ZRdb KZFP & Repeats
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Human_ZNF550

  • Protein
    Zinc finger protein 550
  • Length
    422
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q7Z398
  • NCBI_ID
    162972
Sequence:
MAETKDAAQMLVTFKDVAVTFTREEWRQLDLAQRTLYREVMLETCGLLVSLGHRVPKPELVHLLEHGQELWIVKRGLSHATCAGDRAQVHTREPTTYPPVLSERAFLRGSLTLESSTSSDSRLGRARDEEGLLEMQKGKVTPETDLHKETHLGKVSLEGEGLGTDDGLHSRALQEWLSADVLHECDSQQPGKDALIHAGTNPYKCKQCGKGFNRKWYLVRHQRVHTGMKPYECNACGKAFSQSSTLIRHYLIHTGEKPYKCLECGKAFKRRSYLMQHHPIHTGEKPYECSQCRKAFTHRSTFIRHNRTHTGEKPFECKECEKAFSNRAHLIQHYIIHTGEKPYDCMACGKAFRCSSELIQHQRIHTGEKPYECTQCGKAFHRSTYLIQHSVIHTGEMPYKCIECGKAFKRRSHLLQHQRVHT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 12..83
2 C2h2 203..225
3 C2h2 231..253
4 C2h2 259..281
5 C2h2 287..309
6 C2h2 315..337
7 C2h2 343..365
8 C2h2 371..393
9 C2h2 399..421
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B-int 48 **** 43.0 Weakly correlated
2 L1M4 46 **** 99.0 Moderately correlated
3 THE1D-int 32 **** 28.9 Weakly correlated
4 THE1C-int 31 **** 43.0 Weakly correlated
5 MSTA-int 17 **** 43.0 Weakly correlated
6 L1MB7 16 **** 99.0 Moderately correlated
7 THE1A-int 7 **** 43.0 Weakly correlated
8 AluJb 5 n.s 74.0 Weakly correlated
9 AluY 4 n.s 74.0 Weakly correlated
10 AluSx 3 n.s 74.0 Weakly correlated
11 LTR50 3 **** 99.0 Moderately correlated
12 LTR10A 3 **** 28.9 Weakly correlated
13 L1P1 2 * 19.6 Weakly correlated
14 L2 2 n.s 99.0 Moderately correlated
15 L1P3 2 * 74.0 Weakly correlated
16 L1PA5 2 n.s 19.6 Weakly correlated
17 LTR10F 2 **** 28.9 Weakly correlated
18 MER50 2 ** 43.0 Weakly correlated
19 THE1-int 2 **** 43.0 Weakly correlated
20 THE1B 2 n.s 43.0 Weakly correlated
21 AluSc8 2 n.s 74.0 Weakly correlated
22 L1MB5 2 n.s 99.0 Moderately correlated
23 L1MB4 2 n.s 99.0 Moderately correlated
24 MSTB2 1 ** 74.0 Weakly correlated
25 FLAM_C 1 n.s 74.0 Weakly correlated
26 MER50-int 1 ** 43.0 Weakly correlated
27 MER61A 1 ** 43.0 Weakly correlated
28 MIR 1 n.s 99.0 Moderately correlated
29 MIR3 1 n.s 99.0 Moderately correlated
30 MLT1A 1 n.s 99.0 Moderately correlated
31 MLT1F1 1 * 99.0 Moderately correlated
32 MLT1L 1 n.s 99.0 Moderately correlated
33 AluYm1 1 * 19.6 Weakly correlated
34 MSTB-int 1 * 43.0 Weakly correlated
35 MER21A 1 * 74.0 Weakly correlated
36 SVA_F 1 * 0.0 Weakly correlated
37 AluYh9 1 **** 15.2 Weakly correlated
38 AluSz6 1 n.s 74.0 Weakly correlated
39 AluSx1 1 n.s 74.0 Weakly correlated
40 AluSq10 1 ** 74.0 Weakly correlated
41 AluJr 1 n.s 74.0 Weakly correlated
42 L1MA9 1 n.s 99.0 Moderately correlated
43 L1MEg 1 n.s 99.0 Moderately correlated
44 L1MC 1 n.s 99.0 Moderately correlated
45 L1MB8 1 n.s 99.0 Moderately correlated
46 L1P4 1 n.s 74.0 Weakly correlated
47 L1PA16 1 n.s 74.0 Weakly correlated
48 L1PA2 1 n.s 15.2 Weakly correlated
49 L1PREC2 1 n.s 43.0 Weakly correlated
50 L2b 1 n.s 99.0 Moderately correlated
51 MER39B 1 ** 74.0 Weakly correlated
52 L1MA8 1 n.s 87.0 Weakly correlated
53 LTR13 1 ** 19.6 Weakly correlated
54 LTR16B2 1 ** 99.0 Moderately correlated
55 LTR40b 1 ** 99.0 Moderately correlated
56 FRAM 1 * 74.0 Weakly correlated
57 LTR55 1 *** 99.0 Moderately correlated
58 LTR7C 1 *** 28.9 Weakly correlated
59 L1ME3 1 n.s 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B-int 44 **** 43.0 Weakly correlated
2 THE1C-int 31 **** 43.0 Weakly correlated
3 THE1D-int 31 **** 28.9 Weakly correlated
4 L1M4 31 **** 99.0 Moderately correlated
5 MSTA-int 16 **** 43.0 Weakly correlated
6 L1MB7 9 *** 99.0 Moderately correlated
7 THE1A-int 7 **** 43.0 Weakly correlated
8 L1MB4 2 n.s 99.0 Moderately correlated
9 MSTB-int 1 * 43.0 Weakly correlated
10 LTR50 1 * 99.0 Moderately correlated
11 L1PREC2 1 n.s 43.0 Weakly correlated
12 L1PA16 1 n.s 74.0 Weakly correlated
13 L1ME3 1 n.s 99.0 Moderately correlated
14 L1MEg 1 n.s 99.0 Moderately correlated
15 L1MB5 1 n.s 99.0 Moderately correlated
16 L1MB8 1 n.s 99.0 Moderately correlated
17 THE1-int 1 *** 43.0 Weakly correlated
18 LTR7C 1 *** 28.9 Weakly correlated
19 L2 1 n.s 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP