ZRdb KZFP & Repeats
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Human_ZNF514

  • Protein
    Zinc finger protein 514
  • Length
    400
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q96K75
  • NCBI_ID
    84874
Sequence:
MTFEDVAVEFSQWEWGQLNPAQKDLYREVMLENFRNLAILGLLVSKPYVICQLEEGGEPFMVEREISTGAHSDWKRRSKSKESMPSWGISKEELFQVVSVEKHIQDVLQFSKLKAACGCDGQLEMQQIKQERHLKQMSTIHKSATTLSRDYKWNGFGRSLGLRSVLVNQHSILMGEGSYKCDTEFRQTLGGNNSQRTHPEKKSCKCNECGKSFHFQSELRRHQRCHTGEKPYECSDCGRAFGHISSLIKHQRTHTGEKPYECSECGRAFSQSSSLVLHYRFHTGEKPYKCNECGRAFGHTSSLIKHQRTHTGEKPYECRECGRTFSQSSSLIVHYRFHTGEKPYKCNKCGRAFSQSSSLTQHYRFHTGEKPYKCNECGRAFAHTASLIKHQRSHAGKKTL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 1..72
2 C2h2 204..226
3 C2h2 232..254
4 C2h2 260..282
5 C2h2 288..310
6 C2h2 316..338
7 C2h2 344..366
8 C2h2 372..394
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 18 n.s 74.0 Weakly correlated
2 AluJb 14 n.s 74.0 Weakly correlated
3 AluYj4 12 **** 0.0 Weakly correlated
4 LTR8 12 **** 43.0 Weakly correlated
5 L1P3 11 **** 74.0 Weakly correlated
6 AluSc8 10 ** 74.0 Weakly correlated
7 LTR40a 10 **** 99.0 Moderately correlated
8 AluSp 8 n.s 74.0 Weakly correlated
9 AluYb8 7 **** 15.2 Weakly correlated
10 AluYm1 6 **** 19.6 Weakly correlated
11 FRAM 6 **** 74.0 Weakly correlated
12 MER21B 5 **** 99.0 Moderately correlated
13 AluSx1 4 n.s 74.0 Weakly correlated
14 LTR40A1 4 **** 99.0 Moderately correlated
15 LTR10A 4 **** 28.9 Weakly correlated
16 ERV3-16A3_I-int 3 n.s 99.0 Moderately correlated
17 AluJo 3 n.s 74.0 Weakly correlated
18 LTR10F 3 **** 28.9 Weakly correlated
19 AluJr 3 n.s 74.0 Weakly correlated
20 LTR10B1 2 **** 28.9 Weakly correlated
21 L2c 2 n.s 99.0 Moderately correlated
22 L1PA5 2 n.s 19.6 Weakly correlated
23 LTR13 2 ** 19.6 Weakly correlated
24 L1PA4 2 n.s 19.6 Weakly correlated
25 LTR40b 2 *** 99.0 Moderately correlated
26 MLT1D 2 n.s 99.0 Moderately correlated
27 L1PA2 2 n.s 15.2 Weakly correlated
28 SVA_F 2 * 0.0 Weakly correlated
29 AluSc 2 n.s 74.0 Weakly correlated
30 AluYa5 2 * 15.2 Weakly correlated
31 L1M3 2 n.s 99.0 Moderately correlated
32 AluYc 2 * 74.0 Weakly correlated
33 AluSz 2 n.s 74.0 Weakly correlated
34 AluYh9 2 **** 15.2 Weakly correlated
35 L1HS 2 n.s 8.6 Weakly correlated
36 AluSx4 2 n.s 74.0 Weakly correlated
37 AluSx3 2 n.s 74.0 Weakly correlated
38 LTR1A2 1 * 43.0 Weakly correlated
39 LTR12 1 * 28.9 Weakly correlated
40 LTR28 1 ** 43.0 Weakly correlated
41 AluSx 1 n.s 74.0 Weakly correlated
42 AluSg7 1 n.s 74.0 Weakly correlated
43 MER21C 1 n.s 99.0 Moderately correlated
44 MER52A 1 n.s 74.0 Weakly correlated
45 MIR3 1 n.s 99.0 Moderately correlated
46 MIRb 1 n.s 99.0 Moderately correlated
47 MIRc 1 n.s 99.0 Moderately correlated
48 AluSg 1 n.s 74.0 Weakly correlated
49 MLT1L 1 n.s 99.0 Moderately correlated
50 MSTD 1 n.s 74.0 Weakly correlated
51 SVA_C 1 * 15.2 Weakly correlated
52 SVA_D 1 n.s 15.2 Weakly correlated
53 L1PA10 1 n.s 74.0 Weakly correlated
54 L1M4 1 n.s 99.0 Moderately correlated
55 L1MA8 1 n.s 87.0 Weakly correlated
56 L1MA9 1 n.s 99.0 Moderately correlated
57 L1MB8 1 n.s 99.0 Moderately correlated
58 L1MC4 1 n.s 99.0 Moderately correlated
59 L1MDa 1 n.s 99.0 Moderately correlated
60 L1MEg 1 n.s 99.0 Moderately correlated
61 L1P1 1 n.s 19.6 Weakly correlated
62 L1P4 1 n.s 74.0 Weakly correlated
63 LTR19-int 1 ** 43.0 Weakly correlated
64 HERV17-int 1 n.s 28.9 Weakly correlated
65 AluYk4 1 * 15.2 Weakly correlated
66 AluYi6 1 ** 15.2 Weakly correlated
67 L2a 1 n.s 99.0 Moderately correlated
68 L2b 1 n.s 99.0 Moderately correlated
69 AluYe6 1 *** 74.0 Weakly correlated
70 AluYa8 1 *** 15.2 Weakly correlated
71 LTR18A 1 *** 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 4 **** 0.0 Weakly correlated
2 AluJb 2 n.s 74.0 Weakly correlated
3 AluSc8 1 n.s 74.0 Weakly correlated
4 AluYh9 1 **** 15.2 Weakly correlated
5 L1MDa 1 n.s 99.0 Moderately correlated
6 MER21B 1 n.s 99.0 Moderately correlated
7 AluJr 1 n.s 74.0 Weakly correlated
8 FRAM 1 n.s 74.0 Weakly correlated
9 AluSc 1 n.s 74.0 Weakly correlated
10 AluY 1 n.s 74.0 Weakly correlated
11 AluYa8 1 *** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP