ZRdb KZFP & Repeats
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Human_ZNF525

  • Protein
    Zinc finger protein 525
  • Length
    479
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q8N782
  • NCBI_ID
    170958
Sequence:
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLGISSKCTMKEFSSTAQGNTEVIHTGTLQRHERHHIGDFSFQEIEKDIHNFEFQWQEDERNGHEAPMTKIKKLMGSTEQYDHRHAGNKPIKYQLGSSFHSHLSELHIFQPKGKINNQVEKSINDASSVSTAQRISCRPKTHISNNYGDNFLNYSLLTQRQEVRMREKSFQCIESGKAFNYSSLLRKHQIIHLGEKQYKCDVCDKVFIRKRYLARHRRCHTGEKPYKCNECGKSFSQMSSLTYHHRLHTGEKPYKCEECDKAFRHNSALQRHRRIHTGEKPHKCNECGKTFSQKSYLACHRSIHTGKKPYECEECDKAFSFKSNLESHRITHTGEKPYKCNDCGKTFSHMSTLTCHRRLHTGEKPYKCEECDEAFRFKSSLERHRRIHNGEKLYKCNECGKTFSQELSLTCHCRLHSGEKPCKCGECDKAYSFK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..81
2 dec2h2 215..237
3 C2h2 243..265
4 C2h2 271..293
5 C2h2 299..321
6 C2h2 327..349
7 C2h2 355..377
8 C2h2 383..405
9 C2h2 411..433
10 C2h2 439..461
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 442 **** 19.6 Highly correlated
2 MER11B 170 **** 19.6 Highly correlated
3 MIR 5 n.s 99.0 Weakly correlated
4 AluY 4 n.s 74.0 Weakly correlated
5 L2a 3 n.s 99.0 Weakly correlated
6 L2c 3 n.s 99.0 Weakly correlated
7 LTR10A 3 **** 28.9 Moderately correlated
8 MER11A 3 *** 28.9 Moderately correlated
9 L1ME3A 3 n.s 99.0 Weakly correlated
10 MIRb 3 n.s 99.0 Weakly correlated
11 L1MA9 2 n.s 99.0 Weakly correlated
12 L1MCa 2 n.s 99.0 Weakly correlated
13 AluJb 2 n.s 74.0 Weakly correlated
14 L1PA5 2 n.s 19.6 Highly correlated
15 MER39B 1 ** 74.0 Weakly correlated
16 MIRc 1 n.s 99.0 Weakly correlated
17 MLT1A1 1 n.s 87.0 Weakly correlated
18 LTR13 1 ** 19.6 Highly correlated
19 MLT1J 1 n.s 99.0 Weakly correlated
20 L4_A_Mam 1 n.s 99.0 Weakly correlated
21 X6B_LINE 1 *** 99.0 Weakly correlated
22 L1PA2 1 n.s 15.2 Weakly correlated
23 L1PA3 1 n.s 19.6 Highly correlated
24 L1P4 1 n.s 74.0 Weakly correlated
25 L1P1 1 n.s 19.6 Highly correlated
26 L1ME4a 1 n.s 99.0 Weakly correlated
27 L1ME3E 1 n.s 99.0 Weakly correlated
28 L1ME3Cz 1 n.s 99.0 Weakly correlated
29 L1MCb 1 n.s 99.0 Weakly correlated
30 L1MA8 1 n.s 87.0 Weakly correlated
31 AluYm1 1 n.s 19.6 Highly correlated
32 AluYh9 1 **** 15.2 Weakly correlated
33 AluYa5 1 n.s 15.2 Weakly correlated
34 AluSz 1 n.s 74.0 Weakly correlated
35 AluSp 1 n.s 74.0 Weakly correlated
36 AluSc8 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 426 **** 19.6 Highly correlated
2 MER11B 166 **** 19.6 Highly correlated
3 MER11A 3 *** 28.9 Moderately correlated
4 MIR 2 n.s 99.0 Weakly correlated
5 MIRb 1 n.s 99.0 Weakly correlated
6 L4_A_Mam 1 n.s 99.0 Weakly correlated
7 L1MCa 1 n.s 99.0 Weakly correlated
8 L1ME3A 1 n.s 99.0 Weakly correlated
9 L1ME3Cz 1 n.s 99.0 Weakly correlated
10 L1ME4a 1 n.s 99.0 Weakly correlated
11 L2a 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP