ZRdb KZFP & Repeats
...

Human_ZNF484

  • Protein
    Zinc finger protein 484
  • Length
    852
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5JVG2
  • NCBI_ID
    83744
Sequence:
MTKSLESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNLISVGCQVPKPEVIFSLEQEEPCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEININLFTRDDPYSILEELWKDDEHTRKCGENQNKPLSRVVFINKKTLANDSIFEYKDIGEIVHVNTHLVSSRKRPHNCNSCGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHTEVTACECNQCGKPLHHKQALIQQQKIHTRESLYLFSDYVNVFSPKSHAFAHESICAEEKQHECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYGRAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTGEKPYVCTECGKAFIRKSHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQSHTGERHYECSECGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNRHRRIHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKAFTIRSNLIKHQKIHTKQKPYKCSDLGKALNWKPQLSMPQKSDNGEVECSMPQLWCGDSEGDQGQLSSI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 8..78
2 dec2h2 223..245
3 dec2h2 279..301
4 dec2h2 328..350
5 dec2h2 356..378
6 C2h2 384..406
7 C2h2 412..434
8 C2h2 440..462
9 C2h2 468..490
10 C2h2 496..518
11 C2h2 524..546
12 C2h2 552..574
13 C2h2 580..602
14 C2h2 608..630
15 C2h2 636..658
16 C2h2 664..686
17 C2h2 692..714
18 C2h2 720..742
19 C2h2 748..770
20 C2h2 776..798
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC5 120 **** 99.0 Highly correlated
2 L1MC5a 86 **** 99.0 Highly correlated
3 AluJb 11 n.s 74.0 Weakly correlated
4 L2a 11 n.s 99.0 Highly correlated
5 L1MB5 11 **** 99.0 Highly correlated
6 AluSx1 9 n.s 74.0 Weakly correlated
7 L2c 7 n.s 99.0 Highly correlated
8 L1MB8 7 ** 99.0 Highly correlated
9 L1MB7 6 n.s 99.0 Highly correlated
10 LTR8 6 **** 43.0 Weakly correlated
11 L2 6 n.s 99.0 Highly correlated
12 AluY 6 n.s 74.0 Weakly correlated
13 L1PA5 5 n.s 19.6 Weakly correlated
14 MIRb 4 n.s 99.0 Highly correlated
15 LTR10A 4 **** 28.9 Weakly correlated
16 AluSz 4 n.s 74.0 Weakly correlated
17 HAL1M8 4 **** 99.0 Highly correlated
18 MLT1B 3 n.s 99.0 Highly correlated
19 L2b 3 n.s 99.0 Highly correlated
20 L1MB3 3 n.s 99.0 Highly correlated
21 L1PA2 3 n.s 15.2 Weakly correlated
22 L1MEd 3 n.s 99.0 Highly correlated
23 AluYj4 3 **** 0.0 Weakly correlated
24 L1P1 2 n.s 19.6 Weakly correlated
25 MIR 2 n.s 99.0 Highly correlated
26 MER50-int 2 *** 43.0 Weakly correlated
27 MIR3 2 n.s 99.0 Highly correlated
28 AluSp 2 n.s 74.0 Weakly correlated
29 AluSg7 2 * 74.0 Weakly correlated
30 MER50 2 ** 43.0 Weakly correlated
31 MLT1F2 2 * 99.0 Highly correlated
32 L1MB4 2 n.s 99.0 Highly correlated
33 AluJr4 2 n.s 74.0 Weakly correlated
34 L1M4 2 n.s 99.0 Highly correlated
35 AluJr 2 n.s 74.0 Weakly correlated
36 FLAM_A 2 * 74.0 Weakly correlated
37 MER39B 1 ** 74.0 Weakly correlated
38 LTR1A2 1 * 43.0 Weakly correlated
39 MSTD 1 n.s 74.0 Weakly correlated
40 MER39 1 * 74.0 Weakly correlated
41 MER21A 1 * 74.0 Weakly correlated
42 LTR78 1 n.s 99.0 Highly correlated
43 MER41B 1 * 74.0 Weakly correlated
44 MER51A 1 ** 43.0 Weakly correlated
45 MSTB2 1 * 74.0 Weakly correlated
46 MIRc 1 n.s 99.0 Highly correlated
47 MSTB1 1 n.s 74.0 Weakly correlated
48 MamGypLTR1a 1 ** 99.0 Highly correlated
49 MLT1A1 1 n.s 87.0 Weakly correlated
50 MLT1C 1 n.s 94.0 Weakly correlated
51 MLT1D 1 n.s 99.0 Highly correlated
52 MLT1F1 1 * 99.0 Highly correlated
53 MSTA 1 n.s 43.0 Weakly correlated
54 L1MC4 1 n.s 99.0 Highly correlated
55 AluJo 1 n.s 74.0 Weakly correlated
56 AluSc8 1 n.s 74.0 Weakly correlated
57 AluSq 1 n.s 74.0 Weakly correlated
58 AluSx 1 n.s 74.0 Weakly correlated
59 AluYa5 1 n.s 15.2 Weakly correlated
60 AluYh3 1 * 15.2 Weakly correlated
61 AluYh9 1 **** 15.2 Weakly correlated
62 AluYm1 1 n.s 19.6 Weakly correlated
63 HAL1 1 n.s 99.0 Highly correlated
64 L1MA8 1 n.s 87.0 Weakly correlated
65 L1MA9 1 n.s 99.0 Highly correlated
66 L1MC1 1 n.s 99.0 Highly correlated
67 LTR13 1 ** 19.6 Weakly correlated
68 L1ME1 1 n.s 99.0 Highly correlated
69 L1ME3A 1 n.s 99.0 Highly correlated
70 L1ME3G 1 n.s 99.0 Highly correlated
71 L1ME4b 1 n.s 99.0 Highly correlated
72 L1MEj 1 * 99.0 Highly correlated
73 L1PA4 1 n.s 19.6 Weakly correlated
74 L1PA7 1 n.s 74.0 Weakly correlated
75 L1PB1 1 n.s 74.0 Weakly correlated
76 L2-3_Crp 1 ** 431.0 Weakly correlated
77 LTR101_Mam 1 ** 99.0 Highly correlated
78 LTR10F 1 ** 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC5 116 **** 99.0 Highly correlated
2 L1MC5a 78 **** 99.0 Highly correlated
3 L2a 6 n.s 99.0 Highly correlated
4 HAL1M8 4 **** 99.0 Highly correlated
5 L1MB7 3 n.s 99.0 Highly correlated
6 L1MB5 3 * 99.0 Highly correlated
7 L2c 2 n.s 99.0 Highly correlated
8 L2b 2 n.s 99.0 Highly correlated
9 L1MB8 2 n.s 99.0 Highly correlated
10 L1MEd 1 n.s 99.0 Highly correlated
11 MLT1B 1 n.s 99.0 Highly correlated
12 MIR3 1 n.s 99.0 Highly correlated
13 MER51A 1 ** 43.0 Weakly correlated
14 L1PA2 1 n.s 15.2 Weakly correlated
15 L1MC4 1 n.s 99.0 Highly correlated
16 LTR1A2 1 * 43.0 Weakly correlated
17 L1PA7 1 n.s 74.0 Weakly correlated
18 MIRb 1 n.s 99.0 Highly correlated
19 MER41B 1 * 74.0 Weakly correlated
20 MIR 1 n.s 99.0 Highly correlated
21 L2 1 n.s 99.0 Highly correlated
22 L1PA5 1 n.s 19.6 Weakly correlated
23 L1ME1 1 n.s 99.0 Highly correlated
24 L1MB4 1 n.s 99.0 Highly correlated
25 MLT1C 1 n.s 94.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP