ZRdb KZFP & Repeats
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Human_ZNF527

  • Protein
    Zinc finger protein 527
  • Length
    609
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8NB42
  • NCBI_ID
    84503
Sequence:
MAVGLCKAMSQGLVTFRDVALDFSQEEWEWLKPSQKDLYRDVMLENYRNLVWLGLSISKPNMISLLEQGKEPWMVERKMSQGHCADWESWCEIEELSPKWFIDEDEISQEMVMERLASHGLECSSFREAWKYKGEFELHQGNAERHFMQVTAVKEISTGKRDNEFSNSGRSIPLKSVFLTQQKVPTIQQVHKFDIYDKLFPQNSVIIEYKRLHAEKESLIGNECEEFNQSTYLSKDIGIPPGEKPYESHDFSKLLSFHSLFTQHQTTHFGKLPHGYDECGDAFSCYSFFTQPQRIHSGEKPYACNDCGKAFSHDFFLSEHQRTHIGEKPYECKECNKAFRQSAHLAQHQRIHTGEKPFACNECGKAFSRYAFLVEHQRIHTGEKPYECKECNKAFRQSAHLNQHQRIHTGEKPYECNQCGKAFSRRIALTLHQRIHTGEKPFKCSECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFRTDSQLNRHHRIHTGERPFECSKCGKAFSDALVLIHHKRSHAGEKPYECNKCGKAFSCGSYLNQHQRIHTGEKPYECSECGKAFHQILSLRLHQRIHAGEKPYKCNECGNNFSCVSALRRHQRIHNRETL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..123
2 dec2h2 274..296
3 C2h2 302..324
4 C2h2 330..352
5 C2h2 358..380
6 C2h2 386..408
7 C2h2 414..436
8 C2h2 442..464
9 C2h2 470..492
10 C2h2 498..520
11 C2h2 526..548
12 C2h2 554..576
13 C2h2 582..604
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1K 7 **** 99.0 Highly correlated
2 MLT1N2 5 **** 99.0 Highly correlated
3 LTR10A 3 **** 28.9 Weakly correlated
4 MIR 3 n.s 99.0 Highly correlated
5 MIRb 3 n.s 99.0 Highly correlated
6 THE1D 2 * 43.0 Weakly correlated
7 L1PA5 2 n.s 19.6 Weakly correlated
8 LTR10F 2 **** 28.9 Weakly correlated
9 L1PA17 2 ** 74.0 Weakly correlated
10 L1P3 2 ** 74.0 Weakly correlated
11 MIRc 2 n.s 99.0 Highly correlated
12 AluSx3 2 n.s 74.0 Weakly correlated
13 AluSx1 2 n.s 74.0 Weakly correlated
14 AluSp 2 n.s 74.0 Weakly correlated
15 AluSc8 2 * 74.0 Weakly correlated
16 MLT1F 1 * 99.0 Highly correlated
17 MIR3 1 n.s 99.0 Highly correlated
18 MER50-int 1 ** 43.0 Weakly correlated
19 MER39B 1 ** 74.0 Weakly correlated
20 LTR13 1 ** 19.6 Weakly correlated
21 MLT1J 1 n.s 99.0 Highly correlated
22 LTR12E 1 *** 19.6 Weakly correlated
23 THE1B 1 n.s 43.0 Weakly correlated
24 L1PA2 1 n.s 15.2 Weakly correlated
25 L3 1 n.s 99.0 Highly correlated
26 AluY 1 n.s 74.0 Weakly correlated
27 AluSc 1 n.s 74.0 Weakly correlated
28 AluSg 1 n.s 74.0 Weakly correlated
29 AluSg7 1 * 74.0 Weakly correlated
30 AluSq2 1 n.s 74.0 Weakly correlated
31 AluSx 1 n.s 74.0 Weakly correlated
32 AluSx4 1 n.s 74.0 Weakly correlated
33 AluSz 1 n.s 74.0 Weakly correlated
34 AluSz6 1 n.s 74.0 Weakly correlated
35 L2b 1 n.s 99.0 Highly correlated
36 HAL1 1 n.s 99.0 Highly correlated
37 L1ME4a 1 n.s 99.0 Highly correlated
38 L1ME4b 1 n.s 99.0 Highly correlated
39 L1P1 1 n.s 19.6 Weakly correlated
40 L1P4 1 * 74.0 Weakly correlated
41 AluJb 1 n.s 74.0 Weakly correlated
42 L2a 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 2 ** 74.0 Weakly correlated
2 L2a 1 n.s 99.0 Highly correlated
3 MLT1N2 1 ** 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP