ZRdb KZFP & Repeats
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Human_ZNF556

  • Protein
    Zinc finger protein 556
  • Length
    456
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q9HAH1
  • NCBI_ID
    80032
Sequence:
MDTVVFEDVVVDFTLEEWALLNPAQRKLYRDVMLETFKHLASVDNEAQLKASGSISQQDTSGEKLSLKQKIEKFTRKNIWASLLGKNWEEHSVKDKHNTKERHLSRNPRVERPCKSSKGNKRGRTFRKTRNCNRHLRKNCCTSVRRYECSQCGKLFTHSSSLIRHKRAHSGQKLYKCKECGKAFSRPSYLQTHEKTHSGEKPYACQSCGKTFLRSHSLTEHVRTHTGEKPYECGQCGKGFSCPKSFRAHVMMHAGGRPYECKHCGKAFRCQKSFRVHMIMHAGGRPYECKQCGKAYCWATSFQRHVRIHNGEKPYKCGKCGKAFGWPSSLHKHARTHAKKKPVSGGSVGKSSARPRPSTDVKSQTREKVYKCETCGKTYGWSSSLHKHERKHTGEKPVNAASVGKPSGGLCSSKNVRTQIGQKPSKCEKCGKAFSCPKAFQGHVRSHTGKKSCTSK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..77
2 C2h2 147..169
3 C2h2 175..197
4 C2h2 203..225
5 C2h2 231..253
6 C2h2 259..281
7 C2h2 287..309
8 C2h2 315..337
9 C2h2 370..392
10 C2h2 425..447
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 8 **** 74.0 Weakly correlated
2 LTR8 7 **** 43.0 Weakly correlated
3 AluSc8 6 * 74.0 Weakly correlated
4 MER21B 4 *** 99.0 Moderately correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 L1MB8 3 n.s 99.0 Moderately correlated
7 AluY 2 n.s 74.0 Weakly correlated
8 AluYj4 2 ** 0.0 Weakly correlated
9 AluSp 2 n.s 74.0 Weakly correlated
10 L1M4 2 n.s 99.0 Moderately correlated
11 L2c 2 n.s 99.0 Moderately correlated
12 AluJb 1 n.s 74.0 Weakly correlated
13 MLT1A 1 n.s 99.0 Moderately correlated
14 LTR13 1 * 19.6 Weakly correlated
15 LTR10B1 1 *** 28.9 Weakly correlated
16 MLT1L 1 n.s 99.0 Moderately correlated
17 L1PA5 1 n.s 19.6 Weakly correlated
18 L1PA10 1 n.s 74.0 Weakly correlated
19 L1P4 1 n.s 74.0 Weakly correlated
20 L1P1 1 n.s 19.6 Weakly correlated
21 L1MEg 1 n.s 99.0 Moderately correlated
22 L1MC4 1 n.s 99.0 Moderately correlated
23 L1MA3 1 n.s 74.0 Weakly correlated
24 L1M3 1 n.s 99.0 Moderately correlated
25 L1HS 1 n.s 8.6 Weakly correlated
26 AluYh9 1 **** 15.2 Weakly correlated
27 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP