ZRdb KZFP & Repeats
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Human_ZNF473

  • Protein
    Zinc finger protein 473
  • Length
    871
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q8WTR7
  • NCBI_ID
    25888
Sequence:
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..75
2 C2h2 209..231
3 dec2h2 265..286
4 C2h2 320..342
5 C2h2 347..369
6 C2h2 375..397
7 dec2h2 403..425
8 C2h2 431..453
9 C2h2 459..481
10 C2h2 487..509
11 C2h2 515..537
12 C2h2 562..584
13 C2h2 591..613
14 C2h2 646..668
15 C2h2 674..696
16 C2h2 702..724
17 C2h2 730..752
18 C2h2 758..780
19 C2h2 786..808
20 C2h2 814..836
21 C2h2 842..864
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component Cajal body
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Biological Process mRNA 3'-end processing by stem-loop binding and cleavage
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 11 **** 74.0 Weakly correlated
2 AluSc8 8 *** 74.0 Weakly correlated
3 AluJb 6 n.s 74.0 Weakly correlated
4 LTR8 6 **** 43.0 Highly correlated
5 AluYj4 5 **** 0.0 Weakly correlated
6 AluYm1 4 *** 19.6 Weakly correlated
7 FRAM 4 **** 74.0 Weakly correlated
8 LTR10A 4 **** 28.9 Weakly correlated
9 SVA_F 3 *** 0.0 Weakly correlated
10 MER21B 3 *** 99.0 Weakly correlated
11 LTR10F 3 **** 28.9 Weakly correlated
12 AluY 3 n.s 74.0 Weakly correlated
13 SVA_E 2 *** 0.0 Weakly correlated
14 AluYi6 1 *** 15.2 Weakly correlated
15 AluSz 1 n.s 74.0 Weakly correlated
16 SVA_D 1 n.s 15.2 Weakly correlated
17 MLT1L 1 n.s 99.0 Weakly correlated
18 AluYa8 1 *** 15.2 Weakly correlated
19 LTR13 1 * 19.6 Weakly correlated
20 LTR12C 1 n.s 19.6 Weakly correlated
21 L1MB8 1 n.s 99.0 Weakly correlated
22 LTR10B1 1 *** 28.9 Weakly correlated
23 HERV17-int 1 * 28.9 Weakly correlated
24 L2c 1 n.s 99.0 Weakly correlated
25 L2a 1 n.s 99.0 Weakly correlated
26 L1PA2 1 n.s 15.2 Weakly correlated
27 L1P4 1 n.s 74.0 Weakly correlated
28 L1M3 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 2 ** 0.0 Weakly correlated
2 FRAM 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP