ZRdb KZFP & Repeats
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Human_ZNF548

  • Protein
    Zinc finger protein 548
  • Length
    533
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q8NEK5
  • NCBI_ID
    147694
Sequence:
MNLTEGRVVFEDVAIYFSQEEWGHLDEAQRLLYRDVMLENLALLSSLGSWHGAEDEEAPSQQGFSVGVSEVTASKPCLSSQKVHPSETCGPPLKDILCLVEHNGIHPEQHIYICEAELFQHPKQQIGENLSRGDDWIPSFGKNHRVHMAEEIFTCMEGWKDLPATSCLLQHQGPQSEWKPYRDTEDREAFQTGQNDYKCSECGKTFTCSYSFVEHQKIHTGERSYECNKCGKFFKYSANFMKHQTVHTSERTYECRECGKSFMYNYRLMRHKRVHTGERPYECNTCGKFFRYSSTFVRHQRVHTGERPYECRECGKFFMDSSTLIKHQRVHTGERPYKCNDCGKFFRYISTLIRHQRIHTGERPYECSVCGELFRYNSSLVKHWRNHTGERPYKCSECGKSFRYHCRLIRHQRVHTGERPYECSECGKFFRYNSNLIKHWRNHTGERPYECRECGKAFSHKHILVEHQKIHSGERPYECSECQKAFIRKSHLVHHQKIHSEERLVCSMNVGNSLAKTPTSLNIRDFTMEKVYH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 197..219
3 C2h2 225..247
4 C2h2 253..275
5 C2h2 281..303
6 C2h2 309..331
7 C2h2 337..359
8 C2h2 365..387
9 C2h2 393..415
10 C2h2 421..443
11 C2h2 449..471
12 C2h2 477..499
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1B 71 **** 99.0 Moderately correlated
2 MLT1C 10 **** 94.0 Highly correlated
3 L2a 7 n.s 99.0 Moderately correlated
4 AluJb 5 n.s 74.0 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 L1P3 3 ** 74.0 Weakly correlated
7 MIRb 3 n.s 99.0 Moderately correlated
8 AluY 3 n.s 74.0 Weakly correlated
9 AluSx 2 n.s 74.0 Weakly correlated
10 LTR10F 2 **** 28.9 Weakly correlated
11 AluYh3 2 *** 15.2 Weakly correlated
12 AluSz6 2 n.s 74.0 Weakly correlated
13 MLT1A 2 * 99.0 Moderately correlated
14 AluSp 2 n.s 74.0 Weakly correlated
15 MLT1D 2 n.s 99.0 Moderately correlated
16 L1PA2 2 n.s 15.2 Weakly correlated
17 L1PA4 2 n.s 19.6 Weakly correlated
18 L1PA5 2 n.s 19.6 Weakly correlated
19 MIR1_Amn 1 * 319.0 Weakly correlated
20 L2c 1 n.s 99.0 Moderately correlated
21 L2b 1 n.s 99.0 Moderately correlated
22 LTR13 1 ** 19.6 Weakly correlated
23 LTR1A2 1 ** 43.0 Weakly correlated
24 LTR41 1 ** 99.0 Moderately correlated
25 MER39B 1 ** 74.0 Weakly correlated
26 MER50 1 * 43.0 Weakly correlated
27 MER50-int 1 ** 43.0 Weakly correlated
28 MER51A 1 ** 43.0 Weakly correlated
29 L1P4 1 n.s 74.0 Weakly correlated
30 MLT1G1-int 1 *** 99.0 Moderately correlated
31 MLT1L 1 n.s 99.0 Moderately correlated
32 MSTA-int 1 n.s 43.0 Weakly correlated
33 MSTD 1 n.s 74.0 Weakly correlated
34 MamRTE1 1 * 99.0 Moderately correlated
35 SVA_C 1 ** 15.2 Weakly correlated
36 AluYh9 1 **** 15.2 Weakly correlated
37 AluJo 1 n.s 74.0 Weakly correlated
38 AluJr 1 n.s 74.0 Weakly correlated
39 AluSc 1 n.s 74.0 Weakly correlated
40 AluSc5 1 n.s 74.0 Weakly correlated
41 AluSc8 1 n.s 74.0 Weakly correlated
42 AluSg 1 n.s 74.0 Weakly correlated
43 AluSg7 1 n.s 74.0 Weakly correlated
44 AluSq2 1 n.s 74.0 Weakly correlated
45 AluSq4 1 ** 74.0 Weakly correlated
46 AluSx3 1 n.s 74.0 Weakly correlated
47 AluYa5 1 * 15.2 Weakly correlated
48 L2 1 n.s 99.0 Moderately correlated
49 AluYm1 1 * 19.6 Weakly correlated
50 FLAM_C 1 n.s 74.0 Weakly correlated
51 FRAM 1 * 74.0 Weakly correlated
52 HAL1 1 n.s 99.0 Moderately correlated
53 L1M5 1 n.s 99.0 Moderately correlated
54 L1MA9 1 n.s 99.0 Moderately correlated
55 L1ME2 1 n.s 99.0 Moderately correlated
56 L1ME3F 1 n.s 99.0 Moderately correlated
57 L1ME4b 1 n.s 99.0 Moderately correlated
58 L1P1 1 n.s 19.6 Weakly correlated
59 L1PA7 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P1 1 n.s 19.6 Weakly correlated
2 MLT1B 1 n.s 99.0 Moderately correlated
3 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP