ZRdb KZFP & Repeats
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Human_ZNF496

  • Protein
    Zinc finger protein 496
  • Length
    587
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    160.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96IT1
  • NCBI_ID
    84838
Sequence:
MPTALCPRVLAPKESEEPRKMRSPPGENPSPQGELPSPESSRRLFRRFRYQEAAGPREALQRLWDLCGGWLRPERHTKEQILELLVLEQFLAILPREIQSWVRAQEPESGEQAVAAVEALEREPGRPWQWLKHCEDPVVIDDGDSPLDQEQEQLPVEPHSDLAKNQDAQPITLAQCLGLPSRPPSQLSGDPVLQDAFLLQEENVRDTQQVTTLQLPPSRVSPFKDMILCFSEEDWSLLDPAQTGFYGEFIIGEDYGVSMPPNDLAAQPDLSQGEENEPRVPELQDLQGKEVPQVSYLDSPSLQPFQVEERRKREELQVPEFQACPQTVVPQNTYPAGGNPRSLENSLDEEVTIEIVLSSSGDEDSQHGPYCTEELGSPTEKQRSLPASHRSSTEAGGEVQTSKKSYVCPNCGKIFRWRVNFIRHLRSRREQEKPHECSVCGELFSDSEDLDGHLESHEAQKPYRCGACGKSFRLNSHLLSHRRIHLQPDRLQPVEKREQAASEDADKGPKEPLENGKAKLSFQCCECGKAFQRHDHLARHRSHFHLKDKARPFQCRYCVKSFTQNYDLLRHERLHMKRRSKQALNSY
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 42..124
2 KRAB 221..291
3 dec2h2 406..428
4 C2h2 435..457
5 C2h2 463..485
6 C2h2 522..545
7 C2h2 553..575
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process positive regulation of DNA-templated transcription
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 6 * 74.0 Weakly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 L1P3 3 *** 74.0 Weakly correlated
4 L1PA5 2 n.s 19.6 Weakly correlated
5 L1PA2 2 n.s 15.2 Weakly correlated
6 L1MC2 1 * 99.0 Highly correlated
7 THE1C-int 1 * 43.0 Weakly correlated
8 LTR16A 1 ** 99.0 Highly correlated
9 LTR13 1 *** 19.6 Weakly correlated
10 LTR1 1 *** 43.0 Weakly correlated
11 L1P4 1 * 74.0 Weakly correlated
12 L1P1 1 * 19.6 Weakly correlated
13 L1MA9 1 n.s 99.0 Highly correlated
14 HAL1 1 n.s 99.0 Highly correlated
15 FRAM 1 ** 74.0 Weakly correlated
16 AluYm1 1 ** 19.6 Weakly correlated
17 AluYa5 1 ** 15.2 Weakly correlated
18 AluSx1 1 n.s 74.0 Weakly correlated
19 AluSq 1 n.s 74.0 Weakly correlated
20 AluSg 1 n.s 74.0 Weakly correlated
21 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA9 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP