ZRdb KZFP & Repeats
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Human_ZNF555

  • Protein
    Zinc finger protein 555
  • Length
    628
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q8NEP9
  • NCBI_ID
    148254
Sequence:
MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQFKASGSVSQQDIYGEKIPKESKIATFTRNVSWASVLGKIWDSLSIEDQTTNQGRNLSRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGERPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYSSAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSHPSSFRGHMRVHTGEKPYECKQCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDKSYECKLCGKAFYCHISLQKHMRRHTAEKLYKCKQCGKAFSWPELLQQHVRTHTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCSSSLRRHVRIHTTEKQYKCNVGHPPANEFMCSASEKSHQERDLIKVVNMVLPL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..77
2 dec2h2 172..194
3 C2h2 200..222
4 C2h2 228..250
5 C2h2 256..278
6 C2h2 284..306
7 C2h2 312..334
8 C2h2 340..362
9 C2h2 368..390
10 C2h2 396..418
11 C2h2 424..446
12 C2h2 452..474
13 C2h2 480..502
14 C2h2 508..530
15 C2h2 536..558
16 C2h2 564..586
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 21 ** 74.0 Weakly correlated
2 AluJb 11 n.s 74.0 Weakly correlated
3 AluSx1 9 n.s 74.0 Weakly correlated
4 AluSz 8 n.s 74.0 Weakly correlated
5 AluSp 7 n.s 74.0 Weakly correlated
6 L1PA5 5 n.s 19.6 Weakly correlated
7 L2a 5 n.s 99.0 Moderately correlated
8 L1P3 4 ** 74.0 Weakly correlated
9 L1PA2 4 n.s 15.2 Weakly correlated
10 LTR10A 4 **** 28.9 Weakly correlated
11 L2c 4 n.s 99.0 Moderately correlated
12 AluYj4 4 **** 0.0 Weakly correlated
13 AluYc 4 **** 74.0 Weakly correlated
14 AluSx 4 n.s 74.0 Weakly correlated
15 AluSq2 4 n.s 74.0 Weakly correlated
16 LTR18A 3 **** 43.0 Weakly correlated
17 MIRb 3 n.s 99.0 Moderately correlated
18 AluYm1 3 ** 19.6 Weakly correlated
19 AluSc8 3 n.s 74.0 Weakly correlated
20 AluYa5 2 ** 15.2 Weakly correlated
21 LTR33 2 n.s 99.0 Moderately correlated
22 L1P4 2 * 74.0 Weakly correlated
23 LTR10F 2 **** 28.9 Weakly correlated
24 L1PA4 2 n.s 19.6 Weakly correlated
25 MLT1H2 2 ** 99.0 Moderately correlated
26 L1MC4 2 n.s 99.0 Moderately correlated
27 L1MC2 2 n.s 99.0 Moderately correlated
28 MER50 2 ** 43.0 Weakly correlated
29 AluSg 2 n.s 74.0 Weakly correlated
30 L1M1 2 n.s 74.0 Weakly correlated
31 MIR 2 n.s 99.0 Moderately correlated
32 AluSg7 2 n.s 74.0 Weakly correlated
33 AluSq 2 n.s 74.0 Weakly correlated
34 MIRc 2 n.s 99.0 Moderately correlated
35 L2b 1 n.s 99.0 Moderately correlated
36 MamGypLTR3 1 ** 99.0 Moderately correlated
37 LTR12C 1 n.s 19.6 Weakly correlated
38 L2 1 n.s 99.0 Moderately correlated
39 LTR13 1 * 19.6 Weakly correlated
40 LTR37-int 1 * 99.0 Moderately correlated
41 LTR37A 1 * 99.0 Moderately correlated
42 LTR50 1 * 99.0 Moderately correlated
43 MER31A 1 * 87.0 Weakly correlated
44 MER39B 1 * 74.0 Weakly correlated
45 MER4-int 1 n.s 74.0 Weakly correlated
46 MER57C2 1 ** 87.0 Weakly correlated
47 MER66A 1 *** 43.0 Weakly correlated
48 MER66B 1 * 43.0 Weakly correlated
49 MIR3 1 n.s 99.0 Moderately correlated
50 MLT1J1 1 n.s 99.0 Moderately correlated
51 L1MDa 1 n.s 99.0 Moderately correlated
52 AluJr 1 n.s 74.0 Weakly correlated
53 AluJr4 1 n.s 74.0 Weakly correlated
54 AluSc 1 n.s 74.0 Weakly correlated
55 AluYc3 1 ** 74.0 Weakly correlated
56 AluYh9 1 **** 15.2 Weakly correlated
57 HAL1 1 n.s 99.0 Moderately correlated
58 HERV9NC-int 1 * 19.6 Weakly correlated
59 HERVK-int 1 * 28.9 Weakly correlated
60 L1M4b 1 n.s 99.0 Moderately correlated
61 L1M5 1 n.s 99.0 Moderately correlated
62 L1MB3 1 n.s 99.0 Moderately correlated
63 L1MCa 1 n.s 99.0 Moderately correlated
64 L1MCb 1 n.s 99.0 Moderately correlated
65 L1PREC2 1 n.s 43.0 Weakly correlated
66 L1ME3 1 n.s 99.0 Moderately correlated
67 L1ME4a 1 n.s 99.0 Moderately correlated
68 L1ME4b 1 n.s 99.0 Moderately correlated
69 L1MEc 1 n.s 99.0 Moderately correlated
70 L1MEf 1 n.s 99.0 Moderately correlated
71 L1P1 1 n.s 19.6 Weakly correlated
72 L1PA16 1 n.s 74.0 Weakly correlated
73 L1PA3 1 n.s 19.6 Weakly correlated
74 L1PA6 1 n.s 28.9 Weakly correlated
75 L1PA8A 1 n.s 74.0 Weakly correlated
76 L1PB1 1 n.s 74.0 Weakly correlated
77 L1PBa 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 2 ** 0.0 Weakly correlated
2 AluSc 1 n.s 74.0 Weakly correlated
3 AluYh9 1 **** 15.2 Weakly correlated
4 L1MC4 1 n.s 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP