ZRdb KZFP & Repeats
...

Human_ZNF529

  • Protein
    Zinc finger protein 529
  • Length
    563
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6P280
  • NCBI_ID
    57711
Sequence:
MANSSFIGDHVHGAPHAVMPEVEFPDQFFTVLTMDHELVTLRDVVINFSQEEWEYLDSAQRNLYWDVMMENYSNLLSLDLESRNETKHLSVGKDIIQNTGSQWEVMESSKLCGLEGSIFRNDWQSKSKIDLQGPEVGYFSQMKIISENVPSYKTHESLTLPRRTHDSEKPYEYKEYEKVFSCDLEFDEYQKIHTGGKNYECNQCWKTFGIDNSSMLQLNIHTGVKPCKYMEYGNTCSFYKDFNVYQKIHNEKFYKCKEYRRTFERVGKVTPLQRVHDGEKHFECSFCGKSFRVHAQLTRHQKIHTDEKTYKCMECGKDFRFHSQLTEHQRIHTGEKPYKCMHCEKVFRISSQLIEHQRIHTGEKPYACKECGKAFGVCRELARHQRIHTGKKPYECKACGKVFRNSSSLTRHQRIHTGEKPYKCKECEKAFGVGSELTRHERIHSGQKPYECKECGKFFRLTSALIQHQRIHSGEKPYECKVCGKAFRHSSALTEHQRIHTGEKPYECKACGKAFRHSSSFTKHQRIHTDDKPYECKECGNSFSVVGHLTCQPKIYTGEKSFD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 39..119
2 dec2h2 199..221
3 dec2h2 254..276
4 C2h2 282..304
5 C2h2 310..332
6 C2h2 338..360
7 C2h2 366..388
8 C2h2 394..416
9 C2h2 422..444
10 C2h2 450..472
11 C2h2 478..500
12 C2h2 506..528
13 dec2h2 534..556
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MD2 29 **** 99.0 Highly correlated
2 L1MD3 14 **** 99.0 Highly correlated
3 L1MC4a 14 **** 99.0 Highly correlated
4 L1MD1 11 **** 99.0 Highly correlated
5 L1PA2 4 n.s 15.2 Weakly correlated
6 AluJb 3 n.s 74.0 Weakly correlated
7 L1PA5 3 n.s 19.6 Weakly correlated
8 LTR10A 3 **** 28.9 Weakly correlated
9 AluSc8 2 n.s 74.0 Weakly correlated
10 L1PA13 2 n.s 74.0 Weakly correlated
11 L1P4 2 ** 74.0 Weakly correlated
12 L1P3 2 * 74.0 Weakly correlated
13 L1P1 2 * 19.6 Weakly correlated
14 L1ME1 2 n.s 99.0 Highly correlated
15 L1M4 2 n.s 99.0 Highly correlated
16 AluSx 2 n.s 74.0 Weakly correlated
17 MIR 2 n.s 99.0 Highly correlated
18 MIRb 2 n.s 99.0 Highly correlated
19 MIR3 1 n.s 99.0 Highly correlated
20 THE1C 1 n.s 43.0 Weakly correlated
21 MamRTE1 1 * 99.0 Highly correlated
22 MSTA 1 n.s 43.0 Weakly correlated
23 MLT1L 1 n.s 99.0 Highly correlated
24 L1PA4 1 n.s 19.6 Weakly correlated
25 MLT1F1 1 * 99.0 Highly correlated
26 MLT1A 1 n.s 99.0 Highly correlated
27 MIRc 1 n.s 99.0 Highly correlated
28 MER50 1 * 43.0 Weakly correlated
29 L2c 1 n.s 99.0 Highly correlated
30 LFSINE_Vert 1 ** 319.0 Weakly correlated
31 LOR1-int 1 * 74.0 Weakly correlated
32 MER52D 1 ** 74.0 Weakly correlated
33 LTR13 1 ** 19.6 Weakly correlated
34 LTR55 1 *** 99.0 Highly correlated
35 MER11A 1 * 28.9 Weakly correlated
36 MER39B 1 ** 74.0 Weakly correlated
37 L1M3 1 n.s 99.0 Highly correlated
38 AluSg 1 n.s 74.0 Weakly correlated
39 AluSp 1 n.s 74.0 Weakly correlated
40 AluSq2 1 n.s 74.0 Weakly correlated
41 AluSz 1 n.s 74.0 Weakly correlated
42 AluY 1 n.s 74.0 Weakly correlated
43 AluYa8 1 **** 15.2 Weakly correlated
44 AluYm1 1 * 19.6 Weakly correlated
45 HAL1 1 n.s 99.0 Highly correlated
46 HERVK13-int 1 *** 19.6 Weakly correlated
47 L1HS 1 n.s 8.6 Weakly correlated
48 L1M1 1 n.s 74.0 Weakly correlated
49 L1PA10 1 n.s 74.0 Weakly correlated
50 L1M4a2 1 * 99.0 Highly correlated
51 L1MA8 1 n.s 87.0 Weakly correlated
52 L1MB3 1 n.s 99.0 Highly correlated
53 L1MB4 1 n.s 99.0 Highly correlated
54 L1MC3 1 n.s 99.0 Highly correlated
55 L1MC4 1 n.s 99.0 Highly correlated
56 L1MC5 1 n.s 99.0 Highly correlated
57 L1MD 1 n.s 99.0 Highly correlated
58 L1ME3A 1 n.s 99.0 Highly correlated
59 L1ME4a 1 n.s 99.0 Highly correlated
60 L1MEd 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MD1 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP