ZRdb KZFP & Repeats
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Human_ZNF480

  • Protein
    Zinc finger protein 480
  • Length
    535
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q8WV37
  • NCBI_ID
    147657
Sequence:
MLCDEKAQKRRKRKAKESGMALPQGHLTFRDVAIEFSQAEWKCLDPAQRALYKDVMLENYRNLVSLGISLPDLNINSMLEQRREPWSGESEVKIAKNSDGRECIKGVNTGSSYALGSNAEDKPIKKQLGVSFHLHLSELELFPDERVINGCNQVENFINHSSSVSCLQEMSSSVKTPIFNRNDFDDSSFLPQEQKVHLREKPYECNEHSKVFRVSSSLTKHQVIHTVEKPYKCNSCGKVFSRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFARHQRIHTREKPYECNECGKVFSNNSYLARHQRIHAEEKPYKCNECGKGFSHKSSLANHWRIYTGEKPYKCDECGKAFYRIALLVRHQKIHTGEKPYKCNECGKVFIQNSHLAQHWRIHTGEKPYKCNECGKVFNQLSNLARHRRIHTGEKPYKCNECGKAFSEYSGLSAHLVIHTGEKPYKCSECGKAFRHKLSLTNHQRIHTGERPYKCNECGKVFNRIAHLARHRKIHTGEKPYKCNECGKAFSRISYLAQHWTIHMG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 27..98
2 C2h2 203..225
3 C2h2 231..253
4 C2h2 259..281
5 C2h2 287..309
6 dec2h2 315..337
7 C2h2 343..365
8 C2h2 371..393
9 C2h2 399..421
10 C2h2 427..449
11 C2h2 455..477
12 C2h2 483..505
13 C2h2 511..533
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytosol
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8B 464 **** 43.0 Highly correlated
2 LTR8A 154 **** 43.0 Highly correlated
3 LTR8 92 **** 43.0 Highly correlated
4 L2a 20 n.s 99.0 Weakly correlated
5 MLT1K 15 **** 99.0 Weakly correlated
6 AluSz 14 n.s 74.0 Weakly correlated
7 L2c 14 n.s 99.0 Weakly correlated
8 L1MB2 12 **** 99.0 Weakly correlated
9 AluY 9 n.s 74.0 Weakly correlated
10 AluSg 7 n.s 74.0 Weakly correlated
11 L2 7 n.s 99.0 Weakly correlated
12 AluJb 6 n.s 74.0 Weakly correlated
13 AluJo 6 n.s 74.0 Weakly correlated
14 AluSq2 6 n.s 74.0 Weakly correlated
15 HERVH-int 6 * 28.9 Weakly correlated
16 AluSx1 5 n.s 74.0 Weakly correlated
17 L1PA5 5 n.s 19.6 Weakly correlated
18 L2b 5 n.s 99.0 Weakly correlated
19 AluSc8 4 n.s 74.0 Weakly correlated
20 AluSx 4 n.s 74.0 Weakly correlated
21 MIR3 4 n.s 99.0 Weakly correlated
22 MIRb 4 n.s 99.0 Weakly correlated
23 AluSq 3 n.s 74.0 Weakly correlated
24 AluSx4 3 n.s 74.0 Weakly correlated
25 AluSz6 3 n.s 74.0 Weakly correlated
26 L1MC5 3 n.s 99.0 Weakly correlated
27 L1ME3D 3 ** 99.0 Weakly correlated
28 L1P4 3 * 74.0 Weakly correlated
29 L1PA15 3 n.s 74.0 Weakly correlated
30 LTR10A 3 **** 28.9 Weakly correlated
31 LTR10F 3 **** 28.9 Weakly correlated
32 MIR 3 n.s 99.0 Weakly correlated
33 MLT1J 3 n.s 99.0 Weakly correlated
34 AluJr 2 n.s 74.0 Weakly correlated
35 AluSc 2 n.s 74.0 Weakly correlated
36 AluSp 2 n.s 74.0 Weakly correlated
37 AluSx3 2 n.s 74.0 Weakly correlated
38 L1M4 2 n.s 99.0 Weakly correlated
39 L1MA4 2 n.s 87.0 Weakly correlated
40 L1MB3 2 n.s 99.0 Weakly correlated
41 L1PA2 2 n.s 15.2 Weakly correlated
42 L1PA4 2 n.s 19.6 Weakly correlated
43 LTR12 2 ** 28.9 Weakly correlated
44 LTR13 2 ** 19.6 Weakly correlated
45 LTR16C 2 n.s 99.0 Weakly correlated
46 MER39B 2 ** 74.0 Weakly correlated
47 MER41B 2 * 74.0 Weakly correlated
48 MER50 2 * 43.0 Highly correlated
49 MER74A 2 ** 99.0 Weakly correlated
50 MIRc 2 n.s 99.0 Weakly correlated
51 MLT1B 2 n.s 99.0 Weakly correlated
52 MLT1L 2 n.s 99.0 Weakly correlated
53 MLT1N2 2 * 99.0 Weakly correlated
54 THE1C 2 n.s 43.0 Highly correlated
55 AluSc5 1 n.s 74.0 Weakly correlated
56 AluSg7 1 n.s 74.0 Weakly correlated
57 AluSq4 1 * 74.0 Weakly correlated
58 AluYa5 1 n.s 15.2 Weakly correlated
59 AluYh9 1 **** 15.2 Weakly correlated
60 AluYj4 1 n.s 0.0 Weakly correlated
61 AluYm1 1 n.s 19.6 Weakly correlated
62 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
63 ERVL-E-int 1 n.s 99.0 Weakly correlated
64 FLAM_C 1 n.s 74.0 Weakly correlated
65 FRAM 1 n.s 74.0 Weakly correlated
66 HAL1 1 n.s 99.0 Weakly correlated
67 HERV16-int 1 n.s 99.0 Weakly correlated
68 HERVIP10F-int 1 * 28.9 Weakly correlated
69 L1M1 1 n.s 74.0 Weakly correlated
70 L1M3c 1 * 99.0 Weakly correlated
71 L1M5 1 n.s 99.0 Weakly correlated
72 L1M7 1 n.s 99.0 Weakly correlated
73 L1MA3 1 n.s 74.0 Weakly correlated
74 L1MA5A 1 n.s 87.0 Weakly correlated
75 L1MA9 1 n.s 99.0 Weakly correlated
76 L1MB1 1 n.s 99.0 Weakly correlated
77 L1MC4 1 n.s 99.0 Weakly correlated
78 L1MC5a 1 n.s 99.0 Weakly correlated
79 L1MD2 1 n.s 99.0 Weakly correlated
80 L1MDa 1 n.s 99.0 Weakly correlated
81 L1ME1 1 n.s 99.0 Weakly correlated
82 L1ME2 1 n.s 99.0 Weakly correlated
83 L1ME2z 1 n.s 99.0 Weakly correlated
84 L1ME3B 1 n.s 99.0 Weakly correlated
85 L1ME4b 1 n.s 99.0 Weakly correlated
86 L1ME4c 1 n.s 99.0 Weakly correlated
87 L1MEb 1 * 99.0 Weakly correlated
88 L1MEc 1 n.s 99.0 Weakly correlated
89 L1MEd 1 n.s 99.0 Weakly correlated
90 L1P1 1 n.s 19.6 Weakly correlated
91 L1P2 1 n.s 28.9 Weakly correlated
92 L1P3 1 n.s 74.0 Weakly correlated
93 L1P4e 1 ** 74.0 Weakly correlated
94 L1PA10 1 n.s 74.0 Weakly correlated
95 L1PA13 1 n.s 74.0 Weakly correlated
96 L1PA14 1 n.s 74.0 Weakly correlated
97 L1PA3 1 n.s 19.6 Weakly correlated
98 L2-3_Crp 1 * 431.0 Weakly correlated
99 L3 1 n.s 99.0 Weakly correlated
100 LFSINE_Vert 1 ** 319.0 Weakly correlated
101 LTR12C 1 n.s 19.6 Weakly correlated
102 LTR12E 1 ** 19.6 Weakly correlated
103 LTR16A1 1 n.s 99.0 Weakly correlated
104 LTR16D1 1 *** 99.0 Weakly correlated
105 LTR16E2 1 * 99.0 Weakly correlated
106 LTR19A 1 ** 43.0 Highly correlated
107 LTR22A 1 *** 43.0 Highly correlated
108 LTR22B2 1 **** 28.9 Weakly correlated
109 LTR26C 1 ** 0.0 Weakly correlated
110 LTR2752 1 ** 43.0 Highly correlated
111 LTR31 1 ** 74.0 Weakly correlated
112 LTR45C 1 ** 99.0 Weakly correlated
113 LTR49-int 1 n.s 74.0 Weakly correlated
114 LTR5_Hs 1 * 0.0 Weakly correlated
115 MER4A1 1 n.s 74.0 Weakly correlated
116 MER4D1 1 n.s 74.0 Weakly correlated
117 MER51B 1 ** 43.0 Highly correlated
118 MER52A 1 n.s 74.0 Weakly correlated
119 MER57A1 1 * 43.0 Highly correlated
120 MER61E 1 ** 43.0 Highly correlated
121 MER66-int 1 * 43.0 Highly correlated
122 MER73 1 ** 87.0 Weakly correlated
123 MER74B 1 * 99.0 Weakly correlated
124 MIR1_Amn 1 n.s 319.0 Weakly correlated
125 MLT-int 1 ** 99.0 Weakly correlated
126 MLT1-int 1 *** 99.0 Weakly correlated
127 MLT1A0 1 n.s 99.0 Weakly correlated
128 MLT1C 1 n.s 94.0 Weakly correlated
129 MLT1D 1 n.s 99.0 Weakly correlated
130 MLT1G 1 n.s 99.0 Weakly correlated
131 MSTA 1 n.s 43.0 Highly correlated
132 MSTB2 1 * 74.0 Weakly correlated
133 MamRep1527 1 * 99.0 Weakly correlated
134 Plat_L3 1 * 99.0 Weakly correlated
135 SVA_F 1 n.s 0.0 Weakly correlated
136 THE1A 1 n.s 43.0 Highly correlated
137 THE1D 1 n.s 43.0 Highly correlated
138 THE1D-int 1 n.s 28.9 Weakly correlated
139 X6A_LINE 1 ** 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8B 458 **** 43.0 Highly correlated
2 LTR8A 152 **** 43.0 Highly correlated
3 LTR8 88 **** 43.0 Highly correlated
4 MLT1K 11 **** 99.0 Weakly correlated
5 L1MB2 11 **** 99.0 Weakly correlated
6 L2c 4 n.s 99.0 Weakly correlated
7 L2a 4 n.s 99.0 Weakly correlated
8 L1PA5 2 n.s 19.6 Weakly correlated
9 L2b 2 n.s 99.0 Weakly correlated
10 L2 2 n.s 99.0 Weakly correlated
11 L1PA15 2 n.s 74.0 Weakly correlated
12 MLT1B 1 n.s 99.0 Weakly correlated
13 MER61E 1 ** 43.0 Highly correlated
14 AluSg7 1 n.s 74.0 Weakly correlated
15 L1MA3 1 n.s 74.0 Weakly correlated
16 LTR5_Hs 1 * 0.0 Weakly correlated
17 L1ME4b 1 n.s 99.0 Weakly correlated
18 L1MEb 1 * 99.0 Weakly correlated
19 L1P4e 1 ** 74.0 Weakly correlated
20 HERVH-int 1 n.s 28.9 Weakly correlated
21 L1MB3 1 n.s 99.0 Weakly correlated
22 X6A_LINE 1 ** 99.0 Weakly correlated
23 L2-3_Crp 1 * 431.0 Weakly correlated
24 L1ME3D 1 n.s 99.0 Weakly correlated
25 MLT1J 1 n.s 99.0 Weakly correlated
26 MER74B 1 * 99.0 Weakly correlated
27 LTR16E2 1 * 99.0 Weakly correlated
28 LFSINE_Vert 1 ** 319.0 Weakly correlated
29 LTR31 1 ** 74.0 Weakly correlated
30 MLT1N2 1 n.s 99.0 Weakly correlated
31 MER4A1 1 n.s 74.0 Weakly correlated
32 L1ME3B 1 n.s 99.0 Weakly correlated
33 L1MA4 1 n.s 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR8 43.0 Highly correlated
2 LTR8A 43.0 Highly correlated
3 LTR8B 43.0 Highly correlated
4 MLT1K 99.0 Weakly correlated