ZRdb KZFP & Repeats
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Human_ZNF530

  • Protein
    Zinc finger protein 530
  • Length
    599
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q6P9A1
  • NCBI_ID
    348327
Sequence:
MAAALRAPTQQVFVAFEDVAIYFSQEEWELLDEMQRLLYRDVMLENFAVMASLGCWCGAVDEGTPSAESVSVEELSQGRTPKADTSTDKSHPCEICTPVLRDILQMIELHASPCGQKLYLGGASRDFWMSSNLHQLQKLDNGEKLFKVDGDQASFMMNCRFHVSGKPFTFGEVGRDFSATSGLLQHQVTPTIERPHSRIRHLRVPTGRKPLKYTESRKSFREKSVFIQHQRADSGERPYKCSECGKSFSQSSGFLRHRKAHGRTRTHECSECGKSFSRKTHLTQHQRVHTGERPYDCSECGKSFRQVSVLIQHQRVHTGERPYECSECGKSFSHSTNLYRHRSAHTSTRPYECSECGKSFSHSTNLFRHWRVHTGVRPYECSECGKAFSCNIYLIHHQRFHTGERPYVCSECGKSFGQKSVLIQHQRVHTGERPYECSECGKVFSQSSGLFRHRRAHTKTKPYECSECEKSFSCKTDLIRHQTVHTGERPYECSVCGKSFIRKTHLIRHQTVHTNERPYECDECGKSYSQSSALLQHRRVHTGERPYECRECGKSFTRKNHLIQHKTVHTGERPYECSECGKSFSQSSGLLRHRRVHVQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..94
2 C2h2 239..261
3 C2h2 267..289
4 C2h2 295..317
5 C2h2 323..345
6 C2h2 351..373
7 C2h2 379..401
8 C2h2 407..429
9 C2h2 435..457
10 C2h2 463..485
11 C2h2 491..513
12 C2h2 519..541
13 C2h2 547..569
14 C2h2 575..597
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR48 77 **** 74.0 Weakly correlated
2 MER34C2 21 **** 74.0 Weakly correlated
3 AluJb 18 n.s 74.0 Weakly correlated
4 THE1B-int 16 **** 43.0 Moderately correlated
5 LTR49 12 **** 74.0 Weakly correlated
6 L2a 11 n.s 99.0 Weakly correlated
7 MSTA-int 11 **** 43.0 Moderately correlated
8 THE1B 11 ** 43.0 Moderately correlated
9 AluSx1 10 n.s 74.0 Weakly correlated
10 L2c 9 n.s 99.0 Weakly correlated
11 AluJo 8 n.s 74.0 Weakly correlated
12 AluSz 8 n.s 74.0 Weakly correlated
13 AluSz6 8 n.s 74.0 Weakly correlated
14 AluY 8 n.s 74.0 Weakly correlated
15 AluYj4 8 **** 0.0 Weakly correlated
16 L2 8 n.s 99.0 Weakly correlated
17 MIR 8 n.s 99.0 Weakly correlated
18 MIRb 8 n.s 99.0 Weakly correlated
19 THE1C-int 8 **** 43.0 Moderately correlated
20 THE1D-int 8 **** 28.9 Highly correlated
21 AluSx 7 n.s 74.0 Weakly correlated
22 L2b 7 n.s 99.0 Weakly correlated
23 MSTA 6 n.s 43.0 Moderately correlated
24 AluSp 5 n.s 74.0 Weakly correlated
25 L1M4 5 n.s 99.0 Weakly correlated
26 L1PA5 5 n.s 19.6 Weakly correlated
27 MER21B 5 **** 99.0 Weakly correlated
28 MIR3 5 n.s 99.0 Weakly correlated
29 AluJr 4 n.s 74.0 Weakly correlated
30 FLAM_C 4 * 74.0 Weakly correlated
31 HAL1 4 n.s 99.0 Weakly correlated
32 L3 4 n.s 99.0 Weakly correlated
33 LTR10A 4 **** 28.9 Highly correlated
34 MLT1J 4 n.s 99.0 Weakly correlated
35 L1P3 3 n.s 74.0 Weakly correlated
36 L1PA15-16 3 * 74.0 Weakly correlated
37 L1PA2 3 n.s 15.2 Weakly correlated
38 LTR12C 3 n.s 19.6 Weakly correlated
39 LTR18A 3 **** 43.0 Moderately correlated
40 MER11C 3 ** 19.6 Weakly correlated
41 MER21C 3 * 99.0 Weakly correlated
42 MER50 3 ** 43.0 Moderately correlated
43 SVA_D 3 * 15.2 Weakly correlated
44 THE1A 3 ** 43.0 Moderately correlated
45 THE1A-int 3 * 43.0 Moderately correlated
46 AluJr4 2 n.s 74.0 Weakly correlated
47 AluSc8 2 n.s 74.0 Weakly correlated
48 AluSg 2 n.s 74.0 Weakly correlated
49 AluSq 2 n.s 74.0 Weakly correlated
50 AluSq2 2 n.s 74.0 Weakly correlated
51 AluSx3 2 n.s 74.0 Weakly correlated
52 AluYm1 2 n.s 19.6 Weakly correlated
53 FRAM 2 * 74.0 Weakly correlated
54 L1M2 2 n.s 99.0 Weakly correlated
55 L1MA1 2 n.s 74.0 Weakly correlated
56 L1MB3 2 n.s 99.0 Weakly correlated
57 L1MB7 2 n.s 99.0 Weakly correlated
58 L1ME4b 2 n.s 99.0 Weakly correlated
59 L1MEd 2 n.s 99.0 Weakly correlated
60 L1P1 2 n.s 19.6 Weakly correlated
61 L1PA16 2 n.s 74.0 Weakly correlated
62 LTR33 2 n.s 99.0 Weakly correlated
63 LTR5B 2 ** 28.9 Highly correlated
64 MER50-int 2 ** 43.0 Moderately correlated
65 MER52C 2 *** 74.0 Weakly correlated
66 MER66B 2 ** 43.0 Moderately correlated
67 MIR1_Amn 2 * 319.0 Weakly correlated
68 MLT1C 2 n.s 94.0 Weakly correlated
69 MLT1D 2 n.s 99.0 Weakly correlated
70 AluSc 1 n.s 74.0 Weakly correlated
71 AluSg4 1 n.s 74.0 Weakly correlated
72 AluSg7 1 n.s 74.0 Weakly correlated
73 AluSq10 1 * 74.0 Weakly correlated
74 AluYa5 1 n.s 15.2 Weakly correlated
75 AluYa8 1 *** 15.2 Weakly correlated
76 AluYh3 1 * 15.2 Weakly correlated
77 AluYh9 1 **** 15.2 Weakly correlated
78 ERVL-E-int 1 n.s 99.0 Weakly correlated
79 HERV17-int 1 n.s 28.9 Highly correlated
80 HERVK9-int 1 n.s 28.9 Highly correlated
81 HUERS-P3-int 1 * 43.0 Moderately correlated
82 L1M2c 1 * 87.0 Weakly correlated
83 L1M4b 1 n.s 99.0 Weakly correlated
84 L1MA4A 1 n.s 87.0 Weakly correlated
85 L1MA5A 1 n.s 87.0 Weakly correlated
86 L1MA7 1 n.s 87.0 Weakly correlated
87 L1MA8 1 n.s 87.0 Weakly correlated
88 L1MA9 1 n.s 99.0 Weakly correlated
89 L1MB8 1 n.s 99.0 Weakly correlated
90 L1MC2 1 n.s 99.0 Weakly correlated
91 L1MC4 1 n.s 99.0 Weakly correlated
92 L1MC5a 1 n.s 99.0 Weakly correlated
93 L1MD 1 n.s 99.0 Weakly correlated
94 L1MD3 1 n.s 99.0 Weakly correlated
95 L1MDa 1 n.s 99.0 Weakly correlated
96 L1ME1 1 n.s 99.0 Weakly correlated
97 L1ME3A 1 n.s 99.0 Weakly correlated
98 L1ME3E 1 n.s 99.0 Weakly correlated
99 L1P4 1 n.s 74.0 Weakly correlated
100 L1PA14 1 n.s 74.0 Weakly correlated
101 L1PA15 1 n.s 74.0 Weakly correlated
102 L1PA17 1 n.s 74.0 Weakly correlated
103 L1PA3 1 n.s 19.6 Weakly correlated
104 L1PA7 1 n.s 74.0 Weakly correlated
105 LTR104_Mam 1 * 99.0 Weakly correlated
106 LTR10F 1 ** 28.9 Highly correlated
107 LTR12E 1 ** 19.6 Weakly correlated
108 LTR13 1 * 19.6 Weakly correlated
109 LTR14B 1 ** 28.9 Highly correlated
110 LTR16A1 1 n.s 99.0 Weakly correlated
111 LTR16B 1 ** 99.0 Weakly correlated
112 LTR16C 1 n.s 99.0 Weakly correlated
113 LTR21A 1 *** 28.9 Highly correlated
114 LTR28 1 ** 43.0 Moderately correlated
115 LTR28C 1 ** 43.0 Moderately correlated
116 LTR3B_ 1 ** 28.9 Highly correlated
117 LTR47B2 1 *** 74.0 Weakly correlated
118 LTR49-int 1 n.s 74.0 Weakly correlated
119 LTR64 1 ** 74.0 Weakly correlated
120 LTR78 1 n.s 99.0 Weakly correlated
121 LTR81 1 *** 99.0 Weakly correlated
122 LTR85b 1 ** 99.0 Weakly correlated
123 MER11A 1 n.s 28.9 Highly correlated
124 MER39B 1 * 74.0 Weakly correlated
125 MER41-int 1 n.s 74.0 Weakly correlated
126 MER41A 1 n.s 74.0 Weakly correlated
127 MER41B 1 n.s 74.0 Weakly correlated
128 MER4B 1 n.s 74.0 Weakly correlated
129 MER4D 1 * 74.0 Weakly correlated
130 MER4D1 1 n.s 74.0 Weakly correlated
131 MER57-int 1 n.s 87.0 Weakly correlated
132 MER61-int 1 n.s 43.0 Moderately correlated
133 MER61A 1 ** 43.0 Moderately correlated
134 MER68-int 1 ** 99.0 Weakly correlated
135 MER72 1 * 43.0 Moderately correlated
136 MIRc 1 n.s 99.0 Weakly correlated
137 MLT1A0 1 n.s 99.0 Weakly correlated
138 MLT1A1 1 n.s 87.0 Weakly correlated
139 MLT1B 1 n.s 99.0 Weakly correlated
140 MLT1F1 1 n.s 99.0 Weakly correlated
141 MLT1G1 1 n.s 99.0 Weakly correlated
142 MLT1I 1 n.s 99.0 Weakly correlated
143 MLT1J1 1 n.s 99.0 Weakly correlated
144 MLT1K 1 n.s 99.0 Weakly correlated
145 MLT2F 1 * 99.0 Weakly correlated
146 MamGypLTR3a 1 * 99.0 Weakly correlated
147 MamGypsy2-I 1 * 99.0 Weakly correlated
148 MamSINE1 1 n.s 99.0 Weakly correlated
149 THE1C 1 n.s 43.0 Moderately correlated
150 THE1D 1 n.s 43.0 Moderately correlated
151 UCON51 1 **** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR48 66 **** 74.0 Weakly correlated
2 MER34C2 20 **** 74.0 Weakly correlated
3 THE1B-int 13 **** 43.0 Moderately correlated
4 LTR49 11 **** 74.0 Weakly correlated
5 L2a 8 n.s 99.0 Weakly correlated
6 MSTA-int 5 ** 43.0 Moderately correlated
7 THE1D-int 5 ** 28.9 Highly correlated
8 MER21B 5 **** 99.0 Weakly correlated
9 MLT1J 4 n.s 99.0 Weakly correlated
10 MIR 4 n.s 99.0 Weakly correlated
11 L2c 4 n.s 99.0 Weakly correlated
12 L2 4 n.s 99.0 Weakly correlated
13 AluSz6 3 n.s 74.0 Weakly correlated
14 L1M4 3 n.s 99.0 Weakly correlated
15 AluJb 3 n.s 74.0 Weakly correlated
16 L2b 3 n.s 99.0 Weakly correlated
17 L3 3 n.s 99.0 Weakly correlated
18 AluY 3 n.s 74.0 Weakly correlated
19 THE1C-int 3 * 43.0 Moderately correlated
20 THE1A-int 2 n.s 43.0 Moderately correlated
21 L1M2 2 n.s 99.0 Weakly correlated
22 L1PA15-16 2 n.s 74.0 Weakly correlated
23 AluSx1 2 n.s 74.0 Weakly correlated
24 MLT1C 2 n.s 94.0 Weakly correlated
25 HAL1 2 n.s 99.0 Weakly correlated
26 AluJr 2 n.s 74.0 Weakly correlated
27 AluJo 2 n.s 74.0 Weakly correlated
28 MER21C 2 n.s 99.0 Weakly correlated
29 MER11C 2 * 19.6 Weakly correlated
30 L1MB7 2 n.s 99.0 Weakly correlated
31 MIRb 2 n.s 99.0 Weakly correlated
32 MLT1D 2 n.s 99.0 Weakly correlated
33 L1PA16 2 n.s 74.0 Weakly correlated
34 AluYj4 2 ** 0.0 Weakly correlated
35 MIR3 2 n.s 99.0 Weakly correlated
36 L1MA9 1 n.s 99.0 Weakly correlated
37 MLT1G1 1 n.s 99.0 Weakly correlated
38 LTR21A 1 *** 28.9 Highly correlated
39 MLT1K 1 n.s 99.0 Weakly correlated
40 UCON51 1 **** 319.0 Weakly correlated
41 MIR1_Amn 1 n.s 319.0 Weakly correlated
42 MER39B 1 * 74.0 Weakly correlated
43 LTR28C 1 ** 43.0 Moderately correlated
44 LTR18A 1 *** 43.0 Moderately correlated
45 FRAM 1 n.s 74.0 Weakly correlated
46 LTR12E 1 ** 19.6 Weakly correlated
47 L1MA1 1 n.s 74.0 Weakly correlated
48 LTR85b 1 ** 99.0 Weakly correlated
49 LTR104_Mam 1 * 99.0 Weakly correlated
50 MER4D 1 * 74.0 Weakly correlated
51 SVA_D 1 n.s 15.2 Weakly correlated
52 L1PA17 1 n.s 74.0 Weakly correlated
53 L1MA8 1 n.s 87.0 Weakly correlated
54 LTR12C 1 n.s 19.6 Weakly correlated
55 LTR16A1 1 n.s 99.0 Weakly correlated
56 FLAM_C 1 n.s 74.0 Weakly correlated
57 MER11A 1 n.s 28.9 Highly correlated
58 THE1B 1 n.s 43.0 Moderately correlated
59 MER50 1 n.s 43.0 Moderately correlated
60 AluYh9 1 **** 15.2 Weakly correlated
61 L1MC5a 1 n.s 99.0 Weakly correlated
62 L1ME3A 1 n.s 99.0 Weakly correlated
63 LTR3B_ 1 ** 28.9 Highly correlated
64 LTR78 1 n.s 99.0 Weakly correlated
65 MER52C 1 * 74.0 Weakly correlated
66 MER66B 1 * 43.0 Moderately correlated
67 MLT2F 1 * 99.0 Weakly correlated
68 AluSp 1 n.s 74.0 Weakly correlated
69 AluSz 1 n.s 74.0 Weakly correlated
70 L1MA4A 1 n.s 87.0 Weakly correlated
71 LTR16C 1 n.s 99.0 Weakly correlated
72 LTR64 1 ** 74.0 Weakly correlated
73 MER68-int 1 ** 99.0 Weakly correlated
74 L1PA7 1 n.s 74.0 Weakly correlated
75 MER41A 1 n.s 74.0 Weakly correlated
76 MamGypLTR3a 1 * 99.0 Weakly correlated
77 AluSq2 1 n.s 74.0 Weakly correlated
78 HERV17-int 1 n.s 28.9 Highly correlated
79 L1MB3 1 n.s 99.0 Weakly correlated
80 LTR49-int 1 n.s 74.0 Weakly correlated
81 MLT1I 1 n.s 99.0 Weakly correlated
82 MSTA 1 n.s 43.0 Moderately correlated
83 LTR33 1 n.s 99.0 Weakly correlated
84 MER61A 1 ** 43.0 Moderately correlated
85 MLT1A1 1 n.s 87.0 Weakly correlated
86 AluSq 1 n.s 74.0 Weakly correlated
87 L1ME1 1 n.s 99.0 Weakly correlated
88 L1PA14 1 n.s 74.0 Weakly correlated
89 L1PA5 1 n.s 19.6 Weakly correlated
90 MER41-int 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP