ZRdb KZFP & Repeats
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Human_ZNF487

  • Protein
    Putative zinc finger protein 487
  • Length
    448
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    B1APH4
  • NCBI_ID
    642819
Sequence:
MASRPRPRTPSRGPSDLRFRGEAGLRRVFLKKAGGSVSFSDVAVGFTQEEWQHLDSAQRTPYRDMMLENYSLLLSVGYCITKPEVVCKLEHGQVLWILEEESPSQSHLDCCIDDDLMEKRQENQDQHLQKVDFVNNKTLTMDRNGVLGKTFSLDTNPILSRKIRGNCDSSGMNLNNISELIISNRSSFVRNPAECNVRGKFLLCMKRENPYARGKPLEYDGNGKAVSQNEDLFRHQYIQTLKQCFEYNHRGYTEERNPMNALNVGKLLDIGHALQYIKEHTRDKTYECNECGKNFCEKSNLHVHQRTHTGEKPYGCNECQKAFGDRSALKVHQRIHTGEKPYELHQRTHTGEKPYACSECGKTFYQKSSLTTHQRTHTREQPYEYNESFYQNPNFTKCQRDNIEETLVNILKAQKPSPSWTRSIAETTQVGGSVSLKDVTVDFTQEEW
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 37..108
2 C2h2 286..308
3 C2h2 314..336
4 dec2h2 355..378
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component chromatin
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 14 **** 0.0 Weakly correlated
2 AluSp 7 n.s 74.0 Weakly correlated
3 L1MC4 7 ** 99.0 Weakly correlated
4 AluSc8 6 ** 74.0 Weakly correlated
5 L1P3 6 **** 74.0 Weakly correlated
6 AluYa8 5 **** 15.2 Weakly correlated
7 LTR10A 4 **** 28.9 Highly correlated
8 FRAM 4 **** 74.0 Weakly correlated
9 LTR10F 3 **** 28.9 Highly correlated
10 HERV17-int 3 *** 28.9 Highly correlated
11 AluY 3 n.s 74.0 Weakly correlated
12 HAL1 2 n.s 99.0 Weakly correlated
13 HERVIP10FH-int 2 *** 28.9 Highly correlated
14 AluYh9 2 **** 15.2 Weakly correlated
15 L2b 2 n.s 99.0 Weakly correlated
16 L1ME2z 2 * 99.0 Weakly correlated
17 L1MEg 2 n.s 99.0 Weakly correlated
18 L1PA14 2 n.s 74.0 Weakly correlated
19 MIR 1 n.s 99.0 Weakly correlated
20 LTR12D 1 ** 19.6 Weakly correlated
21 SVA_C 1 ** 15.2 Weakly correlated
22 LTR10B1 1 *** 28.9 Highly correlated
23 L2a 1 n.s 99.0 Weakly correlated
24 L1PA8A 1 n.s 74.0 Weakly correlated
25 L1PA5 1 n.s 19.6 Weakly correlated
26 L1P4 1 n.s 74.0 Weakly correlated
27 AluJo 1 n.s 74.0 Weakly correlated
28 L1P1 1 n.s 19.6 Weakly correlated
29 L1MEd 1 n.s 99.0 Weakly correlated
30 L1MD 1 n.s 99.0 Weakly correlated
31 AluSq 1 n.s 74.0 Weakly correlated
32 L1MB8 1 n.s 99.0 Weakly correlated
33 L1M4 1 n.s 99.0 Weakly correlated
34 L1M3 1 n.s 99.0 Weakly correlated
35 HUERS-P3b-int 1 ** 43.0 Moderately correlated
36 AluSq10 1 * 74.0 Weakly correlated
37 AluYi6 1 *** 15.2 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 7 **** 0.0 Weakly correlated
2 FRAM 2 ** 74.0 Weakly correlated
3 AluSc8 1 n.s 74.0 Weakly correlated
4 AluY 1 n.s 74.0 Weakly correlated
5 AluSq 1 n.s 74.0 Weakly correlated
6 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP