ZRdb KZFP & Repeats
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Human_ZNF551

  • Protein
    Zinc finger protein 551
  • Length
    670
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q7Z340
  • NCBI_ID
    90233
Sequence:
MPAPVGRRSPPSPRSSMAAVALRDSAQGMTFEDVAIYFSQEEWELLDESQRFLYCDVMLENFAHVTSLGYCHGMENEAIASEQSVSIQVRTSKGNTPTQKTHLSEIKMCVPVLKDILPAAEHQTTSPVQKSYLGSTSMRGFCFSADLHQHQKHYNEEEPWKRKVDEATFVTGCRFHVLNYFTCGEAFPAPTDLLQHEATPSGEEPHSSSSKHIQAFFNAKSYYKWGEYRKASSHKHTLVQHQSVCSEGGLYECSKCEKAFTCKNTLVQHQQIHTGQKMFECSECEESFSKKCHLILHKIIHTGERPYECSDREKAFIHKSEFIHHQRRHTGGVRHECGECRKTFSYKSNLIEHQRVHTGERPYECGECGKSFRQSSSLFRHQRVHSGERPYQCCECGKSFRQIFNLIRHRRVHTGEMPYQCSDCGKSFSCKSELIQHQRIHSGERPYECRECGKSFRQFSNLIRHRSIHTGDRPYECSECEKSFSRKFILIQHQRVHTGERPYECSECGKSFTRKSDLIQHRRIHTGTRPYECSECGKSFRQRSGLIQHRRLHTGERPYECSECGKSFSQSASLIQHQRVHTGERPYECSECGKSFSQSSSLIQHQRGHTGERPYECSQCGKPFTHKSDLIQHQRVHTGERPYECSECGKSFSRKSNLIRHRRVHTEERP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 29..100
2 C2h2 251..273
3 C2h2 279..301
4 C2h2 335..357
5 C2h2 363..385
6 C2h2 391..413
7 C2h2 419..441
8 C2h2 447..469
9 C2h2 475..497
10 C2h2 503..525
11 C2h2 531..553
12 C2h2 559..581
13 C2h2 587..609
14 C2h2 615..637
15 C2h2 643..665
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 9 **** 74.0 Weakly correlated
2 AluJb 7 n.s 74.0 Weakly correlated
3 LTR8 6 **** 43.0 Weakly correlated
4 AluSc8 5 n.s 74.0 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 AluSx 3 n.s 74.0 Weakly correlated
7 AluY 3 n.s 74.0 Weakly correlated
8 SVA_F 2 ** 0.0 Weakly correlated
9 L2c 2 n.s 99.0 Moderately correlated
10 L2a 2 n.s 99.0 Moderately correlated
11 L1P4 2 * 74.0 Weakly correlated
12 L1MB8 2 n.s 99.0 Moderately correlated
13 MER21B 2 * 99.0 Moderately correlated
14 L1HS 2 n.s 8.6 Weakly correlated
15 MLT2A1 2 * 74.0 Weakly correlated
16 AluYj4 2 ** 0.0 Weakly correlated
17 AluSz 2 n.s 74.0 Weakly correlated
18 SVA_E 2 *** 0.0 Weakly correlated
19 MIRc 1 n.s 99.0 Moderately correlated
20 MLT1E3 1 * 99.0 Moderately correlated
21 MLT1L 1 n.s 99.0 Moderately correlated
22 MSTB-int 1 n.s 43.0 Weakly correlated
23 SVA_D 1 n.s 15.2 Weakly correlated
24 LTR10B1 1 *** 28.9 Weakly correlated
25 L1P1 1 n.s 19.6 Weakly correlated
26 L1PB1 1 n.s 74.0 Weakly correlated
27 L1PA5 1 n.s 19.6 Weakly correlated
28 L1MC4 1 n.s 99.0 Moderately correlated
29 L1MA9 1 n.s 99.0 Moderately correlated
30 L1M3 1 n.s 99.0 Moderately correlated
31 HAL1 1 n.s 99.0 Moderately correlated
32 ERV3-16A3_I-int 1 n.s 99.0 Moderately correlated
33 AluYm1 1 n.s 19.6 Weakly correlated
34 AluYh9 1 **** 15.2 Weakly correlated
35 AluSz6 1 n.s 74.0 Weakly correlated
36 AluSx1 1 n.s 74.0 Weakly correlated
37 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx1 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP