ZRdb KZFP & Repeats
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Human_ZNF546

  • Protein
    Zinc finger protein 546
  • Length
    836
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q86UE3
  • NCBI_ID
    339327
Sequence:
MQVDPPLHGPPNDFLIFQIIPLHSLSIMPRFLWILCFSMEETQGELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWIVMREGTRNWFTDLEYKYITKNLLSEKNVCKIYLSQLQTGEKSKNTIHEDTIFRNGLQCKHEFERQERHQMGCVSQMLIQKQISHPLHPKIHAREKSYECKECRKAFRQQSYLIQHLRIHTGERPYKCMECGKAFCRVGDLRVHHTIHAGERPYECKECGKAFRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRDLRVHQTIHAGERPYECKECGKAFRLHYQLTEHQRIHTGERPYECKVCGKTFRVQRHISQHQKIHTGVKPYKCNECGKAFSHGSYLVQHQKIHTGEKPYECKECGKSFSFHAELARHRRIHTGEKPYECRECGKAFRLQTELTRHHRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQFISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKPYKCTECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSCKECGNAFRLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHRIHTGEKPYQCKECGKAFIRSDQLTLHQRNHISEEVLCIM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 60..131
2 C2h2 217..239
3 C2h2 245..267
4 C2h2 273..295
5 C2h2 301..323
6 C2h2 329..351
7 C2h2 357..379
8 C2h2 385..407
9 C2h2 413..435
10 C2h2 441..463
11 C2h2 469..491
12 C2h2 497..519
13 C2h2 525..547
14 C2h2 553..575
15 C2h2 581..603
16 C2h2 609..631
17 C2h2 637..659
18 C2h2 665..687
19 C2h2 693..715
20 C2h2 721..743
21 C2h2 749..771
22 C2h2 777..799
23 C2h2 805..827
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8 8 **** 43.0 Weakly correlated
2 AluSc8 7 **** 74.0 Weakly correlated
3 L1P3 5 **** 74.0 Weakly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 AluY 2 n.s 74.0 Weakly correlated
6 FRAM 2 ** 74.0 Weakly correlated
7 AluJb 1 n.s 74.0 Weakly correlated
8 AluSz 1 n.s 74.0 Weakly correlated
9 AluYj4 1 ** 0.0 Weakly correlated
10 AluYm1 1 * 19.6 Weakly correlated
11 L1MB8 1 n.s 99.0 Highly correlated
12 L1P4 1 * 74.0 Weakly correlated
13 L1PA2 1 n.s 15.2 Weakly correlated
14 MER21B 1 * 99.0 Highly correlated
15 MLT1L 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 1 n.s 74.0 Weakly correlated
2 AluYj4 1 ** 0.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP