ZRdb KZFP & Repeats
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Human_ZNF510

  • Protein
    Zinc finger protein 510
  • Length
    683
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9Y2H8
  • NCBI_ID
    22869
Sequence:
MSPHPEAITDCVTLNTVGQLAEGGYPLRFSTLFQEQQKMNISQASVSFKDVTIEFTQEEWQQMAPVQKNLYRDVMLENYSNLVSVGYCCFKPEVIFKLEQGEEPWFSEEEFSNQSHPKDYRGDDLIKQNKKIKDKHLEQAICINNKTLTTEEEKVLGKPFTLHVAAVASTKMSCKCNSWEVNLQSISEFIINNRNYSTKKIGCGNVCENSPFKINFEKTQTGEKFYEHNKNMKALNYNENLPKHPKFQTLEQAFECNKIGKAFNDKANCVKHNSSHTGETSSKDDEFRKNCDKKTLFDHRRTGTGKKHLHLNQCGKSFEKSTVEEYNKLNMGIKHYELNPSGNNFNRKAHLTDPQTAVIEENPLVSNDRTQTWVKSSEYHENKKSYQTSVHRVRRRSHSMMKPYKCNECGKSFCQKGHLIQHQRTHTGEKPFECSECGKTFSQKSHLSTHQRIHTAEKPYKCNECGKTFVQKSTLRGHQRIHTGEKPYECSECGKTFVQKSTLRDHHRIHTGEKSFQCNQCGKTFGQKSNLRIHQRTHTGEKTYQCNECEKSFWRKDHLIQHQKTHTGEKPFKCNECGKTFARTSTLRVHQRIHTGEKPFKCNECGKKFVRKAILSDHQRIHTGEKPFQCNKCGKTFGQKSNLRIHQRTHSGEKSYECNEYGKLCKKSTLSLYQKIQGEGNPY
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 46..117
2 dec2h2 254..276
3 C2h2 404..426
4 C2h2 432..454
5 C2h2 460..482
6 C2h2 488..510
7 C2h2 516..538
8 C2h2 544..566
9 C2h2 572..594
10 C2h2 600..622
11 C2h2 628..650
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR37A 72 **** 99.0 Highly correlated
2 L2a 32 n.s 99.0 Highly correlated
3 AluJb 25 n.s 74.0 Weakly correlated
4 L2c 25 n.s 99.0 Highly correlated
5 MIRb 21 n.s 99.0 Highly correlated
6 LTR37B 18 **** 99.0 Highly correlated
7 MSTA 17 ** 43.0 Weakly correlated
8 AluSx1 16 n.s 74.0 Weakly correlated
9 MSTA-int 14 **** 43.0 Weakly correlated
10 L2b 13 n.s 99.0 Highly correlated
11 MIRc 13 n.s 99.0 Highly correlated
12 AluSx 12 n.s 74.0 Weakly correlated
13 L1P3 11 *** 74.0 Weakly correlated
14 THE1B 11 n.s 43.0 Weakly correlated
15 AluSc8 10 n.s 74.0 Weakly correlated
16 HAL1 10 n.s 99.0 Highly correlated
17 L2 10 n.s 99.0 Highly correlated
18 SVA_F 10 **** 0.0 Weakly correlated
19 AluSz 9 n.s 74.0 Weakly correlated
20 LTR8A 9 **** 43.0 Weakly correlated
21 AluYj4 8 **** 0.0 Weakly correlated
22 MER52A 8 *** 74.0 Weakly correlated
23 L1M4 7 n.s 99.0 Highly correlated
24 MLT1A0 7 n.s 99.0 Highly correlated
25 MLT1J 7 n.s 99.0 Highly correlated
26 THE1D 7 n.s 43.0 Weakly correlated
27 AluSz6 6 n.s 74.0 Weakly correlated
28 L1ME1 6 n.s 99.0 Highly correlated
29 L3 6 n.s 99.0 Highly correlated
30 LTR13 6 **** 19.6 Weakly correlated
31 MIR 6 n.s 99.0 Highly correlated
32 MIR3 6 n.s 99.0 Highly correlated
33 SVA_D 6 * 15.2 Weakly correlated
34 AluJo 5 n.s 74.0 Weakly correlated
35 AluSp 5 n.s 74.0 Weakly correlated
36 AluY 5 n.s 74.0 Weakly correlated
37 MER21B 5 ** 99.0 Highly correlated
38 MLT1A 5 n.s 99.0 Highly correlated
39 MLT1A1 5 n.s 87.0 Weakly correlated
40 AluJr 4 n.s 74.0 Weakly correlated
41 ERVL-E-int 4 n.s 99.0 Highly correlated
42 L1MA2 4 n.s 74.0 Weakly correlated
43 L1MB8 4 n.s 99.0 Highly correlated
44 L1MD3 4 n.s 99.0 Highly correlated
45 L1MDa 4 n.s 99.0 Highly correlated
46 L1MEc 4 n.s 99.0 Highly correlated
47 L1MEg 4 n.s 99.0 Highly correlated
48 L1PB1 4 n.s 74.0 Weakly correlated
49 LTR10A 4 **** 28.9 Weakly correlated
50 LTR8B 4 ** 43.0 Weakly correlated
51 MER61-int 4 * 43.0 Weakly correlated
52 MamRTE1 4 * 99.0 Highly correlated
53 HERVKC4-int 3 **** 28.9 Weakly correlated
54 L1M4c 3 n.s 99.0 Highly correlated
55 L1M6 3 n.s 99.0 Highly correlated
56 L1MA3 3 n.s 74.0 Weakly correlated
57 L1MA4 3 n.s 87.0 Weakly correlated
58 L1MA8 3 n.s 87.0 Weakly correlated
59 L1MA9 3 n.s 99.0 Highly correlated
60 L1MC3 3 n.s 99.0 Highly correlated
61 L1MC4a 3 n.s 99.0 Highly correlated
62 L1MEf 3 n.s 99.0 Highly correlated
63 L2-1_AMi 3 **** 319.0 Weakly correlated
64 LTR10F 3 *** 28.9 Weakly correlated
65 LTR37-int 3 ** 99.0 Highly correlated
66 LTR50 3 * 99.0 Highly correlated
67 MER61A 3 *** 43.0 Weakly correlated
68 MER61C 3 **** 43.0 Weakly correlated
69 MER65D 3 **** 87.0 Weakly correlated
70 MLT1G1 3 n.s 99.0 Highly correlated
71 THE1B-int 3 n.s 43.0 Weakly correlated
72 THE1D-int 3 n.s 28.9 Weakly correlated
73 X7B_LINE 3 **** 319.0 Weakly correlated
74 AluSc 2 n.s 74.0 Weakly correlated
75 AluSg 2 n.s 74.0 Weakly correlated
76 AluSx4 2 n.s 74.0 Weakly correlated
77 AluYa8 2 **** 15.2 Weakly correlated
78 AluYm1 2 n.s 19.6 Weakly correlated
79 AmnSINE1 2 ** 319.0 Weakly correlated
80 ERV3-16A3_I-int 2 n.s 99.0 Highly correlated
81 ERVL-int 2 * 99.0 Highly correlated
82 FLAM_C 2 n.s 74.0 Weakly correlated
83 FRAM 2 n.s 74.0 Weakly correlated
84 L1HS 2 n.s 8.6 Weakly correlated
85 L1M1 2 n.s 74.0 Weakly correlated
86 L1M3 2 n.s 99.0 Highly correlated
87 L1M5 2 n.s 99.0 Highly correlated
88 L1MA5 2 n.s 87.0 Weakly correlated
89 L1MA7 2 n.s 87.0 Weakly correlated
90 L1MB5 2 n.s 99.0 Highly correlated
91 L1MC2 2 n.s 99.0 Highly correlated
92 L1MC4 2 n.s 99.0 Highly correlated
93 L1MC5a 2 n.s 99.0 Highly correlated
94 L1MCb 2 n.s 99.0 Highly correlated
95 L1ME3 2 n.s 99.0 Highly correlated
96 L1ME3A 2 n.s 99.0 Highly correlated
97 L1ME4a 2 n.s 99.0 Highly correlated
98 L1MEd 2 n.s 99.0 Highly correlated
99 L1MEi 2 n.s 99.0 Highly correlated
100 L1P4 2 n.s 74.0 Weakly correlated
101 L1P4a 2 n.s 74.0 Weakly correlated
102 L1PA14 2 n.s 74.0 Weakly correlated
103 L1PA15 2 n.s 74.0 Weakly correlated
104 L1PA16 2 n.s 74.0 Weakly correlated
105 L1PA2 2 n.s 15.2 Weakly correlated
106 L1PA3 2 n.s 19.6 Weakly correlated
107 L1PA5 2 n.s 19.6 Weakly correlated
108 L1PA7 2 n.s 74.0 Weakly correlated
109 L1PBa1 2 n.s 74.0 Weakly correlated
110 L1PREC2 2 n.s 43.0 Weakly correlated
111 LTR12C 2 n.s 19.6 Weakly correlated
112 LTR14 2 **** 28.9 Weakly correlated
113 LTR16 2 n.s 99.0 Highly correlated
114 LTR16B1 2 * 99.0 Highly correlated
115 LTR23 2 ** 74.0 Weakly correlated
116 LTR28C 2 ** 43.0 Weakly correlated
117 LTR33 2 n.s 99.0 Highly correlated
118 LTR36 2 ** 74.0 Weakly correlated
119 LTR41 2 * 99.0 Highly correlated
120 LTR41C 2 ** 99.0 Highly correlated
121 LTR55 2 ** 99.0 Highly correlated
122 LTR78 2 n.s 99.0 Highly correlated
123 MER101-int 2 * 74.0 Weakly correlated
124 MER31B 2 * 99.0 Highly correlated
125 MER4-int 2 n.s 74.0 Weakly correlated
126 MER61E 2 *** 43.0 Weakly correlated
127 MLT1B 2 n.s 99.0 Highly correlated
128 MLT1E2 2 n.s 99.0 Highly correlated
129 MLT1E3 2 n.s 99.0 Highly correlated
130 MLT1L 2 n.s 99.0 Highly correlated
131 MLT1M 2 * 99.0 Highly correlated
132 MSTD 2 n.s 74.0 Weakly correlated
133 MamRep605 2 n.s 99.0 Highly correlated
134 SVA_E 2 ** 0.0 Weakly correlated
135 AluSc5 1 n.s 74.0 Weakly correlated
136 AluSg7 1 n.s 74.0 Weakly correlated
137 AluSq2 1 n.s 74.0 Weakly correlated
138 AluSx3 1 n.s 74.0 Weakly correlated
139 AluYb8 1 n.s 15.2 Weakly correlated
140 AluYh9 1 *** 15.2 Weakly correlated
141 AluYk2 1 * 19.6 Weakly correlated
142 ERVL-B4-int 1 n.s 99.0 Highly correlated
143 HAL1b 1 n.s 99.0 Highly correlated
144 HERV16-int 1 n.s 99.0 Highly correlated
145 HERV17-int 1 n.s 28.9 Weakly correlated
146 HERVE-int 1 n.s 19.6 Weakly correlated
147 HERVH48-int 1 * 28.9 Weakly correlated
148 HERVK9-int 1 n.s 28.9 Weakly correlated
149 HERVS71-int 1 n.s 28.9 Weakly correlated
150 L1M4a1 1 n.s 99.0 Highly correlated
151 L1M4b 1 n.s 99.0 Highly correlated
152 L1M7 1 n.s 99.0 Highly correlated
153 L1M8 1 n.s 99.0 Highly correlated
154 L1MB1 1 n.s 99.0 Highly correlated
155 L1MB3 1 n.s 99.0 Highly correlated
156 L1MB7 1 n.s 99.0 Highly correlated
157 L1MC 1 n.s 99.0 Highly correlated
158 L1MC1 1 n.s 99.0 Highly correlated
159 L1MCa 1 n.s 99.0 Highly correlated
160 L1MD2 1 n.s 99.0 Highly correlated
161 L1MDb 1 n.s 99.0 Highly correlated
162 L1ME3B 1 n.s 99.0 Highly correlated
163 L1ME3Cz 1 n.s 99.0 Highly correlated
164 L1ME3E 1 n.s 99.0 Highly correlated
165 L1ME3G 1 n.s 99.0 Highly correlated
166 L1ME4b 1 n.s 99.0 Highly correlated
167 L1ME4c 1 n.s 99.0 Highly correlated
168 L1MEh 1 n.s 99.0 Highly correlated
169 L1P1 1 n.s 19.6 Weakly correlated
170 L1PA10 1 n.s 74.0 Weakly correlated
171 L1PA13 1 n.s 74.0 Weakly correlated
172 L1PA15-16 1 n.s 74.0 Weakly correlated
173 L1PA4 1 n.s 19.6 Weakly correlated
174 L1PA8 1 n.s 74.0 Weakly correlated
175 L1PA8A 1 n.s 74.0 Weakly correlated
176 L1PB2 1 n.s 74.0 Weakly correlated
177 L1PBa 1 n.s 74.0 Weakly correlated
178 L3b 1 n.s 99.0 Highly correlated
179 L4_A_Mam 1 n.s 99.0 Highly correlated
180 LFSINE_Vert 1 n.s 319.0 Weakly correlated
181 LTR105_Mam 1 * 99.0 Highly correlated
182 LTR10B1 1 ** 28.9 Weakly correlated
183 LTR10D 1 ** 28.9 Weakly correlated
184 LTR12E 1 * 19.6 Weakly correlated
185 LTR12F 1 * 28.9 Weakly correlated
186 LTR16B 1 * 99.0 Highly correlated
187 LTR16C 1 n.s 99.0 Highly correlated
188 LTR1D 1 * 43.0 Weakly correlated
189 LTR2 1 n.s 28.9 Weakly correlated
190 LTR2752 1 * 43.0 Weakly correlated
191 LTR27D 1 ** 43.0 Weakly correlated
192 LTR27E 1 * 43.0 Weakly correlated
193 LTR30 1 ** 28.9 Weakly correlated
194 LTR33B 1 n.s 99.0 Highly correlated
195 LTR4 1 ** 28.9 Weakly correlated
196 LTR40a 1 n.s 99.0 Highly correlated
197 LTR41B 1 * 99.0 Highly correlated
198 LTR49 1 n.s 74.0 Weakly correlated
199 LTR5_Hs 1 n.s 0.0 Weakly correlated
200 LTR71A 1 ** 43.0 Weakly correlated
201 LTR75 1 ** 99.0 Highly correlated
202 LTR76 1 ** 74.0 Weakly correlated
203 LTR79 1 n.s 99.0 Highly correlated
204 LTR85c 1 * 99.0 Highly correlated
205 LTR90A 1 ** 99.0 Highly correlated
206 LTR9A1 1 * 43.0 Weakly correlated
207 MER31A 1 n.s 87.0 Weakly correlated
208 MER34 1 n.s 87.0 Weakly correlated
209 MER34A1 1 * 99.0 Highly correlated
210 MER4C 1 * 74.0 Weakly correlated
211 MER50 1 n.s 43.0 Weakly correlated
212 MER51E 1 ** 43.0 Weakly correlated
213 MER52D 1 n.s 74.0 Weakly correlated
214 MER57E1 1 * 87.0 Weakly correlated
215 MER57E3 1 ** 74.0 Weakly correlated
216 MER66-int 1 n.s 43.0 Weakly correlated
217 MER72 1 n.s 43.0 Weakly correlated
218 MER83B-int 1 * 99.0 Highly correlated
219 MER89 1 n.s 99.0 Highly correlated
220 MER9a1 1 * 19.6 Weakly correlated
221 MIR1_Amn 1 n.s 319.0 Weakly correlated
222 MLT1A0-int 1 n.s 99.0 Highly correlated
223 MLT1D 1 n.s 99.0 Highly correlated
224 MLT1E 1 * 99.0 Highly correlated
225 MLT1F 1 n.s 99.0 Highly correlated
226 MLT1F2 1 n.s 99.0 Highly correlated
227 MLT1G3 1 n.s 99.0 Highly correlated
228 MLT1H1 1 n.s 99.0 Highly correlated
229 MLT1J-int 1 n.s 99.0 Highly correlated
230 MLT1J1 1 n.s 99.0 Highly correlated
231 MLT1J2 1 n.s 99.0 Highly correlated
232 MLT1N2 1 n.s 99.0 Highly correlated
233 MLT2A2 1 n.s 74.0 Weakly correlated
234 MLT2B3 1 n.s 99.0 Highly correlated
235 MLT2B4 1 n.s 99.0 Highly correlated
236 MLT2D 1 n.s 99.0 Highly correlated
237 MSTB 1 n.s 43.0 Weakly correlated
238 MSTB1 1 n.s 74.0 Weakly correlated
239 MSTB2 1 n.s 74.0 Weakly correlated
240 MSTC 1 n.s 74.0 Weakly correlated
241 MamGypLTR2c 1 * 99.0 Highly correlated
242 MamGypLTR3a 1 n.s 99.0 Highly correlated
243 MamSINE1 1 n.s 99.0 Highly correlated
244 Plat_L3 1 n.s 99.0 Highly correlated
245 SVA_A 1 n.s 19.6 Weakly correlated
246 THE1C 1 n.s 43.0 Weakly correlated
247 THE1C-int 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR37A 9 **** 99.0 Highly correlated
2 MER101-int 2 * 74.0 Weakly correlated
3 L2c 2 n.s 99.0 Highly correlated
4 LTR37B 2 * 99.0 Highly correlated
5 LTR16 1 n.s 99.0 Highly correlated
6 MIR 1 n.s 99.0 Highly correlated
7 MER66-int 1 n.s 43.0 Weakly correlated
8 MIRb 1 n.s 99.0 Highly correlated
9 LTR76 1 ** 74.0 Weakly correlated
10 MSTD 1 n.s 74.0 Weakly correlated
11 MSTA 1 n.s 43.0 Weakly correlated
12 LTR36 1 * 74.0 Weakly correlated
13 L1M8 1 n.s 99.0 Highly correlated
14 MLT1J 1 n.s 99.0 Highly correlated
15 MLT1F2 1 n.s 99.0 Highly correlated
16 MIRc 1 n.s 99.0 Highly correlated
17 L1MA8 1 n.s 87.0 Weakly correlated
18 L1M4c 1 n.s 99.0 Highly correlated
19 HAL1 1 n.s 99.0 Highly correlated
20 MER61C 1 ** 43.0 Weakly correlated
21 MER4-int 1 n.s 74.0 Weakly correlated
22 LTR8B 1 n.s 43.0 Weakly correlated
23 L1PA13 1 n.s 74.0 Weakly correlated
24 L1MEg 1 n.s 99.0 Highly correlated
25 MLT1N2 1 n.s 99.0 Highly correlated
26 L1MB8 1 n.s 99.0 Highly correlated
27 LTR2752 1 * 43.0 Weakly correlated
28 L3 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP