99.0 Weakly correlated
124 MLT1M 1 * 99.0 Weakly correlated
125 MLT2B1 1 n.s 99.0 Weakly correlated
126 MamGypLTR3 1 ** 99.0 Weakly correlated
127 MamGypLTR3a 1 ** 99.0 Weakly correlated
128 MamRTE1 1 n.s 99.0 Weakly correlated
129 PABL_A-int 1 ** 74.0 Weakly correlated
130 SVA_A 1 * 19.6 Moderately correlated
131 THE1D-int 1 n.s 28.9 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx 3 n.s 74.0 Weakly correlated
2 L2a 1 n.s 99.0 Weakly correlated
3 L1MB7 1 n.s 99.0 Weakly correlated
4 AluSq2 1 n.s 74.0 Weakly correlated
5 AluY 1 n.s 74.0 Weakly correlated
6 L1MB2 1 n.s 99.0 Weakly correlated
7 L1MD2 1 n.s 99.0 Weakly correlated
8 AluYh9 1 **** 15.2 Highly correlated
9 HERVKC4-int 1 *** 28.9 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP