ZRdb KZFP & Repeats
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Human_ZNF500

  • Protein
    Zinc finger protein 500
  • Length
    480
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    160.0 Mya
  • Time of Changing in binding specificity
    160.0 Mya
  • Uniprot_ID
    O60304
  • NCBI_ID
    26048
Sequence:
MATVPGLQPLPTLEQDLEQEEILIVKVEEDFCLEEEPSVETEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQRKPRKHRQRGSELLSDDEVPLGIGGQFLKHQAEAQPEDLSLEEEARFSSQQPPAQLSHRPQRGPLLWPERGPPAPRHQEMASASPFLSAWSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPLENEGPGIQLEDGGDGREDAPLRMEWYRVLSARCQGPGHPLPGQRPAPVRGLVRPDQPRGGPPPGRRASHGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRRGTDLHKHQRTHMGAGSLPTLQPVAPGGPGAKA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 50..134
2 KRAB 224..260
3 C2h2 325..347
4 C2h2 353..375
5 C2h2 381..403
6 C2h2 409..431
7 C2h2 437..459
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytosol
2 Cellular Component nucleoplasm
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 29 **** 0.0 Weakly correlated
2 SVA_D 15 **** 15.2 Weakly correlated
3 L1P3 11 **** 74.0 Weakly correlated
4 AluJb 10 n.s 74.0 Weakly correlated
5 SVA_E 9 **** 0.0 Weakly correlated
6 AluSc8 8 * 74.0 Weakly correlated
7 LTR8 8 **** 43.0 Weakly correlated
8 AluYj4 6 **** 0.0 Weakly correlated
9 AluJr 5 n.s 74.0 Weakly correlated
10 L1MC1 4 n.s 99.0 Weakly correlated
11 LTR10A 4 **** 28.9 Weakly correlated
12 LTR12C 4 n.s 19.6 Weakly correlated
13 MER21B 4 *** 99.0 Weakly correlated
14 AluSx1 4 n.s 74.0 Weakly correlated
15 AluY 3 n.s 74.0 Weakly correlated
16 MER52A 3 * 74.0 Weakly correlated
17 LTR10F 3 **** 28.9 Weakly correlated
18 AluSp 3 n.s 74.0 Weakly correlated
19 MIRc 2 n.s 99.0 Weakly correlated
20 SVA_C 2 ** 15.2 Weakly correlated
21 L2c 2 n.s 99.0 Weakly correlated
22 L1PA14 2 n.s 74.0 Weakly correlated
23 L1P4 2 n.s 74.0 Weakly correlated
24 L1PA2 2 n.s 15.2 Weakly correlated
25 L1MB3 2 n.s 99.0 Weakly correlated
26 AluJo 2 n.s 74.0 Weakly correlated
27 AluYa8 2 **** 15.2 Weakly correlated
28 FRAM 2 * 74.0 Weakly correlated
29 L1M3 2 n.s 99.0 Weakly correlated
30 L1MB8 2 n.s 99.0 Weakly correlated
31 L1MA9 2 n.s 99.0 Weakly correlated
32 L1MC4 1 n.s 99.0 Weakly correlated
33 AluYh9 1 **** 15.2 Weakly correlated
34 MER41D 1 ** 74.0 Weakly correlated
35 MER50 1 n.s 43.0 Weakly correlated
36 AluSz6 1 n.s 74.0 Weakly correlated
37 MER52D 1 n.s 74.0 Weakly correlated
38 MIRb 1 n.s 99.0 Weakly correlated
39 AluSz 1 n.s 74.0 Weakly correlated
40 MLT1E1A 1 n.s 99.0 Weakly correlated
41 MLT1E3 1 n.s 99.0 Weakly correlated
42 MLT1L 1 n.s 99.0 Weakly correlated
43 MSTA 1 n.s 43.0 Weakly correlated
44 SVA_B 1 * 15.2 Weakly correlated
45 AluSx4 1 n.s 74.0 Weakly correlated
46 AluSg7 1 n.s 74.0 Weakly correlated
47 AluSc 1 n.s 74.0 Weakly correlated
48 L1MA2 1 n.s 74.0 Weakly correlated
49 LTR28C 1 ** 43.0 Weakly correlated
50 LTR2752 1 ** 43.0 Weakly correlated
51 LTR13 1 * 19.6 Weakly correlated
52 LTR12D 1 * 19.6 Weakly correlated
53 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
54 L1ME1 1 n.s 99.0 Weakly correlated
55 LTR10B1 1 *** 28.9 Weakly correlated
56 HAL1 1 n.s 99.0 Weakly correlated
57 L1HS 1 n.s 8.6 Weakly correlated
58 L2a 1 n.s 99.0 Weakly correlated
59 L2 1 n.s 99.0 Weakly correlated
60 L1PA8 1 n.s 74.0 Weakly correlated
61 L1PA5 1 n.s 19.6 Weakly correlated
62 L1PA3 1 n.s 19.6 Weakly correlated
63 L1M4 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 5 ** 74.0 Weakly correlated
2 L1M3 2 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP