ZRdb KZFP & Repeats
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Human_ZNF543

  • Protein
    Zinc finger protein 543
  • Length
    600
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q08ER8
  • NCBI_ID
    125919
Sequence:
MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 9..80
2 C2h2 199..221
3 C2h2 227..249
4 C2h2 255..277
5 C2h2 283..305
6 C2h2 311..333
7 C2h2 339..361
8 C2h2 367..389
9 C2h2 395..417
10 C2h2 423..445
11 C2h2 451..473
12 C2h2 479..501
13 C2h2 507..529
14 C2h2 535..557
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1D 36 **** 99.0 Highly correlated
2 AluY 24 n.s 74.0 Weakly correlated
3 MLT1E3 22 **** 99.0 Highly correlated
4 MLT1E1A 18 **** 99.0 Highly correlated
5 MIRb 16 n.s 99.0 Highly correlated
6 AluSx1 14 n.s 74.0 Weakly correlated
7 L2a 13 n.s 99.0 Highly correlated
8 MIR3 11 * 99.0 Highly correlated
9 MLT1F2 10 **** 99.0 Highly correlated
10 MLT1E2 10 **** 99.0 Highly correlated
11 AluJb 7 n.s 74.0 Weakly correlated
12 MIRc 6 n.s 99.0 Highly correlated
13 L2c 6 n.s 99.0 Highly correlated
14 MLT1E1 5 **** 99.0 Highly correlated
15 AluJo 5 n.s 74.0 Weakly correlated
16 MIR 5 n.s 99.0 Highly correlated
17 LTR8 5 *** 43.0 Weakly correlated
18 L2 5 n.s 99.0 Highly correlated
19 L1PA5 4 n.s 19.6 Weakly correlated
20 L1ME4b 3 n.s 99.0 Highly correlated
21 LTR12E 3 **** 19.6 Weakly correlated
22 LTR10A 3 **** 28.9 Weakly correlated
23 AluSq2 3 n.s 74.0 Weakly correlated
24 AluSx 3 n.s 74.0 Weakly correlated
25 AluSz 3 n.s 74.0 Weakly correlated
26 AluSx3 2 n.s 74.0 Weakly correlated
27 MLT1C 2 n.s 94.0 Weakly correlated
28 MLT1E 2 *** 99.0 Highly correlated
29 AluYm1 2 n.s 19.6 Weakly correlated
30 L1M4b 2 n.s 99.0 Highly correlated
31 AluSq 2 n.s 74.0 Weakly correlated
32 LTR12C 2 n.s 19.6 Weakly correlated
33 L1P3 2 n.s 74.0 Weakly correlated
34 L2b 2 n.s 99.0 Highly correlated
35 AluJr 2 n.s 74.0 Weakly correlated
36 AluSc 2 n.s 74.0 Weakly correlated
37 LTR35 1 *** 43.0 Weakly correlated
38 MLT1F1 1 n.s 99.0 Highly correlated
39 LTR33B 1 * 99.0 Highly correlated
40 MLT1L 1 n.s 99.0 Highly correlated
41 LTR33 1 n.s 99.0 Highly correlated
42 SVA_C 1 * 15.2 Weakly correlated
43 LTR16E2 1 n.s 99.0 Highly correlated
44 MLT1J2 1 n.s 99.0 Highly correlated
45 LTR41B 1 * 99.0 Highly correlated
46 LTR5_Hs 1 n.s 0.0 Weakly correlated
47 MLT2C1 1 n.s 99.0 Highly correlated
48 LTR8B 1 n.s 43.0 Weakly correlated
49 MER39B 1 * 74.0 Weakly correlated
50 MLT1F 1 n.s 99.0 Highly correlated
51 MER49 1 n.s 43.0 Weakly correlated
52 MER50 1 n.s 43.0 Weakly correlated
53 MER52D 1 n.s 74.0 Weakly correlated
54 MLT2B3 1 n.s 99.0 Highly correlated
55 MIR1_Amn 1 n.s 319.0 Weakly correlated
56 MLT1A0 1 n.s 99.0 Highly correlated
57 AluYf1 1 n.s 19.6 Weakly correlated
58 HAL1 1 n.s 99.0 Highly correlated
59 FRAM 1 n.s 74.0 Weakly correlated
60 FLAM_C 1 n.s 74.0 Weakly correlated
61 FAM 1 n.s 87.0 Weakly correlated
62 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
63 AluYk3 1 * 19.6 Weakly correlated
64 AluYh9 1 **** 15.2 Weakly correlated
65 AluYh3 1 n.s 15.2 Weakly correlated
66 HERVK-int 1 * 28.9 Weakly correlated
67 AluYc3 1 ** 74.0 Weakly correlated
68 AluYc 1 n.s 74.0 Weakly correlated
69 AluYa5 1 n.s 15.2 Weakly correlated
70 AluSz6 1 n.s 74.0 Weakly correlated
71 AluSg 1 n.s 74.0 Weakly correlated
72 AluSc5 1 n.s 74.0 Weakly correlated
73 AluJr4 1 n.s 74.0 Weakly correlated
74 L1MEb 1 n.s 99.0 Highly correlated
75 LTR102_Mam 1 ** 99.0 Highly correlated
76 L1PA8 1 n.s 74.0 Weakly correlated
77 L1PA2 1 n.s 15.2 Weakly correlated
78 L1PA16 1 n.s 74.0 Weakly correlated
79 L1P4 1 n.s 74.0 Weakly correlated
80 L1P2 1 n.s 28.9 Weakly correlated
81 L1P1 1 n.s 19.6 Weakly correlated
82 L1MEc 1 n.s 99.0 Highly correlated
83 LTR13 1 * 19.6 Weakly correlated
84 L1ME1 1 n.s 99.0 Highly correlated
85 L1MDb 1 * 99.0 Highly correlated
86 L1MD3 1 n.s 99.0 Highly correlated
87 L1MC5 1 n.s 99.0 Highly correlated
88 L1MC4 1 n.s 99.0 Highly correlated
89 L1MA9 1 n.s 99.0 Highly correlated
90 HERVL18-int 1 * 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1D 23 **** 99.0 Highly correlated
2 AluY 9 n.s 74.0 Weakly correlated
3 MLT1E1A 4 *** 99.0 Highly correlated
4 MLT1E3 2 ** 99.0 Highly correlated
5 MIRb 2 n.s 99.0 Highly correlated
6 L1P3 2 n.s 74.0 Weakly correlated
7 L2c 1 n.s 99.0 Highly correlated
8 AluYh9 1 **** 15.2 Weakly correlated
9 LTR13 1 * 19.6 Weakly correlated
10 L1MD3 1 n.s 99.0 Highly correlated
11 AluYc 1 n.s 74.0 Weakly correlated
12 AluSz 1 n.s 74.0 Weakly correlated
13 MLT1F2 1 n.s 99.0 Highly correlated
14 MER50 1 n.s 43.0 Weakly correlated
15 L2 1 n.s 99.0 Highly correlated
16 AluSq2 1 n.s 74.0 Weakly correlated
17 AluYc3 1 ** 74.0 Weakly correlated
18 L1P1 1 n.s 19.6 Weakly correlated
19 L2a 1 n.s 99.0 Highly correlated
20 L1ME4b 1 n.s 99.0 Highly correlated
21 AluYk3 1 * 19.6 Weakly correlated
22 AluYh3 1 n.s 15.2 Weakly correlated
23 MLT1E 1 * 99.0 Highly correlated
24 L1PA5 1 n.s 19.6 Weakly correlated
25 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP