ZRdb KZFP & Repeats
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Human_ZNF544

  • Protein
    Zinc finger protein 544
  • Length
    715
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    Q6NX49
  • NCBI_ID
    27300
Sequence:
MEARSMLVPPQASVCFEDVAMAFTQEEWEQLDLAQRTLYREVTLETWEHIVSLGLFLSKSDVISQLEQEEDLCRAEQEAPRDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPSTLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCFHGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCIECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSFSQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQLIRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRTHTGEKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 354..374
3 C2h2 380..402
4 C2h2 408..430
5 C2h2 436..458
6 C2h2 464..486
7 C2h2 492..514
8 C2h2 520..542
9 C2h2 548..570
10 C2h2 576..598
11 C2h2 604..626
12 C2h2 632..654
13 C2h2 660..682
14 C2h2 688..710
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 26 **** 0.0 Highly correlated
2 AluJb 13 n.s 74.0 Weakly correlated
3 AluSp 13 n.s 74.0 Weakly correlated
4 L1P3 12 **** 74.0 Weakly correlated
5 LTR8 12 **** 43.0 Weakly correlated
6 L2a 11 n.s 99.0 Weakly correlated
7 L2c 10 n.s 99.0 Weakly correlated
8 AluSc8 8 * 74.0 Weakly correlated
9 FRAM 8 **** 74.0 Weakly correlated
10 AluJo 7 n.s 74.0 Weakly correlated
11 L1MB7 7 n.s 99.0 Weakly correlated
12 AluY 5 n.s 74.0 Weakly correlated
13 AluYa8 5 **** 15.2 Weakly correlated
14 L1PA2 5 n.s 15.2 Weakly correlated
15 L2b 4 n.s 99.0 Weakly correlated
16 L1PA5 4 n.s 19.6 Weakly correlated
17 AluYm1 4 ** 19.6 Weakly correlated
18 LTR10A 4 **** 28.9 Weakly correlated
19 LTR10F 4 **** 28.9 Weakly correlated
20 L1MB8 4 n.s 99.0 Weakly correlated
21 MER21B 4 ** 99.0 Weakly correlated
22 L1MC4 4 n.s 99.0 Weakly correlated
23 L1PA4 3 n.s 19.6 Weakly correlated
24 ERV3-16A3_I-int 3 n.s 99.0 Weakly correlated
25 L1MEg 3 n.s 99.0 Weakly correlated
26 AluSz6 2 n.s 74.0 Weakly correlated
27 L1MA9 2 n.s 99.0 Weakly correlated
28 LTR13 2 ** 19.6 Weakly correlated
29 L1P1 2 n.s 19.6 Weakly correlated
30 AluJr 2 n.s 74.0 Weakly correlated
31 MLT1L 2 n.s 99.0 Weakly correlated
32 L1M3 2 n.s 99.0 Weakly correlated
33 MER4-int 2 n.s 74.0 Weakly correlated
34 HERVK-int 2 ** 28.9 Weakly correlated
35 L1MA8 2 n.s 87.0 Weakly correlated
36 MLT1C 2 n.s 94.0 Weakly correlated
37 SVA_C 1 * 15.2 Weakly correlated
38 THE1D 1 n.s 43.0 Weakly correlated
39 MLT1E2 1 n.s 99.0 Weakly correlated
40 MLT1D 1 n.s 99.0 Weakly correlated
41 MLT1J 1 n.s 99.0 Weakly correlated
42 MIRc 1 n.s 99.0 Weakly correlated
43 LTR10B1 1 *** 28.9 Weakly correlated
44 MER89 1 * 99.0 Weakly correlated
45 LTR16A 1 n.s 99.0 Weakly correlated
46 MLT1N2 1 n.s 99.0 Weakly correlated
47 LTR5_Hs 1 n.s 0.0 Highly correlated
48 SVA_A 1 * 19.6 Weakly correlated
49 LTR1A2 1 * 43.0 Weakly correlated
50 HUERS-P3b-int 1 * 43.0 Weakly correlated
51 AluSg4 1 n.s 74.0 Weakly correlated
52 AluSq 1 n.s 74.0 Weakly correlated
53 AluSq2 1 n.s 74.0 Weakly correlated
54 AluSx 1 n.s 74.0 Weakly correlated
55 AluSx1 1 n.s 74.0 Weakly correlated
56 AluSz 1 n.s 74.0 Weakly correlated
57 AluYh9 1 **** 15.2 Weakly correlated
58 AluYi6 1 ** 15.2 Weakly correlated
59 HAL1 1 n.s 99.0 Weakly correlated
60 HERV17-int 1 n.s 28.9 Weakly correlated
61 HERVIP10FH-int 1 * 28.9 Weakly correlated
62 L1PB 1 n.s 74.0 Weakly correlated
63 L1HS 1 n.s 8.6 Moderately correlated
64 L1M4 1 n.s 99.0 Weakly correlated
65 L1M7 1 n.s 99.0 Weakly correlated
66 L1MB3 1 n.s 99.0 Weakly correlated
67 L1MD 1 n.s 99.0 Weakly correlated
68 L1MDb 1 * 99.0 Weakly correlated
69 L1P4 1 n.s 74.0 Weakly correlated
70 L1PA10 1 n.s 74.0 Weakly correlated
71 L1PA14 1 n.s 74.0 Weakly correlated
72 L1PA15-16 1 n.s 74.0 Weakly correlated
73 L1PA8A 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 14 **** 0.0 Highly correlated
2 FRAM 4 *** 74.0 Weakly correlated
3 AluJb 2 n.s 74.0 Weakly correlated
4 AluYa8 2 **** 15.2 Weakly correlated
5 AluJo 2 n.s 74.0 Weakly correlated
6 AluY 1 n.s 74.0 Weakly correlated
7 AluYh9 1 **** 15.2 Weakly correlated
8 L1MB7 1 n.s 99.0 Weakly correlated
9 AluSq 1 n.s 74.0 Weakly correlated
10 L2 1 n.s 99.0 Weakly correlated
11 AluSc8 1 n.s 74.0 Weakly correlated
12 SVA_A 1 * 19.6 Weakly correlated
13 HUERS-P3b-int 1 * 43.0 Weakly correlated
14 AluJr 1 n.s 74.0 Weakly correlated
15 L1PA5 1 n.s 19.6 Weakly correlated
16 L2a 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP